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Refinement technique validation

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https://www.readbyqxmd.com/read/29217875/deep-auto-context-convolutional-neural-networks-for-standard-dose-pet-image-estimation-from-low-dose-pet-mri
#1
Lei Xiang, Yu Qiao, Dong Nie, Le An, Qian Wang, Dinggang Shen
Positron emission tomography (PET) is an essential technique in many clinical applications such as tumor detection and brain disorder diagnosis. In order to obtain high-quality PET images, a standard-dose radioactive tracer is needed, which inevitably causes the risk of radiation exposure damage. For reducing the patient's exposure to radiation and maintaining the high quality of PET images, in this paper, we propose a deep learning architecture to estimate the high-quality standard-dose PET (SPET) image from the combination of the low-quality low-dose PET (LPET) image and the accompanying T1-weighted acquisition from magnetic resonance imaging (MRI)...
December 6, 2017: Neurocomputing
https://www.readbyqxmd.com/read/29214150/the-physiocam-a-novel-non-contact-sensor-to-measure-heart-rate-variability-in-clinical-and-field-applications
#2
Maria I Davila, Gregory F Lewis, Stephen W Porges
Heart rate variability (HRV) is a reliable indicator of health status and a sensitive index of autonomic stress reactivity. Stress negatively affects physical and psychological wellness by decreasing cardiovascular health and reducing quality of life. Wearable sensors have made it possible to track HRV during daily activity, and recent advances in mobile technology have reduced the cost and difficulty of applying this powerful technique. Although advances have made sensors smaller and lighter, some burden on the subject remains...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29211952/a-profilometry-based-dentifrice-abrasion-method-for-v8-brushing-machines-part-iii-multi-laboratory-validation-testing-of-rda-pe
#3
Eva Schneiderman, Ellen L Colón, Donald J White, Bruce Schemehorn, Tara Ganovsky, Amir Haider, Franklin Garcia-Godoy, Brian R Morrow, Viritpon Srimaneepong, Sujin Chumprasert
OBJECTIVES: We have previously reported on progress toward the refinement of profilometry-based abrasivity testing of dentifrices using a V8 brushing machine and tactile or optical measurement of dentin wear. The general application of this technique may be advanced by demonstration of successful inter-laboratory confirmation of the method. The objective of this study was to explore the capability of different laboratories in the assessment of dentifrice abrasivity using a profilometry-based evaluation technique developed in our Mason laboratories...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29193299/improved-parallel-image-reconstruction-using-feature-refinement
#4
Jing Cheng, Sen Jia, Leslie Ying, Yuanyuan Liu, Shanshan Wang, Yanjie Zhu, Ye Li, Chao Zou, Xin Liu, Dong Liang
PURPOSE: The aim of this study was to develop a novel feature refinement MR reconstruction method from highly undersampled multichannel acquisitions for improving the image quality and preserve more detail information. THEORY AND METHODS: The feature refinement technique, which uses a feature descriptor to pick up useful features from residual image discarded by sparsity constrains, is applied to preserve the details of the image in compressed sensing and parallel imaging in MRI (CS-pMRI)...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29185988/saliency-detection-based-on-multiscale-extrema-of-local-perceptual-color-differences
#5
Keigo Ishikura, Naoto Kurita, Damon M Chandler, Gosuke Ohashi
Visual saliency detection is a useful technique for predicting, which regions humans will tend to gaze upon in any given image. Over the last several decades, numerous algorithms for automatic saliency detection have been proposed and shown to work well on both synthetic and natural images. However, two key challenges remain largely unaddressed: 1) How to improve the relatively low predictive performance for images that contain large objects and 2) how to perform saliency detection on a wider variety of images from various categories without training...
February 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29180485/validation-of-whole-room-indirect-calorimeters-refinement-of-current-methodologies
#6
Russell Rising, Thomas Foerster, Avigdor D Arad, Jeanine Albu, Xavier Pi-Sunyer
Whole room indirect calorimeter (WRIC) validation techniques consist of propane combustion (PC) or infusion of mixed carbon dioxide (CO2) and nitrogen (N2) by a precision blender (PB). To determine the best method, PC of 6, 10, 22-h and PB infusions of 6, 10, and 14-h, were conducted. The 14-h infusion consisted of two metabolic settings. Energy expenditure (EE; kJ), ventilation (V; liters/min) of oxygen (VO2), VCO2, and respiratory quotient (VCO2/VO2) obtained from the WRIC were extrapolated to the respective test durations and compared to similarly calculated values...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29178983/hypofractionated-radiotherapy-for-prostate-cancer-in-the-postoperative-setting-what-is-the-evidence-so-far
#7
REVIEW
Cristina Picardi, Ioan Perret, Raymond Miralbell, Thomas Zilli
Postoperative external beam radiation therapy (EBRT) is a validated treatment option in the adjuvant setting for prostate cancer patients with aggressive pathological features following radical prostatectomy (RP) or as salvage modality in patients with biochemical recurrence after RP. Contemporary randomized phase III trials have provided evidence for using hypofractionation in the definitive treatment setting as an alternative to standard fractionated regimens. Biomathematical modeling for prostate cancer fractionated EBRT associated with widely available refined treatment delivery techniques such as volumetric modulated-arc therapy with image-guided RT may improve the therapeutic ratio...
November 14, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29150665/a-streamlined-cloning-workflow-minimising-the-time-to-strain-pipeline-for-pichia-pastoris
#8
Kate E Royle, Karen Polizzi
Although recent advances in E. coli self-assembly have greatly simplified cloning, these have not yet been harnessed for the high-throughput generation of expression strains in the early research and discovery phases of biopharmaceutical production. Here, we have refined the technique and incorporated it into a streamlined workflow for the generation of Pichia pastoris expression strains, reducing the timeline by a third and removing the reliance on DNA editing enzymes, which often require troubleshooting and increase costs...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29149813/structural-analysis-of-cd59-of-chinese-tree-shrew-a-new-reference-molecule-for-human-immune-system-specific-cd59-drug-discovery
#9
Subhamay Panda, Leena Kumari, Santamay Panda
BACKGROUND: Chinese tree shrews (Tupaia belangeri chinensis) bear several characteristics that are considered to be very crucial for utilizing in animal experimental models in biomedical research. Subsequent to the identification of key aspects and signaling pathways in nervous and immune systems, it is revealed that tree shrews acquires shared common as well as unique characteristics, and hence offers a genetic basis for employing this animal as a prospective model for biomedical research...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29142619/the-formation-of-extragraft-bone-bridging-after-anterior-cervical-discectomy-and-fusion-a-finite-element-analysis
#10
Shin Won Kwon, Chi Heon Kim, Chun Kee Chung, Tae Hyun Park, Su Heon Woo, Sung-Jae Lee, Seung Heon Yang
Objective: In addition to bone bridging inside a cage or graft (intragraft bone bridging, InGBB), extragraft bone bridging (ExGBB) is commonly observed after anterior cervical discectomy and fusion (ACDF) with a stand-alone cage. However, solid bony fusion without the formation of ExGBB might be a desirable condition. We hypothesized that an insufficient contact area for InGBB might be a causative factor for ExGBB. The objective was to determine the minimal area of InGBB by finite element analysis...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29117033/challenges-of-cerebral-perfusion-pressure-measurement
#11
Sarah L Livesay, Molly M McNett, Monica Keller, DaiWai M Olson
Monitoring cerebral perfusion pressure (CPP) is recommended by a number of clinical practice guidelines and is a routine function performed by critical care neuroscience nurses. However, several studies highlight theoretical and practice variations in the measurement of CPP regarding the location of the arterial pressure transducer during measurement. Agreement on the technique and process for obtaining valid measurements is lacking. This article identifies the challenges associated with CPP measurement and highlights opportunities for standardizing CPP measurement to improve consistency in care and findings reported in the research literature...
December 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29103820/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#12
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
November 3, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29049436/minimal-nasolabial-incision-technique-for-nasolabial-fold-modification-in-patients-with-facial-paralysis
#13
Callum Faris, Alyssa Heiser, Nate Jowett, Tessa Hadlock
Importance: Creation of symmetrical nasolabial folds (NLFs) is important in the management of the paralyzed face. Established techniques use a linear incision in the NLF, and technical refinements now allow the linear incision to be omitted. Design, Setting, and Participants: This retrospective case series was conducted in a tertiary care setting from February 2, 2017, to June 7, 2017. Participants were all patients (N = 21) with peripheral facial paralysis who underwent NLF modification that used the minimal nasolabial incision technique at the Massachusetts Eye and Ear Infirmary Facial Nerve Center from February 1, 2015, through August 31, 2016...
October 12, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29045407/bayesian-refinement-of-protein-structures-and-ensembles-against-saxs-data-using-molecular-dynamics
#14
Roman Shevchuk, Jochen S Hub
Small-angle X-ray scattering is an increasingly popular technique used to detect protein structures and ensembles in solution. However, the refinement of structures and ensembles against SAXS data is often ambiguous due to the low information content of SAXS data, unknown systematic errors, and unknown scattering contributions from the solvent. We offer a solution to such problems by combining Bayesian inference with all-atom molecular dynamics simulations and explicit-solvent SAXS calculations. The Bayesian formulation correctly weights the SAXS data versus prior physical knowledge, it quantifies the precision or ambiguity of fitted structures and ensembles, and it accounts for unknown systematic errors due to poor buffer matching...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29036653/mircarta-a-central-repository-for-collecting-mirna-candidates
#15
Christina Backes, Tobias Fehlmann, Fabian Kern, Tim Kehl, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
The continuous increase of available biological data as consequence of modern high-throughput technologies poses new challenges for analysis techniques and database applications. Especially for miRNAs, one class of small non-coding RNAs, many algorithms have been developed to predict new candidates from next-generation sequencing data. While the amount of publications describing novel miRNA candidates keeps steadily increasing, the current gold standard database for miRNAs - miRBase - has not been updated since June 2014...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29031299/marker-discovery-in-volatolomics-based-on-systematic-alignment-of-gc-ms-signals-application-to-food-authentication
#16
S Abou-El-Karam, J Ratel, N Kondjoyan, C Truan, E Engel
Starting with an experiment to authenticate walnut oils based on GC-MS analysis of the volatolome, this paper aims to demonstrate the relevance of a two-step alignment-based strategy for the systematic research of VOC markers. The first step of the treatment consists of roughly reducing the time shifts with efficient, known warping techniques like COW (Correlation Optimized Warping). The second step relies on an accurate peak apex alignment in order to refine residual local misalignments and to enable further systematic marker research through univariate or multivariate data treatments...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28987989/automated-framework-for-accurate-segmentation-of-pressure-ulcer-images
#17
Begonya Garcia-Zapirain, Ahmed Shalaby, Ayman El-Baz, Adel Elmaghraby
Ulcer tissue segmentation is of immense importance in helping medical personnel to assess wounds. This paper introduces a new computational framework employing state-of-the-art image processing techniques to segment pressure ulcer tissue structures from color images. The framework integrates a visual appearance model of an observed input image with prior color information from an available database of previously stored color RGB images. The following four processing steps are performed. First, to minimize the execution time and enhance the segmentation accuracy, a region-of-interest (ROI) of the whole ulcer area is automatically identified based on contrast changes...
September 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28972426/an-investigation-of-a-novel-tendon-transfer-surgery-for-high-median-ulnar-nerve-palsy-in-a-chicken-model
#18
Geoffrey R Browning, Anthony H Le, Jennifer J Warnock, Ravi Balasubramanian
PURPOSE: The state-of-the-art tendon transfer surgery for high median-ulnar nerve palsy involves directly suturing four finger flexor tendons to one wrist extensor muscle. This couples finger flexion limiting the patient's ability to grasp objects. Therefore, we propose a new approach to attach a novel passive implant to the extensor digitorum longus tendon in order to create a differential mechanism in situ. The implant is expected to enable the fingers to adapt to an object's shape during grasping...
October 3, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28958204/application-of-the-delphi-technique-in-healthcare-maintenance
#19
Stanley Njuangang, Champika Liyanage, Akintola Akintoye
Purpose The purpose of this paper is to examine the research design, issues and considerations in the application of the Delphi technique to identify, refine and rate the critical success factors and performance measures in maintenance-associated infections. Design/methodology/approach In-depth literature review through the application of open and axial coding were applied to formulate the interview and research questions. These were used to conduct an exploratory case study of two healthcare maintenance managers, randomly selected from two National Health Service Foundation Trusts in England...
October 9, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28950471/grid-refinement-for-aeroacoustics-in-the-lattice-boltzmann-method-a-directional-splitting-approach
#20
Félix Gendre, Denis Ricot, Guillaume Fritz, Pierre Sagaut
This study focuses on grid refinement techniques for the direct simulation of aeroacoustics, when using weakly compressible lattice Boltzmann models, such as the D3Q19 athermal velocity set. When it comes to direct noise computation, very small errors on the density or pressure field may have great negative consequences. Even strong acoustic density fluctuations have indeed a clearly lower amplitude than the hydrodynamic ones. This work deals with such very weak spurious fluctuations that emerge when a vortical structure crosses a refinement interface, which may contaminate the resulting aeroacoustic field...
August 2017: Physical Review. E
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