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Refinement technique validation

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https://www.readbyqxmd.com/read/29445267/a-patient-and-community-centered-approach-selecting-endpoints-for-a-randomized-trial-of-a-novel-advance-care-planning-tool
#1
John Fp Bridges, Norah L Crossnohere, Anne L Schuster, Judith A Miller, Carolyn Pastorini, Rebecca A Aslakson
Background: Despite a movement toward patient-centered outcomes, best practices on how to gather and refine patients' perspectives on research endpoints are limited. Advanced care planning (ACP) is inherently patient centered and would benefit from patient prioritization of endpoints for ACP-related tools and studies. Objective: This investigation sought to prioritize patient-centered endpoints for the content and evaluation of an ACP video being developed for patients undergoing major surgery...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29398308/transthoracic-ultrasound-evaluation-of-arch-and-descending-thoracic-aortic-pathology
#2
Fabrizio D'Abate, Dare Oladokun, Angelo La Leggia, Robert Hinchliffe, Matthew Thompson, Peter Holt, Jorg de Bruin, Ian Loftus, Benjamin Patterson
BACKGROUND: Duplex ultrasonography (DUS) currently has limited applicability in the diagnosis and surveillance of thoracic aortic pathologies because of associated limitations. This study investigates the feasibility of using an optimised DUS protocol to detect descending thoracic aortic pathology. METHODS: Forty patients were scanned (20 cases and 20 controls). All patients but one had a technically adequate assessment of the thoracic aorta (at least one view of the descending thoracic aorta)...
February 2, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29392383/intramedullary-nailing-in-opening-wedge-high-tibial-osteotomy-in-vitro-test-for-validation-of-a-method-of-fixation
#3
Rene Burchard, Denise Katerla, Marina Hammer, Anke Pahlkötter, Christian Soost, Gerhard Dietrich, Arne Ohrndorf, Wolfgang Richter, Markus Lengsfeld, Hans-Jürgen Christ, Jan Adriaan Graw, Claus-Peter Fritzen
PURPOSE: Opening wedge high tibial osteotomy (HTO) as a treatment in unicompartimental osteoarthritis of the knee can significantly relieve pain and prevent or at least delay an early joint replacement. The fixation of the osteotomy has undergone development and refinements during the last years. The angle-stable plate fixator is currently one of the most commonly used plates in HTOs. The angular stable fixation between screws and the plate offers a high primary stability to retain the correction with early weight-bearing protocols...
February 1, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29375704/diagnosis-and-treatment-of-a-carotid-body-tumor-a-case-report-of-a-rare-bilateral-tumor
#4
Qiang Sun, Chenlu Xie, Zhixing Niu, Lei Su, Xi Wang, Zheng Fang, Junfang Zhao, Shuai Chen, Xinming Li, Minglei Sun
In the present case report, a rare bilateral carotid body tumor (CBT) and the imaging and pathological features of a CBT are described. In the present report, a rare case of bilateral carotid body tumor, which developed in the bifurcation of the common carotid artery, and the clinical manifestations, imaging and pathological features of this CBT are summarized. The imaging cannot validate the diagnosis; however, imaging identified that the tumor exhibited an intact envelope. Immunohistochemical staining revealed that the tumor cells were strongly positive for cluster of differentiation 56, Syn and protein S-100, moderately positive for transcription factor E3, negative for cytokeratin and epithelial membrane antigen, and partial cells were weakly positive for Desmir (<5%)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29369851/psychometric-properties-of-the-glaucoma-treatment-compliance-assessment-tool-gtcat-in-a-brazilian-population
#5
Ricardo Y Abe, Lorena de Campos Wen, Gordon T Barker, Steven L Mansberger
PURPOSE: To determine the psychometric properties of a reduced-version of the Glaucoma Treatment Compliance Assessment Tool, which was translated to Brazilian Portuguese. PATIENTS AND METHODS: We translated into Portuguese the Glaucoma Treatment Compliance Assessment Tool using validated techniques and administered it to primary open glaucoma patients using at least 1 ocular hypotensive eye drop medication. We used principal components analysis to determine construct validity, Rasch analysis and Cronbach's alpha for internal consistency reliability, frequency analysis for floor and ceiling effects, and Spearman rho for test-retest reliability...
January 24, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29284544/comprehensive-measurement-of-stroke-gait-characteristics-with-a-single-accelerometer-in-the-laboratory-and-community-a-feasibility-validity-and-reliability-study
#6
Sarah A Moore, Aodhan Hickey, Sue Lord, Silvia Del Din, Alan Godfrey, Lynn Rochester
BACKGROUND: Application of objective measurement of stroke gait with accelerometer-based wearable technology and associated algorithms is increasing, despite reports questioning the accuracy of this technique in quantifying specific stroke-related gait impairments. The aim of this study is to determine the feasibility, validity and reliability of a low-cost open-source system incorporating algorithms and a single tri-axial accelerometer-based wearable to quantify gait characteristics in the laboratory and community post-stroke...
December 29, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29273100/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#7
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29244762/towards-realistic-urban-traffic-experiments-using-dfrouter-heuristic-validation-and-extensions
#8
Jorge Luis Zambrano-Martinez, Carlos T Calafate, David Soler, Juan-Carlos Cano
Traffic congestion is an important problem faced by Intelligent Transportation Systems (ITS), requiring models that allow predicting the impact of different solutions on urban traffic flow. Such an approach typically requires the use of simulations, which should be as realistic as possible. However, achieving high degrees of realism can be complex when the actual traffic patterns, defined through an Origin/Destination (O-D) matrix for the vehicles in a city, remain unknown. Thus, the main contribution of this paper is a heuristic for improving traffic congestion modeling...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29238747/protocol-for-analyzing-protein-ensemble-structures-from-chemical-cross-links-using-dynaxl
#9
Zhou Gong, Zhu Liu, Xu Dong, Yue-He Ding, Meng-Qiu Dong, Chun Tang
Chemical cross-linking coupled with mass spectroscopy (CXMS) is a powerful technique for investigating protein structures. CXMS has been mostly used to characterize the predominant structure for a protein, whereas cross-links incompatible with a unique structure of a protein or a protein complex are often discarded. We have recently shown that the so-called over-length cross-links actually contain protein dynamics information. We have thus established a method called DynaXL, which allow us to extract the information from the over-length cross-links and to visualize protein ensemble structures...
2017: Biophysics Reports
https://www.readbyqxmd.com/read/29231960/prospective-validation-of-a-screening-tool-to-identify-older-adults-in-need-of-a-driving-evaluation
#10
Marian E Betz, Jason S Haukoos, Robert Schwartz, Carolyn DiGuiseppi, Deepika Kandasamy, Brenda Beaty, Elizabeth Juarez-Colunga, David B Carr
OBJECTIVES: To prospectively validate and refine the 5-item "CRASH" screening tool for identifying older drivers needing a behind-the-wheel (BTW) test. DESIGN: Prospective observational study. SETTING: Geriatric and internal medicine primary care clinics affiliated with a tertiary care hospital and a local BTW program. PARTICIPANTS: Cognitively intact drivers aged 65 and older (N = 315). MEASUREMENTS: Participants completed baseline questionnaire (including CRASH tool) and assessments and BTW test (evaluator blinded to questionnaire results) and participated in 1-month telephone follow-up...
December 12, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29217875/deep-auto-context-convolutional-neural-networks-for-standard-dose-pet-image-estimation-from-low-dose-pet-mri
#11
Lei Xiang, Yu Qiao, Dong Nie, Le An, Qian Wang, Dinggang Shen
Positron emission tomography (PET) is an essential technique in many clinical applications such as tumor detection and brain disorder diagnosis. In order to obtain high-quality PET images, a standard-dose radioactive tracer is needed, which inevitably causes the risk of radiation exposure damage. For reducing the patient's exposure to radiation and maintaining the high quality of PET images, in this paper, we propose a deep learning architecture to estimate the high-quality standard-dose PET (SPET) image from the combination of the low-quality low-dose PET (LPET) image and the accompanying T1-weighted acquisition from magnetic resonance imaging (MRI)...
December 6, 2017: Neurocomputing
https://www.readbyqxmd.com/read/29214150/the-physiocam-a-novel-non-contact-sensor-to-measure-heart-rate-variability-in-clinical-and-field-applications
#12
Maria I Davila, Gregory F Lewis, Stephen W Porges
Heart rate variability (HRV) is a reliable indicator of health status and a sensitive index of autonomic stress reactivity. Stress negatively affects physical and psychological wellness by decreasing cardiovascular health and reducing quality of life. Wearable sensors have made it possible to track HRV during daily activity, and recent advances in mobile technology have reduced the cost and difficulty of applying this powerful technique. Although advances have made sensors smaller and lighter, some burden on the subject remains...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29211952/a-profilometry-based-dentifrice-abrasion-method-for-v8-brushing-machines-part-iii-multi-laboratory-validation-testing-of-rda-pe
#13
Eva Schneiderman, Ellen L Colón, Donald J White, Bruce Schemehorn, Tara Ganovsky, Amir Haider, Franklin Garcia-Godoy, Brian R Morrow, Viritpon Srimaneepong, Sujin Chumprasert
OBJECTIVES: We have previously reported on progress toward the refinement of profilometry-based abrasivity testing of dentifrices using a V8 brushing machine and tactile or optical measurement of dentin wear. The general application of this technique may be advanced by demonstration of successful inter-laboratory confirmation of the method. The objective of this study was to explore the capability of different laboratories in the assessment of dentifrice abrasivity using a profilometry-based evaluation technique developed in our Mason laboratories...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29193299/improved-parallel-image-reconstruction-using-feature-refinement
#14
Jing Cheng, Sen Jia, Leslie Ying, Yuanyuan Liu, Shanshan Wang, Yanjie Zhu, Ye Li, Chao Zou, Xin Liu, Dong Liang
PURPOSE: The aim of this study was to develop a novel feature refinement MR reconstruction method from highly undersampled multichannel acquisitions for improving the image quality and preserve more detail information. THEORY AND METHODS: The feature refinement technique, which uses a feature descriptor to pick up useful features from residual image discarded by sparsity constrains, is applied to preserve the details of the image in compressed sensing and parallel imaging in MRI (CS-pMRI)...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29185988/saliency-detection-based-on-multiscale-extrema-of-local-perceptual-color-differences
#15
Keigo Ishikura, Naoto Kurita, Damon M Chandler, Gosuke Ohashi
Visual saliency detection is a useful technique for predicting, which regions humans will tend to gaze upon in any given image. Over the last several decades, numerous algorithms for automatic saliency detection have been proposed and shown to work well on both synthetic and natural images. However, two key challenges remain largely unaddressed: 1) How to improve the relatively low predictive performance for images that contain large objects and 2) how to perform saliency detection on a wider variety of images from various categories without training...
February 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29180485/validation-of-whole-room-indirect-calorimeters-refinement-of-current-methodologies
#16
Russell Rising, Thomas Foerster, Avigdor D Arad, Jeanine Albu, Xavier Pi-Sunyer
Whole room indirect calorimeter (WRIC) validation techniques consist of propane combustion (PC) or infusion of mixed carbon dioxide (CO2) and nitrogen (N2) by a precision blender (PB). To determine the best method, PC of 6, 10, 22-h and PB infusions of 6, 10, and 14-h, were conducted. The 14-h infusion consisted of two metabolic settings. Energy expenditure (EE; kJ), ventilation (V; liters/min) of oxygen (VO2), VCO2, and respiratory quotient (VCO2/VO2) obtained from the WRIC were extrapolated to the respective test durations and compared to similarly calculated values...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29178983/hypofractionated-radiotherapy-for-prostate-cancer-in-the-postoperative-setting-what-is-the-evidence-so-far
#17
REVIEW
Cristina Picardi, Ioan Perret, Raymond Miralbell, Thomas Zilli
Postoperative external beam radiation therapy (EBRT) is a validated treatment option in the adjuvant setting for prostate cancer patients with aggressive pathological features following radical prostatectomy (RP) or as salvage modality in patients with biochemical recurrence after RP. Contemporary randomized phase III trials have provided evidence for using hypofractionation in the definitive treatment setting as an alternative to standard fractionated regimens. Biomathematical modeling for prostate cancer fractionated EBRT associated with widely available refined treatment delivery techniques such as volumetric modulated-arc therapy with image-guided RT may improve the therapeutic ratio...
January 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29150665/a-streamlined-cloning-workflow-minimising-the-time-to-strain-pipeline-for-pichia-pastoris
#18
Kate E Royle, Karen Polizzi
Although recent advances in E. coli self-assembly have greatly simplified cloning, these have not yet been harnessed for the high-throughput generation of expression strains in the early research and discovery phases of biopharmaceutical production. Here, we have refined the technique and incorporated it into a streamlined workflow for the generation of Pichia pastoris expression strains, reducing the timeline by a third and removing the reliance on DNA editing enzymes, which often require troubleshooting and increase costs...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29149813/structural-analysis-of-cd59-of-chinese-tree-shrew-a-new-reference-molecule-for-human-immune-system-specific-cd59-drug-discovery
#19
Subhamay Panda, Leena Kumari, Santamay Panda
BACKGROUND: Chinese tree shrews (Tupaia belangeri chinensis) bear several characteristics that are considered to be very crucial for utilizing in animal experimental models in biomedical research. Subsequent to the identification of key aspects and signaling pathways in nervous and immune systems, it is revealed that tree shrews acquires shared common as well as unique characteristics, and hence offers a genetic basis for employing this animal as a prospective model for biomedical research...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29142619/the-formation-of-extragraft-bone-bridging-after-anterior-cervical-discectomy-and-fusion-a-finite-element-analysis
#20
Shin Won Kwon, Chi Heon Kim, Chun Kee Chung, Tae Hyun Park, Su Heon Woo, Sung-Jae Lee, Seung Heon Yang
Objective: In addition to bone bridging inside a cage or graft (intragraft bone bridging, InGBB), extragraft bone bridging (ExGBB) is commonly observed after anterior cervical discectomy and fusion (ACDF) with a stand-alone cage. However, solid bony fusion without the formation of ExGBB might be a desirable condition. We hypothesized that an insufficient contact area for InGBB might be a causative factor for ExGBB. The objective was to determine the minimal area of InGBB by finite element analysis...
November 2017: Journal of Korean Neurosurgical Society
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