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Refinement technique validation

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https://www.readbyqxmd.com/read/29651095/validation-of-ultrasound-bioimaging-to-predict-worm-burden-and-treatment-efficacy-in-preclinical-filariasis-drug-screening-models
#1
Amy E Marriott, Hanna Sjoberg, Hayley Tyrer, Joanne Gamble, Emma Murphy, John Archer, Andrew Steven, Mark J Taylor, Joseph D Turner
Filariasis is a global health problem targeted for elimination. Curative drugs (macrofilaricides) are required to accelerate elimination. Candidate macrofilaricides require testing in preclinical models of filariasis. The incidence of infection failures and high intra-group variation means that large group sizes are required for drug testing. Further, a lack of accurate, quantitative adult biomarkers results in protracted timeframes or multiple groups for endpoint analyses. Here we evaluate intra-vital ultrasonography (USG) to identify B...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615360/abr-psychometric-testing-analysis-of-validity-and-effects
#2
Lincoln L Berland, Nancy W Berland, Matthew W Berland
Changes in the certification program of the ABR were first described in some detail in 2008 and have since undergone refinements. Controversies surrounding these changes have included the relevance of test questions, costs, effects of altering the examination scheduling, residency program curriculum changes, and issues related to preparing for the examinations. However, the role of psychometric testing in radiology itself, as the technical foundation for the new ABR Core and Certification Examinations, has undergone less scrutiny...
March 31, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29606592/validating-resolution-revolution
#3
Piotr Neumann, Achim Dickmanns, Ralf Ficner
Recent advances in instrumentation and image-processing software have resulted in a resolution revolution in cryo-electron microscopy (cryo-EM) and a surge in the popularity of this technique. However, despite technical progress and hundreds of structures determined so far, development of standards assessing the agreement between the cryo-EM map and the respective model has fallen behind. Here we establish a validation procedure evaluating this agreement and applied it to a set of 565 cryo-EM structures. Analysis of the results revealed that three-quarters of the validated structures exhibit moderate or low agreement between the map and the corresponding model, mostly due to limited structural features possessed by these maps...
March 19, 2018: Structure
https://www.readbyqxmd.com/read/29587437/research-on-strong-clutter-suppression-for-gaofen-3-dual-channel-sar-gmti
#4
Mingjie Zheng, He Yan, Lei Zhang, Weidong Yu, Yunkai Deng, Robert Wang
In spaceborne synthetic aperture radar (SAR), moving targets are almost buried in ground clutter due to the wide clutter Doppler spectrum and the restricted pulse repetition frequency (PRF), which increases the difficulty of moving target detection. Clutter suppression is one of the key issues in the spaceborne SAR moving target indicator operation. In this paper, we describe the clutter suppression principle and analyze the influence of amplitude and phase error on clutter suppression. In the following, a novel dual-channel SAR clutter suppression algorithm is proposed, which is suitable for the Gaofen-3(GF-3) SAR sensor...
March 26, 2018: Sensors
https://www.readbyqxmd.com/read/29567658/establishment-of-signaling-interactions-with-cellular-resolution-for-every-cell-cycle-of-embryogenesis
#5
Long Chen, Vincy Wing Sze Ho, Ming-Kin Wong, Xiaotai Huang, Lu-Yan Chan, Hon Chun Kaoru Ng, Xiaoliang Ren, Hong Yan, Zhongying Zhao
Intercellular signaling interaction plays a key role in breaking fate symmetry during animal development. Identification of the signaling interaction at cellular resolution is technically challenging, especially in a developing embryo. Here we develop a platform that allows automated inference and validation of signaling interaction for every cell cycle of C. elegans embryogenesis. This is achieved by generation of a systems-level cell contact map that consists of 1,114 highly confident intercellular contacts by modeling analysis and is validated through cell membrane labeling coupled with cell lineage analysis...
March 22, 2018: Genetics
https://www.readbyqxmd.com/read/29554360/evaluation-of-intranasal-flap-perfusion-by-intraoperative-indocyanine-green-fluorescence-angiography
#6
Mathew Geltzeiler, Ana Carolina Igami Nakassa, Meghan Turner, Pradeep Setty, George Zenonos, Andrea Hebert, Eric Wang, Juan Fernandez-Miranda, Carl Snyderman, Paul Gardner
BACKGROUND: Vascularized intranasal flaps are the primary reconstructive option for endoscopic skull base defects. Flap vascularity may be compromised by injury to the pedicle or prior endonasal surgery. There is currently no validated technique for intraoperative evaluation of intranasal flap viability. OBJECTIVE: To evaluate the efficacy of indocyanine green (ICG) near-infrared angiography in predicting the viability of pedicled intranasal flaps during endoscopic skull base surgery through a pilot study...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29512144/thy1-yfp-h-mice-and-the-parallel-rod-floor-test-to-evaluate-short-and-long-term-progression-of-traumatic-brain-injury
#7
Monique Richter, María Luciana Negro-Demontel, Daniela Blanco-Ocampo, Eliseo Taranto, Natalia Lago, Hugo Peluffo
Traumatic brain injury (TBI) is a leading cause of death and disability and is a risk factor for the later development of neuropsychiatric disorders and neurodegenerative diseases. Many models of TBI have been developed, but their further refinement and a more detailed long-term follow-up is needed. We have used the Thy1-YFP-H transgenic mouse line and the parallel rod floor test to produce an unbiased and robust method for the evaluation of the multiple effects of a validated model of controlled cortical injury...
February 21, 2018: Current Protocols in Immunology
https://www.readbyqxmd.com/read/29500143/resident-wellness-and-social-support-development-and-cognitive-validation-of-a-resident-social-capital-assessment-tool
#8
Stephen J Kaplan, Heather M Seabott, Erika B Cunningham, James D Helman, Alvin Calderon, Richard C Thirlby, Kimberly D Schenarts
OBJECTIVE: The purpose of this study is to develop and generate validity evidence for an instrument to measure social capital in residents. DESIGN: Mixed-methods, phased approach utilizing a modified Delphi technique, focus groups, and cognitive interviews. SETTING: Four residency training institutions in Washington state between February 2016 and March 2017. PARTICIPANTS: General surgery, anesthesia, and internal medicine residents ranging from PGY-1 to PGY-6...
February 27, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29492697/gene-editing-by-crispr-cas9-in-the-obligatory-outcrossing-medicago-sativa
#9
Ruimin Gao, Biruk A Feyissa, Mana Croft, Abdelali Hannoufa
The CRISPR/Cas9 technique was successfully used to edit the genome of the obligatory outcrossing plant species Medicago sativa L. (alfalfa). RNA-guided genome engineering using Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR)/Cas9 technology enables a variety of applications in plants. Successful application and validation of the CRISPR technique in a multiplex genome, such as that of M. sativa (alfalfa) will ultimately lead to major advances in the improvement of this crop. We used CRISPR/Cas9 technique to mutate squamosa promoter binding protein like 9 (SPL9) gene in alfalfa...
February 28, 2018: Planta
https://www.readbyqxmd.com/read/29445267/a-patient-and-community-centered-approach-selecting-endpoints-for-a-randomized-trial-of-a-novel-advance-care-planning-tool
#10
John Fp Bridges, Norah L Crossnohere, Anne L Schuster, Judith A Miller, Carolyn Pastorini, Rebecca A Aslakson
Background: Despite a movement toward patient-centered outcomes, best practices on how to gather and refine patients' perspectives on research endpoints are limited. Advanced care planning (ACP) is inherently patient centered and would benefit from patient prioritization of endpoints for ACP-related tools and studies. Objective: This investigation sought to prioritize patient-centered endpoints for the content and evaluation of an ACP video being developed for patients undergoing major surgery...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29398308/transthoracic-ultrasound-evaluation-of-arch-and-descending-thoracic-aortic-pathology
#11
Fabrizio D'Abate, Dare Oladokun, Angelo La Leggia, Robert Hinchliffe, Matthew Thompson, Peter Holt, Jorg de Bruin, Ian Loftus, Benjamin Patterson
BACKGROUND: Duplex ultrasonography (DUS) currently has limited applicability in the diagnosis and surveillance of thoracic aortic pathologies because of associated limitations. This study investigates the feasibility of using an optimised DUS protocol to detect descending thoracic aortic pathology. METHODS: Forty patients were scanned (20 cases and 20 controls). All patients but one had a technically adequate assessment of the thoracic aorta (at least one view of the descending thoracic aorta)...
February 2, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29392383/intramedullary-nailing-in-opening-wedge-high-tibial-osteotomy-in-vitro-test-for-validation-of-a-method-of-fixation
#12
Rene Burchard, Denise Katerla, Marina Hammer, Anke Pahlkötter, Christian Soost, Gerhard Dietrich, Arne Ohrndorf, Wolfgang Richter, Markus Lengsfeld, Hans-Jürgen Christ, Jan Adriaan Graw, Claus-Peter Fritzen
PURPOSE: Opening wedge high tibial osteotomy (HTO) as a treatment in unicompartimental osteoarthritis of the knee can significantly relieve pain and prevent or at least delay an early joint replacement. The fixation of the osteotomy has undergone development and refinements during the last years. The angle-stable plate fixator is currently one of the most commonly used plates in HTOs. The angular stable fixation between screws and the plate offers a high primary stability to retain the correction with early weight-bearing protocols...
February 1, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29375704/diagnosis-and-treatment-of-a-carotid-body-tumor-a-case-report-of-a-rare-bilateral-tumor
#13
Qiang Sun, Chenlu Xie, Zhixing Niu, Lei Su, Xi Wang, Zheng Fang, Junfang Zhao, Shuai Chen, Xinming Li, Minglei Sun
In the present case report, a rare bilateral carotid body tumor (CBT) and the imaging and pathological features of a CBT are described. In the present report, a rare case of bilateral carotid body tumor, which developed in the bifurcation of the common carotid artery, and the clinical manifestations, imaging and pathological features of this CBT are summarized. The imaging cannot validate the diagnosis; however, imaging identified that the tumor exhibited an intact envelope. Immunohistochemical staining revealed that the tumor cells were strongly positive for cluster of differentiation 56, Syn and protein S-100, moderately positive for transcription factor E3, negative for cytokeratin and epithelial membrane antigen, and partial cells were weakly positive for Desmir (<5%)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29369851/psychometric-properties-of-the-glaucoma-treatment-compliance-assessment-tool-gtcat-in-a-brazilian-population
#14
Ricardo Y Abe, Lorena de Campos Wen, Gordon T Barker, Steven L Mansberger
PURPOSE: To determine the psychometric properties of a reduced version of the Glaucoma Treatment Compliance Assessment Tool (GTCAT), which was translated to Brazilian Portuguese. PATIENTS AND METHODS: We translated into Portuguese the GTCAT using validated techniques and administered it to a group of glaucoma patients using at least 1 ocular hypotensive eye drop medication. We used principal components analysis to determine construct validity, Rasch analysis, and Cronbach α for internal consistency reliability, frequency analysis for floor and ceiling effects, and Spearman ρ for test-retest reliability...
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29284544/comprehensive-measurement-of-stroke-gait-characteristics-with-a-single-accelerometer-in-the-laboratory-and-community-a-feasibility-validity-and-reliability-study
#15
Sarah A Moore, Aodhan Hickey, Sue Lord, Silvia Del Din, Alan Godfrey, Lynn Rochester
BACKGROUND: Application of objective measurement of stroke gait with accelerometer-based wearable technology and associated algorithms is increasing, despite reports questioning the accuracy of this technique in quantifying specific stroke-related gait impairments. The aim of this study is to determine the feasibility, validity and reliability of a low-cost open-source system incorporating algorithms and a single tri-axial accelerometer-based wearable to quantify gait characteristics in the laboratory and community post-stroke...
December 29, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29273100/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#16
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29244762/towards-realistic-urban-traffic-experiments-using-dfrouter-heuristic-validation-and-extensions
#17
Jorge Luis Zambrano-Martinez, Carlos T Calafate, David Soler, Juan-Carlos Cano
Traffic congestion is an important problem faced by Intelligent Transportation Systems (ITS), requiring models that allow predicting the impact of different solutions on urban traffic flow. Such an approach typically requires the use of simulations, which should be as realistic as possible. However, achieving high degrees of realism can be complex when the actual traffic patterns, defined through an Origin/Destination (O-D) matrix for the vehicles in a city, remain unknown. Thus, the main contribution of this paper is a heuristic for improving traffic congestion modeling...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29238747/protocol-for-analyzing-protein-ensemble-structures-from-chemical-cross-links-using-dynaxl
#18
Zhou Gong, Zhu Liu, Xu Dong, Yue-He Ding, Meng-Qiu Dong, Chun Tang
Chemical cross-linking coupled with mass spectroscopy (CXMS) is a powerful technique for investigating protein structures. CXMS has been mostly used to characterize the predominant structure for a protein, whereas cross-links incompatible with a unique structure of a protein or a protein complex are often discarded. We have recently shown that the so-called over-length cross-links actually contain protein dynamics information. We have thus established a method called DynaXL, which allow us to extract the information from the over-length cross-links and to visualize protein ensemble structures...
2017: Biophysics Reports
https://www.readbyqxmd.com/read/29231960/prospective-validation-of-a-screening-tool-to-identify-older-adults-in-need-of-a-driving-evaluation
#19
Marian E Betz, Jason S Haukoos, Robert Schwartz, Carolyn DiGuiseppi, Deepika Kandasamy, Brenda Beaty, Elizabeth Juarez-Colunga, David B Carr
OBJECTIVES: To prospectively validate and refine the 5-item "CRASH" screening tool for identifying older drivers needing a behind-the-wheel (BTW) test. DESIGN: Prospective observational study. SETTING: Geriatric and internal medicine primary care clinics affiliated with a tertiary care hospital and a local BTW program. PARTICIPANTS: Cognitively intact drivers aged 65 and older (N = 315). MEASUREMENTS: Participants completed baseline questionnaire (including CRASH tool) and assessments and BTW test (evaluator blinded to questionnaire results) and participated in 1-month telephone follow-up...
February 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29217875/deep-auto-context-convolutional-neural-networks-for-standard-dose-pet-image-estimation-from-low-dose-pet-mri
#20
Lei Xiang, Yu Qiao, Dong Nie, Le An, Qian Wang, Dinggang Shen
Positron emission tomography (PET) is an essential technique in many clinical applications such as tumor detection and brain disorder diagnosis. In order to obtain high-quality PET images, a standard-dose radioactive tracer is needed, which inevitably causes the risk of radiation exposure damage. For reducing the patient's exposure to radiation and maintaining the high quality of PET images, in this paper, we propose a deep learning architecture to estimate the high-quality standard-dose PET (SPET) image from the combination of the low-quality low-dose PET (LPET) image and the accompanying T1-weighted acquisition from magnetic resonance imaging (MRI)...
December 6, 2017: Neurocomputing
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