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https://www.readbyqxmd.com/read/28216598/clinical-signs-staphylococcus-and-atopic-eczema-related-seromarkers
#1
Kam Lun Hon, Kathy Yin Ching Tsang, Jeng Sum C Kung, Ting Fan Leung, Christopher W K Lam, Chun Kwok Wong
: Childhood eczema or atopic dermatitis (AD) is a distressing disease associated with pruritus, sleep disturbance, impaired quality of life and Staphylococcus aureus isolation. The pathophysiology of AD is complex and various seromarkers of immunity are involved. We investigated if anti-staphylococcal enterotoxin IgE (anti-SE), selected seromarkers of T regulatory (Treg), T helper (Th) and antigen-presenting cells (APC) are associated with clinical signs of disease severity and quality of life...
February 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211964/relationship-between-pathological-gambling-alexithymia-and-gambling-type
#2
Céline Bonnaire, Servane Barrault, Ania Aïte, Mathieu Cassotti, Sylvain Moutier, Isabelle Varescon
BACKGROUND AND OBJECTIVES: The aim of this study is to see if: (i) alexithymia is associated with PG and with the severity of gambling behavior; (ii) alexithymia is associated with strategic and non-strategic gambling. METHODS: Two hundred and twenty-six gamblers were recruited in different gambling locations. First, pathological gamblers (PGs) (n = 106) were compared to non-pathological gamblers (NPGs) (n = 120). Second, strategic gamblers (n = 92) were compared to non-strategic gamblers (n = 96)...
February 17, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28203013/-curing-mode-of-universal-adhesives-affects-the-bond-strength-of-resin-cements-to-dentin
#3
Z R Fu, F C Tian, L Zhang, B Han, X Y Wang
OBJECTIVE: To determine the effects of curing mode of one-step and two-step universal adhesives on the micro-tensile bond strength (μTBS) of different dual-cure resin cements to dentin. METHODS: One-step universal adhesive Single Bond Universal (SBU), and two-step universal adhesive OptiBond Versa (VSA) were chosen as the subjects, one-step self-etching adhesive OptiBond All in One (AIO) and two-step self-etching adhesive Clearfil SE Bond (SEB) were control groups, and two dual-cure resin cements RelyX Ultimate (RLX) and Nexus 3 Universal (NX3) were used in this study...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28147655/monte-carlo-simulation-of-photon-emission-below-a-few-hundred-kiloelectronvolts-for-beam-monitoring-in-carbon-ion-therapy
#4
Mitsutaka Yamaguchi, Yuto Nagao, Takahiro Satoh, Hiroyuki Sugai, Makoto Sakai, Kazuo Arakawa, Naoki Kawachi
The purpose of this study is to determine whether the main component of the low-energy (63-68 keV) particles emitted perpendicularly to the (12)C beam from the (12)C-irradiated region in a water phantom is secondary electron bremsstrahlung (SEB). Monte Carlo simulations of a (12)C-beam (290 MeV/u) irradiated on a water phantom were performed. A detector was placed beside the water phantom with a lead collimator between the phantom and the detector. To move the Bragg-peak position, a binary filter was placed in an upper stream of the phantom...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28125395/editorial-for-the-seb-brighton-special-issue-dynamic-organization-of-the-nucleus
#5
David Evans, Iris Meier, Katja Graumann
No abstract text is available yet for this article.
January 2, 2017: Nucleus
https://www.readbyqxmd.com/read/28123509/different-roles-of-staphylococcus-aureus-enterotoxin-in-different-subtypes-of-nasal-polyps
#6
Ke-Jia Cheng, Shen-Qing Wang, Ying-Ying Xu
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28116688/spatiotemporal-variability-in-surface-energy-balance-across-tundra-snow-and-ice-in-greenland
#7
Magnus Lund, Christian Stiegler, Jakob Abermann, Michele Citterio, Birger U Hansen, Dirk van As
The surface energy balance (SEB) is essential for understanding the coupled cryosphere-atmosphere system in the Arctic. In this study, we investigate the spatiotemporal variability in SEB across tundra, snow and ice. During the snow-free period, the main energy sink for ice sites is surface melt. For tundra, energy is used for sensible and latent heat flux and soil heat flux leading to permafrost thaw. Longer snow-free period increases melting of the Greenland Ice Sheet and glaciers and may promote tundra permafrost thaw...
February 2017: Ambio
https://www.readbyqxmd.com/read/28111390/evaluation-of-resin-infiltration-on-demineralized-root-surface-an-in-vitro-study
#8
Yuan Zhou, Khairul Matin, Yasushi Shimada, Yasunori Sumi, Junji Tagami
The aim of this study was to evaluate the effect of resin infiltration on root caries induced by Streptococcus mutans biofilms. Human premolar specimens were divided to 5 groups: negative control (NC), Clearfil SE Bond (SEB), Icon-etch120s+Icon-infiltrant (HA120), Icon-etch10s+Icon-infiltrant (HA10) and K-etchant10s+Icon-infiltrant (PA10). The resin penetration was observed by fluorescent microscope. Biofilm-induced demineralization was conducted again and observed by swept-source optical coherence tomography and confocal laser scanning microscope...
January 20, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28109594/characteristics-of-resistance-and-virulence-factors-in-different-species-of-coagulase-negative-staphylococci-isolated-from-milk-of-healthy-sheep-and-animals-with-subclinical-mastitis
#9
Katheryne B Martins, Patricia Y Faccioli, Mariana F Bonesso, Simone Fernandes, Aline A Oliveira, Ariane Dantas, Luiz F Zafalon, Maria de Lourdes R S Cunha
Coagulase-negative staphylococci (CNS) are among the main responsible agents for mastitis in sheep. Cure rates can be reduced due to several causes, such as those related to virulence factors presented by microorganisms. This study aims at characterizing the virulence and resistance factors to antimicrobial agents in different CNS species isolated from sheep milk. After collecting milk samples, the samples were analyzed and the CNS species were identified. After identification, the susceptibility-sensitivity profile was examined using the disk diffusion technique for 10 antimicrobial agents...
March 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28063655/analysis-of-home-dust-for-staphylococcus-aureus-and-staphylococcal-enterotoxin-genes-using-quantitative-pcr
#10
Shanna Ludwig, Isabel Jimenez-Bush, Emily Brigham, Sonali Bose, Gregory Diette, Meredith C McCormack, Elizabeth C Matsui, Meghan F Davis
BACKGROUND: The bacterium Staphylococcus aureus (SA) is known to induce allergic inflammatory responses, including through secreted staphylococcal enterotoxin (SE) superantigens. To quantify indoor environmental exposures to these potential allergens, which may be associated with worse asthma, we developed a method for the assessment of S. aureus and SE in home dust and applied it to a study of homes of inner-city adults with asthma. METHODS: We conducted laboratory experiments to optimize sample processing and real-time PCR methods for detection and quantification of SA (femB) and SEA-D, based on published primers...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28062087/does-an-integrated-boost-increase-acute-toxicity-in-prone-hypofractionated-breast-irradiation-a-randomized-controlled-trial
#11
Leen Paelinck, Akos Gulyban, Ferenc Lakosi, Tom Vercauteren, Werner De Gersem, Bruno Speleers, Christel Monten, Thomas Mulliez, Patrick Berkovic, Annick van Greveling, Frederik Decoster, Philippe Coucke, Wilfried De Neve, Liv Veldeman
BACKGROUND AND PURPOSE: The safety of a simultaneous integrated boost (SIB) in combination with prone hypofractionated whole-breast irradiation (WBI) was investigated. MATERIALS AND METHODS: 167 patients were randomized between WBI with a sequential boost (SeB) or SIB. All patients were treated in prone position to 40.05Gy in 15 fractions to the whole breast. In the control arm, a SeB of 10Gy in 4 fractions (negative surgical margins) or 14.88Gy in 6 fractions (transsection) was prescribed...
January 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28049431/staphylococcal-enterotoxin-b-administration-in-pregnant-rats-alters-the-splenic-lymphocyte-response-in-adult-offspring-rats
#12
Ping Zhou, Xin-Sheng Zhang, Zhi-Ben Xu, Shu-Xian Gao, Qing-Wei Zheng, Ming-Zhu Xu, Lin Shen, Feng Yu, Jun-Chang Guan
BACKGROUND: Our previous study suggested that SEB exposure in pregnant rats could lead to the change of T cells subpopulation in both peripheral blood and thymus of the offspring rats. However, rarely is known about the influence of SEB exposure in pregnant rats on T cell subpopulation in the spleens of offspring rats. RESULTS: SEB was intravenously administered to the pregnant rats at gestational day 16 in this study. The percentages, in vivo and in vitro responses of CD4 and CD8 T cells were investigated with flow cytometry...
January 3, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28035011/invariant-nkt-cells-are-pathogenic-in-the-hla-dr4-transgenic-humanized-mouse-model-of-toxic-shock-syndrome-and-can-be-targeted-to-reduce-morbidity
#13
Peter A Szabo, Patrick T Rudak, Joshua Choi, Stacey X Xu, Robert Schaub, Bhagirath Singh, John K McCormick, S M Mansour Haeryfar
During toxic shock syndrome (TSS), bacterial superantigens trigger a polyclonal T cell response leading to a potentially catastrophic 'cytokine storm'. Whether innate-like invariant natural killer T(iNKT) cells, with remarkable immunomodulatory properties, participate in TSS is unclear. Using genetic and cell depletion approaches, we generated iNKT cell-deficient, superantigen-sensitive HLA-DR4-transgenic (DR4tg) mice, which were compared with their iNKT-sufficient counterparts for responsiveness to staphylococcal enterotoxin B(SEB)...
December 29, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28034578/staphylococcus-aureus-enterotoxin-sensitization-involvement-and-its-association-with-the-cysltr1-variant-in-different-asthma-phenotypes
#14
Hisako Matsumoto, Yoshihiro Kanemitsu, Tadao Nagasaki, Yuji Tohda, Takahiko Horiguchi, Hideo Kita, Kazunobu Kuwabara, Keisuke Tomii, Kojiro Otsuka, Masaki Fujimura, Noriyuki Ohkura, Katsuyuki Tomita, Akihito Yokoyama, Hiroshi Ohnishi, Yasutaka Nakano, Tetsuya Oguma, Soichiro Hozawa, Yumi Izuhara, Isao Ito, Tsuyoshi Oguma, Hideki Inoue, Tomoko Tajiri, Toshiyuki Iwata, Junya Ono, Shoichiro Ohta, Tomomitsu Hirota, Takahisa Kawaguchi, Mayumi Tamari, Tetsuji Yokoyama, Yasuharu Tabara, Fumihiko Matsuda, Kenji Izuhara, Akio Niimi, Michiaki Mishima
BACKGROUND: Sensitization to Staphylococcus aureus enterotoxin (SE) is a known risk factor for asthma susceptibility and severity. However, how SE sensitization is involved in asthma, particularly nonatopic asthma and/or late-onset asthma, remains uncertain. OBJECTIVE: To clarify the involvement of SE sensitization in nonatopic and/or late-onset asthma and its association with a polymorphism of the cysteinyl leukotriene receptor 1 gene (CysLTR1), which was examined because CysLT signaling is closely associated with late-onset eosinophilic asthma...
December 26, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28024103/multiple-reaction-monitoring-for-multiplex-detection-of-three-bacterial-toxins-using-liquid-chromatography-tandem-mass-spectrometry
#15
S I Alam, A Uppal, P Gupta, D V Kamboj
Clostridium perfringens epsilon toxin, staphylococcal enterotoxin B and shiga toxin are implicated in a number of diseases and food-borne intoxications and are considered potential agents for bioterrorism and warfare. Artificially generated aerosol is the likely mode of delivery of these for nefarious uses, potentially capable of causing mass destruction to human and animal health by inhalation of toxic bioaerosol. Multiplex and unambiguous detection of these agents is of paramount importance for emergency response in a biothreat scenario and for food safety...
December 26, 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28011677/n-acetylcysteine-in-preclinical-mouse-and-baboon-models-of-thrombotic-thrombocytopenic-purpura
#16
Claudia Tersteeg, Jan Roodt, Walter J Van Rensburg, Charlotte Dekimpe, Nele Vandeputte, Inge Pareyn, Aline Vandenbulcke, Barbara Plaimauer, Seb Lamprecht, Hans Deckmyn, José A Lopez, Simon F De Meyer, Karen Vanhoorelbeke
Thrombotic thrombocytopenic purpura (TTP) is a microangiopathic disorder diagnosed by thrombocytopenia and hemolytic anemia, associated with a deficiency in von Willebrand factor (VWF) cleaving protease ADAMTS13. Current treatment is based on plasma infusion for congenital TTP, or plasma exchange, often in combination with immunosuppressive agents, for acquired TTP. These treatment methods are however not always effective and therefore new treatment methods are highly necessary. N-acetylcysteine (NAC), an FDA-approved anti-mucolytic agent, could be a possible new treatment strategy for TTP as it was demonstrated to reduce disulfide bonds in VWF, thereby decreasing VWF multimer size and hence its prothrombotic potential...
December 23, 2016: Blood
https://www.readbyqxmd.com/read/28008711/a-proteomics-assay-to-detect-eight-cbrn-relevant-toxins-in-food
#17
Benoit Gilquin, Michel Jaquinod, Mathilde Louwagie, Sylvie Kieffer-Jaquinod, Alexandra Kraut, Myriam Ferro, François Becher, Virginie Brun
A proteomics assay was set up to analyze food substrates for eight toxins of the CBRN (chemical, biological, radiological and nuclear) threat, namely ricin, Clostridium perfringens epsilon toxin (ETX), Staphylococcus aureus enterotoxins (SEA, SEB and SED), shigatoxins from Shigella dysenteriae and entero-hemorragic Escherichia coli strains (STX1 and STX2) and Campylobacter jejuni cytolethal distending toxin (CDT). The assay developed was based on an antibody-free sample preparation followed by bottom-up LC-MS/MS analysis operated in targeted mode...
January 2017: Proteomics
https://www.readbyqxmd.com/read/28008571/reliability-of-the-ki67-labelling-index-in-core-needle-biopsies-of-luminal-breast-cancers-is-unaffected-by-biopsy-volume
#18
C M Focke, T Decker, P J van Diest
BACKGROUND: Assessing prognostic and predictive factors like the Ki67 labelling index (Ki67-LI) in breast cancer core needle biopsies (CNB) may be hampered by undersampling. Our aim was to arrive at a representative assessment of Ki67-LI in CNB of luminal breast cancers by defining optimal cutoffs and establishing the minimum CNB volume needed for highest concordance of Ki67-LI between CNB and subsequent surgical excision biopsy (SEB). METHODS: We assessed the Ki67-LI in CNB and subsequent SEB of 170 luminal breast cancers according to two counting methods recommended by the International Ki67 in Breast Cancer Working Group and applied the cutoffs to distinguish low and high proliferation given by the St Gallen 2013 and 2015 consensus, respectively...
December 22, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28002799/induction-of-specific-t-helper-9-cells-to-inhibit-glioma-cell-growth
#19
Haiyan Zheng, Baohua Yang, Dedong Xu, Wenbo Wang, Jie Tan, Liyuan Sun, Qinghua Li, Li Sun, Xuewei Xia
The effects of Staphylococcal enterotoxin B (SEB) on regulation of immune response have been recognized; whether SEB can enhance the effects of immunotherapy on glioma remains to be investigated. This study tests a hypothesis that administration with SEB enhances the effects of specific immunotherapy on glioma growth in mice. In this study, a glioma-bearing mouse model was developed by adoptive transfer with GL261 cells (a mouse glioma cell line). The mice were treated with the GL261 cell extracts (used as an Ag) with or without administration of SEB...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27997374/stable-phantom-materials-for-ultrasound-and-optical-imaging
#20
Luciana C Cabrelli, Pedro I B G B Pelissari, Alessandro M Deana, Antonio A O Carneiro, Theo Z Pavan
Phantoms mimicking the specific properties of biological tissues are essential to fully characterize medical devices. Water-based materials are commonly used to manufacture phantoms for ultrasound and optical imaging techniques. However, these materials have disadvantages, such as easy degradation and low temporal stability. In this study, we propose an oil-based new tissue-mimicking material for ultrasound and optical imaging, with the advantage of presenting low temporal degradation. A styrene-ethylene/butylene-styrene (SEBS) copolymer in mineral oil samples was made varying the SEBS concentration between 5%-15%, and low-density polyethylene (LDPE) between 0%-9%...
December 20, 2016: Physics in Medicine and Biology
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