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Seung-Heon Shin, Mi-Kyung Ye, Sung-Yong Choi, Kwan-Kyu Park
Bee venom (BV) has long been used as anti-inflammatory agent in traditional oriental medicine; however, the effect of BV on chronic rhinosinusitis (CRS) is not commonly studied. The aim of the present study was to determine the anti-inflammatory effect of BV on an allergic CRS mouse model. An allergic CRS mouse model was established following the administration of ovalbumin with Staphylococcus aureus enterotoxin B (SEB) into the nose. A total of 0.5 or 5 ng/ml of BV were intranasally applied 3 times a week for 8 weeks...
March 9, 2018: Molecular Medicine Reports
Suixia Li, Panpan Wang, Jialin Zhao, Luhong Zhou, Pengfei Zhang, Chengyu Fu, Jianghong Meng, Xin Wang
The aim of this study was to investigate the toxin gene profile and antimicrobial resistance of Staphylococcus aureus isolates from raw chicken in the People's Republic of China. In total, 289 S. aureus isolates were characterized by antimicrobial susceptibility testing, and genes encoding enterotoxins, exfoliative toxins, Panton-Valentine leukocidin, and toxic shock syndrome toxin were revealed by PCR. Overall, 46.0% of the isolates were positive for one or more toxin genes. A high proportion of toxin genes were pvl (26...
April 2018: Journal of Food Protection
Hasan Alghetaa, Amira Mohammed, Muthanna Sultan, Philip Busbee, Angela Murphy, Saurabh Chatterjee, Mitzi Nagarkatti, Prakash Nagarkatti
Staphylococcal enterotoxin B (SEB) is a potent superantigen produced by Staphylococcus aureus that triggers a strong immune response, characterized by cytokine storm, multi-organ failure, and often death. When inhaled, SEB can cause acute lung injury (ALI) and respiratory failure. In this study, we investigated the effect of resveratrol (RES), a phytoallexin, on SEB-driven ALI and mortality in mice. We used a dual-exposure model of SEB in C3H/HeJ mice, which caused 100% mortality within the first 5 days of exposure, and treatment with RES resulted in 100% survival of these mice up to 10 days post-SEB exposure...
March 7, 2018: Journal of Cellular and Molecular Medicine
Xiaojing Su, Hongqiang Li, Xuejun Lai, Zhonghua Chen, Xingrong Zeng
Superhydrophobic materials integrating stretchability with conductivity have huge potential in the emerging application horizons such as wearable electronic sensors, flexible power storage apparatus and corrosion-resistant circuits. Herein, a facile spraying method is reported to fabricate a durable superhydrophobic coating with excellent stretchable and electrical performance by combing 1-octadecanethiol modified silver nanoparticles (M-AgNPs) with polystyrene-b-poly(ethylene-co-butylene)-b-polystyrene (SEBS) on a pre-stretched natural rubber (NR) substrate...
March 6, 2018: ACS Applied Materials & Interfaces
Nadia Terrazzini, Paola Mantegani, Florian Kern, Claudio Fortis, Anna Mondino, Stefano Caserta
Background: IL-7 promotes the generation, expansion and survival of memory T cells. Previous mouse and human studies showed that IL-7 can support immune cell reconstitution in lymphopenic conditions, expand tumor-reactive T cells for adoptive immunotherapy and enhance effector cytokine expression by autoreactive T cells. Whether pathogen-reactive T cells also benefit from IL-7 exposure remains unknown. Methods: Here we investigated this issue in cultures of peripheral blood mononuclear cells (PBMCs) derived from patients infected with various endemic pathogens...
February 28, 2018: Journal of Infectious Diseases
Susanna Kovaniemi, Jaana Alakortes, Alice S Carter, Anneli Yliherva, Risto Bloigu, Leena O Joskitt, Irma K Moilanen, Hanna E Ebeling
Based on limitations in previous research evidence, we concluded that more research is needed for deeper understanding of how social-emotional and behavioral (SEB) outcomes among infant-toddler-aged children in the general population are associated with early motor development. In this study, we investigated associations between early competencies and problems, as measured by the Brief Infant-Toddler Social and Emotional Assessment (BITSEA), and the timing of achievement of the main gross and fine motor milestones usually attained during the first year of life in a general population context...
February 28, 2018: Infant Behavior & Development
Carmen Lambert, Judit Cubedo, Teresa Padró, Gemma Vilahur, Sergi López-Bernal, Milagros Rocha, Antonio Hernández-Mijares, Lina Badimon
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular (CV) events. The ingestion of high-glycemic index (GI) diets, specially sweetened beverage consumption, has been associated with the development of T2DM and CV disease. OBJECTIVE: We investigated the effects of the intake of a sweetened beverage, obtained from natural carbohydrates containing pinitol (PEB) compared to a sucrose-enriched beverage (SEB) in the context of impaired glucose tolerance (IGT) and diabetes...
February 27, 2018: Nutrients
Chunyang Li, Hong Zhao, Hui Zhang, Ying Wang, Zhijian Wu, Baozhong Han
In this study, we performed a quantum chemical molecular dynamics (QM/MD) simulation to investigate the space charge accumulation process in copolymers of polyethylene (PE) with ethylene acrylic acid (EAA), ethylene vinyl acetate (EVA), styrene-ethylene-butadiene-styrene (SEBS), and black carbon (BC). We predicted that BC, especially branched BC, would possess the highest electron affinity and is identified as the most promising filler in power cable insulation. Following incorporations of 0-4 high-energy electrons into the composites, branched BC exhibited the highest stability and almost all electrons were trapped by it...
February 28, 2018: Journal of Molecular Modeling
Bhairab Mondal, Shylaja Ramlal, Padma S Lavu, Bhavanashri N, Joseph Kingston
A simple, sensitive and selective colorimetric biosensor for the detection of Staphylococcal enterotoxin B (SEB) was developed using SEB-binding aptamer (SEB2) as recognition element and unmodified gold nanoparticles (AuNPs) as colorimetric probes. The assay is based on color change from red to purple due to conformational change of aptamer in the presence of SEB, and the phenomenon of salt-induced AuNPs aggregation which could be monitored by naked eye or UV-vis spectrometer. Results showed that the AuNPs can effectively differentiate the SEB induced conformational change of the aptamer in the presence of a given high salt concentration...
2018: Frontiers in Microbiology
K A Engebretsen, S Kezic, I Jakasa, A Hedengran, A Linneberg, L Skov, J D Johansen, J P Thyssen
BACKGROUND: Epidermal deficiency of filaggrin, and the derived natural moisturizing factors (NMF), is associated with increased risk of atopic dermatitis (AD). While filaggrin gene mutations cause filaggrin deficiency, there is limited insight in causative environmental factors. OBJECTIVE: To explore the effect of selected exogenous skin stressors on NMF and skin cytokines levels in healthy adult epidermis. MATERIAL AND METHODS: 40 healthy volunteers (18-49 years) were exposed to hard, soft, and chlorinated water, 0...
February 27, 2018: British Journal of Dermatology
Georgi Tchernev, Torello Lotti, Ilia Lozev, Georgi Konstantinov Maximov, Uwe Wollina
Periocular malignancies represent between 5% and 10% of all types of skin cancers. The incidence of eyelid (but also the periocular located) malignancies seems to differ in distribution across the continents. The incidence of eyelid tumours (but also the periocular located tumours) in a predominantly white population determined that BCC is the most common malignant periocular eyelid tumour in whites. This finding has been replicated consistently throughout the literature, with BCC representing 85-95% of all eyelid malignancies, SCC representing 3...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
K K Fursova, M P Shchannikova, I V Loskutova, A O Shepelyakovskaya, A G Laman, A M Boutanaev, S L Sokolov, O A Artem'eva, D A Nikanova, N A Zinovieva, F A Brovko
Mastitis, a major veterinary problem widespread in many regions, is caused mainly by Staphylococcus spp. However, there is no current reliable information about the role of Staphylococcus aureus and their toxins in the development of mastitis in cows in the territory of the Russian Federation. The aim of this investigation was to determine the profile of exotoxins of S. aureus from cow milk from farms of Central Russia. A total of 60 isolates of S. aureus were obtained from milk samples of cows with the subclinical form of mastitis...
February 21, 2018: Journal of Dairy Science
Shunsuke Osaka, Katsuko Okuzumi, Shota Koide, Kiyoko Tamai, Tomoaki Sato, Koichi Tanimoto, Haruyoshi Tomita, Masahiro Suzuki, Yukiko Nagano, Keigo Shibayama, Yoshichika Arakawa, Noriyuki Nagano
PURPOSE: The decline in methicillin-resistant Staphylococcus aureus (MRSA) isolation rates has become a general observation worldwide, including Japan. We hypothesized that some genetic shift in MRSA might cause this phenomenon, and therefore we investigated the genetic profiles among MRSA clinical isolates obtained from three different epidemic phases in Japan. METHODOLOGY: A total of 353 MRSA isolates were selected from 202 medical facilities in 1990 (pre-epidemic phase), 2004 (epidemic phase) and 2016 (post-epidemic phase)...
February 2, 2018: Journal of Medical Microbiology
Richard Croker, Alex J Walker, Seb Bacon, Helen J Curtis, Lisa French, Ben Goldacre
BACKGROUND: Minimising prescription costs while maintaining quality is a core element of delivering high-value healthcare. There are various strategies to achieve savings, but almost no research to date on determining the most effective approach. We describe a new method of identifying potential savings due to large national variations in drug cost, including variation in generic drug cost, and compare these with potential savings from an established method (generic prescribing). METHODS: We used English National Health Service (NHS) Digital prescribing data, from October 2015 to September 2016...
February 8, 2018: BMJ Open
F N Costa, N O Belo, E A Costa, G I Andrade, L S Pereira, I A Carvalho, R L Santos
Staphylococcus aureus is among the microorganisms more frequently associated with subclinical bovine mastitis. S. aureus may produce several virulence factors. This study aimed at determining the frequency of virulence factors such as enterotoxins, toxic shock syndrome toxin 1, and ica adhesion genes. In addition, we assessed antimicrobial drug resistance in S. aureus isolated from clinical and subclinical cases of mastitis. A total of 88 cows with clinical or subclinical mastitis were sampled, resulting in 38 S...
February 10, 2018: Tropical Animal Health and Production
Kaisen Chen, Shirong Lin, Peiqun Li, Qiuyue Song, Dong Luo, Tao Liu, Lingbing Zeng, Wei Zhang
BACKGROUND: S.aureus is a predominant pathogen that causes infection in critically ill patients, but little information exists regarding the characterization of S. aureus from different sources in burn patients in southeastern China. METHODS: We enrolled 125 patients with S. aureus infection in burns center between Jan 2014 and Dec 2015. S. aureus isolates were characterized by antimicrobial susceptibility test, toxin gene detection, and molecular typing with multilocus sequence type, staphylococcal protein A (spa) type, and staphylococcal cassette chromosome mec (SCCmec) type...
January 25, 2018: BMC Infectious Diseases
Valeria Velasco, José L Vergara, Ana M Bonilla, Javier Muñoz, Alejandra Mallea, Diego Vallejos, Mario Quezada-Aguiluz, Jorge Campos, Pedro Rojas-García
The detection of methicillin-resistant Staphylococcus aureus (MRSA) and other emerging strains in meat-producing animals and retail meat has increased the risk of contamination of food. The aim of this study was to determine the prevalence and characterize S. aureus strains isolated from the pork chain supply in Chile. A total of 487 samples were collected: 332 samples from pigs at farms and slaughterhouses (nasal, n = 155; skin, n = 177); 85 samples from carcasses at slaughterhouses; and 70 meat samples at supermarkets and retail stores...
January 24, 2018: Foodborne Pathogens and Disease
Bhairab Mondal, Bhavanashri N, Shylaja Ramlal, Joseph Kingston
In the present study, a colorimetric DNAzymes biosensor strategy was devised in combination with immunomagnetic separation for rapid and easy detection of enterotoxin B harbouring Staphylococcus aureus from food and clinical samples. The method employs immunocapture of S. aureus and amplification of seb gene by DNAzyme complementary sequence integrated forward primer and with specific reverse primer. The DNAzyme sequence integrated dsDNA PCR products when treated with hemin and TMB (3, 3', 5, 5'-tetramethylbenzidine) in the presence of H2O2 produce colorimetric signal...
January 19, 2018: Journal of Agricultural and Food Chemistry
Xiao-Xiong Wang, Shang Gao, Xu Yan, Qiang Li, Jun-Cheng Zhang, Yun-Ze Long, Ke-Qing Ruan, Xiao-Guang Li
Spontaneous exchange bias (SEB) under zero field cooling (ZFC) has recently attracted lots of attention due to its underlying physics and potential applications. Here we report the giant SEB (GSEB) of SmFeO3 single crystals by tuning magnetic compensation by temperature, which is rather convenient. A SEB field of up to 1 T at 3.9 K after ZFC (-1.4 T at 3.9 K after field cooling) was obtained. The SEB shows reciprocal relationship with remnant magnetization.
January 18, 2018: Physical Chemistry Chemical Physics: PCCP
Jialing Lin, Yang Peng, Chan Bai, Ting Zhang, Haoqu Zheng, Xiaojie Wang, Jiaping Ye, Xiaohua Ye, Ying Li, Zhenjiang Yao
Diabetic population were reported more likely to suffer carriage and infection with Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) than non-diabetic population. We aim to elucidate the prevalence and characteristics of S. aureus and MRSA nasal carriage among diabetic population in the United States National Health and Nutrition Examination Survey, 2001-2004. Univariate analyses were conducted using Chi-square test, Fisher's exact probability test or student t test, as appropriate...
December 4, 2017: Polish Journal of Microbiology
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