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https://www.readbyqxmd.com/read/27899638/structure-and-folding-of-the-tetrahymena-telomerase-rna-pseudoknot
#1
Darian D Cash, Juli Feigon
Telomerase maintains telomere length at the ends of linear chromosomes using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT). An essential part of TER is the template/pseudoknot domain (t/PK) which includes the template, for adding telomeric repeats, template boundary element (TBE), and pseudoknot, enclosed in a circle by stem 1. The Tetrahymena telomerase holoenzyme catalytic core (p65-TER-TERT) was recently modeled in our 9 Å resolution cryo-electron microscopy map by fitting protein and TER domains, including a solution NMR structure of the Tetrahymena pseudoknot...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27760412/anterior-temporal-lobectomy-for-older-adults-with-mesial-temporal-sclerosis
#2
Lidia M V R Moura, Emad N Eskandar, Mursal Hassan, Joel Salinas, Andrew J Cole, Daniel B Hoch, Sydney S Cash, John Hsu
OBJECTIVE: To compare postoperative seizure-free survival between older and younger adults. METHODS: A retrospective cohort of 107 temporal lobe epilepsy patients with a diagnosis of mesial temporal sclerosis (MTS) received anterior temporal lobectomy (ATL) between 1993 and 2014. We divided the lower three quartiles (younger) and top quartile (older, all 47+ years) of patients, then reviewed patient registry and electronic medical records to determine time to first self-reported seizure after ATL, the primary outcome (mean=3...
November 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27754135/os-26-04-targeting-care-gaps-in-patients-with-hypertension-a-quality-improvement-project-utilizing-emr-hypertension-dashboards-and-a-chronic-disease-coordinator
#3
Daniel Ngui, Michael J H Qiu, Michael Mann
OBJECTIVE: In order to address the systematic and practice management issues associated with managing hypertension, we undertook a quality improvement project at a multi-physician clinic in Vancouver, British Columbia, Canada. We piloted an evidence-based electronic medical record (EMR) hypertension management dashboard based on the 2014 Canadian Hypertension Education Program (CHEP) guideline recommendations. Since June 1, 2015, our chronic disease coordinator utilized our EMR HTN Dashboard to generate patient recalls, create physician reminders and to enhance internal clinic referrals to provide 1:1 patient hypertension self-management education by physicians and our clinical pharmacist team...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748562/disentangling-the-photochemical-salinity-tolerance-in-aster-tripolium-l-connecting-biophysical-traits-with-changes-in-fatty-acid-composition
#4
B Duarte, M T Cabrita, C Gameiro, A R Matos, R Godinho, J C Marques, I Caçador
A profound analysis of A. tripolium photochemical traits under salinity exposure is lacking in the literature, with very few references focusing on its fatty acid profile role in photophysiology. To address this, the deep photochemical processes were evaluated by Pulse Amplitude Modulated (PAM) Fluorometry coupled with a discrimination of its leaf fatty acid profile. Plants exposed to 125-250 mm NaCl showed higher photochemical light harvesting efficiencies and lower energy dissipation rates. under higher NaCl exposure, there is evident damage of the oxygen evolving complexes (OECs)...
October 17, 2016: Plant Biology
https://www.readbyqxmd.com/read/27643062/os-26-04-targeting-care-gaps-in-patients-with-hypertension-a-quality-improvement-project-utilizing-emr-hypertension-dashboards-and-a-chronic-disease-coordinator
#5
Daniel Ngui, Michael J H Qiu, Michael Mann
OBJECTIVE: In order to address the systematic and practice management issues associated with managing hypertension, we undertook a quality improvement project at a multi-physician clinic in Vancouver, British Columbia, Canada. We piloted an evidence-based electronic medical record (EMR) hypertension management dashboard based on the 2014 Canadian Hypertension Education Program (CHEP) guideline recommendations. Since June 1, 2015, our chronic disease coordinator utilized our EMR HTN Dashboard to generate patient recalls, create physician reminders and to enhance internal clinic referrals to provide 1:1 patient hypertension self-management education by physicians and our clinical pharmacist team...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27636873/optimizing-the-use-of-discharge-medication-lists-in-nursing-facilities
#6
Andrea C Backes, Patricia Cash, Jessica Jordan
OBJECTIVE: To highlight the need to optimize the use of discharge medication lists in nursing facilities. SETTING: In January 2014, the care transitions (CT) pharmacists at Frederick Memorial Hospital, Frederick, Maryland, began a pilot project in which they identified and followed high-risk patients transitioning from hospital to nursing facility and from nursing facility to home. PRACTICE DESCRIPTION: This pilot project served as a needs assessment to identify opportunities to improve patients' transition from nursing facility to home with the goal of reducing hospital readmissions...
September 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/27613879/beliefs-practices-and-self-efficacy-of-us-physicians-regarding-smoking-cessation-and-electronic-cigarettes-a-national-survey
#7
Andrew S Nickels, David O Warner, Sarah Michelle Jenkins, Jon Tilburt, J Taylor Hays
INTRODUCTION: We sought to assess physician knowledge/beliefs, self-efficacy, and experience/practice patterns surrounding smoking cessation and electronic cigarettes. METHODS: An eight-page survey sent via US Postal service. The initial invitation included a $10 cash incentive and up to three invitations were sent. Fifteen hundred US physicians were identified with equal representation from primary care physicians (internal medicine and family practice), surgical care physicians (general surgeons and anesthesiologists), and pulmonologists...
August 24, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27295169/evidence-that-the-pi-release-event-is-the-rate-limiting-step-in-the-nitrogenase-catalytic-cycle
#8
Zhi-Yong Yang, Rhesa Ledbetter, Sudipta Shaw, Natasha Pence, Monika Tokmina-Lukaszewska, Brian Eilers, Qingjuan Guo, Nilisha Pokhrel, Valerie L Cash, Dennis R Dean, Edwin Antony, Brian Bothner, John W Peters, Lance C Seefeldt
Nitrogenase reduction of dinitrogen (N2) to ammonia (NH3) involves a sequence of events that occur upon the transient association of the reduced Fe protein containing two ATP molecules with the MoFe protein that includes electron transfer, ATP hydrolysis, Pi release, and dissociation of the oxidized, ADP-containing Fe protein from the reduced MoFe protein. Numerous kinetic studies using the nonphysiological electron donor dithionite have suggested that the rate-limiting step in this reaction cycle is the dissociation of the Fe protein from the MoFe protein...
July 5, 2016: Biochemistry
https://www.readbyqxmd.com/read/27245703/funny-money-the-attentional-role-of-monetary-feedback-detached-from-expected-value
#9
Zachary J J Roper, Shaun P Vecera
Stimuli associated with monetary reward can become powerful cues that effectively capture visual attention. We examined whether such value-driven attentional capture can be induced with monetary feedback in the absence of an expected cash payout. To this end, we implemented images of U.S. dollar bills as reward feedback. Participants knew in advance that they would not receive any money based on their performance. Our reward stimuli-$5 and $20 bill images-were thus dissociated from any practical utility. Strikingly, we observed a reliable attentional capture effect for the mere images of bills...
October 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/26440108/consumer-perspectives-on-gambling-harm-minimisation-measures-in-an-australian-jurisdiction
#10
Alun C Jackson, Darren R Christensen, Kate L Francis, Nicki A Dowling
This paper investigates consumer perspectives of implemented and proposed gambling harm minimisation measures taken from a geographically stratified survey of adult residents in Tasmania, Australia. Electronic gaming machine (EGM) gamblers were asked whether current and proposed EGM harm minimisation measures impacted on their actual or anticipated gambling expenditure and enjoyment. Participants were analysed based on their endorsement of Problem Gambling Severity Index criteria (scores 0-27), and categorised as non-problem gamblers (score 0), low-risk gamblers (scores 1-2), and moderate/problem gamblers (scores 3+)...
June 2016: Journal of Gambling Studies
https://www.readbyqxmd.com/read/26393100/do-incentives-improve-tuberculosis-treatment-outcomes-in-the-republic-of-moldova
#11
A Ciobanu, L Domente, V Soltan, S Bivol, L Severin, V Plesca, R Van den Bergh, A M V Kumar, P de Colombani
SETTING: Tuberculosis (TB) health facilities in the Republic of Moldova, where various incentives were provided to TB patients to improve treatment outcomes. OBJECTIVE: To compare treatment outcomes among new drug-susceptible TB patients registered for treatment before (2008) and after (2011) introduction of incentives. DESIGN: Retrospective cohort study using data from the national electronic patient database and incentive registers. RESULTS: Of 2378 patients registered in 2011, 1895 (80%) received incentives (cash, food vouchers, travel reimbursement)...
October 21, 2014: Public Health Action
https://www.readbyqxmd.com/read/26350040/reproductive-healthcare-utilization-in-urban-poor-settlements-of-delhi-baseline-survey-of-anchul-ante-natal-and-child-health-care-in-urban-slums-project
#12
Niveditha Devasenapathy, Suparna Ghosh Jerath, Elizebeth Allen, Saket Sharma, Anuraj H Shankar, Sanjay Zodpey
BACKGROUND: Disparity in utilization of reproductive healthcare services between the urban poor and the urban non-poor households in the developing nations is well known. However, disparity may also exist within urban poor households. Our objective was to document the extent of disparity in reproductive healthcare utilization among the urban poor and to identify the socio-demographic determinants of underutilization with a view to characterizing this vulnerable subpopulation. METHODS: A survey of 16,221 households was conducted in 39 clusters from two large urban poor settlements in Delhi...
2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26214511/frequency-and-severity-of-parenteral-nutrition-medication-errors-at-a-large-children-s-hospital-after-implementation-of-electronic-ordering-and-compounding
#13
Mark MacKay, Collin Anderson, Sabrina Boehme, Jared Cash, Jeffery Zobell
INTRODUCTION: The Institute for Safe Medication Practices has stated that parenteral nutrition (PN) is considered a high-risk medication and has the potential of causing harm. Three organizations--American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), American Society of Health-System Pharmacists, and National Advisory Group--have published guidelines for ordering, transcribing, compounding and administering PN. These national organizations have published data on compliance to the guidelines and the risk of errors...
April 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/26043302/spending-at-mobile-fruit-and-vegetable-carts-and-using-snap-benefits-to-pay-bronx-new-york-2013-and-2014
#14
MULTICENTER STUDY
Andrew Breck, Kamila M Kiszko, Courtney Abrams, Brian Elbel
This study examines purchases at fruit and vegetable carts and evaluates the potential benefits of expanding the availability of electronic benefit transfer machines at Green Carts. Customers at 4 Green Carts in the Bronx, New York, were surveyed in 3 waves from June 2013 through July 2014. Customers who used Supplemental Nutrition Assistance Program benefits spent on average $3.86 more than customers who paid with cash. This finding suggests that there may be benefits to increasing the availability of electronic benefit transfer machines at Green Carts...
2015: Preventing Chronic Disease
https://www.readbyqxmd.com/read/25794209/first-do-no-harm-by-adopting-evidence-based-policy-initiatives-the-overselling-of-icd-10-by-congress-with-high-expectations
#15
REVIEW
Laxmaiah Manchikanti, Frank J E Falco, Standiford Helm Ii, Joshua A Hirsch
While it appears to be beneficial to apply a detailed disease classification system, the costs, cash flow disruptions, and increased investments with physician time incorporated into learning these processes, patient care might unfortunately suffer. This is essentially an unfunded mandate with much of the burden of transitioning to ICD-10 falling on health care providers,especially small independent practices. This will impact interventional pain management practices substantially.Further, as we have shown in previous manuscripts,the so-called advantages of multiple codes with specificity and granularity does not translate into reality where some specificity is actually lost for various codes...
March 2015: Pain Physician
https://www.readbyqxmd.com/read/25253523/evaluation-of-electronic-money-system-for-remuneration-of-research-participants-in-epidemiological-study
#16
REVIEW
Takahiko Katoh, Kana Matsuo, Shouichiro Kuroda, Xi Lu, Masako Oda, Takashi Ohba
In a long-term large cohort study, we introduced an electronic money system for remuneration of research participants. In comparison with the delivery of cash vouchers, the operation and mailing cost, and the processing time were significantly reduced. The workers were also able to save the time and effort they spent on the inventory management of cash vouchers. In addition, risk management was improved, as demonstrated by the reduction of complaints and associated problems such as nonarrival or content differences of cash vouchers...
2014: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/24982931/date-attachable-offline-electronic-cash-scheme
#17
Chun-I Fan, Wei-Zhe Sun, Hoi-Tung Hau
Electronic cash (e-cash) is definitely one of the most popular research topics in the e-commerce field. It is very important that e-cash be able to hold the anonymity and accuracy in order to preserve the privacy and rights of customers. There are two types of e-cash in general, which are online e-cash and offline e-cash. Both systems have their own pros and cons and they can be used to construct various applications. In this paper, we pioneer to propose a provably secure and efficient offline e-cash scheme with date attachability based on the blind signature technique, where expiration date and deposit date can be embedded in an e-cash simultaneously...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/24898173/the-impact-of-conditional-cash-transfers-on-child-health-in-low-and-middle-income-countries-a-systematic-review
#18
REVIEW
Ebenezer Owusu-Addo, Ruth Cross
OBJECTIVES: The review aimed to assess the effectiveness of conditional cash transfers (CCTs) in improving child health in low- and middle-income countries. METHODS: Seven electronic databases were searched for papers: MEDLINE, EMBASE, PubMed, PsychINFO, BIOSIS Previews, Academic Search Complete, and CSA Sociological Abstracts. The included studies comprised of randomised controlled trials and controlled before-and-after studies evaluating the impact of CCTs on child health...
August 2014: International Journal of Public Health
https://www.readbyqxmd.com/read/24871299/jackpot-expiry-an-experimental-investigation-of-a-new-egm-player-protection-feature
#19
Matthew J Rockloff, Phillip Donaldson, Matthew Browne
Given the evidence for the motivating influence of electronic gaming machines (EGM) jackpots on intensifying player behaviour (Rockloff and Hing in J Gambl Stud 1-7, 2013), there is good reason to explore consumer-protection features. Jackpot Expiry is a potential feature of a mandatory pre-commitment system or player identification system (e.g., loyalty program) whereby the availability of jackpots expires after a fixed interval of play. One hundred and thirty volunteers (males = 56, females = 74) played a laptop-simulated EGM with a starting $20 real-money stake...
December 2015: Journal of Gambling Studies
https://www.readbyqxmd.com/read/24508601/progress-in-structural-studies-of-telomerase
#20
REVIEW
Edward J Miracco, Jiansen Jiang, Darian D Cash, Juli Feigon
Telomerase is the ribonucleoprotein (RNP) reverse transcriptase responsible for synthesizing the 3' ends of linear chromosomes. It plays critical roles in tumorigenesis, cellular aging, and stem cell renewal. The past two years have seen exciting progress in determining telomerase holoenzyme architecture and the structural basis of telomerase activity. Notably, the first electron microscopy structures of telomerase were reported, of the Tetrahymena thermophila telomerase holoenzyme and a human telomerase dimer...
February 2014: Current Opinion in Structural Biology
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