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https://www.readbyqxmd.com/read/28454412/comparison-of-the-seleno-transcriptome-expression-between-human-non-cancerous-mammary-epithelial-cells-and-two-human-breast-cancer-cell-lines
#1
Fabiola Rusolo, Francesca Capone, Raffaella Pasquale, Antonella Angiolillo, Giovanni Colonna, Giuseppe Castello, Maria Costantini, Susan Costantini
Breast cancer is the second most common cause of mortality in women; therefore, the identification of novel putative markers is required to improve its diagnosis and prognosis. Selenium is known to protect mammary epithelial cells from oxidative DNA damage, and to inhibit the initiation phase of carcinogenesis by stimulating DNA repair and apoptosis regulation. Consequently, the present study has focused attention on the selenoprotein family and their involvement in breast cancer. The present study performed a global analysis of the seleno-transcriptome expression in human breast cancer MCF-7 and MDA-MB231 cell lines compared with healthy breast MCF-10A cells using reverse transcription-quantitative polymerase chain reaction...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454115/impact-of-marital-status-during-diagnosis-on-cancer-caused-specific-survival-in-acute-myeloid-leukemia-patients-a-case-control-and-population-based-study
#2
Zhuojun Zheng, Yuandong Zhu, Xiaodong Li, Wenwei Hu, Jingting Jiang
OBJECTIVE: This study investigated the impact of marital status on cancer-caused specific mortality among acute myeloid leukemia (AML) patients in the United States. METHODS: We used the Surveillance, Epidemiology and End Results program to identify 50,825 patients who had their clinical and follow-up information available and were diagnosed for AML between the years 1988 and 2015. The univariate and multivariable Cox regression models were used to analyze the patient data, and to minimize the group differences due to covariates between groups, a 1:1 propensity score matching was used in subsequent subgroup analysis...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453767/the-pattern-of-underlying-cause-of-death-in-patients-with-inflammatory-bowel-disease-in-england-a-record-linkage-study
#3
Thomas P C Chu, Gordon W Moran, Timothy R Card
Background and Aims: Numerous studies have established that mortality risk in inflammatory bowel disease [IBD] patients is higher than in the general population, but the causes of death have seldom been examined. We aimed to describe causes of death in IBD. Methods: A matched cohort study using UK general practice data from Clinical Practice Research Datalink linked to death registration records. We described the distribution of causes of death among IBD patients by age at death and time since IBD diagnosis...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453639/perioperative-morbidity-and-mortality-of-octogenarians-treated-by-radical-cystectomy-a-multi-institutional-retrospective-study-in-japan
#4
Takashige Abe, Norikata Takada, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Naoto Miyajima, Satoru Maruyama, Nobuo Shinohara
Objective: To determine the characteristics of 90-day morbidity and mortality after radical cystectomy in Japanese octogenarians. Methods: A retrospective multi-institutional study. We reviewed the records of 834 patients treated by open radical cystectomy between 1997 and 2010. All complications within 90 days after surgery were sorted into the 11 categories proposed by the Memorial Sloan-Kettering Cancer Center and graded according to the modified Clavien-Dindo system...
April 27, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28453636/vitamin-d-status-and-all-cause-mortality-in-patients-with-chronic-kidney-disease-a-systematic-review-and-dose-response-meta-analysis
#5
Ahmad Jayedi, Sepideh Soltani, Sakineh Shab-Bidar
Context: Prevalence of vitamin D deficiency is high in patients with chronic kidney disease. Less attention has been paid to measurement and correction of serum level of 25(OH)D in these patients. Objective: We examined the association between different levels of serum 25(OH)D and risk of all-cause mortality in patients with chronic kidney disease. Data sources: Systematic search were done using MedLine and EMBASE from inception up to November 2016...
April 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28453574/social-defeat-stress-causes-depression-like-behavior-with-metabolite-changes-in-the-prefrontal-cortex-of-rats
#6
Yi-Yun Liu, Xin-Yu Zhou, Li-Ning Yang, Hai-Yang Wang, Yu-Qing Zhang, Jun-Cai Pu, Lan-Xiang Liu, Si-Wen Gui, Li Zeng, Jian-Jun Chen, Chan-Juan Zhou, Peng Xie
Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography-mass spectrometry. Within the first week after the social defeat procedure, the sucrose preference test (SPT), open field test (OFT), elevated plus maze (EPM) and forced swim test (FST) were conducted to examine the depressive-like and anxiety-like behaviors...
2017: PloS One
https://www.readbyqxmd.com/read/28453545/the-impact-of-gender-difference-on-clinical-and-echocardiographic-outcomes-in-patients-with-heart-failure-after-cardiac-resynchronization-therapy-a-systematic-review-and-meta-analysis
#7
Fa-Hui Yin, Chun-Lei Fan, Ya-Ya Guo, Hai Zhu, Zhi-Lu Wang
BACKGROUND: Cardiac resynchronization therapy(CRT) has been recommended as a standard treatment for patients with advanced heart failure. However, some studies have reported different clinical and echocardiographic outcomes between male and female patients who received CRT. This Meta-analysis is to determine whether gender difference has any significant impact on clinical and echocardiographic outcomes in patients with heart failure after CRT. METHODS AND RESULTS: PubMed, Embase, and the Cochrane library database were searched...
2017: PloS One
https://www.readbyqxmd.com/read/28453536/rtfa-controls-development-secondary-metabolism-and-virulence-in-aspergillus-fumigatus
#8
Ryan R Myers, Timothy D Smith, Sherine F Elsawa, Olivier Puel, Souraia Tadrist, Ana M Calvo
Invasive aspergillosis by Aspergillus fumigatus is a leading cause of infection-related mortality in immune-compromised patients. In order to discover potential genetic targets to control A. fumigatus infections we characterized rtfA, a gene encoding a putative RNA polymerase II transcription elongation factor-like protein. Our recent work has shown that the rtfA ortholog in the model fungus Aspergillus nidulans regulates morphogenesis and secondary metabolism. The present study on the opportunistic pathogen A...
2017: PloS One
https://www.readbyqxmd.com/read/28453503/preface
#9
Cynthia Villarreal-Garza, Andrea Castro-Sanchez, Alfredo Ulloa-Aguirre
Breast cancer (BC) is the most frequently diagnosed malignancy in young women and is the leading cause of cancer-related mortality in this age group. This issue represents a major public health problem in developing countries, where the incidence of BC is rapidly increasing and where young women represent a higher proportion of the total BC patient population compared to developed countries. In Latin America, BC among women aged 40 years or less accounts for up to 11% of new BC cases and 7% of all BC deaths...
March 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28449471/one-year-and-long-term-mortality-in-patients-hospitalized-for-chronic-obstructive-pulmonary-disease
#10
María-Teresa García-Sanz, Juan-Carlos Cánive-Gómez, Laura Senín-Rial, Jorge Aboal-Viñas, Alejandra Barreiro-García, Eva López-Val, Francisco-Javier González-Barcala
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Identifying potentially-modifiable predictors of mortality could help optimize COPD patient management. The aim of this study is to determine long-term mortality following hospitalization due to acute exacerbations of COPD (AECOPD), as well as AECOPD mortality predictors. METHODS: We conducted a retrospective study by reviewing the medical records of all patients admitted with AECOPD in the University Hospital Complex of Santiago de Compostela in 2007 and 2008...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449322/a-bacterium-with-close-genetic-identity-to-pseudomonas-mandelii-associated-with-spring-fish-kills-in-wild-bluegill-lepomis-macrochirus-rafinesque-and-pumpkinseed-sunfish-lepomis-gibbosus-linnaeus
#11
J Lovy, D Dicarlo-Emery, J M Hutcheson
Pseudomonas fluorescens are known bacterial pathogens in fish. The P. fluorescens group contains at least nine different bacterial species, although species from fish have rarely been differentiated. Two isolated fish kills affecting wild bluegills, Lepomis macrochirus Rafinesque, and pumpkinseed sunfish, Lepomis gibbosus (Linnaeus), occurred in the spring of 2015 during cool water temperatures (12.5°C-15.5°C). Disease signs included severe bacteraemia with rare gross external signs. Pure bacterial cultures isolated from kidneys of all affected fish were identified as P...
April 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28449283/physiological-responses-of-reared-sea-bream-sparus-aurata-linnaeus-1758-to-an-amyloodinium-ocellatum-outbreak
#12
M Moreira, D Schrama, F Soares, T Wulff, P Pousão-Ferreira, P Rodrigues
Amyloodiniosis represents a major bottleneck for semi-intensive aquaculture production in Southern Europe, causing extremely high mortalities. Amyloodinium ocellatum is a parasitic dinoflagellate that can infest almost all fish, crustacean and bivalves that live within its ecological range. Fish mortalities are usually attributed to anoxia, associated with serious gill hyperplasia, inflammation, haemorrhage and necrosis in heavy infestations; or with osmoregulatory impairment and secondary microbial infections due to severe epithelial damage in mild infestation...
April 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28449053/fresh-fruit-consumption-and-all-cause-and-cause-specific-mortality-findings-from-the-china-kadoorie-biobank
#13
Huaidong Du, Liming Li, Derrick Bennett, Ling Yang, Yu Guo, Timothy J Key, Zheng Bian, Yiping Chen, Robin G Walters, Iona Y Millwood, Junshi Chen, Junzheng Wang, Xue Zhou, Le Fang, Yijun Li, Xianzhi Li, Rory Collins, Richard Peto, Zhengming Chen
Background: Higher fruit consumption is associated with lower risk of cardiovascular disease (CVD). Substantial uncertainties remain, however, about the associations of fruit consumption with all-cause mortality and mortality from subtypes of CVD and major non-vascular diseases, especially in China. Methods: In 2004-08, the nationwide China Kadoorie Biobank Study recruited > 0.5 million adults aged 30-79 years from 10 diverse localities in China. Fresh fruit consumption was estimated using an interviewer-administered electronic questionnaire, and mortality data were collected from death registries...
April 24, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28448971/pre-esrd-dementia-and-post-esrd-mortality-in-a-large-cohort-of-incident-dialysis-patients
#14
Miklos Z Molnar, Keiichi Sumida, Abduzhappar Gaipov, Praveen K Potukuchi, Tibor Fülöp, Kiran Joglekar, Jun Ling Lu, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Conservative management may be a desirable option for elderly, fragile, or demented patients who reach end-stage renal disease (ESRD), yet some patients with dementia are placed on renal replacement therapy nonetheless. METHODS: From a nationwide cohort of 45,076 US veterans who transitioned to ESRD over 4 contemporary years (October 1, 2007 to September 30, 2011), we identified 1,336 (3.0%) patients with International Classification of Diseases, Ninth Revision, Clinical Modification code-based dementia diagnosis during the prelude (predialysis) period...
April 28, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28448477/evaluation-of-gelatin-tannate-against-symptoms-of-acute-diarrhea-in-pediatric-patients
#15
Eren Çağan, Saime Ceylan, Şenay Mengi, Havva Hasret Çağan
BACKGROUND Acute diarrhea is the second most common cause of morbidity and mortality worldwide, especially in children aged ≤3 years. Some drugs (e.g., the mucoprotector gelatin tannate) plus a reduced osmolality oral rehydration solution (ORS) may effectively reduce symptom duration and severity. The current trial was therefore designed to assess the efficacy and safety of gelatin tannate in pediatric patients with acute diarrhea. MATERIAL AND METHODS This was a randomized, controlled, double-blind, parallel-group, single-center study comparing gelatin tannate plus ORS (103 patients) with ORS plus placebo (100 patients) in children aged 3 months to 12 years with infectious or noninfectious acute diarrhea...
April 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28448189/effect-of-antihypertensive-treatment-on-the-long-term-outcome-of-patients-discharged-after-acute-ischemic-stroke
#16
Konstantinos Tziomalos, Vasilios Giampatzis, Stella D Bouziana, Marianna Spanou, Stavroula Kostaki, Maria Papadopoulou, Stella-Maria Angelopoulou, Eleni Margariti, Christos Savopoulos, Apostolos I Hatzitolios
We aimed to evaluate the effects of the five main classes of antihypertensive agents on the long-term outcome of 313 consecutive patients discharged after acute ischemic stroke (36.4% males, age 78.5 ± 6.3 years). One year after discharge, the functional status [evaluated with the modified Rankin scale (mRS)], the occurrence of cardiovascular events, and vital status were recorded. Patients prescribed angiotensin receptor blockers (ARBs) had lower mRS than patients not prescribed ARBs (1.7 ± 2.0 vs. 2.9 ± 2...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28448093/overweight-and-abdominal-obesity-association-with-all-cause-and-cardiovascular-mortality-in-the-elderly-aged-80-and-over-a-cohort-study
#17
C N David, R B Mello, N M Bruscato, E H Moriguchi
OBJECTIVE: To evaluate the association between overweight and abdominal obesity with all-cause and cardiovascular mortality in the elderly aged 80 and over. DESIGN: A prospective cohort study. SETTING: A population-based study of community-dwelling very elderly adults in a city in southern Brazil. PARTICIPANTS: 236 very elderly adults, number that represents 85% of the population aged 80 and over living in the city in the period (mean age 83...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28448080/adherence-to-the-mediterranean-diet-and-all-cause-mortality-risk-in-an-elderly-italian-population-data-from-the-ilsa-study
#18
F Limongi, M Noale, A Gesmundo, G Crepaldi, S Maggi
OBJECTIVE: The aim of this study was to evaluate adherence to the Mediterranean Diet (MD) and its association with all-cause mortality in an elderly Italian population. DESIGN: Data analysis of a longitudinal study of a representative, age stratified, population sample. SETTING: Study data is based upon the Italian Longitudinal Study on Aging (ILSA) a prospective, community-based cohort study. The baseline evaluation was carried out in 1992 and the follow-up in 1996 and 2000...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28447766/supervised-dosing-with-a-long-acting-opioid-medication-in-the-management-of-opioid-dependence
#19
REVIEW
Rosella Saulle, Simona Vecchi, Linda Gowing
BACKGROUND: Opioid dependence (OD) is an increasing clinical and public health problem worldwide. International guidelines recommend opioid substitution treatment (OST), such as methadone and buprenorphine, as first-line medication treatment for OD. A negative aspect of OST is that the medication used can be diverted both through sale on the black market, and the unsanctioned use of medications. Daily supervised administration of medications used in OST has the advantage of reducing the risk of diversion, and may promote therapeutic engagement, potentially enhancing the psychosocial aspect of OST, but costs more and is more restrictive on the client than dispensing for off-site consumption...
April 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28447583/prevalence-and-clinical-significance-of%C3%A2-diabetes-in-asian-versus-white-patients%C3%A2-with-heart-failure
#20
Ingrid E M Bank, Crystel M Gijsberts, Tiew-Hwa K Teng, Lina Benson, David Sim, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Gerard K T Leong, Lieng H Ling, A Mark Richards, Dominique P V de Kleijn, Ulf Dahlström, Lars H Lund, Carolyn S P Lam
OBJECTIVES: The study sought to compare the prevalence, clinical correlates and prognostic impact of diabetes in Southeast Asian versus white patients with heart failure (HF) with preserved or reduced ejection fraction. BACKGROUND: Diabetes mellitus is common in HF and is associated with impaired prognosis. Asia is home to the majority of the world's diabetic population, yet data on the prevalence and clinical significance of diabetes in Asian patients with HF are sparse, and no studies have directly compared Asian and white patients...
January 2017: JACC. Heart Failure
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