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https://www.readbyqxmd.com/read/29168996/cancer-incidence-and-mortality-due-to-excess-body-weight-in-ireland-an-analysis-of-10-year-data
#1
A Collins, T McCarthy, M Laffoy
Excess body weight (EBW) increases the risk of specific cancers. The prevalence of EBW has risen significantly in Ireland over recent decades. To highlight the impact on cancer, and to inform future policies, we calculated the proportion of cancers in Ireland that were attributable to EBW using the Population Attributable Fraction (PAF). This fraction was then applied to Irish incidence and mortality data for specific cancers from 2003-2012 to estimate the number of new cancers and cancer deaths attributable to EBW...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168984/transcatheter-vs-surgical-aortic-valve-replacement-in-low-to-intermediate-surgical-risk-candidates-a-meta-analysis-and-systematic-review
#2
REVIEW
Safi U Khan, Ahmad N Lone, Muhammad A Saleem, Edo Kaluski
The American and European expert documents recommend transcatheter aortic valve replacement (TAVR) for inoperable or high-surgical-risk patients with severe aortic stenosis. In comparison, efficacy of TAVR is relatively less studied in low- to intermediate-surgical-risk patients. We sought to discover whether TAVR can be as effective as surgical aortic valve replacement (SAVR) in low- to intermediate-surgical-risk candidates. Four randomized clinical trials (RCTs) and 8 prospective matched studies were selected using PubMed/MEDLINE, Embase, and Cochrane Library (inception: March 2017)...
November 23, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29168980/inability-to-reduce-morbidity-of-diarrhea-by-ors-can-we-design-a-better-therapy
#3
Jane E Harrell, Sam X Cheng
Diarrheal disease is a worldwide problem that still causes significant morbidity and mortality among children. Currently, oral rehydration solution (ORS) is the standard of care for acute diarrhea in pediatric patients. While effective in reducing mortality, ORS does not alleviate diarrheal symptoms, thus reducing caregiver compliance and therapeutic efficacy. This manuscript will briefly review the current problem of pediatric diarrhea and the shortcomings of current therapies; however, the focus of this review is to examine the intestinal calcium-sensing receptor (CaSR)...
November 23, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29168569/point-of-use-fortification-of-foods-with-micronutrient-powders-containing-iron-in-children-of-preschool-and-school-age
#4
REVIEW
Luz Maria De-Regil, Maria Elena D Jefferds, Juan Pablo Peña-Rosas
BACKGROUND: Approximately 600 million children of preschool and school age are anaemic worldwide. It is estimated that at least half of the cases are due to iron deficiency. Point-of-use fortification of foods with micronutrient powders (MNP) has been proposed as a feasible intervention to prevent and treat anaemia. It refers to the addition of iron alone or in combination with other vitamins and minerals in powder form, to energy-containing foods (excluding beverages) at home or in any other place where meals are to be consumed...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29168222/the-prognostic-significance-of-frailty-compared-to-peak-oxygen-consumption-and-b-type-natriuretic-peptide-in-patients-with-advanced-heart-failure
#5
Yasbanoo Moayedi, Juan G Duero Posada, Farid Foroutan, Livia A Goldraich, Ana C Alba, Jane MacIver, Heather J Ross
Frailty assessment has become an integral part of the evaluation of potential candidates for heart transplantation and ventricular assist device (HTx/VAD). The impact of frailty, as a heart failure risk factor or to identify those who will derive the greatest benefit with HTx/VAD remains unclear. The aim of this study was to evaluate the independent prognostic relevance of frailty assessment from peak oxygen consumption (peak VO2 ) or B-type natriuretic peptide (BNP) on mortality in patients referred for advanced heart failure therapies...
November 23, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29168211/factors-associated-with-medication-administration-errors-and-why-nurses-fail-to-report-them
#6
Baraa M Hammoudi, Samantha Ismaile, Omar Abu Yahya
BACKGROUND: Patient safety is a significant challenge facing healthcare systems. The administration of medication is pivotal to patient safety, and errors in drug administration are associated with mortality and morbidity. In this study, we assessed the factors contributing to the occurrence and reporting of medication errors from the nurse's perspective. METHODS: In this descriptive cross-sectional study, we distributed a validated questionnaire to 367 nurses at a large public hospital and obtained a response rate of 73...
November 22, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/29168177/tumor-characteristics-and-prognosis-in-women-with-pregnancy-associated-breast-cancer
#7
Anna L V Johansson, Therese M-L Andersson, Chung-Cheng Hsieh, Karin Jirström, Sven Cnattingius, Irma Fredriksson, Paul W Dickman, Mats Lambe
There is evidence of poor prognosis in women with pregnancy-associated breast cancer (PABC) diagnosed during pregnancy or within two years of delivery. Using a large, population-based cohort, we examined clinicopathologic features and survival in women with PABC. A cohort of women diagnosed with invasive breast cancer between 1992 and 2009 at ages 15 to 44 years was identified in the Swedish Cancer Register and the Breast Cancer Quality Registers. Dates of childbirths for each woman were retrieved from the Swedish Multi-Generation Register...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29168175/prognosis-of-status-epilepticus-in-elderly-patients
#8
L Vilella, M González Cuevas, M Quintana Luque, M Toledo, M Sueiras Gil, L Guzmán, J Salas Puig, E Santamarina Pérez
PURPOSE: To evaluate the clinical features and prognosis of status epilepticus (SE) in patients above 70 years old. METHODS: Retrospective analysis of all patients ≥70 years old with SE registered prospectively during 4 years. Follow-up after discharge was performed. RESULTS: Ninety patients were evaluated. Acute symptomatic etiology was the most prevalent. The mean number of antiepileptic drugs (AEDs) used was 2.7 ± 1.2, and 21% of the patients required sedation...
November 22, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29167879/racial-differences-in-plasma-levels-of-n-terminal-pro-b-type-natriuretic-peptide-and-outcomes-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-study
#9
Navkaranbir S Bajaj, Orlando M Gutiérrez, Garima Arora, Suzanne E Judd, Nirav Patel, Aleena Bennett, Sumanth D Prabhu, George Howard, Virginia J Howard, Mary Cushman, Pankaj Arora
Importance: Recent studies have suggested that the natriuretic peptide system may be endogenously suppressed in black individuals who are free of prevalent cardiovascular disease. Whether natriuretic peptide levels contribute to racial disparities in clinical outcomes is unknown. Objective: To examine racial differences in N-terminal pro-B-type natriuretic peptide (NTproBNP) levels and their association with all-cause mortality and cause-specific mortality in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study...
November 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29167672/novel-concept-of-cd4-mediated-activation-of-regulatory-t-cells-for-the-treatment-of-graft-versus-host-disease
#10
REVIEW
Janine Schlöder, Carsten Berges, Andrea Tuettenberg, Helmut Jonuleit
Allogeneic hematopoietic stem cell transplantation is the only curative treatment option for several hematological malignancies and immune deficiency syndromes. Nevertheless, the development of a graft-versus-host disease (GvHD) after transplantation is a high risk and a severe complication with high morbidity and mortality causing therapeutic challenges. Current pharmacological therapies of GvHD lead to generalized immunosuppression followed by severe adverse side effects including infections and relapse of leukemia...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29167614/thirty-day-and-one-year-clinical-outcomes-of-bioresorbable-vascular-scaffold-implantation-a-single-center-experience
#11
Wei-Chieh Lee, Chiung-Jen Wu, Chien-Jen Chen, Cheng-Hsu Yang, Shu-Kai Hsueh, Hon-Kan Yip, Chi-Ling Hang, Chih-Yuan Fang, Hsiu-Yu Fang
Background: Available data on the use of the Bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, CA) in real-world patients is limited, particularly in Asian populations. The aim of this study was to assess clinical outcomes of patients treated with a BVS in real-world practice in Taiwan. Methods: This study focused on 156 patients with coronary artery disease and a total of 249 lesions who received BVS implantation from October 2012 to October 2015...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29167612/the-value-of-cha2ds2vasc-score-in-predicting-all-cause-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-who-have-undergone-primary-percutaneous-coronary-intervention
#12
Kudret Keskin, Süleyman Sezai Yıldız, Gökhan Çetinkal, Gökhan Aksan, Hakan Kilci, Şükrü Çetin, Serhat Sığırcı, Kadriye Kılıçkesmez
Background: Acute coronary syndrome is the most common cause of cardiac morbidity and death. Various scoring systems have been developed in order to identify patients who are at risk for adverse outcome and may benefit from more aggressive and effective therapies. Objectives: This study was designed to evaluate the CHA2DS2VASC score as a predictor of mortality inpatients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (p-PCI)...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29167301/prevalence-of-persistent-blood-eosinophilia-relation-to-outcomes-in-patients-with-copd
#13
Ciro Casanova, Bartolome R Celli, Juan P de-Torres, Cristina Martínez-Gonzalez, Borja G Cosio, Victor Pinto-Plata, Pilar de Lucas-Ramos, Miguel Divo, Antonia Fuster, Germán Peces-Barba, Myriam Calle-Rubio, Ingrid Solanes, Ramón Aguero, Nuria Feu-Collado, Inmaculada Alfageme, Alfredo De Diego, Amparo Romero, Eva Balcells, Antonia Llunell, Juan B Galdiz, Margarita Marin, Amalia Moreno, Carlos Cabrera, Rafael Golpe, Celia Lacarcel, Joan B Soriano, José Luis López-Campos, Juan J Soler-Cataluña, José M Marin
The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial.To evaluate the prevalence and stability of a high level of blood eosinophils (≥300 cells·μL(-1)) and its relationship to outcomes, we determined blood eosinophils at baseline and over 2 years in 424 COPD patients (forced expiratory volume in 1 s (FEV1) 60% predicted) and 67 smokers without COPD from the CHAIN cohort, and in 308 COPD patients (FEV1 60% predicted) in the BODE cohort. We related eosinophil levels to exacerbations and survival using Cox hazard analysis...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29167212/cardiovascular-disease-cancer-and-mortality-among-people-with-type-2-diabetes-and-alcoholic-or-nonalcoholic-fatty-liver-disease-hospital-admission
#14
Sarah H Wild, Jeremy J Walker, Joanne R Morling, David A McAllister, Helen M Colhoun, Bassam Farran, Stuart McGurnaghan, Rory McCrimmon, Stephanie H Read, Naveed Sattar, Christopher D Byrne
OBJECTIVE: To describe associations between alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) hospital admission and cardiovascular disease (CVD), cancer, and mortality in people with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We performed a retrospective cohort study by using linked population-based routine data from diabetes registry, hospital, cancer, and death records for people ages 40-89 years diagnosed with T2DM in Scotland between 2004 and 2013 who had one or more hospital admission records...
November 22, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29167141/impact-of-automatic-infectious-diseases-consultation-on-the-management-of-fungemia-at-a-large-academic-medical-center
#15
Travis M Jones, Richard H Drew, Dustin T Wilson, Christina Sarubbi, Deverick J Anderson
PURPOSE: The impact of automatic infectious diseases (ID) consultation for inpatients with fungemia at a large academic medical center was studied. METHODS: In this single-center, retrospective study, the time to appropriate antifungal therapy before and after implementing a policy requiring automatic ID consultation for the management of fungemia for all patients with an inpatient positive blood culture for fungus was examined. The rates of ID consultation; the likelihood of receiving appropriate antifungal therapy; central venous catheter (CVC) removal rates; performance of ophthalmologic examinations; infection-related length of stay (LOS); rates of all-cause inhospital mortality, death, or transfer to an intensive care unit within 7 days of first culture; and inpatient cost of antifungals were also evaluated...
December 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29167102/coffee-consumption-and-health-umbrella-review-of-meta-analyses-of-multiple-health-outcomes
#16
Robin Poole, Oliver J Kennedy, Paul Roderick, Jonathan A Fallowfield, Peter C Hayes, Julie Parkes
Objectives To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes.Design Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any health outcome.Data sources PubMed, Embase, CINAHL, Cochrane Database of Systematic Reviews, and screening of references.Eligibility criteria for selecting studies Meta-analyses of both observational and interventional studies that examined the associations between coffee consumption and any health outcome in any adult population in all countries and all settings...
November 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29166958/insights-into-the-factors-associated-with-achieving-the-preference-of-home-death-in-terminal-cancer-a-national-population-based-study
#17
Finian Bannon, Victoria Cairnduff, Deirdre Fitzpatrick, Janine Blaney, Barbara Gomes, Anna Gavin, Conan Donnelly
OBJECTIVES: Most terminally ill cancer patients prefer to die at home, yet only a minority are able to achieve this. Our aim was to investigate the factors associated with cancer patients achieving their preference to die at home. METHODS: This study took the form of a mortality followback, population-based, observational survey of the relatives of deceased cancer patients in Northern Ireland. Individuals who registered the death of a friend or relative (aged ≥ 18 years) between 1 December 2011 and 31 May 2012, where the primary cause of death was cancer (ICD10: C00-D48), who were invited to take part...
November 23, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29166948/cause-specific-mortality-for-249-causes-in-brazil-and-states-during-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#18
Elisabeth B França, Valéria Maria de Azeredo Passos, Deborah Carvalho Malta, Bruce B Duncan, Antonio Luiz P Ribeiro, Mark D C Guimarães, Daisy M X Abreu, Ana Maria N Vasconcelos, Mariângela Carneiro, Renato Teixeira, Paulo Camargos, Ana Paula S Melo, Bernardo L Queiroz, Maria Inês Schmidt, Lenice Ishitani, Roberto Marini Ladeira, Otaliba L Morais-Neto, Maria Tereza Bustamante-Teixeira, Maximiliano R Guerra, Isabela Bensenor, Paulo Lotufo, Meghan Mooney, Mohsen Naghavi
BACKGROUND: Reliable data on cause of death (COD) are fundamental for planning and resource allocation priorities. We used GBD 2015 estimates to examine levels and trends for the leading causes of death in Brazil from 1990 to 2015. METHODS: We describe the main analytical approaches focused on both overall and specific causes of death for Brazil and Brazilian states. RESULTS: There was an overall improvement in life expectancy at birth from 1990 to 2015, but with important heterogeneity among states...
November 22, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/29166899/medical-thoracoscopy-for-exudative-pleural-effusion-an-eight-year-experience-from-a-country-with-a-young-population
#19
Merlin Thomas, Wanis H Ibrahim, Tasleem Raza, Kamran Mushtaq, Adeel Arshad, Mushtaq Ahmed, Salma Taha, Saber Al Sarafandi, Hanfa Karim, Hisham A Abdul-Sattar
BACKGROUND: With the exception of areas with high prevalence of tuberculosis, medical thoracoscopy is becoming the diagnostic modality of choice for exudative pleural effusions. The aims of this study were to determine the diagnostic yield and safety of medical thoracoscopy for exudative pleural effusions and ascertain the etiology of such effusions in Qatar. METHODS: This is a retrospective-descriptive study of 407 patients who underwent diagnostic medical thoracoscopy for exudative pleural effusions from January, 2008 till December, 2015 at the only tertiary referral center performing this procedure in Qatar...
November 22, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29166873/mortality-patterns-and-risk-among-older-men-and-women-with-intellectual-disability-a-swedish-national-retrospective-cohort-study
#20
Nawi Ng, Eva Flygare Wallén, Gerd Ahlström
BACKGROUND: Sweden has closed all institutions and imposed legislation to ensure service and support for individuals with intellectual disability (ID). Understanding mortality among older individuals with ID is essential to inform development of health promotion and disease control strategies. We investigated patterns and risk of mortality among older adults with ID in Sweden. METHODS: This retrospective cohort study compared older adults aged 55 years and older with ID with a control population...
November 22, 2017: BMC Geriatrics
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