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https://www.readbyqxmd.com/read/28934213/sports-engagement-and-age-at-first-myocardial-infarction-in-men-under-55-years-of-age
#1
Christoph Janggen, Christoph Gräni, Jonas Brunner, Lukas D Trachsel, Stephan Windecker, Prisca Eser, Lorenz Räber, Matthias Wilhelm
OBJECTIVE: Low levels of physical activity in childhood are associated with clustering of cardiovascular risk factors (CVRF) as predisposition for atherosclerosis. We assessed the association between sports engagement and age at first myocardial infarction (MI) in a cohort of men under 55 years of age. METHODS: The Bern percutaneous coronary intervention Registry (NCT 02241291) was analyzed from March 2009 until January 2012. Male patients with first MI, age 18 to 54 years and body mass index ≤25kg/m2 were included...
2017: PloS One
https://www.readbyqxmd.com/read/28933599/skap2-regulates-arp2-3-complex-for-actin-mediated-asymmetric-cytokinesis-by-interacting-with-wave2-in-mouse-oocytes
#2
Shu-Wen He, Bai-Hui Xu, Yu Liu, Ya-Long Wang, Ming-Huang Chen, Lin Xu, Bao-Qiong Liao, Rui Lui, Fei-Ping Li, Yan-Hong Lin, Xian-Pei Fu, Bin-Bin Fu, Zi-Wei Hong, Yu-Xin Liu, Zhong-Quan Qi, Hai-Long Wang
SKAP2 (Src kinase-associated phosphoprotein 2), a substrate of Src family kinases, has been suggested to be involved in actin-mediated cellular processes. However, little is known about its role in mouse oocyte maturation. In this study, we thus investigated the expression, localization, and functions of SKAP2 during mouse oocyte asymmetric division. SKAP2 protein expression was detected at all developmental stages in mouse oocytes. Immunofluorescent staining showed that SKAP2 was mainly distributed at the cortex of the oocytes during maturation...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933119/-research-on-rat-models-of-acute-liver-injury-with-syndrome-of-liver-depression-and-spleen-deficiency
#3
Na-Na Huang, Xiao-Qian Sun, Qian Yang, Xiao-Yu Li, Rong Sun
This paper aimed to establish animal models which are suitable for the activity found, efficacy evaluation of herbs resistant to acute liver injury with syndrome of liver depression and spleen deficiency and new drug research and development based on corresponding of formula and syndrome. The symptoms that are suitable for evaluating the rat models of acute liver injury with syndrome of liver depression and spleen deficiency were extracted according to the evolution rule of the etiology and pathogenesis in traditional Chinese medicine and the modern pathological mechanism...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932995/pharmacokinetics-and-preliminary-pharmacodynamics-of-single-and-multiple-dose-lyophilized-recombinant-glucagon-like-peptide-1-receptor-agonist-re-4-in-chinese-patients-with-type-2-diabetes-mellitus
#4
Yitong Wang, Bingfeng Xu, Lixia Zhu, Kun Lou, Yingli Chen, Xia Zhao, Qian Wang, Ling Xu, Xiaohui Guo, Linong Ji, Yimin Cui, Yi Fang
BACKGROUND AND OBJECTIVES: Recombinant glucagon-like peptide-1 receptor agonist (rE-4) is a glucagon-like peptide-1 receptor agonist, which has the same amino acid sequence to exenatide, except for the C-terminal deamidated. This study assessed the pharmacokinetics and preliminary pharmacodynamics of rE-4, following single and multiple subcutaneous injections in Chinese patients with type 2 diabetes mellitus (T2DM). DESIGN AND METHODS: In the randomized, open-label study, Chinese patients with T2DM (n = 36) were randomly assigned to three groups of rE-4 (n = 12), rE-4 with metformin (n = 12) and exenatide (n = 12, as the control group) for 12 weeks...
September 20, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28932915/outcomes-in-patients-with-advanced-heart-failure-and-small-body-size-undergoing-continuous-flow-left-ventricular-assist-device-implantation
#5
Nastasya Volkovicher, Chitaru Kurihara, Andre Critsinelis, Masashi Kawabori, Tadahisa Sugiura, Marcos Manon, Andrew B Civitello, Jeffrey A Morgan
Left ventricular assist devices (LVADs) have become a preferred treatment option for patients with end-stage heart failure when used as a bridge to transplant or as a destination therapy. However, the association between small body size and postoperative outcomes for continuous-flow (CF) LVAD recipients is still being studied. We sought to determine whether body surface area (BSA) is associated with patient outcomes after CF-LVAD implantation. The study cohort of our single-center, retrospective review consisted of all patients (n = 526) who underwent CF-LVAD implantation (n = 403 HeartMate II, n = 123 HeartWare) between November 2003 and March 2016 regardless of indication...
September 20, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28932009/relation-between-respiratory-function-and-arterial-stiffness-assessed-using-brachial-ankle-pulse-wave-velocity-in-healthy-workers
#6
Atsushi Inomoto, Rika Fukuda, Junko Deguchi, Toshihiro Toyonaga
[Purpose] Current studies report that patients with chronic obstructive pulmonary disease (COPD) may also have arteriosclerosis. This study aimed to investigate the relationship between respiratory function and arterial stiffness in healthy workers using the brachial-ankle pulse wave velocity (baPWV). [Subjects and Methods] This study included 104 male Japanese workers without COPD. We collected participant information and measured hemodynamics, body composition, and respiratory function. [Results] In the correlation analysis, baPWV showed a significant positive correlation with age, smoking index, systolic blood pressure, diastolic blood pressure, and heart rate, and a significant negative correlation with height, fat free mass, lower limb muscle mass, forced vital capacity (FVC), and forced expiratory volume in one second (FEV1)...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28931688/a-selective-bottleneck-shapes-the-evolutionary-mutant-spectra-of-enterovirus-a71-during-viral-dissemination-in-humans
#7
Sheng-Wen Huang, Yi-Hui Huang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Jen-Ren Wang
RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary pathway by which enterovirus A71 evolves fitness for invading the central nervous system in humans...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28931585/fatty-acid-proportions-in-plasma-cholesterol-esters-and-phospholipids-are-positively-correlated-in-various-swedish-populations
#8
Matti Marklund, Ronnie Pingel, Fredrik Rosqvist, Anna Karin Lindroos, Jan W Eriksson, Bengt Vessby, Jan Oscarsson, Lars Lind, Ulf Risérus
Background: Fatty acid (FA) proportions in cholesterol esters (CEs) and plasma phospholipids are widely used as dietary biomarkers. Information on how proportions in these fractions correlate could have implications for interpretation and use of FA biomarkers in observational and interventional studies.Objective: We investigated correlations between FA proportions in CEs and phospholipids in free-living individuals and assessed how diet-induced alterations of FA proportions correlate between fractions.Methods: Spearman's rank correlation coefficients (rs) between FA proportions (percentage of total FAs) in circulating CEs and phospholipids were calculated separately in 8 individual study populations including Swedish females and males (N = 2052; age range: 11-84 y), and pooled by inverse-variance weighted meta-analysis...
September 20, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#9
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28931321/interstitial-glucose-and-lactate-levels-are-inversely-correlated-with-the-body-mass-index-need-for-in-vivo-calibration-of-glucose-sensor-results-with-blood-values-in-obese-patients
#10
Barbara Enderle, Isabella Moser, Cecil Kannan, Karl Otfried Schwab, Gerald Urban
BACKGROUND: Continuously measured glucose and lactate levels in interstitial fluid (ISF) may markedly differ from their respective blood levels. METHODS: Combining microdialysis with a bioanalytical microsystem, the interstitial glucose and lactate concentrations of eight male volunteers with different body mass index (BMI) were monitored during a 2-fold glucose tolerance test over the period of three hours. RESULTS: Significant correlations were found between abdominally measured sensor results and reference measurements ( R(2) = ...
September 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28929011/in-rats-fed-high-energy-diets-taste-rather-than-fat-content-is-the-key-factor-increasing-food-intake-a-comparison-of-a-cafeteria-and-a-lipid-supplemented-standard-diet
#11
Laia Oliva, Tània Aranda, Giada Caviola, Anna Fernández-Bernal, Marià Alemany, José Antonio Fernández-López, Xavier Remesar
BACKGROUND: Food selection and ingestion both in humans and rodents, often is a critical factor in determining excess energy intake and its related disorders. METHODS: Two different concepts of high-fat diets were tested for their obesogenic effects in rats; in both cases, lipids constituted about 40% of their energy intake. The main difference with controls fed standard lab chow, was, precisely, the lipid content. Cafeteria diets (K) were self-selected diets devised to be desirable to the rats, mainly because of its diverse mix of tastes, particularly salty and sweet...
2017: PeerJ
https://www.readbyqxmd.com/read/28928767/genome-wide-epigenetic-characterization-of-tissues-from-three-germ-layers-isolated-from-sheep-fetuses
#12
Emanuele Capra, Paola Toschi, Marcello Del Corvo, Barbara Lazzari, Pier A Scapolo, Pasqualino Loi, John L Williams, Alessandra Stella, Paolo Ajmone-Marsan
DNA methylation of regulatory and growth-related genes contributes to fetal programming which is important for maintaining the correct development of three germ layers of the embryo that develope into different tissues and organs, and which persists into adult life. In this study, a preliminary epigenetic screen was performed to define genomic regions that are involved in fetal epigenome remodeling. Embryonic ectodermic tissues (origin of nervous tissue), mesenchymal tissues (origin of connective and muscular tissues), and foregut endoderm tissues (origin of epithelial tissue), from day 28 sheep fetuses were collected and the distribution of methylated CpGs was analyzed using whole-genome bisulfite sequencing...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28928331/outcomes-according-to-body-mass-index-following-laparoscopic-surgery-in-patients-with-colorectal-cancer
#13
Han Deok Kwak, Jae Kyun Ju, Dong Woo Kang, Se-Jin Baek, Jung Myun Kwak, Jin Kim, Seon-Hahn Kim
PURPOSE: Body mass index (BMI) may not be appropriate for different populations. Therefore, the World Health Organization (WHO) suggested 25 kg/m2 as a measure of obesity for Asian populations. The purpose of this report was to compare the oncologic outcomes of laparoscopic colorectal resection with BMI classified from the WHO Asia-Pacific perspective. PATIENTS AND METHODS: All patients underwent laparoscopic colorectal resection from September 2006 to March 2015 at a tertiary referral hospital...
September 20, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28926602/autoimmune-disease-mouse-model-exhibits-pulmonary-arterial-hypertension
#14
Koichi Sugimoto, Kazuhiko Nakazato, Akihiko Sato, Satoshi Suzuki, Akiomi Yoshihisa, Takeshi Machida, Shu-Ichi Saitoh, Hideharu Sekine, Yasuchika Takeishi
BACKGROUND: Pulmonary arterial hypertension is often associated with connective tissue disease. Although there are some animal models of pulmonary hypertension, an autoimmune disease-based model has not yet been reported. MRL/lpr mice, which have hypergammaglobulinemia, produce various autoimmune antibodies, and develop vasculitis and nephritis spontaneously. However, little is known about pulmonary circulation in these mice. In the present study, we examined the pulmonary arterial pressure in MRL/lpr mice...
2017: PloS One
https://www.readbyqxmd.com/read/28925487/mir-370-functions-as-prognostic-marker-in-patients-with-hepatocellular-carcinoma
#15
X-P Pan, L-H Huang, X Wang
OBJECTIVE: Large body of evidence has shown that microRNAs (miRNAs) have the potential to serve as prognosis marker. This study is designed to investigate the expression of miR-370 in hepatocellular carcinoma (HCC) patients and to analyze its potential prognostic value. PATIENTS AND METHODS: Quantitative real-time quantitative PCR (qPCR) was performed to examine the miR-370 level in HCC tissue and matched normal tissue from 83 HCC patients. The correlation of miR-370 level in HCC tissue with the clinicopathological characteristics was analyzed...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28924924/predictors-of-microbiologically-confirmed-intrathoracic-tuberculosis
#16
Rakhi Jain, Aparna Mukherjee, Mohit Singla, Yogita Verma, Hitender Gautam, Rakesh Lodha, Urvashi B Singh, Sushil K Kabra
OBJECTIVE: To identify risk factors for microbiologically confirmed intrathoracic tuberculosis in children. METHODS: Children, 6 mo to 15 y of age, attending the out-patient department of a tertiary care centre in India, with probable intrathoracic tuberculosis were enrolled. Microbiological confirmation of tuberculosis was defined as positivity on smear (Ziehl-Neelsen staining) and/or Xpert MTB/RIF and/or MGIT-960 culture. Association of various factors with microbiological confirmation were assessed by univariate and multivariate analysis...
September 19, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28924598/carbon-dioxide-insufflation-is-associated-with-increased-serrated-polyp-detection-rate-when-compared-to-room-air-insufflation-during-screening-colonoscopy
#17
Michael Riverso, Yaseen B Perbtani, Jonathan J D Shuster, Joydeep Chakraborty, Tony S Brar, Mitali Agarwal, Han Zhang, Anand Gupte, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov, Dennis Yang
BACKGROUND AND STUDY AIMS : Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) have been increasingly recognized as precursors of colorectal cancer. The aim of this study was to compare the effect of carbon dioxide insufflation (CO 2 I) vs. room air insufflation (AI) on serrated polyp detection rate (SPDR) and to identify factors associated with SPDR. PATIENTS AND METHODS : Single-center retrospective cohort study of 2083 screening colonoscopies performed with AI (November 2011 through January 2013) or CO 2 I (February 2013 to June 2015)...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28924590/physical-activity-during-video-capsule-endoscopy-correlates-with-shorter-bowel-transit-time
#18
Peter P Stanich, Joshua Peck, Christopher Murphy, Kyle M Porter, Marty M Meyer
BACKGROUND AND STUDY AIM:  Video capsule endoscopy (VCE) is limited by reliance on bowel motility for propulsion, and lack of physical activity has been proposed as a cause of incomplete studies. Our aim was to prospectively investigate the association between physical activity and VCE bowel transit. PATIENTS AND METHODS:  Ambulatory outpatients receiving VCE were eligible for the study. A pedometer was attached at the time of VCE ingestion and step count was recorded at the end of the procedure...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28923188/poor-sleep-moderates-the-relationship-between-daytime-napping-and-inflammation-in-black-and-white-men
#19
Karen P Jakubowski, Jennifer M Boylan, Jenny M Cundiff, Karen A Matthews
OBJECTIVES: To test whether napping was associated with 2 inflammatory markers with known relationships to cardiovascular disease: high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6). Because IL-6 is known to impact central inflammatory processes that relate to sleep regulation, including subjective fatigue, we tested whether this relationship was moderated by sleep duration, sleep efficiency, and self-reported sleep quality. DESIGN: Cross-sectional...
October 2017: Sleep Health
https://www.readbyqxmd.com/read/28923051/perceived-neighborhood-safety-related-to-physical-activity-but-not-recreational-screen-based-sedentary-behavior-in-adolescents
#20
Clare M Lenhart, Andrew Wiemken, Alexandra Hanlon, Mackenzie Perkett, Freda Patterson
BACKGROUND: A growing proportion of adolescents have poor cardiovascular health behaviors, including low levels of physical activity and high levels of sedentary behavior, thus increasing the likelihood of poor heart health in later years. This study tested the hypothesis that low perceived neighborhood safety would be associated with low levels of physical activity and high levels of recreational sedentary behavior in high-school students. METHODS: Using cross-sectional, weighted data from the 2015 Pennsylvania (USA) State and Philadelphia city Youth Risk Behavior Survey, multivariable logistic regression modeling was used to examine the association between perceived neighborhood safety, and physical activity levels and recreational screen-based sedentary behavior time respectively, while controlling for potential confounders...
September 18, 2017: BMC Public Health
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