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https://www.readbyqxmd.com/read/29149438/patient-predicted-sleep-position-vs-hst-data-a-tendency-to-underestimate-supine-sleep
#1
Adam J Sorscher, Anthony P Anzivino, Todd Mackenzie
PURPOSE: The purpose of this study is to measure people's accuracy when they estimate what proportion of their nightly sleep at home is supine vs. non-supine. METHODS: A series of patients referred for obstructive sleep apnea (OSA) evaluation were asked if they "knew with confidence" how they slept with regard to their body position. "Yes" responders were then asked to estimate what percentage of their sleep was supine vs. non-supine. This value was compared with the actual proportion of supine vs...
November 17, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29149429/population-analysis-of-predictors-of-difficult-intubation-with-direct-laryngoscopy-in-pediatric-patients-with-and-without-thyroid-disease
#2
Aalap C Shah, William C K Ng, Sean Sinnott, Joseph P Cravero
PURPOSE: There are no data on the prevalence and predictors of difficult intubation (DI) in pediatric patients with thyroid disease. This study (1) assesses the prevalence of DI in patients with thyroid disease undergoing elective operations, (2) identifies other predictors of DI in children, and (3) evaluates the effect of DI on postoperative care and length-of-stay. METHODS: A single-center retrospective cohort analysis of procedures in patients assigned with an ICD-9 code for thyroid disease between June 2012 and February 2016...
November 17, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29149323/should-the-dilated-ascending-aorta-be-repaired-at-the-time-of-bicuspid-aortic-valve-replacement
#3
Tsuyoshi Kaneko, Prem Shekar, Vladimir Ivkovic, Nicholas T Longford, Chuan-Chin Huang, Martin I Sigurdsson, Robert C Neely, Maroun Yammine, Julius I Ejilofor, Vanessa Montiero Vieira, Jasmine T Shahram, Karam M Habchi, Gregory W Malzberg, Peter S Martin, Jordan Bloom, Eric M Isselbacher, J Daniel Muehlschlegel, Thoralf M Sundt, Simon C Body
OBJECTIVES: Bicuspid aortic valve (BAV) is the most common congenital valvular abnormality and frequently presents with accelerated calcific aortic valve disease, requiring aortic valve replacement (AVR) and thoracic aortic aneurysm and dissection. Supporting evidence for Association Guidelines of aortic dimensions for aortic resection is sparse. We sought to determine whether concurrent repair of dilated or aneurysmal aortic disease during AVR in patients with BAV substantially improves morbidity and mortality outcomes...
November 14, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29149189/perioperative-body-weight-change-is-associated-with-in-hospital-mortality-in-cardiac-surgical-patients-with-postoperative-acute-kidney-injury
#4
Chih-Chung Shiao, Ya-Ting Huang, Tai-Shuan Lai, Tao-Min Huang, Jian-Jhong Wang, Chun-Te Huang, Pei-Chen Wu, Che-Hsiung Wu, I-Jung Tsai, Li-Jung Tseng, Chih-Hsien Wang, Tzong-Shinn Chu, Kwan-Dun Wu, Vin-Cent Wu
BACKGROUND: Postoperative acute kidney injury (AKI) is common following cardiac surgery (CS). Body weight (BW) may be an amenable variable by representing the summation of the nutritional and the fluid status. However, the predictive role of perioperative BW changes in CS patients with severe postoperative AKI is never explored. This study aimed to evaluate this association. METHODS: This study was conducted using a prospectively collected multicenter cohort, NSARF (National Taiwan University Hospital Study Group on Acute Renal Failure) database...
2017: PloS One
https://www.readbyqxmd.com/read/29147870/changes-in-body-composition-and-muscle-attenuation-during-taxane-based-chemotherapy-in-patients-with-metastatic-breast-cancer
#5
Hánah N Rier, Agnes Jager, Stefan Sleijfer, Joost van Rosmalen, Marc C J M Kock, Mark-David Levin
PURPOSE: Body composition parameters including low muscle mass, muscle attenuation (which reflects muscle quality) and adipose tissue measurements have emerged as prognostic factors in cancer patients. However, knowledge regarding the possibility of excessive muscle loss during specific systemic therapies is unknown. We describe the changes in body composition and muscle attenuation (MA) during taxane- and anthracycline-based regimens and its association with overall survival (OS) in metastatic breast cancer patients...
November 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29146982/photonic-simulation-of-entanglement-growth-and-engineering-after-a-spin-chain-quench
#6
Ioannis Pitsios, Leonardo Banchi, Adil S Rab, Marco Bentivegna, Debora Caprara, Andrea Crespi, Nicolò Spagnolo, Sougato Bose, Paolo Mataloni, Roberto Osellame, Fabio Sciarrino
The time evolution of quantum many-body systems is one of the most important processes for benchmarking quantum simulators. The most curious feature of such dynamics is the growth of quantum entanglement to an amount proportional to the system size (volume law) even when interactions are local. This phenomenon has great ramifications for fundamental aspects, while its optimisation clearly has an impact on technology (e.g., for on-chip quantum networking). Here we use an integrated photonic chip with a circuit-based approach to simulate the dynamics of a spin chain and maximise the entanglement generation...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146686/specific-force-of-the-vastus-lateralis-in-adults-with-achondroplasia
#7
David Thomas Sims, Gladys L Onambele-Pearson, Adrian Burden, Carl Payton, Christopher I Morse
Achondroplasia is a clinical condition defined by shorter stature and disproportionate limb length. Force production in able-bodied individuals (controls) is proportional to muscle size, but given the disproportionate nature of Achondroplasia, normalising to anatomical cross sectional area (ACSA) is inappropriate. The aim of this study was to assess specific force of the vastus lateralis (VL) in 10 adults with Achondroplasia (22 ±3 yrs) and 18 gender matched controls (22 ±2 yrs). Isometric torque (iMVCτ) of the dominant knee extensors (KE) and in vivo measures of VL muscle architecture, volume, activation and patella tendon moment arm were used to calculate VL physiological CSA (PCSA), fascicle force and specific force in both groups...
November 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29145263/ldl-cholesterol-goal-attainment-under-persistent-lipid-lowering-therapy-in-northeast-china-subgroup-analysis-of-the-dyslipidemia-international-study-of-china-dysis-china
#8
Wen Zheng, Yu-Jiao Zhang, Xiang-Ting Bu, Xin-Zhu Guo, Da-Yi Hu, Zhan-Quan Li, Jian Sun
Lipid-lowering therapy with statins reduces the risk of cardiovascular events, but the efficacy of persistent treatment in a real-world setting may vary from regions. Routine lipid-lowering therapy in the region with a high prevalence of cardiovascular disease may lead to more failures of goal attainment. We therefore performed a study to observe different lipid-lowering strategies in northeast (NE) China with respect to low-density lipoprotein-cholesterol (LDL-C) reduction and goal attainments.A cross-sectional study (DYSIS-China) was conducted in 2012, involving 25,317 patients from 122 centers across China who were diagnosed with hyperlipidemia and treated with lipid-lowering therapy for at least 3 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144022/collagen-a-review-on-its-sources-and-potential-cosmetic-applications
#9
REVIEW
María Isabela Avila Rodríguez, Laura G Rodríguez Barroso, Mirna Lorena Sánchez
Collagen is a fibrillar protein that conforms the conjunctive and connective tissues in the human body, essentially skin, joints, and bones. This molecule is one of the most abundant in many of the living organisms due to its connective role in biological structures. Due to its abundance, strength and its directly proportional relation with skin aging, collagen has gained great interest in the cosmetic industry. It has been established that the collagen fibers are damaged with the pass of time, losing thickness and strength which has been strongly related with skin aging phenomena [Colágeno para todo...
November 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29143718/prediction-of-a-new-body-shape-index-and-body-adiposity-estimator-for-development-of-type-2-diabetes-mellitus-the-rural-chinese-cohort-study
#10
Chengyi Han, Yu Liu, Xizhuo Sun, Xinping Luo, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Ming Zhang, Dongsheng Hu
To compare the ability of a body shape index (ABSI) and body adiposity estimator (BAE) to BMI, waist circumference (WC) and waist:height ratio (WHtR) for predicting development of type 2 diabetes mellitus (T2DM) in rural adult Chinese. The prospective cohort study included 11 687 eligible participants who were free of T2DM at baseline. The risk of new-onset T2DM for ABSI, BAE, BMI, WC and WHtR quintiles was estimated by Cox proportional-hazards regression at follow-up. We also compared the power of ABSI and BAE to BMI, WC and WHtR for predicting the development of T2DM...
November 16, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29143150/the-impact-of-sea-ice-conditions-on-breeding-decisions-is-modulated-by-body-condition-in-an-arctic-partial-capital-breeder
#11
Frankie Jean-Gagnon, P Legagneux, G Gilchrist, S Bélanger, O P Love, J Bêty
Determining how environmental conditions interact with individual intrinsic properties is important for unravelling the underlying mechanisms that drive variation in reproductive decisions among migratory species. We investigated the influence of sea ice conditions and body condition at arrival on the breeding propensity, i.e. the decision to reproduce or not within a single breeding season, and timing of laying in migrating common eiders (Somateria mollissima) breeding in the Arctic. Using Radarsat satellite images acquired from 2002 to 2013, we estimated the proportion of open water in the intertidal zone in early summer to track the availability of potential foraging areas for pre-breeding females...
November 15, 2017: Oecologia
https://www.readbyqxmd.com/read/29142294/administration-of-increasing-doses-of-gonadotropin-releasing-hormone-in-men-with-spinal-cord-injury-to-investigate-dysfunction-of-the-hypothalamic-pituitary-gonadal-axis
#12
William A Bauman, Michael F La Fountaine, Christopher M Cirnigliaro, Steven C Kirshblum, Ann M Spungen
STUDY DESIGN: Prospective. OBJECTIVES: To determine the optimum gonadotropin-releasing hormone (GnRH) dose to identify dysfunction of the hypothalamic-pituitary-gonadal axis in men with spinal cord injury (SCI). SETTING: Metropolitan Area Hospitals, New York and New Jersey, USA. METHODS: SCI men (16 hypogonadal (HG = serum testosterone <12.1 nmol/l) and 14 eugonadal (EG)) and able-bodied (AB) men (27 HG and 11 EG) were studied...
November 15, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29142108/growth-and-size-control-during-development
#13
REVIEW
Jannik Vollmer, Fernando Casares, Dagmar Iber
The size and shape of organs are characteristic for each species. Even when organisms develop to different sizes due to varying environmental conditions, such as nutrition, organ size follows species-specific rules of proportionality to the rest of the body, a phenomenon referred to as allometry. Therefore, for a given environment, organs stop growth at a predictable size set by the species's genotype. How do organs stop growth? How can related species give rise to organs of strikingly different size? No definitive answer has been given to date...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29141994/type-ii-diabetes-and-incidence-of-estrogen-receptor-negative-breast-cancer-in-african-american-women
#14
Julie R Palmer, Nelsy Castro-Webb, Kimberly Bertrand, Traci N Bethea, Gerald V Denis
White women with type II diabetes (T2D) have an estimated 20% increased risk of developing breast cancer. Little is known about associations by breast cancer subtype or among African American (AA) women, who are disproportionately affected by T2D and estrogen receptor negative (ER-) breast cancer. We assessed the relation of T2D to incidence of ER- and ER+ breast cancer in data from the Black Women's Health Study, a prospective cohort of AA women enrolled in 1995 and followed biennially. During 847,934 person-years of follow-up, there were 1,851 incident invasive breast cancers, including 914 ER+ and 468 ER- cases...
November 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/29141856/impact-of-diabetes-mellitus-on-outcomes-in-patients-supported-with-left-ventricular-assist-devices-a-single-institutional-9-year-experience
#15
Rabea Asleh, Alexandros Briasoulis, Sarah D Schettle, Vakhtang Tchantchaleishvili, Naveen L Pereira, Brooks S Edwards, Alfredo L Clavell, Simon Maltais, David L Joyce, Lyle D Joyce, Richard C Daly, Sudhir S Kushwaha, John M Stulak
BACKGROUND: Diabetes mellitus (DM) is a risk factor for morbidity and mortality in patients with heart failure. The effect of DM on post-left ventricular assist device (LVAD) implantation outcomes is unclear. This study sought to investigate whether patients with DM had worse outcomes than patients without DM after LVAD implantation and whether LVAD support resulted in a better control of DM. METHODS AND RESULTS: We retrospectively reviewed 341 consecutive adults who underwent implantation of LVAD from 2007 to 2016...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29141396/proposal-of-a-pretreatment-nomogram-for-predicting-local-recurrence-after-intensity-modulated-radiation-therapy-in-t4-nasopharyngeal-carcinoma-a-retrospective-review-of-415-chinese-patients
#16
Lu-Lu Zhang, Yi-Yang Li, Jiang Hu, Guan-Qun Zhou, Lei Chen, Wen-Fei Li, Ai-Hua Lin, Jun Ma, Zhen-Yu Qi, Ying Sun
Purpose: Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT). Methods and Materials: Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013...
November 15, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29140420/growth-trajectories-breast-size-and-breast-tissue-composition-in-a-british-pre-birth-cohort-of-young-women
#17
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Martin O Leach, David J Hawkes, Isabel Dos-Santos-Silva
Mammographic % density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations between magnetic resonance imaging (MRI) breast-tissue composition at age 21 years and prospectively-collected measures of body size and composition from birth to early adulthood, and markers of puberty (all standardized), in a sample of 500 nulliparous women from a pre-birth cohort of children born in Avon, England, in 1991-1992 and followed up to 2011-2014...
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29140179/relationship-between-two-standardized-tackling-proficiency-tests-and-rugby-league-match-play-tackle-performance
#18
Michael Speranza, Tim Gabbett, David A Greene, Richard D Johnston, Andrew D Townshend
This study investigated the relationship between two different assessments of tackling ability, physical qualities, and match-play performance in semi-professional rugby league players. Eighteen semi-professional rugby league players (mean ± SD age, 23.1 ± 2.0 yrs; mass 98.8 ± 11.8 kg) underwent tests of upper- and lower-body strength and power. Tackling ability was assessed using video analysis under-the-ball and over-the-ball tackle drills. A total of 2,360 tackles were analyzed from match-play. Over-the-ball tackle ability was positively related to the proportion of dominant tackles (rs = 0...
November 15, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29140158/endosomal-trafficking-regulates-receptor-mediated-transcytosis-of-antibodies-across-the-blood-brain-barrier
#19
Arsalan S Haqqani, Christie E Delaney, Eric Brunette, Ewa Baumann, Graham K Farrington, William Sisk, John Eldredge, Wen Ding, Tammy-Lynn Tremblay, Danica B Stanimirovic
Current methods for examining antibody trafficking are either non-quantitative such as immunocytochemistry or require antibody labeling with tracers. We have developed a multiplexed quantitative method for antibody 'tracking' in endosomal compartments of brain endothelial cells. Rat brain endothelial cells were co-incubated with blood-brain barrier (BBB)-crossing FC5, monovalent FC5Fc or bivalent FC5Fc fusion antibodies and control antibodies. Endosomes were separated using sucrose-density gradient ultracentrifugation and analyzed using multiplexed mass spectrometry to simultaneously quantify endosomal markers, receptor-mediated transcytosis (RMT) receptors and the co-incubated antibodies in each fraction...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29139618/beyond-sarcopenia-characterization-and-integration-of-skeletal-muscle-quantity-and-radiodensity-in-a-curable-breast-cancer-population
#20
Marc S Weinberg, Shlomit S Shachar, Hyman B Muss, Allison M Deal, Karteek Popuri, Hyeon Yu, Kirsten A Nyrop, Shani M Alston, Grant R Williams
Skeletal muscle loss, commonly known as sarcopenia, is highly prevalent and prognostic of adverse outcomes in oncology. However, there is limited information on adults with early breast cancer and examination of other skeletal muscle indices, despite the potential prognostic importance. This study characterizes and examines age-related changes in body composition of adults with early breast cancer and describes the creation of a novel integrated muscle measure. Female patients diagnosed with stage I-III breast cancer with abdominal computerized tomography (CT) scans within 12 weeks from diagnosis were identified from local tumor registry (N = 241)...
November 15, 2017: Breast Journal
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