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Tania M Cortázar, Iain B H Wilson, Alba Hykollari, Edgar A Reyes, Nohora A Vega
The carbohydrate specificities of Dioclea grandiflora lectins DGL-I1 and DGL-II, and Galactia lindenii lectin II (GLL-II) were explored by use of remodeled glycoproteins as well as by the lectin hemagglutinating activity against erythrocytes from various species with different glycomic profiles. The three lectins exhibited differences in glycan binding specificity but also showed overlapping recognition of some glycotopes (i.e. Tα glycotope for the three lectins; IIβ glycotope for DGL-II and GLL-II lectins); in many cases the interaction with distinct glycotopes was influenced by the structural context, i...
January 27, 2018: Glycoconjugate Journal
Antonio A Faundez, Jonathon Richards, Philippe Maxy, Rachel Price, Amélie Léglise, Jean-Charles Le Huec
PURPOSE: To identify risk factors, in 12 patients with junctional breakdown (JBD) after thoraco-sacral fusions and to test a software locating maximal bending moment on full spine EOS images. METHODS: Twelve patients underwent long fusions for lumbar degenerative pathologies. Preop EOS images were compared to first postop EOS showing JBD. Parameters analyzed were: spinopelvic parameters [pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), sagittal vertical axis (SVA), spinosacral angle (SSA), lordosis, and kyphosis], proximal junctional angle (PJA), odontoid-hip axis angle (ODHA), and CIA...
February 2018: European Spine Journal
Dasiel O Borroto-Escuela, Alexander O Tarakanov, Karl Bechter, Kjell Fuxe
The mild neuroinflammation hypothesis of schizophrenia was introduced by Bechter in 2001. It has been hypothesized that a hypofunction of glutamatergic signaling via N-methyl-D-aspartate receptors (NMDARs) and hyperactivation of dopamine D2 receptors play a role in schizophrenia. The triplet puzzle theory states that sets of triplet amino acid homologies guide two different receptors toward each other and contributes to the formation of a receptor heteromer. It is, therefore, proposed that putative NMDAR-C-C chemokine receptor type 2 (CCR2), NMDAR-C-X-C chemokine receptor type 4 (CXCR4), and NMDAR- interleukin 1 receptor type II (IL1R2) heteromers can be formed in the neuronal networks in mild neuroinflammation due to demonstration of Gly-Leu-Leu (GLL), Val-Ser-Thr (VST), and/or Ser-Val-Ser (SVS) amino acid homologies between these receptor protomers...
2017: Frontiers in Psychiatry
Ben Hu, Zheng-Kun Kuang, Shi-Yu Feng, Dong Wang, Song-Bing He, De-Xin Kong
The crystallized ligands in the Protein Data Bank (PDB) can be treated as the inverse shapes of the active sites of corresponding proteins. Therefore, the shape similarity between a molecule and PDB ligands indicated the possibility of the molecule to bind with the targets. In this paper, we proposed a shape similarity profile that can be used as a molecular descriptor for ligand-based virtual screening. First, through three-dimensional (3D) structural clustering, 300 diverse ligands were extracted from the druggable protein-ligand database, sc-PDB...
November 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
M Adeel Akhtar, R Bhattacharya, J F Keating
BACKGROUND: The aim of the present study was to investigate the relationship between generalised ligamentous laxity (GLL) and requirement for revision anterior cruciate ligament (ACL) reconstruction. METHODS: The study cohort consisted of 139 patients undergoing primary ACL reconstruction, 44 patients undergoing revision ACL surgery and a control group of 70 patients without any knee ligament injury. A Beighton score of four or more was classified as generalised ligamentous laxity...
December 2016: Knee
Kavita Kumari Kakarala, Kaiser Jamil
Protease activated receptor 2 (PAR2) has emerged as one of the promising therapeutic targets to inhibit rapidly metastasizing breast cancer cells. However, its elusive molecular mechanism of activation and signaling has made it a difficult target for drug development. In this study, in silico methods were used to unfold PAR2 molecular mechanism of signaling based on the concept of GPCR receptor plasticity. Although, there are no conclusive evidences of the presence of specific endogenous ligands for PAR2, the efficacy of synthetic agonist and antagonist in PAR2 signaling has opened up the possibilities of ligand-mediated signaling...
June 2016: Journal of Biomolecular Structure & Dynamics
A Wiedemann, R Maykan, J Pennekamp, H Heppner
OBJECTIVE: Detection of changes in cognition after transurethral resection (TURP) or 180-Watt green-light XPS laser treatment (GLL) of the prostate is required by the German "Krankenhausbedarfsplan" which demands an interdisciplinary dialogue including special aspects of the operating discipline. This has as yet not been investigated in Germany or in Europe. METHODS: Assessments of the cognitive capacity were made by application of the "Mini Mental State Examination" and the "Uhrentest" preoperatively and on postoperative day 2 in addition to documentation of clinical parameters such as patient age, prostate size, duration of surgery, comorbidities, co-medication, changes in haemoglobin and sodium...
February 2016: Aktuelle Urologie
M Jovanović, Z Džamić, M Aćimović, B Kajmaković, T Pejčić
INTRODUCTION: Laser therapy has gained increasing acceptance as a relatively less invasive treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). From the early procedure of interstitial laser coagulation through to the use of holmium laser enucleation of the prostate, there has been an expanding body of evidence on the efficacy of such procedures. One of the newer lasers is the Green Light HPS 180 W laser. Studies with this GreenLight laser (GLL) (American Medical Systems, Inc, Minnetonka, MN, USA) showing results as good as those of transurethral resection of the prostate (TURP)...
2014: Acta Chirurgica Iugoslavica
Elnaz Hajizadeh, B D Todd, P J Daivis
We present nonequilibrium molecular dynamics (NEMD) simulation results for the miscibility, structural properties, and melt rheological behavior of polymeric blends under shear flow. The polymeric blends consist of chemically identical linear polymer chains (187 monomers per chain) and dendrimer polymers of generations g = 1-4. The number fraction x of the dendrimer species is varied (4%, 8%, and 12%) in the blend melt. The miscibility of blend species is measured, using the pair distribution functions gDL, gLL, and gDD...
November 21, 2014: Journal of Chemical Physics
Patrícia Bahls de Almeida Farhat, Fábio André Santos, João Carlos Gomes, Osnara Maria Mongruel Gomes
OBJECTIVE: This study determined the efficacy of LED-laser treatment and the control of sensitivity caused by in-office bleaching. BACKGROUND DATA: Auxiliary power sources (halogen light, arc plasma, LED, LED-laser, and laser) are used in in-office teeth bleaching techniques to accelerate the redox reaction of the whitening gel to increase ease of use, to improve comfort and safety, and to decrease the procedure time. METHODS: Sixteen volunteers participated in this randomized, blinded and split-mouth clinical study...
July 2014: Photomedicine and Laser Surgery
Jie Xia, Hongwei Jin, Zhenming Liu, Liangren Zhang, Xiang Simon Wang
Benchmarking data sets have become common in recent years for the purpose of virtual screening, though the main focus had been placed on the structure-based virtual screening (SBVS) approaches. Due to the lack of crystal structures, there is great need for unbiased benchmarking sets to evaluate various ligand-based virtual screening (LBVS) methods for important drug targets such as G protein-coupled receptors (GPCRs). To date these ready-to-apply data sets for LBVS are fairly limited, and the direct usage of benchmarking sets designed for SBVS could bring the biases to the evaluation of LBVS...
May 27, 2014: Journal of Chemical Information and Modeling
T Y Cheng, H H Smith
A differential influence of the two parental genomes on cell proliferation and morphogenesis in pith tissue explants can be observed among the various tumorous hybrid combinations between Nicotiana glauca Grah. and N. langsdorffii Weinm.: the F1 hybrid (GL), its amphiploid (GGLL), and two different triploids (GGL and GLL). This influence was evident when the explants were cultured in the presence of exogenous auxin (indole-3-acetic acid, 2.5 μM), supplied either continuously or for a brief period of time. Compared with the F1 and the amphiploid, the higher proportion of N...
March 1973: Planta
Radomir Banjanac, Aleksandar Dragić, Vladimir Udovičić, Dejan Joković, Dimitrije Maletić, Nikola Veselinović, Mihailo Savić
During the last three years we investigated the variations of background simultaneously in two laboratories, the ground level (GLL) and the underground laboratory. The Forbush-like effect from March 2010 was observed in the GLL using a Ge detector and plastic veto scintillator. The underground plastic scintillator saw the same effect but the coincident veto spectrum did not detect the decrease of cosmic-ray intensity. Using a time series analysis of prominent post-radon lines, a significant radon daily variability was detected in the Ge detector background spectrum, but only in the GLL...
May 2014: Applied Radiation and Isotopes
Ru Wang, Markku Alen, Zhusheng Yu, Petri Wiklund, Shu Mei Cheng, Timo Törmäkangas, Peijie Chen, Sulin Cheng
Vitamin D is well known for its regulatory role in calcium and phosphate homeostasis, but its role in muscle mass and strength during growth remains inconclusive. We explored the association of serum 25-hydroxyvitamin D (25(OH)D) with muscle development in girls from 11 to 18-years old. Whole body lean tissue mass (LMWB), appendicular lean mass (aLM), muscle cross-sectional area at the lower leg (mCSA), maximal voluntary contraction of elbow flexors (MVC elbow) and knee extensors (MVC knee) were assessed in 217 girls aged 10-13 years (at baseline), 215 in 2-year and 226 in 7...
2013: PloS One
Amrita Singh, Shri Singh
We present comprehensive results of the Monte Carlo (MC) simulations of the phase ordering dynamics in d = 2 nematic liquid crystals. We study a system of size N (2)(N = 512) with molecules confined to a 512×512 square lattice and report the results for two LC Hamiltonians: generalized Lebwohl-Lasher (GLL) model and r(-6) dependent anisotropic dispersion interaction potential. In these Hamiltonians a fourth-rank Legendre polynomial P4 interaction term is added to the usual second-rank P2 term. We find that in both the cases the presence of the P4 interaction term significantly influences the nematic domains morphology...
October 2013: European Physical Journal. E, Soft Matter
Ebrahim Ghayem-Hasankhani, Farzad Omidi-Kashani
BACKGROUND: Many factors effect on management (surgical and nonsurgical) of adolescent idiopathic scoliosis (AIS). OBJECTIVES: The purpose of this study was evaluation of the effects of generalized ligamentous laxity (GLL) on surgical treatment of AIS. MATERIALS AND METHODS: 72 patients with AIS were studied between 2002 and 2009. 24 cases (33.4%) were placed in group A (normal) while 48 patients (66.6%) with GLL in group B. Our threshold for adding anterior approach was a curve which could not be corrected to < 50° on the supine lateral bending view...
November 2012: Iranian Red Crescent Medical Journal
Edgar A Gatica, Claudio N Cavasotto
We compiled a G protein-coupled receptor (GPCR) ligand library (GLL) for 147 targets, selecting for each ligand 39 decoy molecules, collected in the GPCR Decoy Database (GDD). Decoys were chosen ensuring a ligand-decoy similarity of six physical properties, while enforcing ligand-decoy chemical dissimilarity. The performance in docking of the GDD was evaluated on 19 GPCRs, showing a marked decrease in enrichment compared to bias-uncorrected decoy sets. Both the GLL and GDD are freely available for the scientific community...
January 23, 2012: Journal of Chemical Information and Modeling
Umesh U Jadhav, Vishal V Dawkar, Mital U Jadhav, Sanjay P Govindwar
Polyphenol oxidase (PPO) purified using DEAE-cellulose and Biogel P-100 column chromatography from banana pulp showed 12.72-fold activity and 2.49% yield. The optimum temperature and pH were found to be 30 degrees C and 7.0, respectively for its activity. Catechol was found to be a suitable substrate for banana pulp PPO that showed V(max), 0.041 mM min(-1) and K(m), 1.6 mM. The enzyme activity was inhibited by sodium metabisulfite, citric acid, cysteine, and beta-mercaptoethanol at 10 mM concentration. The purified enzyme could decolorize (90%) Direct Red 5B (160 microg mL(-1)) dye within 48 h and Direct Blue GLL (400 microg mL(-1)) dye up to 85% within 90 h...
April 2011: International Journal of Phytoremediation
P Correale, M Caraglia, A Procopio, M Marinetti, R Guarrasi, A Fabbrocini, A Bianco, P Tagliaferri
Extracellular ATP can often induce tumor cell cytotoxicity; however, the molecular mechanisms of these effects are mostly unknown. We investigated whether modifications in transmembrane ion fluxes are involved in the determination of ATP-cytotoxicity. We have found that cultured human tumor cells derived from colon (LoVo) and lung (A549) carcinomas are resistant to ATP, while LoVo-Dx cells (a doxorubicin-resistant derivative of LoVo cells) and melanoma GLL-19 cells are highly sensitive to this nucleotide. 48 h exposure to 100 nM verapamil increases sensitivity of LoVo and A549 cells to ATP...
November 1993: International Journal of Oncology
Orit Taubman-Ben-Ari, Tsippy Lotan
Young drivers in Israel, as in other parts of the world, are at an elevated risk of being involved in car crashes more than any other age group. A Graduated Driver Licensing System (GDL) has been introduced in Israel, requiring new drivers to be accompanied by an experienced driver during the first 3 months after obtaining a driving license. In an effort to ensure the effectiveness of the accompanied driving phase, a novel program which targets both young drivers and their parents, called green light for life (GLL), was initiated...
January 2011: Accident; Analysis and Prevention
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