keyword
https://read.qxmd.com/read/38642899/replicating-human-characteristics-a-promising-animal-model-of-central-fatigue
#1
JOURNAL ARTICLE
Yifei Zhang, Zehan Zhang, Qingqian Yu, Bijuan Lan, Qinghuan Shi, Ruting Li, Ziheng Jiao, Weiyue Zhang, Feng Li
Central fatigue is a common pathological state characterized by psychological loss of drive, lack of appetite, drowsiness, and decreased psychic alertness. The mechanism underlying central fatigue is still unclear, and there is no widely accepted successful animal model that fully represents human characteristics. We aimed to construct a more clinically relevant and comprehensive animal model of central fatigue. In this study, we utilized the Modified Multiple Platform Method (MMPM) combined with alternate-day fasting (ADF) to create the animal model...
April 18, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38638069/grape-seed-proanthocyanidin-extract-promotes-skeletal-muscle-fiber-type-transformation-through-modulation-of-cecal-microbiota-and-enhanced-butyric-acid-production
#2
JOURNAL ARTICLE
Yiqiang Li, Xiaoling Chen, Jun He, Ping Zheng, Yuheng Luo, Bing Yu, Daiwen Chen, Zhiqing Huang
The conversion of fast-twitch fibers into slow-twitch fibers within skeletal muscle plays a crucial role in improving physical stamina and safeguarding against metabolic disorders in individuals. Grape seed proanthocyanidin extract (GSPE) possesses numerous pharmacological and health advantages, effectively inhibiting the onset of chronic illnesses. However, there is a lack of research on the specific mechanisms by which GSPE influences muscle physiology and gut microbiota. This study aims to investigate the role of gut microbiota and their metabolites in GSPE regulation of skeletal muscle fiber type conversion...
April 18, 2024: Journal of Food Science
https://read.qxmd.com/read/38625726/factors-influencing-recovery-from-pediatric-stroke-based-on-discussions-from-a-uk-based-online-stroke-community-qualitative-thematic-study
#3
JOURNAL ARTICLE
Charlotte Howdle, William James Alexander Wright, Jonathan Mant, Anna De Simoni
BACKGROUND: The incidence of stroke in children is low, and pediatric stroke rehabilitation services are less developed than adult ones. Survivors of pediatric stroke have a long poststroke life expectancy and therefore have the potential to experience impairments from their stroke for many years. However, there are relatively few studies characterizing these impairments and what factors facilitate or counteract recovery. OBJECTIVE: This study aims to characterize the main barriers to and facilitators of recovery from pediatric stroke...
April 16, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38616516/in-season-training-load-variation-heart-rate-recovery-perceived-recovery-status-and-performance-in-elite-male-water-polo-players-a-pilot-study
#4
JOURNAL ARTICLE
Petros G Botonis, Gavriil G Arsoniadis, Ilias Smilios, Argyris G Toubekis
BACKGROUND: Increased training and competition demands of the in-season period may disturb athlete fatigue and recovery balance. The aim of this study was to describe the training load distribution applied in a competitive period and the training adaptations and fatigue/recovery status of elite water polo players. HYPOTHESIS: Effective workload management during tapering (TAP) would restore player recovery and enhance performance. STUDY DESIGN: Case series...
April 14, 2024: Sports Health
https://read.qxmd.com/read/38593898/polysaccharides-from-polygonatum-kingianum-collett-hemsl-ameliorated-fatigue-by-regulating-nrf2-ho-1-nqo1-and-ampk-pgc-1%C3%AE-tfam-signaling-pathways-and-gut-microbiota
#5
JOURNAL ARTICLE
Xingrui Xu, Meimei Shan, Chuanqi Chu, Shenke Bie, He Wang, Shengbao Cai
Polygonatum kingianum Coll & Hemsl is an important Chinese medicine used for enhancing physical function and anti-fatigue, and polysaccharides (PKPs) are considered as the main bioactive components. However, the mechanisms through which PKPs exert their anti-fatigue effects are not fully understood. This study aimed more comprehensively to explore the anti-fatigue mechanisms of PKPs, focusing on metabolism, protein expression, and gut flora, by using exhaustive swimming experiments in mice. Results showed a significant increase in the exhaustive swimming time of the mice treated with PKPs, especially in the high-dose group (200 mg/kg/day)...
April 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38542293/effect-of-hy7602-fermented-deer-antler-on-physical-fatigue-and-antioxidant-activity-in-mice
#6
JOURNAL ARTICLE
Hyejin Jeon, Kippeum Lee, Yong-Tae Kim, Joo-Yun Kim, Jae-Jung Shim, Jae-Hwan Lee
Lactobacillus curvatus HY7602 fermented antler (FA) ameliorates sarcopenia and improves exercise performance by increasing muscle mass, muscle fiber regeneration, and mitochondrial biogenesis; however, its anti-fatigue and antioxidant effects have not been studied. Therefore, this study aimed to investigate the anti-fatigue and antioxidant effects and mechanisms of FA. C2C12 and HepG2 cells were stimulated with 1 mM of hydrogen peroxide (H2 O2 ) to induce oxidative stress, followed by treatment with FA. Additionally, 44-week-old C57BL/6J mice were orally administered FA for 4 weeks...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38535433/exploring-indicators-for-training-load-control-in-young-swimmers-the-role-of-inspiratory-spirometry-outcomes
#7
JOURNAL ARTICLE
Adrián Feria-Madueño, Nuno Batalha, Germán Monterrubio-Fernández, Jose A Parraca
One of the most important implications of technology in swimming is to control training loads. Lactate control, video-analysis of the technique or the assessment of specific actions, i.e., the vertical jump, have helped to provide load adaptation indicators in swimmers in recent decades. However, these indicators have led to a longer application time, due to their indirect procedure and the need to analyze each variable. The aim of this study was to analyze whether inspiratory spirometry values can serve as a training load control tool in swimmers...
March 18, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38502788/gamma-aminobutyric-acid-in-rice-bran-extract-exerts-antistress-effects-in-mouse-models-with-depressive-like-behaviors
#8
JOURNAL ARTICLE
Ji-Hye Song, Hyunhee Kim, Min-Jeong Kong, Yoon-Taek Hong, Su-Jin Oh, Kyung-Chul Choi
Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the effects of gamma-aminobutyric acid-rich rice bran extract (GRBe) in mice stressed by forced swimming and tail suspension tests. Four weeks of oral administration of GRBe (500-2000 mg/kg) reduced the levels of dopamine and corticosterone in the blood and brain while increasing serotonin levels. GRBe was involved not only in stress but also in regulating sleep and obesity-related genes. Modern society experiences diverse and tense lives because of urbanization and informatization, which cause excessive stress due to complicated interpersonal relationships, heavy work burden, and fatigue from the organized society...
March 2024: Journal of Medicinal Food
https://read.qxmd.com/read/38472881/maltodextrin-from-sweet-cassava-a-promising-endurance-enhancer
#9
JOURNAL ARTICLE
Kakanang Posridee, Anant Oonsivilai, Ratchadaporn Oonsivilai
The effects of maltodextrin and crude extract from sweet cassava on exercise endurance were examined in the male Wistar rat. The rats were randomly assigned to either an exercise training group or a non-exercise training group. Both groups were further divided into subgroups that received either a control, crude extract (250 or 500 mg/kg), or maltodextrin (250 or 500 mg/kg) orally once daily for 16 days. The time to the point of exhaustion after weight-loaded forced swimming was measured on day 16. Body weight gain, relative organ weight, biochemical parameters, and liver and gastrocnemius muscle glycogen content were also determined...
March 1, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472356/inspiratory-muscles-pre-activation-in-young-swimmers-submitted-to-a-tethered-swimming-test-effects-on-mechanical-physiological-and-skin-temperature-parameters
#10
JOURNAL ARTICLE
Lara Soares de Araujo, Anita Brum Marostegan, Pedro Paulo Menezes Scariot, Juan Bordon Orsi, Carolina Cirino, Marcelo Papoti, Claudio Alexandre Gobatto, Fúlvia Barros Manchado-Gobatto
Inspiratory muscles pre-activation (IMPA ) has been studied to improve subsequent performance in swimming. However, the effects of IMPA on various parameters in swimmers are still unknown. Therefore, this study aimed to investigate the effects of IMPA on the mechanical parameters, physiological responses, and their possible correlations with swimming performance. A total of 14 young swimmers (aged 16 ± 0 years) underwent a 30-s all-out tethered swimming test, preceded or not by IMPA, a load of 40% of the maximal inspiratory pressure (MIP), and with a volume of 2 sets of 15 repetitions...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38458179/countermovement-jump-and-pull-up-performance-before-and-after-a-swimming-race-in-preparatory-and-competitive-phases-of-a-swimming-season
#11
JOURNAL ARTICLE
José M Gonzalez-Rave, Vincenzo Sorgente, Aaron Agudo-Ortega, Víctor Rodrigo-Carranza, Stelios Psycharakis, Anthony P Turner
PURPOSE: Monitoring performance athletes' training responses can be efficiently completed at competitive events. This study aimed to explore the changes in swimming, countermovement-jump (CMJ), and pull-up (PU) performance following training across a competitive phase, as well as immediately before and after each race. METHODS: Fourteen well-trained male sprint/middle-distance swimmers (height 179 [7] cm, mass 70 [8] kg, age 18 [2] y), from 3 regional training groups, completed CMJ and PU tests before and after the national competitions in October and May, when race performance was also assessed...
March 7, 2024: International Journal of Sports Physiology and Performance
https://read.qxmd.com/read/38450281/effect-of-the-pre-taper-level-of-fatigue-on-the-taper-induced-changes-in-performance-in-elite-swimmers
#12
JOURNAL ARTICLE
Quentin Bretonneau, Antonio Morales-Artacho, Robin Pla, Laurent Bosquet
INTRODUCTION: In swimming, performance gains after tapering could be influenced by the pre-taper level of fatigue. Moreover, this level of fatigue could be associated with sleep. This study aimed to assess (1) the effect of tapering on performance according to the pre-taper level of fatigue in swimmers and (2) the association between sleep and pre-taper level of fatigue. METHODS: Physiological, psychological and biomechanical profiles were evaluated in 26 elite swimmers on 2 occasions to estimate the pre-taper level of fatigue: at T 0 and T 1, scheduled respectively 10 and 3 weeks before the main competition...
2024: Frontiers in sports and active living
https://read.qxmd.com/read/38450192/physical-exercise-recommendations-for-patients-with-chronic-myeloid-leukemia-based-on-individual-preferences-identified-in-a-large-international-patient-survey-study-of-the-east-german-study-group-for-hematology-and-oncology-osho-97
#13
JOURNAL ARTICLE
Lina Hollenbach, Julia Rogahn, Philipp le Coutre, Susann Schulze, Lars-Olof Muegge, Jan Geissler, Julia Gruen, Christian Junghanss, Sabine Felser
BACKGROUND: Tyrosine kinase inhibitors (TKIs) have significantly lowered mortality of chronic myeloid leukemia (CML) patients adjusting life expectancy to that of the standard population. However, CML and its treatment with TKIs causes a high disease burden. Physical exercise (PE) could be a non-pharmacological approach to reducing these and improving quality of life. PURPOSE: The aim of this study was to determine the individual disease burden as well as PE preferences of CML patients and to deduce thereof specific PE recommendations...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38408231/ultrafast-sound-production-mechanism-in-one-of-the-smallest-vertebrates
#14
JOURNAL ARTICLE
Verity A N O Cook, Antonia H Groneberg, Maximilian Hoffmann, Mykola Kadobianskyi, Johannes Veith, Lisanne Schulze, Jörg Henninger, Ralf Britz, Benjamin Judkewitz
Motion is the basis of nearly all animal behavior. Evolution has led to some extraordinary specializations of propulsion mechanisms among invertebrates, including the mandibles of the dracula ant and the claw of the pistol shrimp. In contrast, vertebrate skeletal movement is considered to be limited by the speed of muscle, saturating around 250 Hz. Here, we describe the unique propulsion mechanism by which Danionella cerebrum , a miniature cyprinid fish of only 12 mm length, produces high amplitude sounds exceeding 140 dB (re...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38407402/stilbenes-enriched-peanut-sprouts-alleviated-physical-fatigue-via-regulating-interactions-of-nutrients-microbiota-metabolites-revealed-by-multi-omics-analysis
#15
JOURNAL ARTICLE
Tong Zhu, Qi Pan, Kunpeng Xiao, Changzhou Zuo, Qiang Liu, Dandan Zhou, Kang Tu
In this study, the antifatigue effect and mechanism of peanut sprouts were explored. BALB/c mice divided into three groups (control, dark and UV-C) were respectively supplemented with a normal diet, peanut sprouts (dark germination) added diet and stilbenes-enriched peanut sprouts (UV-C radiated germination) added diet. Results showed that swimming time and levels of blood glucose and antioxidant enzymes significantly increased, while contents of triglyceride and malondialdehyde notably decreased by peanut sprout supplementation...
February 26, 2024: Food & Function
https://read.qxmd.com/read/38383920/neuron-microglia-interaction-is-involved-in-anti-inflammatory-response-by-vagus-nerve-stimulation-in-the-prefrontal-cortex-of-rats-injected-with-polyinosinic-polycytidylic-acid
#16
JOURNAL ARTICLE
Ki-Joong Kim, Jinyeon Hwang, Kang-Woo Lee, Jieun Kim, Yunha Han, Uk Namgung
Injection of polyinosinic:polycytidylic acid (poly(I:C)) into experimental animals induces neuroimmunological responses and thus has been used for the study of neurological disorders such as anxiety, depression, and chronic fatigue. Here, we investigated the effects of vagus nerve stimulation (VNS) on poly(I:C)-induced neuroinflammation and associated behavioral consequences in rats. The microglia in the prefrontal cortex (PFC) displayed the activated form of morphology in poly(I:C)-injected rats and changed to a normal shape after acute VNS (aVNS)...
February 22, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38382315/uplc-qtof-ms-based-metabolomics-unravels-the-modulatory-effect-of-ginseng-water-extracts-on-rats-with-qi-deficiency
#17
JOURNAL ARTICLE
Yanyi Li, Yi Wu, Hanlin Li, Meiyuan Wang, Yang Gao, Shuhua Pei, Shu Liu, Zhiqiang Liu, Zhongying Liu, Lihui Men
Ginseng is commonly used as a nutritional supplement and daily wellness product due to its ability to invigorate qi. As a result, individuals with Qi-deficiency often use ginseng as a health supplement. Ginsenosides and polysaccharides are the primary components of ginseng. However, the therapeutic effects and mechanisms of action of these components in Qi-deficiency remain unclear. This study aimed to determine the modulatory effects and mechanisms of ginseng water extract, ginsenosides, and ginseng polysaccharides in a rat model of Qi-deficiency using metabolomics and network analysis...
February 7, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38370048/antifatigue-effects-and-antioxidant-activity-in-polysaccharide-fractions-from-chinese-yam-bulbils
#18
JOURNAL ARTICLE
Hai-Xu Zhou, Xiao Zhang, Ren-Gui Huang, Tong-Chao Su
Polysaccharides are the principal component in Chinese yam ( Dioscorea opposita Thunb.) bulbils . The properties and antifatigue of polysaccharides from yam bulbils (PYB) were identified and compared. Their molecular weights (PYB-1 and PYB-2) were approximately 145 and 11 kDa, respectively, with active β-configurations. Meanwhile, the antifatigue activities of PYBs were tested in mice via exhaustive swimming tests (EST). The EST results indicated that PYB-1 and PYB-2 significantly prolonged swimming time in mice ( p  < ...
February 2024: Food Science & Nutrition
https://read.qxmd.com/read/38338624/the-synergistic-effect-of-compound-sugar-with-different-glycemic-indices-combined-with-creatine-on-exercise-related-fatigue-in-mice
#19
JOURNAL ARTICLE
Hui Liao, Song Zhu, Yue Li, Dejian Huang
In this study, a compound sugar (CS) with different glycemic index sugars was formulated via hydrolysis characteristics and postprandial glycemic response, and the impact of CS and creatine emulsion on exercise-related fatigue in mice was investigated. Thirty-five C57BL/6 mice were randomly divided into five groups to supply different emulsions for 4 weeks: initial emulsion (Con), glucose emulsion (62 mg/10 g MW glucose; Glu), CS emulsion (62 mg/10 g MW compound sugar; CS), creatine emulsion (6 mg/10 g MW creatine; Cr), and CS and creatine emulsion (62 mg/10 g MW compound sugar, 6 mg/10 g MW creatine, CS-Cr)...
February 3, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38336843/counteracting-mental-fatigue-for-athletes-a-systematic-review-of-the-interventions
#20
JOURNAL ARTICLE
He Sun, Kim Geok Soh, Alireza Mohammadi, Zakaria Toumi, Lingling Zhang, Cong Ding, Xiaojuan Gao, Jian Tian
The deleterious effects of mental fatigue (MF) on athletes have been carefully studied in various sports, such as soccer, badminton, and swimming. Even though many researchers have sought ways to ameliorate the negative impact of MF, there is still a lack of studies that review the interventions used to counteract MF among athletes. This review aims to report the current evidence exploring the effects of interventions on MF and sport-specific performance, including sport-specific motor performance and perceptual-cognitive skills...
February 9, 2024: BMC Psychology
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