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https://www.readbyqxmd.com/read/29349537/timing-of-spirometry-may-impact-hospital-length-of-stay-for-cystic-fibrosis-pulmonary-exacerbation
#1
Katelyn Krivchenia, Dmitry Tumin, Christopher J Nemastil, Joseph D Tobias, Don Hayes
PURPOSE: The optimal timing of spirometry during hospitalization for acute pulmonary exacerbation (PEx) in patients with cystic fibrosis (CF) is unclear. We retrospectively evaluated whether measuring spirometry earlier during hospitalization was associated with a shorter length of stay (LOS). METHODS: In this retrospective study, we analyzed data from the electronic medical record of CF patients 6 years of age and older admitted to a single center for acute PEx requiring IV antibiotic therapy between 2009 and 2016...
January 18, 2018: Lung
https://www.readbyqxmd.com/read/29339003/direct-recovery-of-bacillus-subtilis-xylanase-from-fermentation-broth-with-an-alcohol-salt-aqueous-biphasic-system
#2
Hui Suan Ng, Cindy Xin Yi Chai, Yin Hui Chow, Wai Leng Carmen Loh, Hip Seng Yim, Joo Shun Tan, John Chi-Wei Lan
Xylanase enzyme degrades linear polysaccharide β-1,4 xylan and the hemicellulose of the plant cell wall. There is a growing demand in finding a cost-effective alternative for industrial scale production of xylanase with high purity for pharmaceutical applications. In this study, an alcohol/salt aqueous biphasic system (ABS) was adopted to recover xylanase from the Bacillus subtilis fermentation broth. The effects of several ABS parameters such as types and concentrations of alcohols and salts (i.e., sulphate, phosphate, and citrate), amount of crude loading and pH of the system on the recovery of xylanase were investigated...
January 12, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29336961/chronic-lung-disease-and-mortality-after-cardiac-surgery-a-prospective-cohort-study
#3
Dmitry Ponomarev, Oksana Kamenskaya, Asya Klinkova, Irina Loginova, Pavel Vedernikov, Igor Kornilov, Vladimir Shmyrev, Vladimir Lomivorotov, Aleksander Chernavskiy, Aleksander Karaskov
OBJECTIVE: To investigate the 1-year survival in cardiac surgical patients with lung disease, including previously undiagnosed cases. DESIGN: Prospective cohort study. SETTING: Tertiary hospital. PARTICIPANTS: Patients scheduled for elective coronary artery bypass graft (CABG) surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Pulmonary function tests (PFTs) were performed in 454 patients before surgery...
December 11, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29320941/progressive-delayed-respiratory-complications-of-sulfur-mustard-poisoning-in-43-iranian-veterans-three-decades-after-exposure
#4
E Darchini-Maragheh, M Balali-Mood, M Malaknezhad, S R Mousavi
The most common delayed complication of sulfur mustard (SM) poisoning has been observed in the respiratory tracts. It was thus aimed to investigate the delayed respiratory complications in SM-exposed patients around 25 years before the study. Forty-three veterans with more than 25% disability of due to SM poisoning were investigated. Clinical examinations as well as pulmonary function test (PFT) were performed. High-resolution computed tomography (HRCT) of the lungs was done as clinically indicated. Triad of chronic cough, dyspnea, and expectoration were the most common symptoms that were recorded in 88...
February 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29319026/sequelae-of-pulmonary-multidrug-resistant-tuberculosis-at-the-completion-of-treatment
#5
Rupak Singla, Manashree Mallick, Parul Mrigpuri, Neeta Singla, Amitesh Gupta
BACKGROUND: Treatment of multidrug-resistant (MDR-TB) mainly focuses on bacteriological cure. However, only limited studies have evaluated the sequelae left after the completion of treatment among MDR-TB patients. OBJECTIVE: To assess the persistent symptoms, radiological sequelae, pulmonary function impairment and quality of life at the completion of treatment among MDR-TB patients. METHODS: Forty six MDR-TB patients were enrolled, who completed two years of treatment under programmatic management of Drug Resistant tuberculosis at a tertiary referral institute in Delhi, India...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29315018/molecular-characterization-and-expression-of-pft-an-fhb-resistance-gene-at-the-fhb1-qtl-in-wheat
#6
Yi He, Xu Zhang, Yu Zhang, Dawood Ahmad, Lei Wu, Peng Jiang, Hongxiang Ma Ma
Fusarium head blight (FHB) is a destructive fungal disease in wheat worldwide. Efforts have been carried out to combat this disease, and the PFT (pore-forming toxin-like) gene at the quantitative trait locus (QTL) Fhb1 was isolated and found to confer resistance to FHB in Sumai 3. In this study, we characterized PFT in 348 wheat accessions. Four haplotypes of PFT were identified. The wild haplotype of PFT had higher resistance than other haplotypes and explained 13.8% of phenotypic variation in FHB resistance by association analysis...
January 9, 2018: Phytopathology
https://www.readbyqxmd.com/read/29302137/rethinking-pyogenic-flexor-tenosynovitis-biofilm-formation-treated-in-a-cadaveric-model
#7
Constantinos Ketonis, Noreen J Hickock, Asif M Ilyas
Introduction  Pyogenic flexor tenosynovitis (PFT) of the hand remains a challenging problem that often requires surgical irrigation and parenteral or oral antibiotics. The authors hypothesize that the pathophysiology and microenvironment of PFT can be likened to that of periprosthetic joint infections (PJIs), in which bacteria thrive in a closed synovial space with limited blood supply. As such, they postulate that PFT is also facilitated by bacterial attachment and biofilm formation rendering standard treatments less effective...
December 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29288683/what-is-difficult-for-you-can-be-easy-for-me-effects-of-increasing-individual-task-demand-on-prefrontal-lateralization-a-tdcs-study
#8
A Vergallito, Leonor J Romero Lauro, Rolando Bonandrini, Laura Zapparoli, Laura Danelli, Manuela Berlingeri
Neuroimaging studies suggest that increment of the cognitive load associated with a specific task may induce the recruitment of a more bilateral brain network. In most studies, however, task demand has been manipulated in a static and pre-specified way, regardless of individual cognitive resources. Here we implemented a new paradigm based on a pre-experimental assessment to set up subject-specific levels of task demand and applied tDCS (transcranial direct current stimulation) to assess each hemisphere involvement in task performance...
December 27, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29258820/p53-modulates-hepatic-insulin-sensitivity-through-nf-%C3%AE%C2%BAb-and-p38-erk-mapk-pathways
#9
Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhong
Besides its well-established oncosuppressor activity, the role of p53 in regulating metabolic pathways has been recently identified. Nevertheless, the function of p53 with respect to insulin resistance appears highly controversial. To address this issue, we investigated the expression of p53 in experimental model of insulin resistance. Then we used activator (nutlin-3α) and inhibitor (pifithrin-α, PFT-α) of p53 in HepG2 cell. Here we showed that p53 protein level was decreased in the hepatic tissue of high-fat diet-induced insulin resistance mice, genetically diabetic ob/ob mice and palmitate (PA) treated HepG2 cells...
December 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29225708/ranges-of-phenotypic-flexibility-in-healthy-subjects
#10
T J van den Broek, G C M Bakker, C M Rubingh, S Bijlsma, J H M Stroeve, B van Ommen, M J van Erk, S Wopereis
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of metabolic health. Furthermore, it was demonstrated that quantification of PFT response was more sensitive as compared to fasting markers in demonstrating reduced phenotypic flexibility in metabolically impaired type 2 diabetes subjects...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/29224585/long-term-implications-of-feed-energy-source-in-different-genetic-types-of-reproductive-rabbit-females-i-resource-acquisition-and-allocation
#11
A Arnau-Bonachera, C Cervera, E Blas, T Larsen, E Martínez-Paredes, L Ródenas, J J Pascual
To achieve functional but also productive females, we hypothesised that it is possible to modulate acquisition and allocation of animals from different genetic types by varying the main energy source of the diet. To test this hypothesis, we used 203 rabbit females belonging to three genetic types: H (n=66), a maternal line characterised by hyper-prolificacy; LP (n=67), a maternal line characterised by functional hyper-longevity; R (n=79), a paternal line characterised by growth rate. Females were fed with two isoenergetic and isoprotein diets differing in energy source: animal fat (AF) enhancing milk yield; cereal starch (CS) promoting body reserves recovery...
December 11, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29221318/lung-densitometry-why-how-and-when
#12
REVIEW
Mario Mascalchi, Gianna Camiciottoli, Stefano Diciotti
Lung densitometry assesses with computed tomography (CT) the X-ray attenuation of the pulmonary tissue which reflects both the degree of inflation and the structural lung abnormalities implying decreased attenuation, as in emphysema and cystic diseases, or increased attenuation, as in fibrosis. Five reasons justify replacement with lung densitometry of semi-quantitative visual scales used to measure extent and severity of diffuse lung diseases: (I) improved reproducibility; (II) complete vs. discrete assessment of the lung tissue; (III) shorter computation times; (IV) better correlation with pathology quantification of pulmonary emphysema; (V) better or equal correlation with pulmonary function tests (PFT)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221297/current-status-of-asthma-care-in-south-korea-nationwide-the-health-insurance-review-and-assessment-service-database
#13
Joon Young Choi, Hyoung Kyu Yoon, Jae Ha Lee, Kwang Ha Yoo, Bo Yeon Kim, Hye Won Bae, Young Kyoon Kim, Chin Kook Rhee
Background: Quality control is important for patients with asthma because of its prevalence and because the social burden is substantial. This study analyzed the Health Insurance Review and Assessment Service (HIRA) database to assess asthma quality control in South Korea. Methods: We investigated the HIRA nationwide database for reimbursed insurance claims from all medical institutions in South Korea from July 2013 to June 2014. The number of patients with asthma were evaluated and the medical institutions were categorized by type of medical institution...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29219795/-platelet-function-tests-tailored-antiplatelet-therapy-for-vascular-patients
#14
A R T Brand, S J A Korporaal, R T Urbanus, G Pasterkamp, G J de Borst
- Platelet aggregation inhibitors, also known as antiplatelet therapy (APT), are prescribed for the prevention of secondary cardiovascular events (CVE) after endovascular revascularization procedures.- Platelet aggregation inhibitors are not equally effective in all patients. The phenomenon of high residual platelet reactivity despite APT is called 'high on-treatment platelet reactivity' (HTPR); it bears an increased risk of secondary CVE.- Platelet function tests (PFT) can be used to diagnose HTPR. There are various tests available; of those, light transmission aggregometry (LTA) is considered the gold standard...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29200373/retropharyngeal-dissection-by-parker-flex-tip-nasal-endotracheal-tube
#15
Makoto Terumitsu, Mikiko Hirahara, Kenji Seo
Possible complications of nasotracheal intubation include injury to the nasal or pharyngeal mucosa. Dissection of the retropharyngeal tissue by the endotracheal tube is one of the rarer of the more severe complications. Previous studies have indicated that the Parker Flex-Tip (PFT) tracheal tube (Parker Medical, Highlands Ranch, Colo) reduces the incidence of mucosal injury. We experienced a case involving inadvertent retropharyngeal placement of a PFT tube in a 29-year-old patient during nasotracheal intubation under general anesthesia for elective dental treatment...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/29196525/mapping-local-and-global-variability-in-plant-trait-distributions
#16
Ethan E Butler, Abhirup Datta, Habacuc Flores-Moreno, Ming Chen, Kirk R Wythers, Farideh Fazayeli, Arindam Banerjee, Owen K Atkin, Jens Kattge, Bernard Amiaud, Benjamin Blonder, Gerhard Boenisch, Ben Bond-Lamberty, Kerry A Brown, Chaeho Byun, Giandiego Campetella, Bruno E L Cerabolini, Johannes H C Cornelissen, Joseph M Craine, Dylan Craven, Franciska T de Vries, Sandra Díaz, Tomas F Domingues, Estelle Forey, Andrés González-Melo, Nicolas Gross, Wenxuan Han, Wesley N Hattingh, Thomas Hickler, Steven Jansen, Koen Kramer, Nathan J B Kraft, Hiroko Kurokawa, Daniel C Laughlin, Patrick Meir, Vanessa Minden, Ülo Niinemets, Yusuke Onoda, Josep Peñuelas, Quentin Read, Lawren Sack, Brandon Schamp, Nadejda A Soudzilovskaia, Marko J Spasojevic, Enio Sosinski, Peter E Thornton, Fernando Valladares, Peter M van Bodegom, Mathew Williams, Christian Wirth, Peter B Reich
Our ability to understand and predict the response of ecosystems to a changing environment depends on quantifying vegetation functional diversity. However, representing this diversity at the global scale is challenging. Typically, in Earth system models, characterization of plant diversity has been limited to grouping related species into plant functional types (PFTs), with all trait variation in a PFT collapsed into a single mean value that is applied globally. Using the largest global plant trait database and state of the art Bayesian modeling, we created fine-grained global maps of plant trait distributions that can be applied to Earth system models...
December 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29183008/correlates-of-pulmonary-function-in-children-with-sickle-cell-disease-and-elevated-fetal-hemoglobin
#17
Adekunle D Adekile, Asmaa Azab, Abdullah Owayed, Mousa Khadadah
OBJECTIVE: The current study was carried out to compare pulmonary function tests (PFT) in pediatric Kuwaiti sickle cell disease (SCD) patients to age-matched normal controls and to investigate the association of PFTS to selected clinical and laboratory parameters. SUBJECTS AND METHODS: There were 38 patients with SCD and 36 controls in the study. The patients were recruited from the Pediatric Hematology Clinics of Mubarak Al-Kabeer and Al-Amiri Hospitals, Kuwait and were studied in steady state...
November 28, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29180572/the-atpase-activity-of-asna1-trc40-is-required-for-pancreatic-progenitor-cell-survival
#18
Stefan Norlin, Vishal Parekh, Helena Edlund
Asna1, also known as TRC40, is implicated in delivery of tail anchored (TA) proteins into the ER, in vesicle-mediated transport, and in chaperoning unfolded proteins during oxidative stress/ATP depletion. We recently showed that Asna1 inactivation in β-cells resulted in impaired retrograde transport, ER stress and diabetes in mice. Here we show that Asna1 inactivation in pancreatic progenitor cells leads to redistribution of the Golgi TA SNAREs Syntaxin-5 and Syntaxin-6, Golgi fragmentation, and accumulation of cytosolic p62+ puncta...
November 27, 2017: Development
https://www.readbyqxmd.com/read/29160063/effect-on-electrode-work-function-by-changing-molecular-geometry-of-conjugated-polymer-electrolytes-and-application-for-hole-transporting-layer-of-organic-optoelectronic-devices
#19
Eui Jin Lee, Min Hee Choi, Yong Woon Han, Doo Kyung Moon
In this study, we synthesized three conjugated polymer electrolytes (CPEs) with different conjugation lengths to control their dipole moments by varying spacers. p-type CPEs (PFT-D, PFtT-D, and PFbT-D) were generated by the facile oxidation of n-type CPEs (PFT, PFtT, PFbT) and introduced as the hole-transporting layers (HTLs) of organic solar cells (OSCs) and polymer light-emitting diodes (PLEDs). To identify the effect on electrode work function tunability by changing the molecular conformation and arrangement, we simulated density function theory calculations of these molecules and performed ultraviolet photoelectron spectroscopy analysis for films of indium tin oxide/CPEs...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29156833/targeting-aggressive-prostate-cancer-associated-cd44v6-using-phage-display-selected-peptides
#20
Ying Peng, Austin R Prater, Susan L Deutscher
There is a crucial need to identify new biomarkers associated with aggressive prostate cancer (PCa) including those associated with cancer stem cells (CSCs). CD44v6, generated by alternative splicing of CD44, has been proposed as a CSC biomarker due to its correlation with aggressive PCa disease. We hypothesized that phage display selected peptides that target CD44v6 may serve as theranostic agents for aggressive PCa. Here, a 15 amino acid peptide ("PFT") was identified by affinity selection against a peptide derived from the v6 region of CD44v6...
October 17, 2017: Oncotarget
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