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Impulse oscillometry system

M Bullone, P Hélie, P Joubert, J-P Lavoie
BACKGROUND: Remodeling of the peripheral airways persists during the asymptomatic phase of heaves. Assessing the histology of large bronchi could facilitate the diagnosis of heaves during remission of the disease. HYPOTHESIS: Airway inflammation and remodeling in endobronchial biopsy (EBB) specimens differentiate horses with heaves from controls, independently of their clinical status (exacerbation or remission). ANIMALS: Fourteen healthy horses and 24 horses with heaves...
September 2016: Journal of Veterinary Internal Medicine
Maíra S de Assumpção, Renata M Gonçalves, Renata Martins, Tatiana G Bobbio, Camila Is Schivinski
BACKGROUND: The impulse oscillometry system is a noninvasive method of evaluating respiratory mechanics that is being increasingly used in the pediatric population. To date, no reference equations have been developed for healthy Brazilian children and adolescents. The purpose of the study was to determine the reference equations for impulse oscillometry system parameters in healthy children and adolescents. METHODS: We undertook an observational cross-sectional analytical study with healthy students age 6-14 y from educational institutions in the Greater Florianópolis area...
August 2016: Respiratory Care
Beno W Oppenheimer, Kenneth I Berger, Saleem Ali, Leopoldo N Segal, Robert Donnino, Stuart Katz, Manish Parikh, Roberta M Goldring
RATIONALE: Obesity is characterized by increased systemic and pulmonary blood volumes (pulmonary vascular congestion). Concomitant abnormal alveolar membrane diffusion suggests subclinical interstitial edema. In this setting, functional abnormalities should encompass the entire distal lung including the airways. OBJECTIVES: We hypothesize that in obesity: 1) pulmonary vascular congestion will affect the distal lung unit with concordant alveolar membrane and distal airway abnormalities; and 2) the degree of pulmonary congestion and membrane dysfunction will relate to the cardiac response...
2016: PloS One
Toshihiro Shirai, Hajime Kurosawa
The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory system resistance and reactance during tidal breathing. Recently, its clinical application has spread worldwide with the expansion of commercially available broadband frequency FOT devices, including MostGraph and Impulse Oscillometry. An increasing number of reports have supported the usefulness of the FOT in the management of asthma and chronic obstructive pulmonary disease (COPD). However, the FOT is not a surrogate test for spirometry, but should be used complementarily...
2016: Internal Medicine
Hiroyuki Ohbayashi, Yasuhiro Setoguchi, Yoshinosuke Fukuchi, Kai Shibata, Yukinori Sakata, Toshihisa Arai
BACKGROUND: Mucolytic agents are often used in Japan to ease excessive mucus production in patients with chronic obstructive pulmonary disease (COPD) or bronchial asthma (BA); the treatment ameliorates dyspnea and improves quality of life (QOL). AIM: Efficacy and safety of lysozyme hydrochloride (LYS), an oral mucolytic enzyme preparation, for patients with COPD or BA were investigated. PATIENTS AND METHODS: This study was a placebo-controlled, double-blind, randomized, cross-over design...
April 2016: Pulmonary Pharmacology & Therapeutics
Hirsh D Komarow, Robert Sokolic, Michael S Hershfield, Donald B Kohn, Michael Young, Dean D Metcalfe, Fabio Candotti
Adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) is characterized by impaired T-, B- and NK-cell function. Affected children, in addition to early onset of infections, manifest non-immunologic symptoms including pulmonary dysfunction likely attributable to elevated systemic adenosine levels. Lung disease assessment has primarily employed repetitive radiography and effort-dependent functional studies. Through impulse oscillometry (IOS), which is effort-independent, we prospectively obtained objective measures of lung dysfunction in 10 children with ADA-SCID...
2015: Orphanet Journal of Rare Diseases
Kim D G van de Kant, Paolo Paredi, Sally Meah, Harpal S Kalsi, Peter J Barnes, Omar S Usmani
BACKGROUND/OBJECTIVES: Obesity is a global health problem that adversely influences the respiratory system. We assessed the effects of body mass index (BMI) on distal airway function and airway inflammation. SUBJECTS/METHODS: Impulse oscillometry (IOS) as a measure of distal airway function, together with spirometry, were assessed in adults with a range of different BMIs. Airway inflammation was assessed with the fraction of exhaled nitric oxide (FeNO) and participants exhaled at various exhalation flows to determine alveolar and bronchial NO...
September 2016: Obesity Research & Clinical Practice
Per Wollmer, Sophia Frantz, Gunnar Engström, Magnus Dencker, Claes-Göran Löfdahl, Ulf Nihlén
There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for obstructive lung disease recommends a fixed ratio between forced expiratory volume in one-second (FEV1 ) and forced vital capacity (FVC) of <0·7 (FR) for the diagnosis of COPD. European Respiratory Society and American Thoracic Society favour the use of the fifth percentile of the age-related FEV1 /FVC ratio (the lower limit of normal, LLN). The purpose of this study was to analyse extensive lung function tests in groups of subjects fulfilling none, either or both of the spirometric criteria for COPD...
October 6, 2015: Clinical Physiology and Functional Imaging
Clélia Buchs, Laurianne Coutier, Stéphanie Vrielynck, Virginie Jubin, Catherine Mainguy, Philippe Reix
A literature search identified one retrospective study on the responsiveness of impulse oscillometry (IOS) in pediatric patients with cystic fibrosis. The aim of this prospective observational study was to assess this property in an adequately powered study after intravenous antibiotic therapy (IVAT) administered for an acute episode of pulmonary exacerbation. Spirometry and IOS were done on the same day as the start and the end of IVAT. Data from 34 patients' of mean age 11.9 years (range, 5-17 years) were studied...
November 2015: Pediatric Pulmonology
Bill Brashier, Sundeep Salvi
Measuring lung function is an important component in the decision making process for patients with obstructive airways disease (OAD). Not only does it help in arriving at a specific diagnosis, but it also helps in evaluating severity so that appropriate pharmacotherapy can be instituted, it helps determine prognosis and it helps evaluate response to therapy. Spirometry is currently the most commonly performed lung function test in clinical practice and is considered to be the gold standard diagnostic test for asthma and COPD...
March 2015: Breathe
Roberta Pisi, Marina Aiello, Andrea Zanini, Panagiota Tzani, Davide Paleari, Emilio Marangio, Antonio Spanevello, Gabriele Nicolini, Alfredo Chetta
BACKGROUND: We investigated whether a relationship between small airways dysfunction and bronchodilator responsiveness exists in patients with chronic obstructive pulmonary disease (COPD). METHODS: We studied 100 (20 female; mean age: 68±10 years) patients with COPD (forced expiratory volume in 1 second [FEV1]: 55% pred ±21%; FEV1/forced vital capacity [FVC]: 53%±10%) by impulse oscillometry system. Resistance at 5 Hz and 20 Hz (R5 and R20, in kPa·s·L(-1)) and the fall in resistance from 5 Hz to 20 Hz (R5 - R20) were used as indices of total, proximal, and peripheral airway resistance; reactance at 5 Hz (X5, in kPa·s·L(-1)) was also measured...
2015: International Journal of Chronic Obstructive Pulmonary Disease
Francyne Kubaski, Shunji Tomatsu, Pravin Patel, Tsutomu Shimada, Li Xie, Eriko Yasuda, Robert Mason, William G Mackenzie, Mary Theroux, Michael B Bober, Helen M Oldham, Tadao Orii, Thomas H Shaffer
In clinical practice, respiratory function tests are difficult to perform in Morquio syndrome patients due to their characteristic skeletal dysplasia, small body size and lack of cooperation of young patients, where in some cases, conventional spirometry for pulmonary function is too challenging. To establish feasible clinical pulmonary endpoints and determine whether age impacts lung function in Morquio patients non-invasive pulmonary tests and conventional spirometry were evaluated. The non-invasive pulmonary tests: impulse oscillometry system, pneumotachography, and respiratory inductance plethysmography in conjunction with conventional spirometry were evaluated in twenty-two Morquio patients (18 Morquio A and 4 Morquio B) (7 males), ranging from 3 to 40 years of age...
August 2015: Molecular Genetics and Metabolism
Angeliki Kazeros, Enhan Zhang, Xin Cheng, Yongzhao Shao, Mengling Liu, Meng Qian, Caralee Caplan-Shaw, Kenneth I Berger, Roberta M Goldring, Muhammad Ghumman, Neel P Chokshi, Nomi Levy-Carrick, Maria Elena Fernandez-Beros, Sam Parsia, Michael Marmor, Joan Reibman
BACKGROUND: Destruction of the World Trade Center (WTC) towers on September 11, 2001, released massive dust, gas, and fumes with environmental exposures for community members. Many community members have lower respiratory symptoms (LRSs) that began after September 11, 2001, and remain persistent. We evaluated whether systemic inflammation measured by C-reactive protein was associated with WTC dust exposures, persistent LRS, and lung function. METHODS: Community members self-referred for the treatment of symptoms related to September 11, 2001...
June 2015: Journal of Occupational and Environmental Medicine
C Püllen, S Becker, P Reinhold, H-J Smith, G Reiner
The aim of the present study was to assess the contribution of clinical data to the variability of impulse oscillometric test results observed previously by Püllen et al. (2014). Fifty-eight German hybrid pigs from 29 different herds with unknown respiratory status were examined in the context of routine diagnostics as part of herd health service. Routine clinical examination was extended to a total set of 29 parameters, representing detailed clinical signs of the respiratory system, and to lung function testing applying the impulse oscillometry system (IOS)...
February 2015: Research in Veterinary Science
Laura Gochicoa-Rangel, Luis Torre-Bouscoulet, David Martínez-Briseño, Luis Rodríguez-Moreno, Gabriela Cantú-González, Mario H Vargas
BACKGROUND: The impulse oscillometry system (IOS) is increasingly used to evaluate lung function, but individual results must be compared with appropriate reference values. We aimed to obtain such reference values in Mexican children and adolescents. METHODS: Healthy subjects were recruited from kindergartens and schools after their parents signed a consent letter. Respiratory system impedances (Zrs), resistances (Rrs), and reactances (Xrs) were measured at 5, 10, 15, and 20 Hz, and the resonant frequency, reactance area, and difference between Rrs5 minus Rrs20 were also calculated...
January 2015: Respiratory Care
Misa Nakagawa, Noboru Hattori, Yoshinori Haruta, Aya Sugiyama, Hiroshi Iwamoto, Nobuhisa Ishikawa, Kazunori Fujitaka, Hiroshi Murai, Junko Tanaka, Nobuoki Kohno
BACKGROUND AND OBJECTIVE: Airway resistance and reactance measured by forced oscillometry have been used to measure the severity of airway obstruction in chronic obstructive pulmonary disease (COPD) patients. The aims of this study were to assess the effects of tachypnoea on airway resistance and reactance and to correlate these with the severity of dyspnoea. We also evaluated the effects of short-acting β2-agonist (SABA) on these measurements. METHODS: Airway resistance and reactance were measured with an impulse oscillation system (IOS) in 20 COPD and 10 control participants during resting respiration and metronome-paced breathing at 20, 30 and 40 tidal breaths/min...
January 2015: Respirology: Official Journal of the Asian Pacific Society of Respirology
Su-Gang Gong, Wen-Lan Yang, Wei Zheng, Jin-Ming Liu
An impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. The present study investigated which IOS measurement is correlated with airflow obstruction, airway conductance and lung volume in chronic obstructive pulmonary disease (COPD). A total of 180 patients with COPD were selected and 95 agreed to follow‑up 1 year after the initial tests. IOS measurements [R5, R20, X5 and resonant frequency (Fres)], body plethysmography [forced end‑expiratory flow (FEF)75, total lung capacity, residual volume (RV) and total inspiratory resistance (Rtot)] and spirometry [forced expiratory volume in 1 sec (FEV1)] were performed...
November 2014: Molecular Medicine Reports
Veronica Alfieri, Marina Aiello, Roberta Pisi, Panagiota Tzani, Elisa Mariani, Emilio Marangio, Dario Olivieri, Gabriele Nicolini, Alfredo Chetta
BACKGROUND: We investigated whether a relationship between small airways dysfunction and bronchial hyperresponsiveness (BHR), expressed both in terms of ease of airway narrowing and of excessive bronchoconstriction, could be demonstrated in asthma. METHODS: 63 (36 F; mean age 42 yr ± 14) stable, mild-to-moderate asthmatic patients (FEV1 92% pred ±14; FEV1/FVC 75% ± 8) underwent the methacholine challenge test (MCT). The degree of BHR was expressed as PD20 (in μg) and as ∆FVC%...
2014: Respiratory Research
E van der Wiel, D S Postma, T van der Molen, L Schiphof-Godart, N H T Ten Hacken, M van den Berge
BACKGROUND: The small airways are an important site of inflammation in asthma. However, the relation between small airway dysfunction and clinical expression of asthma has hardly been studied. AIM: To investigate the association of small and large airway dysfunction with asthma symptoms and bronchial hyper-responsiveness (BHR). METHODS: Fifty-eight patients with asthma were characterized with spirometry, body plethysmography, impulse oscillometry, alveolar and bronchial exhaled nitric oxide, and a methacholine provocation...
December 2014: Allergy
M Mineshita, Y Shikama, H Nakajima, R Nishihira, S Komatsu, M Kubota, H Kobayashi, F Kokubu, M Shinkai, T Kaneko, T Miyazawa
There are only a few reports of the use of impulse oscillation system (IOS) for the evaluation of COPD treatment. In this study, we applied IOS and spirometry to evaluate the effectiveness of fluticasone propionate and salmeterol (SFC) combined with tiotropium (TIO) in COPD patients. Following a 4-week run-in period with TIO (18 μg once daily) treatment, COPD patients were randomized to SFC (250/50 μg twice daily; SFC+TIO group, n=25), or TIO alone (TIO group, n=31). Pulmonary functions were recorded by IOS and spirometry before and after the study period...
October 1, 2014: Respiratory Physiology & Neurobiology
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