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https://www.readbyqxmd.com/read/29331872/effect-of-physical-activity-on-cognitive-flexibility-depression-and-rbd-in-healthy-elderly
#1
Stefanie Lerche, Alexandra Gutfreund, Kathrin Brockmann, Markus A Hobert, Isabel Wurster, Ulrike Sünkel, Gerhard W Eschweiler, Florian G Metzger, Walter Maetzler, Daniela Berg
OBJECTIVE: The prevalence of Alzheimer's disease and Parkinson's disease increases with the raising number of elderly, which will be a challenging situation for the healthcare systems and society in the future. There is evidence that there are modifiable risk-factors e.g. physical activity for these diseases. Here, we study the interaction between sports inactivity with prodromal markers for neurodegeneration. PATIENTS AND METHODS: We investigated 667 neurologically healthy individuals cross-sectional and a subgroup longitudinal over six years...
January 9, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29329513/the-behavioural-phenotype-of-potocki-lupski-syndrome-a-cross-syndrome-comparison
#2
Stacey Bissell, Lucy Wilde, Caroline Richards, Jo Moss, Chris Oliver
BACKGROUND: Potocki-Lupski syndrome (PTLS) and Smith-Magenis syndrome (SMS) are related genomic disorders, as duplication 17p11.2 (associated with PTLS) is the reciprocal recombination product of the SMS microdeletion. While SMS has a relatively well-delineated behavioural phenotype, the behavioural profile in PTLS is less well defined, despite purported associations with autism spectrum disorder (ASD) and the suggestion that some behaviours may be diametric to those seen in SMS. METHODS: Caregivers of individuals with PTLS (N = 34; M age = 12...
January 10, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29327600/population-based-serum-omentin-1-levels-paradoxical-association-with-cardiometabolic-disorders-primarily-in-men
#3
Altan Onat, Evin Ademoglu, Yusuf Karadeniz, Gunay Can, Ahmet Okan Uzun, Barıs Simsek, Aysem Kaya
AIM: The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methodology: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29320948/the-profiles-of-soluble-adhesion-molecules-in-the-great-obstetrical-syndromes
#4
Nikolina Docheva, Roberto Romero, Piya Chaemsaithong, Adi L Tarca, Gaurav Bhatti, Percy Pacora, Bogdan Panaitescu, Noppadol Chaiyasit, Tinnakorn Chaiworapongsa, Eli Maymon, Sonia S Hassan, Offer Erez
OBJECTIVE: The objective of this study was to determine the profiles of maternal plasma soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) fetuses, acute pyelonephritis, preterm labor with intact membranes (PTL), preterm prelabor rupture of the membranes (preterm PROM), and fetal death. MATERIALS AND METHODS: A cross-sectional study was conducted to determine maternal plasma concentrations of sE-selectin, sL-selectin, and sP-selectin as well as sICAM-1, sVCAM-1, and sPECAM-1 in patients with 1) an uncomplicated pregnancy (control, n = 100); 2) preeclampsia (n = 94); 3) SGA fetuses (in women without preeclampsia/hypertension, n = 45); 4) acute pyelonephritis (n = 25); 5) PTL (n = 53); 6) preterm PROM (n = 24); and 7) fetal death (n = 34)...
January 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29319419/in-vivo-and-ex-vivo-inflammatory-markers-of-common-metabolic-phenotypes-in-humans
#5
Rasmus Baadsgaard Mærkedahl, Hanne Frøkiær, Marie Grøntved Stenbæk, Camilla Betak Nielsen, Mads V Lind, Christian Lundtoft, Marietta Boje Bohr, Sabine Ibrügger, Stine Broeng Metzdorff, Henrik Vestergaard, Oluf Pedersen, Lotte Lauritzen
BACKGROUND: Low-grade systemic inflammation (LGSI) is often characterized by elevated levels of interleukin (IL)6, tumor necrosis factor (TNF)α, and C-reactive protein (CRP). Other serum proteins, ex vivo-stimulated cytokine production, and leukocyte count have, however, also been suggested LGSI-markers, but their associations with the metabolic syndrome (MS) are less clear. We aimed to evaluate mutual relationships between in vivo and ex vivo inflammatory markers and their association with MS and its subcomponents...
January 10, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29319054/association-between-metabolic-syndrome-and-job-rank
#6
Ramin Mehrdad, Gholamreza Pouryaghoub, Mahboubeh Moradi
BACKGROUND: The occupation of the people can influence the development of metabolic syndrome. OBJECTIVE: To determine the association between metabolic syndrome and its determinants with the job rank in workers of a large car factory in Iran. METHODS: 3989 male workers at a large car manufacturing company were invited to participate in this cross-sectional study. Demographic and anthropometric data of the participants, including age, height, weight, and abdominal circumference were measured...
January 2018: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29313228/extension-of-the-metabolic-syndrome-cluster
#7
S I Kseneva, E V Borodulina, V V Udut
In a one-stage cross-sectional study, a continuous sample of 102 patients (mean age 47.81±0.63 years) with metabolic syndrome was examined. It was found that autonomic dysfunction determines specific features of arterial hypertension in this group of patients, it causes cardiac autonomic neuropathy and underlies the mechanisms of lower urinary tract symptoms development.
January 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29313103/plant-synthetic-gp4-and-gp5-proteins-from-porcine-reproductive-and-respiratory-syndrome-virus-elicit-immune-responses-in-pigs
#8
Chul Han An, Salik Nazki, Sung-Chul Park, Yu Jeong Jeong, Ju Huck Lee, Su-Jin Park, Amina Khatun, Won-Il Kim, Youn-Il Park, Jae Cheol Jeong, Cha Young Kim
We demonstrated successful overexpression of porcine reproductive and respiratory syndrome virus (PRRSV)-derived GP4D and GP5D antigenic proteins in Arabidopsis. Pigs immunized with transgenic plants expressing GP4D and GP5D proteins generated both humoral and cellular immune responses to PRRSV. Porcine reproductive and respiratory syndrome virus (PRRSV) causes PRRS, the most economically significant disease affecting the swine industry worldwide. However, current commercial PRRSV vaccines (killed virus or modified live vaccines) show poor efficacy and safety due to concerns such as reversion of virus to wild type and lack of cross protection...
January 8, 2018: Planta
https://www.readbyqxmd.com/read/29301128/features-and-outcomes-of-patients-with-calcified-nodules-at-culprit-lesions-of-acute-coronary-syndrome-an-optical-coherence-tomography-study
#9
Nobuaki Kobayashi, Masamichi Takano, Masafumi Tsurumi, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Hirotake Okazaki, Akihiro Shirakabe, Yoshihiko Seino, Noritake Hata, Wataru Shimizu
OBJECTIVES: We sought to clarify clinical features and outcomes related to calcified nodules (CN) compared with plaque rupture (PR) and plaque erosion (PE) detected by optical coherence tomography (OCT) at the culprit lesions in patients with acute coronary syndrome (ACS). METHODS: Based on OCT findings for culprit lesion plaque morphologies, ACS patients with analyzable OCT images (n = 362) were classified as CN, PR, PE, and other. RESULTS: The prevalence of CN, PR, and PE was 6% (n = 21), 45% (n = 163), and 41% (n = 149), respectively...
January 5, 2018: Cardiology
https://www.readbyqxmd.com/read/29300424/association-between-insulin-like-growth-factor-1-and-frailty-among-older-adults
#10
T Doi, H Makizako, K Tsutsumimoto, R Hotta, S Nakakubo, K Makino, T Suzuki, H Shimada
OBJECTIVES: Frailty is a course experienced in advanced aging. Identification of a biological factor associated with frailty is required. Although serum insulin-like growth factor-1 (IGF-1) is a potential factor related with frailty, consensus has not been reached regarding this relationship. This study aimed to investigate the association between IGF-1 and frailty in older adults. DESIGN: Cross-sectional study. SETTING: Cohort study that was part of the "National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29297976/platelet-responses-to-pharmacological-and-physiological-interventions-in-middle-aged-men-with-different-habitual-physical-activity-levels
#11
M H Lundberg Slingsby, L Gliemann, M Thrane, N Rytter, J Egelund, M V Chan, P C Armstrong, T D Warner, Y Hellsten
The current guidelines following an acute coronary syndrome recommend dual anti-platelet therapy (aspirin plus a P2Y12 antagonist) alongside lifestyle modifications, including more regular physical activity. It is currently unknown if regular exercise affects the pharmacology of dual anti-platelet therapy. AIM: To explore how exercise-induced improvements in vascular and platelet function affect the efficacy of dual anti-platelet therapy, in a cross-sectional study of men with different physical activity level (training status)...
January 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29295801/prevalence-of-idiopathic-epilepsy-among-school-children-in-gharbia-governorate-egypt
#12
Azza Kamal Alshahawy, Amira Hamed Darwish, Safynaz Elsaid Shalaby, Wegdan Mawlana
BACKGROUND: Epilepsy is one of the most common neurological disorders among children. Data about its prevalence in Egypt is limited. Our aim was to study the prevalence of idiopathic epilepsy among school children in Gharbia governorate, Egypt. SUBJECTS AND METHODS: A Cross-sectional school-based survey study was conducted; a validated screening questionnaire was distributed among urban and rural primary and preparatory school children. Students with suspected epilepsy were subjected to clinical evaluation, Electroencephalogram (EEG), and neuroimaging...
December 30, 2017: Brain & Development
https://www.readbyqxmd.com/read/29288183/performance-of-syndromic-management-for-the-detection-and-treatment-of-genital-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-among-women-attending-antenatal-well-woman-and-sexual-health-clinics-in-papua-new-guinea-a-cross-sectional-study
#13
Lisa M Vallely, Pamela Toliman, Claire Ryan, Glennis Rai, Johanna Wapling, Josephine Gabuzzi, Joyce Allen, Christine Opa, Gloria Munnull, Petronia Kaima, Benny Kombuk, Antonia Kumbia, Zure Kombati, Greg Law, Angela Kelly-Hanku, Handan Wand, Peter M Siba, Glen D L Mola, John M Kaldor, Andrew J Vallely
OBJECTIVE: Papua New Guinea (PNG) has among the highest estimated prevalences of genital Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) of any country in the Asia-Pacific region. Diagnosis and treatment of these infections have relied on the WHO-endorsed syndromic management strategy that uses clinical presentation without laboratory confirmation to make treatment decisions. We evaluated the performance of this strategy in clinical settings in PNG...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29287846/congenital-respiratory-tract-disorders-in-22q11-2-deletion-syndrome
#14
Emmy Verheij, Lucienne Speleman, Aebele B Mink van der Molen, Henricus G X M Thomeer
OBJECTIVE: Respiratory tract disorders have been reported in patients with 22q11.2 deletion syndrome, however infrequently. This study describes the respiratory tract disorders encountered in a cohort of 278 patients with 22q11.2 deletion syndrome. METHODS: We conducted a retrospective, cross-sectional, study at a single tertiary referral center. We identified the patients with 22q11.2 deletion syndrome and with an upper and/or lower respiratory tract disorder at our otorhinolaryngologic department...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29285778/in-women-with-pcos-waist-circumference-is-a-better-surrogate-of-glucose-and-lipid-metabolism-than-disease-status-per-se
#15
A Pazderska, T Kyaw Tun, N Phelan, A McGowan, M Sherlock, L A Behan, G Boran, J Gibney
OBJECTIVE: Cardiometabolic abnormalities are recognised in polycystic ovary syndrome (PCOS). However, over-emphasis on PCOS as a risk factor potentially results in over-investigation and treatment of some women with, and under-recognition of cardiometabolic risk in obese women without PCOS. Our objective was to explore the association between waist circumference (WC) and indices of glucose and lipid metabolism in women with and without PCOS. DESIGN, PATIENTS AND MEASUREMENTS: (1) an exploratory cross-sectional study investigating association of potential cardiometabolic risk markers (PCOS status, anthropometric measures, hsCRP, HOMA-IR, SHBG, testosterone) with indices of glucose (frequently-sampled-intravenous-glucose-tolerance-test) and lipid metabolism (post-prandial studies and lipoprotein particle size) in 61 women with (n=29) and without (n=32) PCOS; (2) a cross-sectional study in 103 PCOS women and 102 BMI-matched controls to explore if between-group differences in indices of lipid and glucose metabolism persist after adjusting for WC...
December 29, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29284896/neutrophil-to-lymphocyte-ratio-and-its-relation-with-markers-of-inflammation-and-myocardial-necrosis-in-patients-with-acute-coronary-syndrome
#16
Ema Tahto, Radivoj Jadric, Lamija Pojskic, Esmeralda Kicic
Introduction: Inflammation plays an important role in atherosclerosis which is the primary cause of acute coronary syndrome (ACS) that encompasses acute myocardial infarction (AMI) and unstable angina (UA). Objective: To investigate and characterize white blood cells (WBC) count, differential blood count in peripheral blood and neutrophil to lymphocyte ratio (NLR) in patients by the type of ACS. Patients and methods: The cross-sectional study included 100 patients with ACS (50 males, 50 females), aged 41 to 91 years, classified into two groups: AMI group (n=50) and UA group (n=50)...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29284161/ultrasound-guided-corticosteroid-injection-in-patients-with-carpal-tunnel-syndrome-efficacy-of-intra-epineurial-injection
#17
Yi-Chih Hsu, Fu-Chi Yang, Hsian-He Hsu, Guo-Shu Huang
PURPOSE:  To identify the ultrasound (US) findings of intra-epineurial corticosteroid injection during US-guided hydrodissection in patients with carpal tunnel syndrome (CTS), and to determine their clinical relevance in relation to treatment outcomes. MATERIALS AND METHODS:  We performed 101 US-guided hydrodissections and corticosteroid injections in 101 patients with CTS, and evaluated their pre- and post-injection US findings. We categorized these injections into two groups based on the occurrence of intra-epineurial injection...
December 28, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29277137/effects-of-stress-on-critical-care-nurses-a-national-cross-sectional-study
#18
Amir Vahedian-Azimi, Mohammadreza Hajiesmaeili, Mari Kangasniemi, Joana Fornés-Vives, Rita L Hunsucker, Farshid Rahimibashar, Mohammad A Pourhoseingholi, Leily Farrokhvar, Andrew C Miller
BACKGROUND: Health care is a demanding field, with a high level of responsibility and exposure to emotional and physical danger. High levels of stress may result in depression, anxiety, burnout syndrome, and in extreme cases, post-traumatic stress disorder. The aim of this study was to determine which personal, professional, and organizational variables are associated with greater perceived stress among critical care nurses for purposes of developing integrative solutions to decrease stress in the future...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29276865/high-frequency-oscillatory-ventilation-versus-conventional-mechanical-ventilation-in-pediatric-acute-respiratory-distress-syndrome-a-randomized-controlled-study
#19
Ahmed El-Nawawy, Azza Moustafa, Hassan Heshmat, Ahmed Abouahmed
El-Nawawy A, Moustafa A, Heshmat H, Abouahmed A. High frequency oscillatory ventilation versus conventional mechanical ventilation in pediatric acute respiratory distress syndrome: A randomized controlled study. Turk J Pediatr 2017; 59: 130-143. The aim of this prospective randomized study is to compare the outcomes of the early use of either high frequency oscillation (HFO) or conventional mechanical ventilation (CMV) in patients with pediatric acute respiratory distress syndrome (PARDS). We allocated two hundred PARDS patients over 5 years in 1:1 ratio to either mode...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29258212/dietary-patterns-in-relation-to-metabolic-syndrome-among-adults-in-poland-a-cross-sectional-study
#20
Edyta Suliga, Dorota Kozieł, Elżbieta Cieśla, Dorota Rębak, Stanisław Głuszek
In several populations the associations between diet and the risk of metabolic syndrome have not been fully examined yet. The aim of the study is to identify the main dietary patterns among Polish adults and the evaluation of the relationships of these patterns with metabolic syndrome and its components. The study was conducted on a group of 7997 participants, aged between 37 and 66 years old. Dietary patterns were identified by factor analysis. Metabolic syndrome was defined according to the International Diabetes Federation...
December 17, 2017: Nutrients
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