keyword
MENU ▼
Read by QxMD icon Read
search

hpa and fetus

keyword
https://www.readbyqxmd.com/read/29136116/prenatal-stress-glucocorticoids-and-developmental-programming-of-the-stress-response
#1
Patrick O McGowan, Stephen G Matthews
The early environment has a major impact on the developing embryo, fetus and infant. Parental adversity (maternal and paternal) and glucocorticoid exposure prior to conception and during pregnancy have profound effects on the development and subsequent function of the hypothalamic-pituitary-adrenal (HPA) axis and related behaviours. These effects are species-, sex- and age-specific, and depend on the timing and duration of exposure. The impact of these early exposures can extend across multiple generations, via both the maternal and paternal lineage, and recent studies have begun to determine the mechanisms by which this occurs...
November 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/29041862/impact-of-chronic-maternal-stress-during-early-gestation-on-maternal-fetal-stress-transfer-and-fetal-stress-sensitivity-in-sheep
#2
Michelle Dreiling, Rene Schiffner, Sabine Bischoff, Sven Rupprecht, Nasim Kroegel, Harald Schubert, Otto W Witte, Matthias Schwab, Florian Rakers
Acute stress-induced reduction of uterine blood flow (UBF) is an indirect mechanism of maternal-fetal stress transfer during late gestation. Effects of chronic psychosocial maternal stress (CMS) during early gestation, as may be experienced by many working women, on this stress signaling mechanism are unclear. We hypothesized that CMS in sheep during early gestation augments later acute stress-induced decreases of UBF, and aggravates the fetal hormonal, cardiovascular, and metabolic stress responses during later development...
October 18, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28837581/fetal-exposure-to-maternal-human-platelet-antigen-1a-does-not-induce-tolerance-an-analytical-observational-study
#3
Mette Kjær, Heidi Tiller, Gøril Heide, Jens Kjeldsen-Kragh, Bjørn Skogen, Anne Husebekk
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that may cause severe bleeding complications with risk of perinatal death or lifelong disability. The main cause of FNAIT is maternal antibodies against human platelet antigen (HPA)-1a. Both fetomaternal bleeding and transplacental trafficking of fetal cells during pregnancy could be the cause of alloimmunization. Persistence of fetal cells in the mother (fetal microchimerism) and maternal cells in the child (maternal microchimerism) are well-recognized phenomena...
2017: PloS One
https://www.readbyqxmd.com/read/28815406/successful-management-of-a-hydropic-fetus-with-severe-anemia-and-thrombocytopenia-caused-by-anti-cd36-antibody
#4
Xiuzhang Xu, Lin Li, Wenjie Xia, Haoqiang Ding, Dawei Chen, Jing Liu, Jing Deng, Yangkai Chen, Zhiming He, Jiali Wang, Yuan Shao, Sentot Santoso, Xin Ye, Qun Fang
Cases of CD36 deficiency are not rare in Asian populations, foetal and neonatal alloimmune thrombocytopenia (FNAIT) caused by anti-CD36 isoantibodies appears more frequent than other HPA alloantibodies. However, little is known about the treatment of anti-CD36 mediated FNAIT in this region. A Chinese male foetus, whose mother had a history of multiple intrauterine foetal demise and/or hydrops, was diagnosed with severe FNAIT at 27 weeks of gestational age. Immunological analysis revealed total absence of CD36 on platelets and monocytes from mother, caused by a 329-330delAC mutation of the CD36 gene...
August 16, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28695270/maternal-use-of-prednisolone-is-unlikely-to-be-associated-with-neonatal-adrenal-suppression-a-single-center-study-of-16-cases
#5
Leanne de Vetten, Margriet van Stuijvenberg, Ido P Kema, Gianni Bocca
The use of supra-physiological, exogenous corticosteroids in pregnancy may lead to neonatal adrenal suppression. We report on a single-center, case series study carried out between 2006 and 2014, which included all newborns (n = 16) of mothers using prednisolone ≥10 mg/day during pregnancy. Newborns were routinely assessed according to hospital protocol, with follow-up until 6 weeks after birth. We investigated the clinical symptoms and biochemical findings of adrenal suppression occurring in the newborns...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28641158/determinants-of-cortisol-during-pregnancy-the-abcd-cohort
#6
Laura S Bleker, Tessa J Roseboom, Tanja G Vrijkotte, Rebecca M Reynolds, Susanne R de Rooij
BACKGROUND: Psychosocial stress during pregnancy has been proposed as a major contributor of glucocorticoid-mediated programming of the fetal hypothalamic-pituitary adrenal (HPA) axis, with later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28587668/alterations-of-hair-cortisol-and-dehydroepiandrosterone-in-mother-infant-dyads-with-maternal-childhood-maltreatment
#7
K Schury, A M Koenig, D Isele, A L Hulbert, S Krause, M Umlauft, S Kolassa, U Ziegenhain, A Karabatsiakis, F Reister, H Guendel, J M Fegert, I-T Kolassa
BACKGROUND: Child maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition...
June 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28389369/prenatal-stress-and-depression-associated-neuronal-development-in-neonates
#8
REVIEW
Mahino Fatima, Saurabh Srivastav, Amal Chandra Mondal
Prenatal maternal depression has its direct effects on early brain development deficits with permanent changes in neuroendocrine functions and impaired behavior in offsprings. Prenatal stress (PS) transmits its affect on developing fetus and on pregnancy outcomes in adult offsprings. This results in impaired neurodevelopment, delayed cognitive and motor development with impaired behavior towards stressful conditions. There are sufficient evidences in animal models suggesting depression responsive hypothalamic-pituitary-adrenal (HPA) axis and its hormonal response via cortisol, responsible for its critical effects in both the mother and offspring...
August 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28361282/prenatal-maternal-distress-seems-to-be-associated-with-the-infant-s-temperament-and-motor-development-an-explorative-study
#9
Christin Haselbeck, Uwe Niederberger, Alexandra Kulle, Katharina Wache, Ellen Brauner, Merlin Gutermuth, Paul-Martin Holterhus, Wolf-Dieter Gerber, Michael Siniatchkin
According to the concept of fetal programming, prenatal distress has long-lasting consequences on the offspring's health later in life. The hypothalamic-pituitary-adrenal axis is considered a mediating system by which maternal distress is transferred to the fetus in intrauterine environment. In this longitudinal explorative study on 30 mother-child-dyads, reported maternal distress and salivary cortisol were collected during pregnancy. Infant temperament, motor and cognitive development were assessed at 16 months...
July 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28293926/prenatal-maternal-distress-and-allergic-diseases-in-offspring-review-of-evidence-and-possible-pathways
#10
REVIEW
Dong In Suh, Hyoung Yoon Chang, Eun Lee, Song I Yang, Soo Jong Hong
Recent studies have suggested a close association between prenatal maternal distress and allergic diseases in the offspring. We selected relevant birth-cohort or national registry studies using a keyword search of the PubMed database and summarized current evidence on the impact of prenatal maternal distress on the development of offspring's allergic diseases. Moreover, we postulated possible pathways linking prenatal distress and allergic diseases based on relevant human and animal studies. Both dysregulated hypothalamic-pituitary-adrenal axis and increased oxidative stress may cause structural (altered brain/lung development) and functional (skewed immune development) changes, which may predispose the fetus to developing allergic diseases during childhood...
May 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28237726/transfer-of-maternal-psychosocial-stress-to-the-fetus
#11
REVIEW
Florian Rakers, Sven Rupprecht, Michelle Dreiling, Christoph Bergmeier, Otto W Witte, Matthias Schwab
Psychosocial maternal stress experienced during different vulnerable periods throughout gestation is thought to increase the individual's risk to develop neuropsychiatric, cardiovascular and metabolic disease in later life. Cortisol has generally been identified as the major mediator of maternal stress transfer to the fetus. Its lipophilic nature allows a trans-placental passage and thus excessive maternal cortisol could persistently impair the development of the fetal hypothalamic-pituitary-adrenal axis (HPAA)...
February 22, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28097780/a-man-made-disease-fetal-neonatal-alloimmune-thrombocytopenia-due-to-incompatibility-between-oocyte-donor-and-gestational-mother
#12
Assaf Arie Barg, Aviya Dvir Ifrah, Tzipi Strauss, Michal J Simchen, Raoul Orvieto, Nurit Rosenberg, Gili Kenet
The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.
August 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27806668/contemporary-management-of-neonatal-alloimmune-thrombocytopenia-good-outcomes-in-the-intravenous-immunoglobulin-era-results-from-the-australian-neonatal-alloimmune-thrombocytopenia-registry
#13
Gemma L Crighton, Ri Scarborough, Zoe K McQuilten, Louise E Phillips, Helen F Savoia, Bronwyn Williams, Rhonda Holdsworth, Amanda Henry, Erica M Wood, Stephen A Cole
OBJECTIVE: To describe the natural history, antenatal and postnatal therapy, and clinical outcomes of Australian patients with fetomaternal/neonatal alloimmune thrombocytopenia (NAIT) recorded in the Australian NAIT registry. METHODS: Analysis of registry data of Australian mothers treated antenatally for NAIT and any fetus/newborn with thrombocytopenia (TCP) and maternal human platelet antigen (HPA) antibodies. RESULTS: Ninety four potential cases (91 pregnancies; three twin pregnancies) were registered between December 2004 and September 2015 with 76 confirmed or treated as NAIT...
October 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27771566/prenatal-maternal-cortisol-concentrations-predict-neurodevelopment-in-middle-childhood
#14
Elysia Poggi Davis, Kevin Head, Claudia Buss, Curt A Sandman
Glucocorticoids (cortisol in humans) are the end product of the hypothalamic-pituitary-adrenocortical (HPA) axis and are proposed as a key mechanism for programming fetal brain development. The present prospective longitudinal study evaluates the association between prenatal maternal cortisol concentrations and child neurodevelopment. Participants included a low risk sample of 91 mother-child pairs. Prenatal maternal plasma cortisol concentrations were measured at 19 and 31 gestational weeks. Brain development and cognitive functioning were assessed when children were 6-9 years of age...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27728915/fetal-and-neonatal-alloimmune-thrombocytopenia-management-and-outcome-of-a-large-international-retrospective-cohort
#15
Marije M Kamphuis, Heidi Tiller, E S van den Akker, Magnus Westgren, Eleonor Tiblad, Dick Oepkes
OBJECTIVE: To evaluate the management and outcome of a large international cohort of cases of pregnancies complicated by fetal and neonatal alloimmune thrombocytopenia (FNAIT). METHODS: This was an observational prospective and retrospective cohort study of all cases of FNAIT entered into the international multicentre No IntraCranial Haemorrhage (NOICH) registry during the period of 2001-2010. We evaluated human platelet antigen (HPA) specificity, the antenatal and postnatal interventions performed, and clinical outcome...
2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27465226/antenatal-endogenous-and-exogenous-glucocorticoids-and-their-impact-on-immune-ontogeny-and-long-term-immunity
#16
REVIEW
María Emilia Solano, Megan C Holmes, Paul R Mittelstadt, Karen E Chapman, Eva Tolosa
Endogenous levels of glucocorticoids rise during pregnancy to warrant development and maturation of the fetal organs close to birth. However, during most of the gestation, the fetus is protected from excessive biologically active endogenous glucocorticoids by placental and fetal expression of 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). Maternal stress, which may overwhelm placental 11β-HSD2 activity with high glucocorticoid levels, or administration of synthetic glucocorticoids to improve the survival chances of the premature newborn, are associated to postnatal increased risk for immune diseases...
November 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/27423986/dexamethasone-exposure-affects-paraventricular-nucleus-and-pituitary-corticotrophs-in-female-rat-fetuses-an-unbiased-stereological-and-immunohistochemical-study
#17
Milica Manojlović-Stojanoski, Nataša Nestorović, Svetlana Trifunović, Nataša Ristić, Ivana Jarić, Branko Filipović, Verica Milošević
The hypothalamic paraventricular nucleus (PVN) drives the stress response by activating the hypothalamo-pituitary-adrenal (HPA) axis, particularly vulnerable to glucocorticoid exposure during development. To evaluate the effects of fetal dexamethasone (Dx) exposure on the stereological features of PVN and HPA axis activity in female rat fetuses, pregnant rats received 0.5mg Dx/kg/b.w./day on days 16, 17 and 18 of pregnancy and 21-day-old fetuses were obtained; controls received the same volume of saline. In an unbiased stereological approach, Cavalieri's principle and an optical fractionator were used for estimating volume and total cell number of the PVN, respectively...
October 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27393907/antenatal-glucocorticoid-treatment-is-associated-with-diurnal-cortisol-regulation-in-term-born-children
#18
M N Edelmann, C A Sandman, L M Glynn, D A Wing, E P Davis
Due to the rapid developmental changes that occur during the fetal period, prenatal influences can affect the developing central nervous system with lifelong consequences for physical and mental health. Glucocorticoids are one of the proposed mechanisms by which fetal programing occurs. Glucocorticoids pass through the blood-brain barrier and target receptors throughout the central nervous system. Unlike endogenous glucocorticoids, synthetic glucocorticoids readily pass through the placental barrier to reach the developing fetus...
October 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27352901/stress-induced-decrease-of-uterine-blood-flow-in-sheep-is-mediated-by-alpha-1-adrenergic-receptors
#19
Michelle Dreiling, Sabine Bischoff, Rene Schiffner, Sven Rupprecht, Michael Kiehntopf, Harald Schubert, Otto W Witte, Peter W Nathanielsz, Matthias Schwab, Florian Rakers
Prenatal maternal stress can be transferred to the fetus via a catecholamine-dependent decrease of uterine blood flow (UBF). However, it is unclear which group of adrenergic receptors mediates this mechanism of maternal-fetal stress transfer. We hypothesized that in sheep, alpha 1-adrenergic receptors may play a key role in catecholamine mediated UBF decrease, as these receptors are mainly involved in peripheral vasoconstriction and are present in significant number in the uterine vasculature. After chronic instrumentation at 125 ± 1 days of gestation (dGA; term 150 dGA), nine pregnant sheep were exposed at 130 ± 1 dGA to acute isolation stress for one hour without visual, tactile, or auditory contact with their flockmates...
September 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27263073/fluoxetine-normalizes-the-effects-of-prenatal-maternal-stress-on-depression-and-anxiety-like-behaviors-in-mouse-dams-and-male-offspring
#20
Ali-Akbar Salari, Laleh Fatehi-Gharehlar, Negar Motayagheni, Judith R Homberg
Maternal depression during pregnancy and the postpartum period (lactation) is a common debilitating condition affecting mother-fetus/-infant interactions, which can be a risk factor for cognitive and affective disorders in mothers and their children. Selective-serotonin-reuptake-inhibitor-(SSRI) pharmacotherapy is known as the first-line treatment of maternal depression. However, its use during pregnancy and lactation is a topic of concern. The present study aimed to investigate the effects of prenatal stress alone or in combination with fluoxetine (FLX) on hypothalamic-pituitary-adrenal axis (HPA) activity, anxiety-/depression-like behaviors in dams and in offspring...
September 15, 2016: Behavioural Brain Research
keyword
keyword
6462
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"