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https://www.readbyqxmd.com/read/29234148/quality-improvement-to-reduce-chronic-lung-disease-rates-in-very-low-birth-weight-infants-high-compliance-with-a-respiratory-care-bundle-in-a-small-nicu
#1
Zuzanna Kubicka, Eyad Zahr, Tamara Rousseau, Henry A Feldman, John Fiascone
OBJECTIVE: Reduce chronic lung disease by 10% among very-low birth weight infants by implementing a consistent respiratory care bundle. STUDY DESIGN: Prospective quality improvement study of infants below 32 weeks gestation in a small neonatal intensive care unit. A respiratory care bundle to eliminate inter-provider variability and minimize use of mechanical ventilation was implemented. This included: defining delivery room management with use of continuous positive airway pressure/nasal intermittent positive pressure ventilation, uniform intubation/extubation criteria, and standardizing ventilation/post-extubation support...
December 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29233790/preclinical-evidence-for-combined-use-of-aromatase-inhibitors-and-nsaids-as-preventive-agents-of-tobacco-induced-lung-cancer
#2
Laura P Stabile, Mariya Farooqui, Beatriz Kanterewicz, Shira Abberbock, Brenda F Kurland, Brenda Diergaarde, Jill M Siegfried
INTRODUCTION: A hormonal role in non-small cell lung cancer (NSCLC) development is well documented. We previously showed that the aromatase inhibitor (AI) anastrozole decreased the development of tobacco carcinogen-induced lung tumors in a murine lung cancer prevention model and that aromatase and estrogen receptor (ER) were expressed in pulmonary inflammatory cells. METHODS: We utilized a tobacco carcinogen-induced lung tumor mouse model [4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK)] to determine whether an AI combined with non-steroidal anti-inflammatory drugs (NSAIDs) results in greater lung tumor prevention effects than single agent treatment...
December 9, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29233151/suppression-of-ptpn6-exacerbates-aluminum-oxide-nanoparticle-induced-copd-like-lesions-in-mice-through-activation-of-stat-pathway
#3
Xiaobo Li, Hongbao Yang, Shenshen Wu, Qingtao Meng, Hao Sun, Runze Lu, Jian Cui, Yuxin Zheng, Wen Chen, Rong Zhang, Michael Aschner, Rui Chen
BACKGROUND: Inhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced lung injury have yet to be identified. RESULTS: Using whole-body dynamic inhalation model, we studied the interactions between aluminum oxide nanoparticles (Al2O3 NPs) and the pulmonary system in vivo. We found that seven-day-exposure to Al2O3 NPs resulted in emphysema and small airway remodeling in murine lungs, accompanied by enhanced inflammation and apoptosis...
December 12, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29231896/differential-expression-of-serum-micrornas-supports-cd4%C3%A2-%C2%BA-t-cell-differentiation-into-th2-th17-cells-in-severe-equine-asthma
#4
Alicja Pacholewska, Matthias F Kraft, Vincent Gerber, Vidhya Jagannathan
MicroRNAs (miRNAs) regulate post-transcriptional gene expression and may be exported from cells via exosomes or in partnership with RNA-binding proteins. MiRNAs in body fluids can act in a hormone-like manner and play important roles in disease initiation and progression. Hence, miRNAs are promising candidates as biomarkers. To identify serum miRNA biomarkers in the equine model of asthma we investigated small RNA derived from the serum of 34 control and 37 asthmatic horses. These samples were used for next generation sequencing, novel miRNA identification and differential miRNA expression analysis...
December 12, 2017: Genes
https://www.readbyqxmd.com/read/29231759/screening-for-lung-cancer-incidental-pulmonary-parenchymal-findings
#5
Jonathan H Chung, J Caleb Richards, Tilman L Koelsch, Heber MacMahon, David A Lynch
OBJECTIVE: Incidental pulmonary findings are commonly detected at lung cancer screening chest CT. Though most of these findings are clinically insignificant, it is difficult to prospectively determine which are potentially important to clinical care. The purpose of this review is to discuss the incidental pulmonary findings commonly detected at lung cancer screening chest CT. CONCLUSION: Incidental pulmonary findings most commonly fall into one of three categories: interstitial lung disease, emphysema, and airways disease (both small and large airways)...
December 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29227043/the-association-of-air-pollutants-and-allergic-and-nonallergic-rhinitis-in-chronic-rhinosinusitis
#6
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas M Kaffenberger, Thomas J Willson, Stella E Lee
BACKGROUND: There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity. METHODS: CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial modeling from pollutant monitoring sites was used to estimate exposures for patients meeting the inclusion criteria (total, n = 125; CRSsNP, n = 67; CRSsNP, n = 58)...
December 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29214060/interstitial-lung-disease-the-diagnostic-role-of-bronchoscopy
#7
REVIEW
Jad Kebbe, Tony Abdo
Interstitial lung diseases (ILDs) form one of the most fascinating fields in pulmonary medicine. They also pose one of the greatest challenges for accurate diagnosis and proper treatment. Even within the recommended and warranted multidisciplinary approach, differentiating between one disease and another may lead to frustration, especially when proper lung tissue is not available for adequate pathological review. A surgical lung biopsy (SLB) might render enough tissue for histopathology, but this could come at the expense of high morbidity and even mortality, as in the case of usual interstitial pneumonia (UIP)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29212834/lung-ageing-and-copd-is-there-a-role-for-ageing-in-abnormal-tissue-repair
#8
Corry-Anke Brandsma, Maaike de Vries, Rita Costa, Roy R Woldhuis, Melanie Königshoff, Wim Timens
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29206658/lung-function-trajectories-and-chronic-obstructive-pulmonary-disease-current-understanding-and-knowledge-gaps
#9
Jamuna K Krishnan, Fernando J Martinez
PURPOSE OR REVIEW: Population-based studies have shown a significant heterogeneity in patients with chronic obstructive pulmonary disease (COPD), regarding both the attainment of maximal lung function and the subsequent decline over time. This review will highlight recent advances in the understanding of lung function trajectory in COPD, focusing on factors that influence peak adult lung function, markers of accelerated lung function decline and pharmacologic interventions in early phases of the disease...
December 4, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29206631/extrafine-compared-to-non-extrafine-particle-inhaled-corticosteroids-in-smokers-and-ex-smokers-with-asthma
#10
Claire A Cox, Ilse M Boudewijn, Sebastiaan J Vroegop, Siebrig Schokker, Anne J Lexmond, Henderik W Frijlink, Paul Hagedoorn, Judith M Vonk, Martijn P Farenhorst, Nick H T Ten Hacken, Huib A M Kerstjens, Dirkje S Postma, Maarten van den Berge
BACKGROUND: Smoking is as prevalent in asthmatics as in the general population. Asthmatic smokers benefit less from inhaled corticosteroids (ICS) than non-smoking asthmatics, possibly due to more smoking-induced small airways disease. Thus targeting small airways may be important in treating asthmatic (ex-)smokers. We hypothesized that extrafine particle ICS improve small airways function more than non-extrafine particle ICS in asthmatic (ex-)smokers. METHODS: We performed an open-label, randomized, three-way cross-over study comparing extrafine beclomethasone (HFA-QVAR) to non-extrafine beclomethasone (HFA-Clenil) and fluticasone (HFA-Flixotide) in 22 smokers and 21 ex-smokers with asthma (?5 packyears)...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29193495/premature-birth-affects-the-degree-of-airway-dysanapsis-and-mechanical-ventilatory-constraints
#11
Joseph W Duke, Igor M Gladstone, A William Sheel, Andrew T Lovering
Adult survivors of very preterm birth (≤32 weeks gestational age) without (PRE) and with bronchopulmonary dysplasia (BPD) have obstructive lung disease as evidenced by reduced expiratory airflow at rest and have significant mechanical ventilatory constraints during exercise. Airflow obstruction, under any condition, could be due to several factors including small airways. PRE and/or BPD could have smaller airways than their counterparts born at full-term (CON) due to a greater degree of dysanaptic airway development during the pre- and/or post-natal period...
November 29, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29191600/mig-6-deficiency-cooperates-with-oncogenic-kras-to-promote-mouse-lung-tumorigenesis
#12
Jian Liu, Sung-Nam Cho, San-Pin Wu, Nili Jin, Seyed Javad Moghaddam, Jennifer L Gilbert, Ignacio Wistuba, Francesco J DeMayo
OBJECTIVES: Lung cancer is the leading cause of cancer related deaths worldwide and mutation activating KRAS is one of the most frequent mutations found in lung adenocarcinoma. Identifying regulators of KRAS may aid in the development of therapies to treat this disease. The mitogen-induced gene 6, MIG-6, is a small adaptor protein modulating signaling in cells to regulate the growth and differentiation in multiple tissues. Here, we investigated the role of Mig-6 in regulating adenocarcinoma progression in the lungs of genetically engineered mice with activation of Kras...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29187726/expression-of-interleukin-27-il-27-in-the-lower-airways-diseases-increased-levels-of-il-27-in-early-clinical-stages-of-non-small-cell-lung-cancer-nsclc-patients
#13
Piotr Kopiński, Tomasz Wandtke, Andrzej Dyczek, Ewelina Wędrowska, Adriana Roży, Tomasz Senderek, Grzegorz Przybylski, Joanna Chorostowska-Wynimko
INTRODUCTION    Interleukin-27, is a cytokine secreted mostly by antigen presenting cells, key for the Th1 cells immune polarization. Its role in interstitial lung diseases (ILD) as well as in lung cancer has been investigated.  OBJECTIVES    Assessment of IL-27 expression in the lower airways of patients with selected ILD and early-stage non-small cell lung cancer (NSCLC).  PATIENTS AND METHODS    IL-27 concentration was examined by ELISA in bronchoalveolar lavage (BAL) supernatants collected from patients with pulmonary sarcoidosis (PS), extrinsic allergic alveolitis (EAA), idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP) and I-IIa NSCLC with peripheral localization, as well as in control subjects (n = 14, 30, 12, 14, 16 and 14, respectively)...
November 29, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29176571/health-state-dependent-multiphoton-induced-autofluorescence-in-human-3d-in-vitro-lung-cancer-model
#14
Vasyl Kilin, Christophe Mas, Samuel Constant, Jean-Pier Wolf, Luigi Bonacina
Lung diseases pose the highest risk of death and lung cancer is a top killer among cancers with a mortality rate up to 70% within 1 year after diagnosis. Such a fast escalation of this cancer development makes early diagnosis and treatment a highly challenging task, and currently there are no effective tools to diagnose the disease at an early stage. The ability to discriminate between healthy and tumorous tissue has made autofluorescence bronchoscopy a promising tool for detection of lung cancer; however, specificity of this method remains insufficiently low...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167011/-four-cases-report-on-primary-lung-adenoid-cystic-carcinoma
#15
Xilan He, Jianhua Chen
BACKGROUND: Lung adenoid cystic carcinoma is a kind of rare lung cancer. Diagnosis and treatment is not enough understandable for them. We collected and analyzed 4 cases of lung adenoid cystic carcinoma for broadening the sight of this disease. METHODS: Retrospectively analysed the 4 cases we collected from Hunan Cancer Hospital Between January 2012 and December 2016. We depicted the pathology, immunohistochemical, epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) arrangement in these cases...
November 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29163164/lassbio-897-reduces-lung-injury-induced-by-silica-particles-in-mice-potential-interaction-with-the-a2a-receptor
#16
Vinicius F Carvalho, Tatiana P T Ferreira, Ana C S de Arantes, François Noël, Roberta Tesch, Carlos M R Sant'Anna, Eliezer J L Barreiro, Carlos A M Fraga, Patrícia M Rodrigues E Silva, Marco A Martins
Silicosis is a lethal fibro-granulomatous pulmonary disease highly prevalent in developing countries, for which no proper therapy is available. Among a small series of N-acylhydrazones, the safrole-derived compound LASSBio-897 (3-thienylidene-3, 4-methylenedioxybenzoylhydrazide) raised interest due to its ability to bind to the adenosine A2A receptor. Here, we evaluated the anti-inflammatory and anti-fibrotic potential of LASSBio-897, exploring translation to a mouse model of silicosis and the A2A receptor as a site of action...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29160380/frequency-of-copd-in-health-care-workers-who-smoke
#17
Ivan Kopitovic, Aleksandar Bokan, Ilija Andrijevic, Miroslav Ilic, Sanja Marinkovic, Dragana Milicic, Marija Vukoja
OBJECTIVE: COPD is one of the major causes of morbidity and mortality worldwide. Health care providers should counsel their smoking patients with COPD to quit smoking as the first treatment step. However, in countries with high prevalences of smoking, health care workers may also be smokers. The aim of this study was to determine the frequency and severity of COPD in health care workers who smoke. METHODS: This was a cross-sectional study. All health care workers who smoke, from nine health care centers in Serbia, were invited to participate in the study and perform spirometry...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29155458/localization-of-surfactant-protein-d-in-the-rheumatoid-synovial-membrane
#18
Anne Friesgaard Christensen, Grith Lykke Sorensen, Kirsten Junker, Peter Hvidbak Revald, Claus Varnum, Flemming Brandt Sorensen, Peter Junker
Surfactant protein-D (SP-D) is a collectin, which plays an important role in airway protection and inflammation. The molecule has both pro- and anti-inflammatory capacities depending on its molecular size. Its involvement in joint diseases is largely unknown and the aim of this investigation was to study SP-D occurrence and distribution in the synovial membrane of patients with long-standing rheumatoid arthritis (RA) and osteoarthritis (OA). Six RA patients and six OA patients, who underwent total hip arthroplasty, were included in the study...
November 20, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29152899/lung-function-after-extremely-preterm-birth-a-population-based-cohort-study-express
#19
Per Thunqvist, Ellen Tufvesson, Leif Bjermer, Anna Winberg, Vineta Fellman, Magnus Domellöf, Erik Melén, Mikael Norman, Jenny Hallberg
BACKGROUND AND OBJECTIVES: Follow-up studies of children and young adults born very-to-moderately preterm show persistent and significant lung function deficits. The aim of the study was to determine lung function and airway mechanics in school-aged children born in 2004 to 2007 and extremely preterm (after 22-26 weeks of gestation). METHODS: In a population-based cohort of children born extremely preterm and controls born at term (n = 350), follow-up at 6½-years-of-age was performed using spirometry and impulse oscillometry...
November 20, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29151293/-clinical-analysis-of-36-cases-of-advanced-non-small-cell-lung-cancer-nsclc-with-performance-status-ps-scores-between-2-and-4
#20
Y Y Qin, D H Zhang, X Q Lin, M Ouyang, J X Zhang, Z H Xie, Y Q Liu, S Y Li, C Z Zhou
Objective: To analyze the treatment of advanced non-small cell lung cancer (NSCLC) with performance status (PS) scores between 2 and 4, in order to improve the diagnosis and treatment of these patients. Methods: A total of 36 patients with advanced NSCLC with hypoxemia were reviewed. The clinical data of disease characteristics, etiology, complications, manifestation, therapy, progression, and secondary biopsy were collected. The clinical efficacy was graded according to the Response Evaluation Criteria In Solid Tumors (RECIST): complete response (CR), partial response (PR), stable disease (SD) and disease progression (PD)...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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