Andrew James Mead, Kabir Ahluwalia, Brandon Ebright, Zeyu Zhang, Priyal Dave, Zeyang Li, Eugene Zhou, Aditya Anil Naik, Rachael Ngu, Catherine Chester, Angela Lu, Isaac Asante, Dimitrios Pollalis, Juan Carlos Martinez, Mark Humayun, Stan Louie
Retinitis pigmentosa (RP) is a retinal degenerative disease associated with a diversity of genetic mutations. In a natural progression study (NPS) evaluating the molecular changes in Royal College of Surgeons (RCS) rats using lipidomic profiling, RNA sequencing, and gene expression analyses, changes associated with retinal degeneration from p21 to p60 were evaluated, where reductions in retinal ALOX15 expression corresponded with disease progression. This important enzyme catalyzes the formation of specialized pro-resolving mediators (SPMs) such as lipoxins (LXs), resolvins (RvDs), and docosapentaenoic acid resolvins (DPA RvDs), where reduced ALOX15 corresponded with reduced SPMs...
February 15, 2024: International Journal of Molecular Sciences