Suzanne King, Sue Kildea, Marie-Paule Austin, Alain Brunet, Vanessa E Cobham, Paul A Dawson, Mark Harris, Elizabeth M Hurrion, David P Laplante, Brett M McDermott, H David McIntyre, Michael W O'Hara, Norbert Schmitz, Helen Stapleton, Sally K Tracy, Cathy Vaillancourt, Kelsey N Dancause, Sue Kruske, Nicole Reilly, Laura Shoo, Gabrielle Simcock, Anne-Marie Turcotte-Tremblay, Erin Yong Ping
BACKGROUND: Retrospective studies suggest that maternal exposure to a severe stressor during pregnancy increases the fetus' risk for a variety of disorders in adulthood. Animal studies testing the fetal programming hypothesis find that maternal glucocorticoids pass through the placenta and alter fetal brain development, particularly the hypothalamic-pituitary-adrenal axis. However, there are no prospective studies of pregnant women exposed to a sudden-onset independent stressor that elucidate the biopsychosocial mechanisms responsible for the wide variety of consequences of prenatal stress seen in human offspring...
2015: BMC Pregnancy and Childbirth