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https://www.readbyqxmd.com/read/27906414/delphi-consensus-on-attention-deficit-hyperactivity-disorder-adhd-evaluation-by-a-panel-of-experts
#1
Amaia Hervás, Teresa de Santos, Javier Quintero, Pedro M Ruíz-Lázaro, José A Alda, Alberto Fernández-Jaén, Josep A Ramos-Quiroga
INTRODUCTION: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders in childhood, which is frequently maintained in adolescent and adult age. It presents great clinical heterogeneity, significantly affecting the functioning of those who suffer it. Although drug treatments obtain results by themselves, the approach should be multidisciplinary and be adapted to the specific needs of each patient and his/ her family. Given the variety of drugs currently available to treat ADHD, there are diverse opinions on the most effective way to approach this disorder...
November 2016: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/27905916/study-protocol-a-dose-escalating-phase-2-study-of-oral-lisdexamfetamine-in-adults-with-methamphetamine-dependence
#2
Nadine Ezard, Adrian Dunlop, Brendan Clifford, Raimondo Bruno, Andrew Carr, Alexandra Bissaker, Nicholas Lintzeris
BACKGROUND: The treatment of methamphetamine dependence is a continuing global health problem. Agonist type pharmacotherapies have been used successfully to treat opioid and nicotine dependence and are being studied for the treatment of methamphetamine dependence. One potential candidate is lisdexamfetamine, a pro-drug for dexamphetamine, which has a longer lasting therapeutic action with a lowered abuse potential. The purpose of this study is to determine the safety of lisdexamfetamine in this population at doses higher than those currently approved for attention deficit hyperactivity disorder or binge eating disorder...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27904519/mind-conduct-disorders-in-children-with-poor-oral-hygiene-habits-and-attention-deficit-hyperactivity-disorder-in-children-with-excessive-tooth-decay
#3
Onur Burak Dursun, Fatih Şengül, İbrahim Selçuk Esin, Tevfik Demirci, Nermin Yücel, Mehmet Melih Ömezli
INTRODUCTION: Dental caries and poor oral hygiene are among the major childhood public health problems. Although dental research frequently refers to the link between these conditions and behavioural issues, little attention has been paid to understanding the reason for oral health problems from a psychiatric point of view. The aim of this study was to examine the relationship between poor oral health and hygiene and parental attitudes towards child rearing, parents' and children's oral hygiene behaviours, and childhood psychiatric disorders...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27903419/short-term-efficacy-and-tolerability-of-methylphenidate-in-children-with-traumatic-brain-injury-and-attention-problems
#4
Ozalp Ekinci, Meltem Çobanoğulları Direk, Serkan Gunes, Halenur Teke, Nuran Ekinci, Fatma Yıldırım, Çetin Okuyaz
PURPOSE: This study aims to investigate the short-term efficacy and tolerability of immediate-release methylphenidate (IR-MPH) in children with a history of traumatic brain injury (TBI). METHODS: Twenty children with TBI (mean age: 12.7±3.1years) who had clinically significant attention deficit and/or hyperactivity-impulsivity symptoms and twenty children with primary Attention Deficit Hyperactivity Disorder (ADHD) (mean age: 12.3±3.05years) were included. Study measures, which included the Turgay DSM-IV based ADHD rating Scale (T-DSM-IV-S), Conners' Parent Rating Scale (CPRS), Conners' Teacher Rating Scale (CTRS-R) and Clinical Global Impression-Improvement Scale (CGI-I), were completed at the baseline for both of the groups...
November 28, 2016: Brain & Development
https://www.readbyqxmd.com/read/27902832/association-of-irritability-and-anxiety-with-the-neural-mechanisms-of-implicit-face-emotion-processing-in-youths-with-psychopathology
#5
Joel Stoddard, Wan-Ling Tseng, Pilyoung Kim, Gang Chen, Jennifer Yi, Laura Donahue, Melissa A Brotman, Kenneth E Towbin, Daniel S Pine, Ellen Leibenluft
Importance: Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology. Objective: To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial emotions during functional magnetic resonance imaging...
November 30, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27902544/academic-achievement-in-adults-with-a-history-of-childhood-attention-deficit-hyperactivity-disorder-a-population-based-prospective-study
#6
Robert G Voigt, Slavica K Katusic, Robert C Colligan, Jill M Killian, Amy L Weaver, William J Barbaresi
OBJECTIVE: Previous research on the developmental course of attention-deficit/hyperactivity disorder (ADHD) is limited by biased clinic-referred samples and other methodological problems. Thus, questions about adult academic outcomes associated with childhood ADHD remain unanswered. Thus, the objective of this study was to describe academic outcomes in adulthood among incident cases of research-identified childhood ADHD versus non-ADHD referents from a population-based birth cohort. METHOD: Young adults with research-identified childhood ADHD (N = 232; mean age 27...
November 23, 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27902542/impact-of-mental-health-comorbidities-on-the-community-based-pediatric-treatment-and-outcomes-of-children-with-attention-deficit-hyperactivity-disorder
#7
Nour Al Ghriwati, Joshua M Langberg, William Gardner, James Peugh, Kelly J Kelleher, Rebecca Baum, William B Brinkman, Phil Lichtenstein, Jeffery N Epstein
OBJECTIVE: Children with attention deficit hyperactivity disorder (ADHD) often exhibit psychiatric comorbidities, which may impact illness presentation, diagnosis, and treatment outcomes. Guidelines exist for dealing with these complex cases but little is known about how comorbidities are being handled in community pediatric settings. The purpose of this study was to evaluate how mental health comorbidities affect community physicians' ADHD care practices and patients' symptom trajectories...
November 23, 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27902448/rasgrp1-promotes-amphetamine-induced-motor-behavior-through-a-rhes-interaction-network-rhesactome-in-the-striatum
#8
Neelam Shahani, Supriya Swarnkar, Vincenzo Giovinazzo, Jenny Morgenweck, Laura M Bohn, Catherina Scharager-Tapia, Bruce Pascal, Pablo Martinez-Acedo, Kshitij Khare, Srinivasa Subramaniam
The striatum of the brain coordinates motor function. Dopamine-related drugs may be therapeutic to patients with striatal neurodegeneration, such as Huntington's disease (HD) and Parkinson's disease (PD), but these drugs have unwanted side effects. In addition to stimulating the release of norepinephrine, amphetamines, which are used for narcolepsy and attention-deficit/hyperactivity disorder (ADHD), trigger dopamine release in the striatum. The guanosine triphosphatase Ras homolog enriched in the striatum (Rhes) inhibits dopaminergic signaling in the striatum, is implicated in HD and L-dopa-induced dyskinesia, and has a role in striatal motor control...
November 15, 2016: Science Signaling
https://www.readbyqxmd.com/read/27901266/maternal-prepregnancy-body-mass-index-and-offspring-attention-deficit-hyperactivity-disorder-a%C3%A2-quasi-experimental-sibling-comparison-population-based-design
#9
Erica D Musser, Michael T Willoughby, Suzanne Wright, Elinor L Sullivan, Diane D Stadler, Brent F Olson, Robert D Steiner, Joel T Nigg
BACKGROUND: High maternal prepregnancy body mass index (BMI) has been associated with increased risk of offspring attention-deficit/hyperactivity disorder (ADHD). However, whether this effect is attributable to maternal or familial level confounds has been little examined. METHODS: The present study sought to examine these associations, utilizing data from the medical records of a health care system which treats 350,000 patients annually and a sibling-comparison design in a sample of 4,682 children born to 3,645 mothers...
November 30, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27900342/cacna1c-protecting-young-hippocampal-neurons-in-the-adult-brain
#10
Héctor De Jesús-Cortés, Anjali M Rajadhyaksha, Andrew A Pieper
Neuropsychiatric disease is the leading cause of disability in the United States, and fourth worldwide.(1,2) Not surprisingly, human genetic studies have revealed a common genetic predisposition for many forms of neuropsychiatric disease, potentially explaining why overlapping symptoms are commonly observed across multiple diagnostic categories. For example, the CACNA1C gene was recently identified in the largest human genome-wide association study to date as a risk loci held in common across 5 major forms of neuropsychiatric disease: bipolar disorder, schizophrenia, major depressive disorder (MDD), autism spectrum disorder and attention deficit-hyperactivity disorder...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27899902/aggressive-antisocial-behaviors-are-related-to-character-maturity-in-young-swedish-violent-offenders-independent-of-adhd
#11
Thomas Nilsson, Örjan Falk, Eva Billstedt, Nóra Kerekes, Henrik Anckarsäter, Märta Wallinius, Björn Hofvander
BACKGROUND: Antisocial personality and psychopathic traits have constantly been found to accompany criminal and aggressive behaviors, but little attention has been given to aspects of character maturity and its relation to such behaviors. The present study investigated (1) whether level of character maturity (low, medium, and high) is associated with amount of aggressive antisocial behaviors (AABs) and psychopathic traits in young men imprisoned for violent criminality, and (2) whether such an association is independent of coexisting attention-deficit hyperactivity disorder (ADHD)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27896942/mid-childhood-outcomes-of-infant-siblings-at-familial-high-risk-of-autism-spectrum-disorder
#12
Elizabeth Shephard, Bosiljka Milosavljevic, Greg Pasco, Emily J H Jones, Teodora Gliga, Francesca Happé, Mark H Johnson, Tony Charman
Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling with an ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-risk infants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age 7, high-risk children without ASD, and low-risk control children...
November 29, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27896136/attention-deficit-hyperactivity-disorder-suffers-from-mitochondrial-dysfunction
#13
Poonam Verma, Alpana Singh, Dominic Ngima Nthenge-Ngumbau, Usha Rajamma, Swagata Sinha, Kanchan Mukhopadhyay, Kochupurackal P Mohanakumar
BACKGROUND: Pathophysiology of attention-deficit hyperactivity disorder (ADHD) is not known, and therefore the present study investigated mitochondrial defects, if any in cybrids created from patients and control population. METHODS: To investigate mitochondrial pathology in ADHD, cybrids cell lines were created from ADHD probands and controls by fusing their platelets with ρ(0)-cells prepared from SH-SY5Y neuroblastoma cell line. Cellular respiration, oxidative stress, mitochondrial membrane potential and morphology were evaluated employing oxygraph, mitochondria-specific fluorescence staining and evaluation by FACS, and immunocytochemistry...
December 2016: BBA Clinical
https://www.readbyqxmd.com/read/27895485/adhd-and-present-hedonism-time-perspective-as-a-potential-diagnostic-and-therapeutic-tool
#14
REVIEW
S Weissenberger, M Klicperova-Baker, P Zimbardo, K Schonova, D Akotia, J Kostal, M Goetz, J Raboch, R Ptacek
The article draws primarily from the behavioral findings (mainly psychiatric and psychological observations) and points out the important relationships between attention-deficit/hyperactivity disorder (ADHD) symptoms and time orientation. Specifically, the authors argue that there is a significant overlap between the symptoms of ADHD and Present Hedonism. Present Hedonism is defined by Zimbardo's time perspective theory and assessed by Zimbardo Time Perspective Inventory. Developmental data on Present Hedonism of males and females in the Czech population sample (N=2201) are also presented...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27895292/attention-deficit-hyperactivity-disorder-like-traits-and-distractibility-in-the-visual-periphery
#15
Maria Panagiotidi, Paul G Overton, Tom Stafford
We examined the performance of nonclinical subjects with high and low levels of self-reported attention-deficit hyperactivity disorder (ADHD)-like traits in a novel distractibility paradigm with far peripheral visual distractors, the likely origin of many distractors in everyday life. Subjects were tested on a Sustained Attention to Response Task with distractors appearing before some of the target or nontarget stimuli. When the distractors appeared 80 ms before the targets or nontargets, participants with high levels of ADHD-like traits were less affected in their reaction times than those with lower levels...
November 28, 2016: Perception
https://www.readbyqxmd.com/read/27895253/diagnosis-of-attention-deficit-hyperactivity-disorder
#16
Steven Karceski
No abstract text is available yet for this article.
November 29, 2016: Neurology
https://www.readbyqxmd.com/read/27895238/combined-modality-intervention-for-adhd-with-comorbid-reading-disorders-a-proof-of-concept-study
#17
Rosemary Tannock, Jan C Frijters, Rhonda Martinussen, Erin Jacquelyn White, Abel Ickowicz, Nancy J Benson, Maureen W Lovett
To evaluate the relative efficacy of two reading programs with and without adjunctive stimulant medication for children with attention-deficit/hyperactivity disorder and comorbid reading disorder (ADHD+RD). Sixty-five children (7-11 years in age) were assigned randomly to one of three intensive remedial academic programs (phonologically or strategy-based reading instruction, or general academic strategy and social skills training) in combination with either immediate-release methylphenidate or placebo. Multiple-blind procedures were used for medication/placebo, given twice daily...
November 28, 2016: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/27895149/psychotherapy-for-adolescents-with-attention-deficit-hyperactivity-disorder-a-pediatrician-s-guide
#18
Vania Modesto-Lowe, Victoria Charbonneau, Pantea Farahmand
Attention-deficit hyperactivity disorder (ADHD) presents with high levels of inattention, impulsiveness, and hyperactivity. ADHD starts in childhood and results in impairments that continue into adulthood. ADHD symptoms lead to decreased functionality in various life domains and result in poor academics, behavioral challenges, delayed independence, and strained relationships. Despite advances in diagnosis and treatment, persistent residual symptoms are common, highlighting the need for novel treatment strategies...
November 27, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27893955/using-a-patient-centered-outcome-measure-to-test-methylphenidate-versus-placebo-in-children-with-autism-spectrum-disorder
#19
Lawrence Scahill, Karen Bearss, Rena Sarhangian, Christopher J McDougle, L Eugene Arnold, Michael G Aman, James T McCracken, Elaine Tierney, Scott Gillespie, Valentina Postorino, Benedetto Vitiello
OBJECTIVES: Parent rating scales are commonly used to evaluate change in clinical trials. Despite advantages, these measures may not capture parental impression of the child's most salient problems. We examine the use of parent target problems (PTPs) in a randomized trial of methylphenidate (MPH) in children with autism spectrum disorder and symptoms of attention-deficit/hyperactivity disorder. METHODS: This multisite, 4-week, randomized crossover trial compared three dose levels (low, medium, and high) of MPH with placebo...
November 28, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27893232/narrative-production-in-children-with-autism-spectrum-disorder-asd-and-children-with-attention-deficit-hyperactivity-disorder-adhd-similarities-and-differences
#20
Sanne J M Kuijper, Catharina A Hartman, Suzanne T M Bogaerds-Hazenberg, Petra Hendriks
The present study focuses on the similarities and differences in language production between children with autism spectrum disorder (ASD) and children with attention-deficit/hyperactivity disorder (ADHD). In addition, we investigated whether Theory of Mind (ToM), working memory, and response inhibition are associated with language production. Narratives, produced by 106 Dutch-speaking children (36 with ASD, 34 with ADHD, and 36 typically developing) aged 6 to 12 during ADOS assessment, were examined on several linguistic measures: verbal productivity, speech fluency, syntactic complexity, lexical semantics, and discourse pragmatics...
November 28, 2016: Journal of Abnormal Psychology
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