Héctor Carbajal-Contreras, Adrian Rafael Murillo-de-Ozores, Germán Magaña-Avila, Alejandro Marquez-Salinas, Laurent Bourqui, Michelle Tellez-Sutterlin, Jessica P Bahena-Lopez, Eduardo Cortes-Arroyo, Sebastián González-Behn-Eschemburg, Alejandro Lopez-Saavedra, Norma Vazquez, David H Ellison, Johannes Loffing, Gerardo Gamba, María Castañeda-Bueno
Vasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involved...
December 14, 2023: American Journal of Physiology. Renal Physiology