keyword
https://read.qxmd.com/read/38495498/illuminating-shared-genetic-associations-between-oesophageal-carcinoma-and-pulmonary-carcinoma-risk
#1
JOURNAL ARTICLE
Dengfeng Zhang, Jing Li, Tianxing Lu, Fangchao Zhao, Pengfei Guo, Zhirong Li, Xiaoliang Duan, Yishuai Li, Shujun Li, Jianhang Li
Background: Lung cancer and oesophageal cancer are prevalent malignancies with rising incidence and mortality worldwide. While some environmental and behavioural risk factors for these cancers are established, the contribution of genetic factors to their pathogenesis remains incompletely defined. This study aimed to interrogate the intricate genetic relationship between lung cancer and oesophageal cancer and their potential comorbidity. Methods: We utilised linkage disequilibrium score regression (LDSC) to analyse the genetic correlation between oesophageal carcinoma and lung carcinoma...
2024: Journal of Cancer
https://read.qxmd.com/read/38474601/constituents-of-chimaphila-japonica-and-their-diuretic-activity
#2
JOURNAL ARTICLE
Yue Yu, Deri Hu, Jinze Liu, Chenghao Wu, Yuhong Sun, Mingyue Lang, Xuan Han, Dongzhou Kang, Jun Zhe Min, Hong Cui, Mingshan Zheng
Three new phenols ( 1 - 3 ), one new cyclohexanol ( 4 ), two known phenols ( 5 - 6 ), and six known flavonoids ( 7 - 12 ) were isolated from the n -butanol of the 75% ethanol extract of all plants of Chimaphila japonica Miq. Among them, compound 5 was named and described in its entirety for the first time, and compounds 9 and 10 were reported in C. japonica for the first time. The structures of all compounds were confirmed using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. Biological results show that compounds 4 , 7 , and 11 exhibited potent diuretic activity...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38271566/profiling-kinase-activities-for-precision-oncology-in-diffuse-gastric-cancer
#3
JOURNAL ARTICLE
Smrita Singh, K T Shreya Parthasarathi, Mohd Younis Bhat, Champaka Gopal, Jyoti Sharma, Akhilesh Pandey
Gastric cancer (GC) remains a leading cause of cancer-related mortality globally. This is due to the fact that majority of the cases of GC are diagnosed at an advanced stage when the treatment options are limited and prognosis is poor. The diffuse subtype of gastric cancer (DGC) under Lauren's classification is more aggressive and usually occurs in younger patients than the intestinal subtype. The concept of personalized medicine is leading to the identification of multiple biomarkers in a large variety of cancers using different combinations of omics technologies...
January 25, 2024: Omics: a Journal of Integrative Biology
https://read.qxmd.com/read/38269409/ks-wnk1-is-required-for-the-renal-response-to-extreme-changes-in-potassium-intake
#4
JOURNAL ARTICLE
Jessica Paola Bahena-Lopez, Laura Vergara, Valeria De la Peña, Miguel A Gutiérrez-Gallardo, Paulina López-Ibargüen, Janeth Alejandra García, Héctor Carbajal-Contreras, Norma Vázquez, Ruth Rincón-Heredia, Felipe Masso, Norma A Bobadilla, María Castañeda-Bueno, David H Ellison, Gerardo Gamba, María Chávez-Canales
KS-WNK1 is an isoform of WNK1 kinase that is predominantly found in the distal convoluted tubule of the kidney. The precise physiological function of KS-WNK1 remains unclear. Some studies suggest that it could play a role in regulating potassium renal excretion by modulating the activity of the Na+ -Cl- cotransporter (NCC). However, changes in the potassium diet from normal to high failed to reveal a role for KS-WNK1, but under a normal potassium diet, the expression of KS-WNK1 is negligible. It is only detectable when mice are exposed to a low potassium diet...
January 25, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38096266/arginine-vasopressin-regulates-the-renal-na-cl-and-na-k-cl-cotransporters-through-with-no-lysine-kinase-4-and-inhibitor-1-phosphorylation
#5
JOURNAL ARTICLE
Héctor Carbajal-Contreras, Adrian Rafael Murillo-de-Ozores, Germán Magaña-Avila, Alejandro Marquez-Salinas, Laurent Bourqui, Michelle Tellez-Sutterlin, Jessica P Bahena-Lopez, Eduardo Cortes-Arroyo, Sebastián González-Behn-Eschemburg, Alejandro Lopez-Saavedra, Norma Vazquez, David H Ellison, Johannes Loffing, Gerardo Gamba, María Castañeda-Bueno
Vasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involved...
December 14, 2023: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38084409/anoctamin-1-is-induced-by-tgf-beta-and-contributes-to-lung-myofibroblast-differentiation
#6
JOURNAL ARTICLE
Eleanor B Reed, Shaina Orbeta, Bernadette A Miao, Albert Sitikov, Bohao Chen, Irena Levitan, Julian Solway, Gökhan M Mutlu, Yun Fang, Alexander A Mongin, Nickolai O Dulin
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs and resulting in deterioration in lung function. Transforming growth factor-beta (TGF-β) is one of the most established drivers of fibrotic processes. TGF-β promotes transformation of tissue fibroblasts to myofibroblasts, a key finding in the pathogenesis of pulmonary fibrosis. We report here that TGF-β robustly upregulates the expression of the calcium-activated chloride channel Anoctamin-1 (ANO1) in human lung fibroblasts (HLF) at mRNA and protein levels...
December 12, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/38057317/t-cell-migration-requires-ion-and-water-influx-to-regulate-actin-polymerization
#7
JOURNAL ARTICLE
Leonard L de Boer, Lesley Vanes, Serena Melgrati, Joshua Biggs O'May, Darryl Hayward, Paul C Driscoll, Jason Day, Alexander Griffiths, Renata Magueta, Alexander Morrell, James I MacRae, Robert Köchl, Victor L J Tybulewicz
Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the chemokine receptor CCR7 leads to activation of WNK1 and its downstream pathway at the leading edge of migrating CD4+ T cells, resulting in ion influx and water entry by osmosis. We propose that WNK1-induced water entry is required to swell the membrane at the leading edge, generating space into which actin filaments can polymerize, thereby facilitating forward movement of the cell...
December 6, 2023: Nature Communications
https://read.qxmd.com/read/37980468/lymphocyte-migration-regulation-related-proteins-in-urine-exosomes-may-serve-as-a-potential-biomarker-for-lung-cancer-diagnosis
#8
JOURNAL ARTICLE
Shuai Jin, Tianci Liu, Weiwei Wang, Tao Li, Zhefeng Liu, Man Zhang
BACKGROUND: The migration of lymphocytes shares many similarities in mode and mechanism with the metastasis of lung cancer tumor cells. But changes in the expression of lymphocyte migration regulation related proteins in urine exosomes remain unclear. This study is to investigate the expression changes of lymphocyte migration regulation related proteins in urine exosomes of lung cancer patients, and further verify their correlation with the development and progression of lung cancer. METHODS: Urine exosomes were collected from lung cancer patients and healthy people aged 15-79 years...
November 18, 2023: BMC Cancer
https://read.qxmd.com/read/37961262/rna-isoform-expression-landscape-of-the-human-dorsal-root-ganglion-drg-generated-from-long-read-sequencing
#9
Asta Arendt-Tranholm, Juliet M Mwirigi, Theodore J Price
Splicing is a post-transcriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. Diversity in splicing in the mammalian nervous system is associated with neuronal development, synaptic function and plasticity, and is also associated with diseases of the nervous system ranging from neurodegeneration to chronic pain. We aimed to characterize the isoforms expressed in the human peripheral nervous system, with the goal of creating a resource to identify novel isoforms of functionally relevant genes associated with somatosensation and nociception...
November 1, 2023: bioRxiv
https://read.qxmd.com/read/37909881/hereditary-causes-of-hypertension-due-to-increased-sodium-transport
#10
JOURNAL ARTICLE
Jinwei Zhang
PURPOSE OF REVIEW: Hypertension, commonly known as high blood pressure, is a widespread health condition affecting a large number of individuals across the globe. Although lifestyle choices and environmental factors are known to have a significant impact on its development, there is growing recognition of the influence of genetic factors in the pathogenesis of hypertension. This review specifically focuses on the hereditary causes of hypertension that are associated with increased sodium transport through the thiazide-sensitive NaCl cotransporter (NCC) or amiloride-sensitive epithelial sodium channel (ENaC), crucial mechanisms involved in regulating blood pressure in the kidneys...
November 2, 2023: Current Opinion in Pediatrics
https://read.qxmd.com/read/37895227/a-spanish-family-with-gordon-syndrome-due-to-a-variant-in-the-acidic-motif-of-wnk1
#11
JOURNAL ARTICLE
Ramón Peces, Carlos Peces, Laura Espinosa, Rocío Mena, Carolina Blanco, Jair Tenorio-Castaño, Pablo Lapunzina, Julián Nevado
(1) Background: Gordon syndrome (GS) or familial hyperkalemic hypertension is caused by pathogenic variants in the genes WNK1 , WNK4 , KLHL3, and CUL3 . Patients presented with hypertension, hyperkalemia despite average glomerular filtration rate, hyperchloremic metabolic acidosis, and suppressed plasma renin (PR) activity with normal plasma aldosterone (PA) and sometimes failure to thrive. GS is a heterogeneous genetic syndrome, ranging from severe cases in childhood to mild and sometimes asymptomatic cases in mid-adulthood...
September 27, 2023: Genes
https://read.qxmd.com/read/37818405/trapa-bispinosa-roxb-inhibits-the-insulin-dependent-akt-wnk1-pathway-to-induce-autophagy-in-mice-with-type-2-diabetes
#12
JOURNAL ARTICLE
Takahiro Suzuki, Takehito Sato, Kaori Masuhara, Mizuki Tokusanai, Hisako Akatsuka, Tomohiro Kashikawa, Yasuyuki Suzuki
PURPOSE: To elucidate the antiglycation activity of Trapa bispinosa Roxb. extract (TBE) and the related mechanism using a mouse model with type 2 diabetes. MATERIALS AND METHODS: We prepared control mice by giving them a normal diet, leptin-deficient ob/ob mouse (ob/ob mice) with a normal diet (normal ob/ob mice), and ob/ob mice with a diet containing TBE (TBE ob/ob mice). The effect of TBE on diabetic retina was evaluated by immunohistochemical staining and quantitative real-time polymerase chain reaction (qPCR) analysis...
2023: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/37793538/expression-pattern-analysis-and-characterization-of-the-hereditary-sensory-and-autonomic-neuropathy-2%C3%A2-a-hsan2a-gene-with-no-lysine-kinase-wnk1-in-human-dorsal-root-ganglion
#13
JOURNAL ARTICLE
Matthew R Sapio, Diana M King, Ellen S Staedtler, Dragan Maric, Jahandar Jahanipour, Natalya A Kurochkina, Allison P Manalo, Andre Ghetti, Andrew J Mannes, Michael J Iadarola
Inherited painless neuropathies arise due to genetic insults that either block the normal signaling of or destroy the sensory afferent neurons in the dorsal root ganglion (DRG) responsible for transducing noxious stimuli. Complete loss of these neurons leads to profound insensitivity to all sensory modalities including pain. Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare genetic neuropathy characterized by a progressive distal early onset sensory loss. This syndrome is caused by autosomal recessive mutations in the with-no-lysine protein kinase 1 (WNK1) serine-threonine kinase gene...
October 2, 2023: Experimental Neurology
https://read.qxmd.com/read/37787401/focal-adhesion-kinase-confers-lenvatinib-resistance-in-hepatocellular-carcinoma-via-the-regulation-of-lysine-deficient-kinase-1
#14
JOURNAL ARTICLE
Wei Hou, Shaimaa A Gad, Xianzhong Ding, Asha Dhanarajan, Wei Qiu
Lenvatinib is a clinically effective multikinase inhibitor approved for first-line therapy of advanced hepatocellular carcinoma (HCC). Although resistance against lenvatinib often emerges and limits its antitumor activity, the underlying molecular mechanisms involved in endogenous and acquired resistance remain elusive. In this study, we identified focal adhesion kinase (FAK) as a critical contributor to lenvatinib resistance in HCC. The elevated expression and phosphorylation of FAK were observed in both acquired and endogenous lenvatinib-resistant (LR) HCC cells...
October 3, 2023: Molecular Carcinogenesis
https://read.qxmd.com/read/37779914/association-study-of-wnk1-genetic-variants-and-essential-hypertension-risk-in-the-northern-han-chinese-in-beijing
#15
JOURNAL ARTICLE
Kuo Liu, Jielin Liu, Ya Liu, Hao Wang, Zuoguang Wang, Jinghua Liu, Shaojun Wen
Background: Essential hypertension (EH) is a complex disorder resulting from interaction of genetic and environmental factors. Lysine deficient protein kinase 1 (WNK1) plays a very important role in maintaining renal potassium, sodium and chlorine ions balance as well as the regulation of blood pressure, so the WNK1 gene is considered a key gene for EH. This study thus sought to evaluate possible genetic associations between the WNK1 genetic variants and EH risk in the Northern Han Chinese population in Beijing...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37719376/erratum-author-correction-to-tmem16a-inhibits-angiotensin-ii-induced-basilar-artery-smooth-muscle-cell-migration-in-a-wnk1-dependent-manner-acta-pharmaceutica-sinica-b-11-2021-3994-4007
#16
Huaqing Zheng, Xiaolong Li, Xin Zeng, Chengcui Huang, Mingming Ma, Xiaofei Lv, Yajuan Zhang, Lu Sun, Guanlei Wang, Yanhua Du, Yongyuan Guan
[This corrects the article DOI: 10.1016/j.apsb.2021.04.013.].
September 2023: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/37694147/wnk1-is-required-during-male-pachynema-to-sustain-fertility
#17
JOURNAL ARTICLE
Ru-Pin Alicia Chi, Xiaojiang Xu, Jian-Liang Li, Xin Xu, Guang Hu, Paula Brown, Cynthia Willson, Oleksandr Kirsanov, Christopher Geyer, Chou-Long Huang, Marcos Morgan, Francesco DeMayo
WNK1 is an important regulator in many physiological functions, yet its role in male reproduction is unexplored. In the male germline, WNK1 is upregulated in preleptotene spermatocytes indicating possible function(s) in spermatogenic meiosis. Indeed, deletion of Wnk1 in mid-pachytene spermatocytes using the Wnt7a-Cre mouse led to male sterility which resembled non-obstructive azoospermia in humans, where germ cells failed to complete spermatogenesis and produced no sperm. Mechanistically, we found elevated MTOR expression and signaling in the Wnk1 -depleted spermatocytes...
September 15, 2023: IScience
https://read.qxmd.com/read/37693587/water-and-chloride-as-allosteric-inhibitors-in-wnk-kinase-osmosensing
#18
Liliana R Teixeira, Radha Akella, John M Humphreys, Haixia He, Elizabeth J Goldsmith
Previous observations showed that chloride and osmotic stress regulate the autophosphorylation and activity of the kinase domains of WNK1 and WNK3. Further, prior crystallography on the asymmetric dimeric of the unphosphorylated WNK1 kinase domain (WNK1/S382A, WNK1/SA) revealed conserved waters in the active site. Here we show by crystallography that PEG400 applied to crystals of dimeric WNK1/SA grown in space group P1 induces de-dimerization with a change in space group to P2 1 . Both the conserved waters, referred to here as conserved water network 1 (CWN1) and the chloride binding site are disrupted by PEG400...
August 31, 2023: bioRxiv
https://read.qxmd.com/read/37692528/zyx-promotes-invasion-and-metastasis-of-gastric-cancer-cells-via-wnk1-snai1axis
#19
JOURNAL ARTICLE
Yi Jiang, Dongfang Xiang, Xianmei Wen, Mingmin He, Yan Qin, Xiaoxue Yao, Zexuan Yan, Xiuli Geng, Yong Ren, Xiongwei Cai, Youhong Cui, Yan Wang
No abstract text is available yet for this article.
March 2024: Genes & Diseases
https://read.qxmd.com/read/37666233/association-of-familial-hyperkalemia-and-hypertension-fhht-with-proximal-renal-tubular-acidosis-and-epileptic-seizures
#20
JOURNAL ARTICLE
Neta Shirin, Grace Rabinowitz, Ilan Blatt, Steven J D Karlish, Zvi Farfel, Haim Mayan
UNLABELLED: Abstract: Introduction: Familial Hyperkalemic Hypertension (FHHt) is an inherited disease characterized by hyperkalemia, hypertension and hyperchloremic acidosis. The primary defect is a hyperactive sodium chloride co-transporter, expressed in the renal distal tubule (DCT). FHHt is caused by mutation in either, WNK1, WNK4, KLHL3 or Cul3. The mechanism of hyperchloremic acidosis is not completely understood. METHODS: Clinical and genetic data were collected from the largest family with FHHt described in the literature...
September 4, 2023: Nephron
keyword
keyword
64603
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.