keyword
MENU ▼
Read by QxMD icon Read
search

sodium chloride cotransporter

keyword
https://www.readbyqxmd.com/read/27861335/response-of-fibroblast-growth-factor-23-to-volume-interventions-in-arterial-hypertension-and-diabetic-nephropathy
#1
Jelmer K Humalda, Sarah Seiler-Muler, Arjan J Kwakernaak, Marc G Vervloet, Gerjan Navis, Danilo Fliser, Gunnar H Heine, Martin H de Borst
Fibroblast growth factor 23 (FGF-23) rises progressively in chronic kidney disease and is associated with adverse cardiovascular outcomes. FGF-23 putatively induces volume retention by upregulating the sodium-chloride cotransporter (NCC). We studied whether, conversely, interventions in volume status affect FGF-23 concentrations.We performed a post hoc analysis of 1) a prospective saline infusion study with 12 patients with arterial hypertension who received 2 L of isotonic saline over 4 hours, and 2) a randomized controlled trial with 45 diabetic nephropathy (DN) patients on background angiotensin-converting enzyme -inhibition (ACEi), who underwent 4 6-week treatment periods with add-on hydrochlorothiazide (HCT) or placebo, combined with regular sodium (RS) or low sodium (LS) diet in a cross-over design...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27789743/channel-transporter-complexes-an-emerging-theme-in-cell-signaling
#2
Geoffrey W Abbott
In a recent edition of Biochemical Journal, Mistry and colleagues described the discovery of a novel protein complex, formed from the epithelial sodium channel (ENaC) and the sodium chloride cotransporter (NCC) [Biochem. J. (2016) Hoover, S.R]. The importance of these two proteins in the regulation of salt balance and blood pressure has long been known, as has their overlapping expression in the distal convoluted tubule of the kidney. The new study by Mistry et al. now demonstrates their physical interaction in the kidney and when heterologously co-expressed...
November 1, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27784676/a-role-for-sodium-chloride-cotransporters-in-the-rapid-regulation-of-ion-uptake-following-acute-environmental-acidosis-new-insights-from-the-zebrafish-model
#3
Raymond W M Kwong, Steve F Perry
The effects of acute exposure to acidic water on Na(+) and Cl(-) homeostasis, and the mechanisms underlying their compensatory regulation, were investigated in the larval zebrafish Danio rerio Exposure to acidic water (pH 4.0; control pH 7.6) for 2 h significantly reduced Na(+) uptake and whole body Na(+) content. Nevertheless, the capacity for Na(+) uptake was substantially increased in fish preexposed to acidic water but measured in control water. Based on the accumulation of the Na(+)-selective dye, Sodium Green, two ionocyte subtypes exhibited intracellular Na(+) enrichment after preexposure to acidic water: H(+)-ATPase rich (HR) cells, which coexpress the Na(+)/H(+) exchanger isoform 3b (NHE3b), and a non-HR cell population...
December 1, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27754276/ed-09-1-renal-sodium-handling-and-salt-sensitivity
#4
Richard Wainford
This lecture will provide a background on the physiology of renal sodium handling and its importance in long term blood pressure regualtion. A brief overview of the classical Guytonion Pressure-Natriuresis Hypothesis of blood pressure control will be provided. The global impact of dietary salt intake on hypertension incidence and cardiovasular health will be discussed. Addtionally, recent insights into the mechanisitc regualtion of renal sodium handling during health and the pathophysiology of salt-sensitive hypertension - including a focus on the regulation of the sodium chloride cotransport will be provided...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753931/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#5
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753890/ish-nia-os-05-interleukin-6-transactivation-of-the-mineralocorticoid-receptor
#6
Brandi Wynne, Trinity Kronk, Otor Al-Khalili, Benjamin Ko, Franziska Theilig, Douglas Eaton, Robert Hoover
OBJECTIVE: Hypertension is characterized by increased sodium reabsorption along the aldosterone-sensitive distal nephron (ASDN) and systemic inflammation. Interleukin-6 (IL-6) is a possible mediator, signaling via the transmembrane IL-6 receptor alpha (IL-6Rα); however, whether IL-6Rα is present in the distal convoluted tubule (DCT) is unknown. Increased sodium reabsorption is not always correlated with increased aldosterone (Aldo). Thus, understanding how Aldo-independent sodium reabsorption occurs is critical...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748541/a-novel-variant-in-the-slc12a1-gene-in-two-families-with-antenatal-bartter-syndrome
#7
Anders Breinbjerg, Charlotte Siggaard Rittig, Niels Gregersen, Søren Rittig, Jane Hvarregaard Christensen
AIM: Bartter syndrome is an autosomal recessive inherited disease in which patients present with hypokalaemia and metabolic alkalosis. We present two apparently non-related cases with antenatal Bartter syndrome type I, due to a novel variant in the SLC12A1 gene encoding the bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 in the thick ascending limb of the loop of Henle. METHODS: Blood samples were received from the two cases and 19 of their relatives and deoxyribonucleic acid was extracted...
October 17, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27643324/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#8
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643273/ed-09-1-renal-sodium-handling-and-salt-sensitivity
#9
Richard Wainford
This lecture will provide a background on the physiology of renal sodium handling and its importance in long term blood pressure regualtion. A brief overview of the classical Guytonion Pressure-Natriuresis Hypothesis of blood pressure control will be provided. The global impact of dietary salt intake on hypertension incidence and cardiovasular health will be discussed. Addtionally, recent insights into the mechanisitc regualtion of renal sodium handling during health and the pathophysiology of salt-sensitive hypertension - including a focus on the regulation of the sodium chloride cotransport will be provided...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643236/ish-nia-os-05-interleukin-6-transactivation-of-the-mineralocorticoid-receptor
#10
Brandi Wynne, Trinity Kronk, Otor Al-Khalili, Benjamin Ko, Franziska Theilig, Douglas Eaton, Robert Hoover
OBJECTIVE: Hypertension is characterized by increased sodium reabsorption along the aldosterone-sensitive distal nephron (ASDN) and systemic inflammation. Interleukin-6 (IL-6) is a possible mediator, signaling via the transmembrane IL-6 receptor alpha (IL-6Rα); however, whether IL-6Rα is present in the distal convoluted tubule (DCT) is unknown. Increased sodium reabsorption is not always correlated with increased aldosterone (Aldo). Thus, understanding how Aldo-independent sodium reabsorption occurs is critical...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27622885/fgf23-klotho-signaling-axis-in-the-kidney
#11
Reinhold G Erben, Olena Andrukhova
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. The kidney is one of the main target organs of FGF23 signaling. The purpose of this review is to highlight the recent advances in the area of FGF23-Klotho signaling in the kidney. During recent years, it has become clear that FGF23 acts independently on proximal and distal tubular epithelium...
September 10, 2016: Bone
https://www.readbyqxmd.com/read/27600183/potassium-supplementation-prevents-sodium-chloride-cotransporter-stimulation-during-angiotensin-ii-hypertension
#12
Luciana C Veiras, Jiyang Han, Donna L Ralph, Alicia A McDonough
Angiotensin II (AngII) hypertension increases distal tubule Na-Cl cotransporter (NCC) abundance and phosphorylation (NCCp), as well as epithelial Na(+) channel abundance and activating cleavage. Acutely raising plasma [K(+)] by infusion or ingestion provokes a rapid decrease in NCCp that drives a compensatory kaliuresis. The first aim tested whether acutely raising plasma [K(+)] with a single 3-hour 2% potassium meal would lower NCCp in Sprague-Dawley rats after 14 days of AngII (400 ng/kg per minute). The potassium-rich meal neither decreased NCCp nor increased K(+) excretion...
October 2016: Hypertension
https://www.readbyqxmd.com/read/27599528/diuretic-action-of-sodium-glucose-cotransporter-2-inhibitors-and-its-importance-in-the-management-of-heart-failure
#13
Genjiro Kimura
Primarily, the sodium-glucose cotransporter 2 (SGLT2) inhibitors suppress the cotransport of glucose and sodium from the tubular lumen of the proximal tubules to the blood, and excrete glucose into the urine. Therefore, glucose and caloric balances become negative, reducing both the blood glucose level and insulin secretion. On the other hand, the proximal tubular fluid, constituted with low chloride concentration because of SGLT2 inhibition, is transferred to the loop of Henle. Under low chloride conditions, the reabsorption mechanisms in the loop of Henle do not work, similar to when loop diuretics are given...
September 7, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27579038/hyperemesis-gravidarum-in-undiagnosed-gitelman-s-syndrome
#14
Maria Czarina Acelajado, R Michael Culpepper, Wilburn D Bolton Iii
Introduction. Gitelman's syndrome (GS) is an autosomal recessive inherited defect in the thiazide-sensitive sodium-chloride cotransporter (NCCT) in the renal distal convoluted tubule. Physiologic changes of pregnancy promote renal potassium wasting, but serum potassium levels are kept in the physiologic range by increased levels of progesterone, which resist kaliuresis. In the presence of GS, this compensatory mechanism is easily overwhelmed, resulting in profound hypokalemia. We present a case of an 18-year-old primigravida with undiagnosed GS who presented with hyperemesis gravidarum in her 7th week of pregnancy...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27517916/serum-and-glucocorticoid-regulated-kinase-1-in-sodium-homeostasis
#15
REVIEW
Yiyun Lou, Fan Zhang, Yuqin Luo, Liya Wang, Shisi Huang, Fan Jin
The ubiquitously expressed serum and glucocorticoid regulated kinase 1 (SGK1) is tightly regulated by osmotic and hormonal signals, including glucocorticoids and mineralocorticoids. Recently, SGK1 has been implicated as a signal hub for the regulation of sodium transport. SGK1 modulates the activities of multiple ion channels and carriers, such as epithelial sodium channel (ENaC), voltage-gated sodium channel (Nav1.5), sodium hydrogen exchangers 1 and 3 (NHE1 and NHE3), sodium-chloride symporter (NCC), and sodium-potassium-chloride cotransporter 2 (NKCC2); as well as the sodium-potassium adenosine triphosphatase (Na⁺/K⁺-ATPase) and type A natriuretic peptide receptor (NPR-A)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27470878/sodium-glucose-cotransporter-2-inhibitors-in-the-treatment-of-diabetes-mellitus-cardiovascular-and-kidney-effects-potential-mechanisms-and-clinical-applications
#16
Hiddo J L Heerspink, Bruce A Perkins, David H Fitchett, Mansoor Husain, David Z I Cherney
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their unique glycosuric mechanism, SGLT2 inhibitors also reduce weight. Perhaps more important are the osmotic diuretic and natriuretic effects contributing to plasma volume contraction, and decreases in systolic and diastolic blood pressures by 4 to 6 and 1 to 2 mm Hg, respectively, which may underlie cardiovascular and kidney benefits...
September 6, 2016: Circulation
https://www.readbyqxmd.com/read/27467688/wnk3-kinase-enhances-the-sodium-chloride-cotransporter-expression-via-an-erk-1-2-signaling-pathway
#17
Dexuan Wang, Yiqian Zhang, Jinhua Han, Shufang Pan, Ning Xu, Xiuyan Feng, Zhizhi Zhuang, Courtney Caroti, Jieqiu Zhuang, Robert S Hoover, Dingying Gu, Qiyi Zeng, Hui Cai
BACKGROUND: WNK kinase is a serine/threonine kinase that plays an important role in normal blood pressure homeostasis. WNK3 was previously found to enhance the activity of sodium chloride cotransporter (NCC) in Xenopus oocyte. However, the mechanism through which it works remains unclear. METHODS: Using overexpression and siRNA knock-down techniques, the effects of WNK3 on NCC in both Cos-7 and mouse distal convoluted cells were analyzed by Western blot. RESULTS: We found that WNK3 significantly increased NCC protein expression in a dose-dependent manner...
2016: Nephron
https://www.readbyqxmd.com/read/27443990/renal-sodium-transport-in-renin-deficient-dahl-salt-sensitive-rats
#18
Tengis S Pavlov, Vladislav Levchenko, Daria V Ilatovskaya, Carol Moreno, Alexander Staruschenko
OBJECTIVE: The Dahl salt-sensitive rat is a well-established model of salt-sensitive hypertension. The goal of this study was to assess the expression and activity of renal sodium channels and transporters in the renin-deficient salt-sensitive rat. METHODS: Renin knockout (Ren(-/-)) rats created on the salt-sensitive rat background were used to investigate the role of renin in the regulation of ion transport in salt-sensitive hypertension. Western blotting and patch-clamp analyses were utilized to assess the expression level and activity of Na(+) transporters...
July 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27422782/the-sodium-chloride-cotransporter-ncc-and-epithelial-sodium-channel-enac-associate
#19
Abinash C Mistry, Brandi M Wynne, Ling Yu, Viktor Tomilin, Qiang Yue, Yiqun Zhou, Otor Al-Khalili, Rickta Mallick, Hui Cai, Abdel A Alli, Benjamin Ko, Alexa Mattheyses, Hui-Fang Bao, Oleh Pochynyuk, Franziska Theilig, Douglas C Eaton, Robert S Hoover
The thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC) are two of the most important determinants of salt balance and thus systemic blood pressure. Abnormalities in either result in profound changes in blood pressure. There is one segment of the nephron where these two sodium transporters are coexpressed, the second part of the distal convoluted tubule. This is a key part of the aldosterone-sensitive distal nephron, the final regulator of salt handling in the kidney...
October 1, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27381844/in-primary-aldosteronism-mineralocorticoids-influence-exosomal-sodium-chloride-cotransporter-abundance
#20
Martin J Wolley, Aihua Wu, Shengxin Xu, Richard D Gordon, Robert A Fenton, Michael Stowasser
Distal tubular sodium retention is a potent driver of hypertension, and the thiazide-sensitive sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors regulating NCC are unclear, but in animal models, aldosterone is a potent regulator, possibly via effects on plasma potassium. We studied the effects of the mineralocorticoid fludrocortisone on the abundance of NCC and its phosphorylated form (pNCC) as well as WNK lysine deficient protein kinase 4 (WNK4) and STE20/SPS1-related, proline alanine-rich kinase (SPAK) in human urinary exosomes...
July 5, 2016: Journal of the American Society of Nephrology: JASN
keyword
keyword
64601
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"