keyword
https://read.qxmd.com/read/38535452/synthesis-and-hypoglycemic-effect-of-insulin-from-the-venom-of-sea-anemone-exaiptasia-diaphana
#1
JOURNAL ARTICLE
Qiqi Guo, Tianle Tang, Jingyue Lu, Meiling Huang, Junqing Zhang, Linlin Ma, Bingmiao Gao
Sea anemone venom, abundant in protein and peptide toxins, serves primarily for predatory defense and competition. This study delves into the insulin-like peptides (ILPs) present in sea anemones, particularly focusing on their role in potentially inducing hypoglycemic shock in prey. We identified five distinct ILPs in Exaiptasia diaphana , exhibiting varied sequences. Among these, ILP-Ap04 was successfully synthesized using solid phase peptide synthesis (SPPS) to evaluate its hypoglycemic activity. When tested in zebrafish, ILP-Ap04 significantly reduced blood glucose levels in a model of diabetes induced by streptozotocin (STZ) and glucose, concurrently affecting the normal locomotor behavior of zebrafish larvae...
February 27, 2024: Marine Drugs
https://read.qxmd.com/read/38535443/metabolomics-guided-discovery-of-new-dimeric-xanthones-from-co-cultures-of-mangrove-endophytic-fungi-phomopsis-asparagi-dhs-48-and-phomopsis-sp-dhs-11
#2
JOURNAL ARTICLE
Jingwan Wu, Dandan Chen, Qing Li, Ting Feng, Jing Xu
The co-culture strategy, which mimics natural ecology by constructing an artificial microbial community, is a useful tool for the activation of biosynthetic gene clusters (BGCs) to generate new metabolites, as well as to increase the yield of respective target metabolites. As part of our project aiming at the discovery of structurally novel and biologically active natural products from mangrove endophytic fungi, we selected the co-culture of a strain of Phomopsis asparagi DHS-48 with another Phomopsis genus fungus DHS-11, both endophyted in mangrove Rhizophora mangle considering the impart of the taxonomic criteria and ecological data...
February 23, 2024: Marine Drugs
https://read.qxmd.com/read/38534988/structural-brain-connectivity-and-treatment-improvement-in-mood-disorder
#3
JOURNAL ARTICLE
Sébastien Dam, Jean-Marie Batail, Gabriel Hadrien Robert, Dominique Drapier, Pierre Maurel, Julie Coloigner
BACKGROUND: The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment. Identifying the brain structural basis of treatment-resistant depression could prevent useless pharmacological prescriptions, adverse events, and lost therapeutic opportunities. METHODS: Using diffusion magnetic resonance imaging, we performed structural connectivity analyses on a cohort of 154 patients with mood disorder (MD) - and 77 sex- and age-matched healthy control (HC) participants...
March 27, 2024: Brain Connectivity
https://read.qxmd.com/read/38534359/insights-into-disease-progression-of-translational-preclinical-rat-model-of-interstitial-pulmonary-fibrosis-through-endpoint-analysis
#4
JOURNAL ARTICLE
Anil H Kadam, Jan E Schnitzer
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the relentless deposition of extracellular matrix (ECM), causing lung distortions and dysfunction. Animal models of human IPF can provide great insight into the mechanistic pathways underlying disease progression and a means for evaluating novel therapeutic approaches. In this study, we describe the effect of bleomycin concentration on disease progression in the classical rat bleomycin model. In a dose-response study (1...
March 15, 2024: Cells
https://read.qxmd.com/read/38533950/evaluations-of-artificial-intelligence-and-machine-learning-in-neurodiagnostics
#5
JOURNAL ARTICLE
Kristin Williams
This paper evaluates the ethical implications of utilizing artificial intelligence (AI) algorithms in neurological diagnostic examinations. Applications of AI technology have been utilized to aid in the determination of pharmacological dosages of gadolinium for brain lesion detection, localization of seizure foci, and the characterization of large vessel occlusion in ischemic stroke patients. Multiple subtypes of AI- machine learning (AI/ML) algorithms are analyzed as AI-assisted neurology utilizes supervised, unsupervised, artificial neural network (ANN), and deep neural network (DNN) learning models...
March 27, 2024: Journal of Neurophysiology
https://read.qxmd.com/read/38533569/mangiferin-a-potential-supplement-to-improve-metabolic-syndrome-current-status-and-future-opportunities
#6
JOURNAL ARTICLE
Gelin Xiang, Sa Guo, Nan Xing, Qinyun Du, Jing Qin, Huimin Gao, Yi Zhang, Shaohui Wang
Metabolic syndrome (MetS) represents a considerable clinical and public health burden worldwide. Mangiferin (MF), a flavonoid compound present in diverse species such as mango (Mangifera indica L.), papaya ( Pseudocydonia sinensis (Thouin) C. K. Schneid.), zhimu ( Anemarrhena asphodeloides Bunge), and honeybush tea ( Cyclopia genistoides), boasts a broad array of pharmacological effects. It holds promising uses in nutritionally and functionally targeted foods, particularly concerning MetS treatment. It is therefore pivotal to systematically investigate MF's therapeutic mechanism for MetS and its applications in food and pharmaceutical sectors...
March 26, 2024: American Journal of Chinese Medicine
https://read.qxmd.com/read/38533537/network-pharmacology-approach-to-identify-the-calotropis-phytoconstituents-potential-epileptic-targets-and-evaluation-of-molecular-docking-md-simulation-and-mm-pbsa-performance
#7
JOURNAL ARTICLE
Punam Salaria, Amarendar Reddy M
Epilepsy originates from unusual electrical rhythm within brain cells, causes seizures. Calotropis species have been utilized to treat a wide spectrum of ailments since antiquity. Despite chemical and biological investigations, there have been minimal studies on their anticonvulsant activity, and the molecular targets of this plant constituents are unexplored. This study was aimed at investigating the plausible epileptic targets of Calotropis phytoconstituents through network pharmacology, and to evaluate their binding strength and stability with the identified targets...
March 27, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38533261/potential-pharmacological-mechanisms-of-tanshinone-iia-in-the-treatment-of-human-neuroblastoma-based-on-network-pharmacological-and-molecular-docking-technology
#8
JOURNAL ARTICLE
Ning Tang, Yan Wang, Jiarui Miao, Yang Zhao, Yue Cao, Wentao Sun, Jingke Zhang, Hua Sui, Bing Li
Tanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate of Tan-IIA is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tan-IIA also has inhibitory effects on tumor cells such as gastric cancer, but its therapeutic effect and mechanism on human neuroblastoma have not been evaluated, so its pharmacological mechanism is systematically evaluated by the combined method of network pharmacology and molecular docking...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533257/naodesheng-decoction-regulating-vascular-function-via-g-protein-coupled-receptors-network-analysis-and-experimental-investigations
#9
JOURNAL ARTICLE
Shuhan Chen, Ziran Niu, Yanjia Shen, Wendan Lu, Jiaying Zhao, Huilin Yang, Minmin Guo, Li Zhang, Ruifang Zheng, Guanhua Du, Li Li
Introduction: Ischemic stroke (IS) is a detrimental neurological disease with limited treatment options. Recanalization of blocked blood vessels and restoring blood supply to ischemic brain tissue are crucial for post-stroke rehabilitation. The decoction Naodesheng (NDS) composed of five Chinese botanical drugs, including Panax notoginseng (Burk.) F. H. Chen, Ligusticum chuanxiong Hort., Carthamus tinctorius L., Pueraria lobata (Willd.) Ohwi, and Crataegus pinnatifida Bge., is a blood-activating and stasis-removing herbal medicine commonly used for the clinical treatment of cerebrovascular diseases in China...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533254/a-real-world-disproportionality-analysis-of-everolimus-data-mining-of-the-public-version-of-fda-adverse-event-reporting-system
#10
JOURNAL ARTICLE
Bin Zhao, Yumei Fu, Shichao Cui, Xiangning Chen, Shu Liu, Lan Luo
Background: Everolimus is an inhibitor of the mammalian target of rapamycin and is used to treat various tumors. The presented study aimed to evaluate the Everolimus-associated adverse events (AEs) through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS). Methods: The AE records were selected by searching the FDA Adverse Event Reporting System database from the first quarter of 2009 to the first quarter of 2022. Potential adverse event signals were mined using the disproportionality analysis, including reporting odds ratio the proportional reporting ratio the Bayesian confidence propagation neural network and the empirical Bayes geometric mean and MedDRA was used to systematically classify the results...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533079/-scutellaria-baicalensis-georgi-stems-and-leaves-flavonoids-promote-neuroregeneration-and-ameliorate-memory-loss-in-rats-through-camp-pka-creb-signaling-pathway-based-on-network-pharmacology-and-bioinformatics-analysis
#11
JOURNAL ARTICLE
Yinhui Yao, Qianqian Liu, Shengkai Ding, Yan Chen, Tangtang Song, Yazhen Shang
The aim of this study was to investigate the possible molecular mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids (SSF) in Alzheimer's disease (AD). The active ingredients of SSF and their targets were identified via network pharmacology and bioinformatics analysis. To test the successful establishment of a rat model of AD by Aβ25-35 combined with RHTGF- β 1 and AlCl3 , the Morris water maze test was used. To intervene, three different doses of SSF were administered. The model group and the control group were included among the parallel groups...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533074/hotspots-and-frontiers-in-helicobacter-pylori-biofilm-research-a-bibliometric-and-visualization-analysis-from-1998-to-2023
#12
JOURNAL ARTICLE
Jinyun Wang, Yang Hu, Yong Xie
BACKGROUND: Helicobacter pylori ( H. pylori ) biofilm formation is a key factor in refractory H. pylori infection. The aim of this study was to understand research trends in H. pylori biofilms. METHODS: The Web of Science Core Collection database was used to retrieve publications published from 1998 to 2023. Different kinds of software, EXCEL, an online bibliometric analysis platform, and the VOS viewer were used to evaluate and visualize the bibliometric data. RESULTS: In total, 184 publications were identified, and the number of publications increased annually...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533054/utilizing-network-pharmacology-and-experimental-validation-to-investigate-the-underlying-mechanism-of-denglao-qingguan-decoction-against-hcov-229e
#13
JOURNAL ARTICLE
Yajing Xue, Xuejun Cai, Yutao Wang, Li Ban, Manxue Mei, Shuqi Chen, Qihua Xu, Boqian Chen, Shuhua Liang, Xinhua Wang
BACKGROUND: Denglao Qingguan decoction (DLQGD) has been extensively utilized for the treatment of colds, demonstrating significant therapeutic efficacy. Human Coronavirus 229E (HCoV-229E) is considered a crucial etiological agent of influenza. However, the specific impact and underlying mechanisms of DLQGD on HCoV-229E remain poorly understood. METHODS: Active ingredients and targets information of DLQGD were collected from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), literature search, and Swiss ADEM database...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533033/elucidating-the-anti-cancer-potential-of-cinnamomum-tamala-essential-oil-against-non-small-cell-lung-cancer-a-multifaceted-approach-involving-gc-ms-profiling-network-pharmacology-and-molecular-dynamics-simulations
#14
JOURNAL ARTICLE
Debajani Mohanty, Sucheesmita Padhee, Arpita Priyadarshini, Bibhuti Bhusan Champati, Prabhat Kumar Das, Sudipta Jena, Ambika Sahoo, Pratap Chandra Panda, Sanghamitra Nayak, Asit Ray
Cinnamomum tamala (Buch.-Ham.) T.Nees & Eberm., or Indian Bay Leaf, is a well-known traditional ayurvedic medicine used to treat various ailments. However, the molecular mechanism of action of Cinnamomum tamala essential oil (CTEO) against non-small cell lung cancer (NSCLC) remains elusive. The present study aims to decipher the molecular targets and mechanism of CTEO in treating NSCLC. GC-MS analysis detected 49 constituents; 44 successfully passed the drug-likeness screening and were identified as active compounds...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532354/the-impact-of-depressive-and-anxious-symptoms-on-non-suicidal-self-injury-behavior-in-adolescents-a-network-analysis
#15
JOURNAL ARTICLE
Muzhen Guan, Junchang Liu, Xinhong Li, Min Cai, Jing Bi, Ping Zhou, Zhongheng Wang, Songwen Wu, Li Guo, Huaning Wang
PURPOSE: Conceptualizing adolescent NSSI and emotional symptoms as a system of causal elements could provide valuable insights into the development of non-suicidal self-injury (NSSI) in adolescent. This study aimed to explore the intricate relationship between NSSI, depressive symptoms, and anxious symptoms in adolescents, identifying key symptoms to establish a theoretical foundation for targeted and effective interventions addressing NSSI behaviors in this population. METHODS: A total of 412 adolescents with NSSI behaviors were selected from outpatients...
March 26, 2024: BMC Psychiatry
https://read.qxmd.com/read/38532341/exploring-the-effect-of-xiao-chai-hu-decoction-on-treating-psoriasis-based-on-network-pharmacology-and-experiment-validation
#16
JOURNAL ARTICLE
Ke He, Ziyang Wang, Meng Liu, Wenqian Du, Tingyi Yin, Ruimin Bai, Qiqi Duan, Yuqian Wang, Hao Lei, Yan Zheng
BACKGROUND: Psoriasis is a chronic, inflammatory and recurrent skin disease. Xiao-Chai-Hu Decoction (XCHD) has shown good effects against some inflammatory diseases and cancers. However, the pharmacological effect and mechanisms of XCHD on psoriasis are not yet clear. OBJECTIVE: To uncover the effect and mechanisms of XCHD on psoriasis by integrating network pharmacology, molecular docking, and in vivo experiments. METHODS: The active ingredients and corresponding targets of XCHD were screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis (TCMSP) and Traditional Chinese Medicine Integrated Database (TCMID)...
2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38532084/on-inductive-biases-for-the-robust-and-interpretable-prediction-of-drug-concentrations-using-deep-compartment-models
#17
JOURNAL ARTICLE
Alexander Janssen, Frank C Bennis, Marjon H Cnossen, Ron A A Mathôt
Conventional pharmacokinetic (PK) models contain several useful inductive biases guiding model convergence to more realistic predictions of drug concentrations. Implementing similar biases in standard neural networks can be challenging, but might be fundamental for model robustness and predictive performance. In this study, we build on the deep compartment model (DCM) architecture by introducing constraints that guide the model to explore more physiologically realistic solutions. Using a simulation study, we show that constraints improve robustness in sparse data settings...
March 26, 2024: Journal of Pharmacokinetics and Pharmacodynamics
https://read.qxmd.com/read/38531252/integrating-network-pharmacology-with-microrna-microarray-analysis-to-identify-the-role-of-mirnas-in-thrombosis-treated-by-the-dahuang-zhechong-pill
#18
JOURNAL ARTICLE
Rui Shi, Shan Gao, Huichao Huang, Ke Jiang, Dongsheng Wang
BACKGROUND: Thrombotic diseases are the leading causes of death worldwide, urging for improvements in treatment strategies. Dahuang Zhechong pill (DHZCP) is a traditional Chinese medicine widely used for treating thrombotic diseases; however, the underlying mechanisms remain unclear. This study aimed to explore the potential mechanisms of DHZCP in treating thrombosis with a focus on bioinformatics and miRNAs. METHODS: We used network pharmacology to explore the targets of thrombosis treated with DHZCP and performed microarray analysis to acquire miRNA profiles and predict the target genes in thrombin-stimulated MEG-01 cells treated with DHZCP...
March 19, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38531249/toxicity-prediction-and-classification-of-gunqile-7-with-small-sample-based-on-transfer-learning-method
#19
JOURNAL ARTICLE
Hongkai Zhao, Sen Qiu, Meirong Bai, Luyao Wang, Zhelong Wang
Drug-induced diseases are the most important component of iatrogenic disease. It is the duty of doctors to provide a reasonable and safe dose of medication. Gunqile-7 is a Mongolian medicine with analgesic and anti-inflammatory effects. As a foreign substance in the body, even with reasonable medication, it may produce varying degrees of adverse reactions or toxic side effects. Since the cost of collecting Gunqile-7 for pharmacological animal trials is high and the data sample is small, this paper employs transfer learning and data augmentation methods to study the toxicity of Gunqile-7...
March 20, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38531150/discovery-of-cinnamylaldehyde-derived-mono-carbonyl-curcumin-analogs-as-anti-gastric-cancer-agents-via-suppression-of-stat3-and-akt-pathway
#20
JOURNAL ARTICLE
Xi Chen, Peiqin Zhang, Huating Zhang, Xueqiang Ma, Ye Zhang, Yajie Wu, Kaiwen Jin, Jiabing Wang, Jianzhang Wu
The structural modification of curcumin has always been a hotspot in drug development. In this paper, a class of cinnamylaldehyde-derived mono-carbonyl curcumin analogs (MCAs) with 7-carbon-links were designed and synthesized and their anticancer properties were evaluated. Through screening anti-gastric cancer activity of these compounds, H1 exhibited the strongest cytotoxic activity by inhibiting cell viability and colony formation, inducing cell cycle G2/M phase arrest in vitro (SGC-7901 and AGS gastric cancer cells)...
March 24, 2024: Bioorganic Chemistry
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