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https://www.readbyqxmd.com/read/29596928/cardiac-safety-evaluation-in-zebrafish-and-in-silico-adme-prediction-of-cephalosporins-with-an-aminothiazoyl-ring-at-the-c-7-position
#1
Ying Han, Bo Chen, Jingpu Zhang, Changqin Hu
Systems toxicology approaches have been used as important tools in the drug discovery and medicine quality control processes. The aim of this study was to assess the pharmacokinetic and toxicity properties of cephalosporins with an aminothiazoyl ring at the C-7 position (CATRs). Cardiac toxicity of the compounds was assessed in zebrafish embryos, and it was determined that CATRs disturbed the formation and development of the heart in a dose-dependent manner. Differentially expressed genes (DEGs) related to the heart were also identified by transcriptome analysis, and co-DEGs were obtained in the protein-protein interaction (PPI) network...
March 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29549817/are-we-closer-to-the-vision-a-proposed-framework-for-incorporating-omics-into-environmental-assessments
#2
REVIEW
Christopher J Martyniuk
Environmental science has benefited a great deal from omics-based technologies. High-throughput toxicology has defined adverse outcome pathways (AOPs), prioritized chemicals of concern, and identified novel actions of environmental chemicals. While many of these approaches are conducted under rigorous laboratory conditions, a significant challenge has been the interpretation of omics data in "real-world" exposure scenarios. Clarity in the interpretation of these data limits their use in environmental monitoring programs...
March 8, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29547380/maternal-opioid-use-disorder-and-neonatal-abstinence-syndrome-in-northwest-ontario-a-7-year-retrospective-analysis
#3
Joe Dooley, Gareth Ryan, Lianne Gerber Finn, Megan Bollinger, Cai-Lei Matsumoto, Wilma M Hopman, Len Kelly
INTRODUCTION: Opioid use in pregnancy is increasing globally. In northwest Ontario, rates of neonatal abstinence syndrome (NAS) are alarmingly high. We sought to document the increasing rates of opioid exposure during pregnancy and associated cases of NAS over a 7-year period in northwest Ontario. METHODS: We conducted a retrospective chart review at the Sioux Lookout Meno Ya Win Health Centre catchment area (population 29 000) maternity program in northwest Ontario of mother-infant dyads of live births from Jan...
2018: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/29544899/design-and-validation-of-an-ontology-driven-animal-free-testing-strategy-for-developmental-neurotoxicity-testing
#4
Ellen V S Hessel, Yvonne C M Staal, Aldert H Piersma
Developmental neurotoxicity entails one of the most complex areas in toxicology. Animal studies provide only limited information as to human relevance. A multitude of alternative models have been developed over the years, providing insights into mechanisms of action. We give an overview of fundamental processes in neural tube formation, brain development and neural specification, aiming at illustrating complexity rather than comprehensiveness. We also give a flavor of the wealth of alternative methods in this area...
March 12, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29536823/ensemble-of-rankers-for-efficient-gene-signature-extraction-in-smoke-exposure-classification
#5
Maurizio Giordano, Kumar Parijat Tripathi, Mario Rosario Guarracino
BACKGROUND: System toxicology aims at understanding the mechanisms used by biological systems to respond to toxicants. Such understanding can be leveraged to assess the risk of chemicals, drugs, and consumer products in living organisms. In system toxicology, machine learning techniques and methodologies are applied to develop prediction models for classification of toxicant exposure of biological systems. Gene expression data (RNA/DNA microarray) are often used to develop such prediction models...
March 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29533390/human-pluripotent-stem-cell-derived-hlc-transcriptome-data-enables-molecular-dissection-of-hepatogenesis
#6
Wasco Wruck, James Adjaye
Induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) differentiated into hepatocyte-like cells (HLCs) provide a defined and renewable source of cells for drug screening, toxicology and regenerative medicine. We previously reprogrammed human fetal foreskin fibroblast cells (HFF1) into iPSCs employing an episomal plasmid-based integration-free approach, this iPSC-line and the hESC lines H1 and H9 were used to model hepatogenesis in vitro. Biochemical characterisation confirmed glycogen storage, ICG uptake and release, urea and bile acid production, as well as CYP3A4 activity...
March 13, 2018: Scientific Data
https://www.readbyqxmd.com/read/29526584/a-systematic-review-of-pharmacokinetic-studies-on-herbal-drug-fuzi-implications-for-fuzi-as-personalized-medicine
#7
Jin-Jun Wu, Zhen-Zhen Guo, Yuan-Feng Zhu, Zhi-Jian Huang, Xia Gong, Yu-Huan Li, Wen-Jie Son, Xiao-Yan Li, Yan-Mei Lou, Li-Jun Zhu, Lin-Lin Lu, Zhong-Qiu Liu, Liang Liu
BACKGROUND: Fuzi, which is the processed lateral roots of Aconitum carmichaeli Debx. (Ranunculaceae), is a traditional herbal medicine that is well known for its excellent pharmacological effects and acute toxicity. Aconitum alkaloids are responsible for its pharmacological activity and toxicity. Although a large number of studies on Fuzi have been reported, no comprehensive review on its pharmacokinetics has yet been published. PURPOSE: This paper seeks to present a comprehensive review regarding the phytochemistry, pharmacokinetic features and toxicity of Fuzi...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29497473/booting-up-the-organism-during-development-pre-behavioral-functions-of-the-vertebrate-brain-in-guiding-body-morphogenesis
#8
Celia Herrera-Rincon, Michael Levin
A recent study in Xenopus laevis embryos showed that the very early brain has important functions long before behavior. While the nascent brain is being constructed, it is required for normal patterning of the muscle and peripheral nerve networks, including those far away from the head. In addition to providing important developmental signals to remote tissues in normal embryogenesis, its presence is also able to render harmless exposure to specific chemicals that normally act as teratogens. These activities of the early brain can be partially compensated for in a brainless embryo by experimental modulation of neurotransmitter and ion channel signaling...
2018: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/29495342/hazard-screening-methods-for-nanomaterials-a-comparative-study
#9
Barry Sheehan, Finbarr Murphy, Martin Mullins, Irini Furxhi, Anna L Costa, Felice C Simeone, Paride Mantecca
Hazard identification is the key step in risk assessment and management of manufactured nanomaterials (NM). However, the rapid commercialisation of nano-enabled products continues to out-pace the development of a prudent risk management mechanism that is widely accepted by the scientific community and enforced by regulators. However, a growing body of academic literature is developing promising quantitative methods. Two approaches have gained significant currency. Bayesian networks (BN) are a probabilistic, machine learning approach while the weight of evidence (WoE) statistical framework is based on expert elicitation...
February 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29492998/adverse-outcome-pathway-networks-ii-network-analytics
#10
Daniel L Villeneuve, Michelle M Angrish, Marie C Fortin, Ioanna Katsiadaki, Marc Leonard, Luigi Margiotta-Casaluci, Sharon Munn, Jason M O'Brien, Nathan L Pollesch, L Cody Smith, Xiaowei Zhang, Dries Knapen
Toxicological responses to stressors are more complex than the simple one biological perturbation to one adverse outcome model portrayed by individual adverse outcome pathways (AOPs). Consequently, the AOP framework was designed to facilitate de facto development of AOP networks that can aid understanding and prediction of pleiotropic and interactive effects more common to environmentally realistic, complex exposure scenarios. The present paper introduces nascent concepts related to the qualitative analysis of AOP networks...
February 28, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29490646/a-bibliometric-analysis-of-the-published-road-traffic-injuries-research-in-india-post-1990
#11
REVIEW
Neeraj Sharma, Mohan Bairwa, B Gowthamghosh, S D Gupta, D K Mangal
BACKGROUND: Globally, road traffic injuries are the leading cause of death among those aged 15-29 years. However, road traffic injury research has not received adequate attention from the scientific community in low- and middle-income countries, including India. The present study aims to provide a bibliometric overview of research assessing road traffic injuries in India. METHODS: We used Scopus to extract relevant research in road traffic injuries published from 1991 to 2017...
March 1, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29481836/nonclinical-evaluation-of-immunological-safety-in-g%C3%A3-ttingen-minipigs-the-confirm-initiative
#12
REVIEW
Jacques Descotes, Linda Allais, Philippe Ancian, Henrik Duelund Pedersen, Claire Friry-Santini, Antonio Iglesias, Tina Rubic-Schneider, Hollie Skaggs, Peter Vestbjerg
There is a growing need to consider non-rodent species for the immunological safety evaluation of drug candidates. The EU Framework-6 RETHINK Project demonstrated that the Göttingen Minipig is a relevant animal model for regulatory toxicology studies. Extensive knowledge on the immune system of domestic pigs is available and fewer differences from humans have been identified as compared to other species, such as mice or non-human primates. Minipig data are too scarce to allow for claiming full immunological comparability with domestic pigs...
February 23, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29474122/non-animal-methods-to-predict-skin-sensitization-ii-an-assessment-of-defined-approaches
#13
Nicole C Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, David Allen, Takao Ashikaga, Warren Casey, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Göbel, Petra S Kern, Martina Klaric, Jochen Kühnl, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Judy Strickland, Erwin van Vliet, Qingda Zang, Dirk Petersohn
Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic understanding and concurrent necessity for non-animal testing approaches have evolved to a critical juncture, with many available options for predicting sensitization without using animals. Cosmetics Europe and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods collaborated to analyze the performance of multiple non-animal data integration approaches for the skin sensitization safety assessment of cosmetics ingredients...
February 23, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29397954/defining-toxicological-tipping-points-in-neuronal-network-development
#14
Christopher L Frank, Jasmine P Brown, Kathleen Wallace, John F Wambaugh, Imran Shah, Timothy J Shafer
Measuring electrical activity of neural networks by microelectrode array (MEA) has recently shown promise for screening level assessments of chemical toxicity on network development and function. Important aspects of interneuronal communication can be quantified from a single MEA recording, including individual firing rates, coordinated bursting, and measures of network synchrony, providing rich datasets to evaluate chemical effects. Further, multiple recordings can be made from the same network, including during the formation of these networks in vitro...
February 2, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29388697/emerging-roles-of-long-non-coding-rnas-in-the-toxicology-of-environmental-chemicals
#15
REVIEW
Qiansheng Huang, Yiyao Liu, Sijun Dong
Environmental chemicals (ECs) are drawing great attention to their effects on health and their toxicological mechanisms are being investigated. Long non-coding RNA (lncRNA) is a class of RNA with more than 200 nucleotides and does not have protein coding potential. Recently, it is emerging as a star molecule that participates in a wide range of physiological and pathological processes. It has been reported to be abnormally expressed in diseases. As an epigenetic factor, lncRNAs play an important role in the response of organisms to environmental stress...
February 1, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29384873/acute-recreational-drug-toxicity-comparison-of-self-reports-and-results-of-immunoassay-and-additional-analytical-methods-in-a-multicenter-european-case-series
#16
Evangelia Liakoni, Christopher Yates, Alison M Dines, Paul I Dargan, Fridtjof Heyerdahl, Knut Erik Hovda, David M Wood, Florian Eyer, Matthias E Liechti
The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity.We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project.Among the 10,956 cases of acute recreational drug toxicity during the study period, 831 could be included. Between the self-reported substance use and the toxicological results, the highest agreement was found for heroin (86...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29378501/comparative-proteomic-analysis-of-liver-steatosis-and-fibrosis-after-oral-hepatotoxicant-administration-in-sprague-dawley-rats
#17
B Claire McDyre, Mohamed Diwan M AbdulHameed, Matthew G Permenter, William E Dennis, Christine E Baer, Jason M Koontz, Molly H Boyle, Anders Wallqvist, John A Lewis, Danielle L Ippolito
The past decade has seen an increase in the development and clinical use of biomarkers associated with histological features of liver disease. Here, we conduct a comparative histological and global proteomics analysis to identify coregulated modules of proteins in the progression of hepatic steatosis or fibrosis. We orally administered the reference chemicals bromobenzene (BB) or 4,4'-methylenedianiline (4,4'-MDA) to male Sprague-Dawley rats for either 1 single administration or 5 consecutive daily doses. Livers were preserved for histopathology and global proteomics assessment...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29317273/mitochondrial-network-responses-in-oxidative-physiology-and-disease
#18
REVIEW
Young-Mi Go, Jolyn Fernandes, Xin Hu, Karan Uppal, Dean P Jones
Mitochondrial activities are linked directly or indirectly to all cellular functions in aerobic eukaryotes. Omics methods enable new approaches to study functional organization of mitochondria and their adaptive and maladaptive network responses to bioenergetic fuels, physiologic demands, environmental challenges and aging. In this review, we consider mitochondria collectively within a multicellular organism as a macroscale "mitochondriome", functioning to organize bioenergetics and metabolism as an organism utilizes environmental resources and protects against environmental threats...
February 20, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29217848/a-radio-frequency-radiation-exposure-system-for-rodents-based-on-reverberation-chambers
#19
Myles Capstick, Niels Kuster, Sven Kuehn, Veronica Berdinas-Torres, Yijian Gong, Perry Wilson, John Ladbury, Galen Koepke, David L McCormick, James Gauger, Ronald L Melnick
In this paper we present the novel design features, their technical implementation, and an evaluation of the radio Frequency (RF) exposure systems developed for the National Toxicology Program (NTP) of the National Institute of Environmental Health Sciences (NIEHS) studies on the potential toxicity and carcinogenicity of 2nd and 3rd generation mobile-phone signals. The system requirements for this 2-year NTP cancer bioassay study were the tightly-controlled lifetime exposure of rodents (1568 rats and 1512 mice) to three power levels plus sham simulating typical daily, and higher, exposures of users of GSM and CDMA (IS95) signals...
August 2017: IEEE Transactions on Electromagnetic Compatibility
https://www.readbyqxmd.com/read/29190471/influence-of-shape-and-dispersion-media-of-titanium-dioxide-nanostructures-on-microvessel-network-and-ossification
#20
Verónica Freyre-Fonseca, Estefany I Medina-Reyes, Darío I Téllez-Medina, Gloria L Paniagua-Contreras, Eric Monroy-Pérez, Felipe Vaca-Paniagua, Norma L Delgado-Buenrostro, José O Flores-Flores, Edgar O López-Villegas, Gustavo F Gutiérrez-López, Yolanda I Chirino
Titanium dioxide nanoparticles (TiO2 NPs) production has been used for pigment, food and cosmetic industry and more recently, shaped as belts for treatment of contaminated water, self-cleaning windows and biomedical applications. However, the toxicological data have demonstrated that TiO2 NPs inhalation induce inflammation in in vivo models and in vitro exposure leads to cytotoxicity and DNA damage. Dermal exposure has limited adverse effects and the possible risks for implants used for tissue regeneration is still under research...
February 1, 2018: Colloids and Surfaces. B, Biointerfaces
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