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https://www.readbyqxmd.com/read/28231612/the-pro-inflammatory-cytokine-tnf-%C3%AE-inhibits-lymphatic-pumping-via-activation-of-the-nf-%C3%AE%C2%BAb-inos-signaling-pathway
#1
Yingxuan Chen, Sonia Rehal, Simon Roizes, Hai-Lei Zhu, William C Cole, Pierre-Yves von der Weid
OBJECTIVE: Mesenteric lymphatic vessels pumping, important to propel lymph and immune cells from the intestinal interstitium to the mesenteric lymph nodes, is compromised during intestinal inflammation. The objective of this study was to test the hypothesis that the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α), is a significant contributor to the inflammation-induced lymphatic contractile dysfunction, and to determine its mode of action. METHODS: Contractile parameters were obtained form isolated rat mesenteric lymphatic vessels mounted on a pressure myograph after 24-h incubation with or without TNF-α...
February 23, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28231520/medicinal-plants-used-as-anthelmintics-ethnomedical-pharmacological-and-phytochemical-studies
#2
REVIEW
Juan Carlos Romero-Benavides, Ana Lucía Ruano, Ronal Silva-Rivas, Paola Castillo-Veintimilla, Sara Vivanco-Jaramillo, Natalia Bailon-Moscoso
Intestinal parasites delay mental and physical development in children. Infection with these parasites can result in complications during pregnancy and alter the health of newborns, which has long-term effects on educational attainment and economic productivity. The appearance of resistance against classical drug treatments generates interest in the development of new deworming alternatives. We think that research of new plants species may reveal potential antiparasitic compounds. This review is focused on the use of plants and secondary metabolites against intestinal parasites...
February 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28231497/dienogest-and-deep-infiltrating-endometriosis-the-remission-of-symptoms-is-not-related-to-endometriosis-nodule-remission
#3
Joao Paulo Leonardo-Pinto, Cristina Laguna Benetti-Pinto, Kleber Cursino, Daniela Angerame Yela
OBJECTIVE: To evaluate the effectiveness of dienogest in controlling pain caused by deep infiltrating endometriosis (DIE), its influence on the quality of live (QoL) of women affected by the disease, and the effect of the drug on the volume of endometriotic lesions. STUDY DESIGN: A prospective cohort study including 30 women with a sonographic diagnosis of DIE (intestinal and posterior fornix) treated with dienogest 2mg per day for 12 months. We evaluated the pain symptoms and the volume of the intestinal and posterior fornix lesions before and after 12 months of use of dienogest...
February 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28231471/pathogenic-potential-and-virulence-genotypes-of-intestinal-and-faecal-isolates-of-porcine-post-weaning-enteropathogenic-escherichia-coli
#4
Anna Malik, Béla Nagy, Renáta Kugler, Ama Szmolka
Enteropathogenic Escherichia coli (EPEC) are frequent causes of diarrhoea in infants and in young mammals by inducing attaching effacing (AE) lesions of the intestinal epithelium. EPEC bacteria have also been implicated in cases of porcine post-weaning diarrhoea but their pathogenicity for conventional weaned pigs remains less elucidated. This present study investigates differences in pathogenic potential and virulence genotypes of intestinal and faecal isolates of EPEC from newly-weaned pigs. For this we inoculated ligated ileal loops of four weeks old weaned pigs to assess EPEC adherence to enterocytes by histology and immunohistology...
February 9, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28231157/breads-fortified-with-freeze-dried-vegetables-quality-and-nutritional-attributes-part-ii-breads-not-containing-oil-as-an-ingredient
#5
Viren Ranawana, Fiona Campbell, Charles Bestwick, Phyllis Nicol, Lesley Milne, Garry Duthie, Vassilios Raikos
The present article describes the second part of a study investigating the effect of adding vegetables on the nutritional, physico-chemical, and oxidative properties of wheat bread, and specifically focuses on bread that does not contain oil as an added ingredient. Wheat flour breads fortified with freeze-dried carrot, tomato, beetroot or broccoli were developed and assessed for their nutritional composition, antioxidant potential, oxidative stability, and storage properties. Using a simulated in vitro model, the study also examined the impact of vegetable addition on the oxidative stability of macronutrients during gastro-intestinal digestion...
September 8, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231153/microbial-proteases-in-baked-goods-modification-of-gluten-and-effects-on-immunogenicity-and-product-quality
#6
REVIEW
Nina G Heredia-Sandoval, Maribel Y Valencia-Tapia, Ana M Calderón de la Barca, Alma R Islas-Rubio
Gluten-related diseases are a range of inflammatory disorders of the small intestine, characterized by an adverse response to gluten ingestion; therefore, the treatment is a gluten withdrawal. In spite of the increased market of gluten-free products, widely available breads with high acceptability are still missing due to the technological challenge of substituting the special gluten properties. Instead of using alternative ingredients for baking, some attempts have been done to decrease gluten immunogenicity by its enzymatic degradation with microbial proteases...
August 30, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231144/effects-of-two-step-transamidation-of-wheat-semolina-on-the-technological-properties-of-gluten
#7
Salvatore Moscaritolo, Lucia Treppiccione, Antonio Ottombrino, Mauro Rossi
Celiac disease (CD) is an immune-mediated disorder caused by the ingestion of wheat gluten. A lifelong, gluten-free diet is required to alleviate symptoms and to normalize the intestinal mucosa. We previously found that transamidation reaction by microbial transglutaminase (mTG) was effective in down-regulating the gliadin-specific immune response in CD patients. In this study, the two-step transamidation protocol was adopted to treat commercial wheat semolina on a pilot scale. The effectiveness of the enzymatic reaction was tested by means of consolidated biochemical and immunological methods on isolated prolamins...
June 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231129/seafood-processing-and-safety
#8
EDITORIAL
Michael L Jahncke
Food microorganisms are found on all surfaces (skin and gills) and in the intestines of fishery products.[...].
May 13, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231114/breads-fortified-with-freeze-dried-vegetables-quality-and-nutritional-attributes-part-1-breads-containing-oil-as-an-ingredient
#9
Viren Ranawana, Vassilios Raikos, Fiona Campbell, Charles Bestwick, Phyllis Nicol, Lesley Milne, Garry Duthie
There is increasing emphasis on reformulating processed foods to make them healthier. This study for the first time comprehensively investigated the effects of fortifying bread (containing oil as an ingredient) with freeze-dried vegetables on its nutritional and physico-chemical attributes. Breads fortified with carrot, tomato, beetroot or broccoli were assessed for nutrition, antioxidant potential, storage life, shelf stability, textural changes and macronutrient oxidation. Furthermore, using an in vitro model the study for the first time examined the impact of vegetable addition on the oxidative stability of macronutrients during human gastro-intestinal digestion...
March 14, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230764/cinnamic-acid-and-its-derivatives-mechanisms-for-prevention-and-management-of-diabetes-and-its-complications
#10
REVIEW
Sirichai Adisakwattana
With recent insight into the development of dietary supplements and functional foods, search of effective phytochemical compounds and their mechanisms involved in prevention and management of diabetes and its complications are now being assessed. Cinnamic acid and its derivatives occur naturally in high levels of plant-based foods. Among various biological activities, cinnamic acid and its derivatives are associated with a beneficial influence on diabetes and its complications. The aim of the review is to summarize the potential mechanisms of these compounds for prevention and management of diabetes and its complications...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28230729/catechol-groups-enable-reactive-oxygen-species-scavenging-mediated-suppression-of-pkd-nfkappab-il-8-signaling-pathway-by-chlorogenic-and-caffeic-acids-in-human-intestinal-cells
#11
Hee Soon Shin, Hideo Satsu, Min-Jung Bae, Mamoru Totsuka, Makoto Shimizu
Chlorogenic acid (CHA) and caffeic acid (CA) are phenolic compounds found in coffee, which inhibit oxidative stress-induced interleukin (IL)-8 production in intestinal epithelial cells, thereby suppressing serious cellular injury and inflammatory intestinal diseases. Therefore, we investigated the anti-inflammatory mechanism of CHA and CA, both of which inhibited hydrogen peroxide (H₂O₂)-induced IL-8 transcriptional activity. They also significantly suppressed nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcriptional activity, nuclear translocation of the p65 subunit, and phosphorylation of IκB kinase (IKK)...
February 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28230723/bifidobacterium-adolescentis-exerts-strain-specific-effects-on-constipation-induced-by-loperamide-in-balb-c-mice
#12
Linlin Wang, Lujun Hu, Qi Xu, Boxing Yin, Dongsheng Fang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Constipation is one of the most common gastrointestinal complaints worldwide. This study was performed to determine whether Bifidobacterium adolescentis exerts inter-strain differences in alleviating constipation induced by loperamide in BALB/c mice and to analyze the main reasons for these differences. BALB/c mice underwent gavage with B. adolescentis (CCFM 626, 667, and 669) once per day for 17 days. The primary outcome measures included related constipation indicators, and the secondary outcome measures were the basic biological characteristics of the strains, the concentration changes of short-chain fatty acids in feces, and the changes in the fecal flora...
February 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230606/secretions-of-bifidobacterium-infantis-and-lactobacillus-acidophilus-protect-intestinal-epithelial-barrier-function
#13
Shuangshuang Guo, Tyler Gillingham, Yuming Guo, Di Meng, Weishu Zhu, W Allen Walker, Kriston Ganguli
OBJECTIVES: The secreted metabolites of probiotics are cytoprotective to intestinal epithelium and have been shown to attenuate inflammation and reduce gut permeability. The present study was designed to determine the protective effects of probiotic conditioned media (PCM) from Bifidobacterium infantis (BCM) and Lactobacillus acidophilus (LCM) on interleukin (IL)-1β-induced intestinal barrier compromise. METHODS: The epithelial barrier was determined by measuring the transepithelial electrical resistance (TER) across a Caco-2 cell monolayer using a Transwell model...
March 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28230559/anti-tnf%C3%AE-treatment-after-surgical-resection-for-crohn-s-disease-is-effective-despite-previous-pharmacodynamic-failure
#14
Amit Assa, Jiri Bronsky, Kaija-Leena Kolho, Kristyna Zarubova, Tim de Meij, Oren Ledder, Margaret Sladek, Stephanie van Biervliet, Caterina Strisciuglio, Raanan Shamir
BACKGROUND: The outcome of patients with Crohn's disease who failed anti-tumor necrosis factor alpha (anti-TNFα) therapy despite adequate serum drug levels (pharmacodynamic failure) is unclear. We aimed to assess such pediatric patients who underwent intestinal resection and were re-treated with the same anti-TNFα agent postoperatively. METHODS: Pediatric patients with Crohn's disease who underwent intestinal resection and were treated with anti-TNFα agents postoperatively were assessed retrospectively...
February 22, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28230475/ultrastructural-changes-of-small-intestine-in-whipple-disease-patient
#15
Andres Piirsoo, Triin Remmel, Anu Kõiveer
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230360/capsaicin-reduces-blood-glucose-by-increasing-insulin-levels-and-glycogen-content-better-than-capsiate-in-streptozotocin-induced-diabetic-rats
#16
Shiqi Zhang, Xiaohan Ma, Zhang Lei, Hui Sun, Xiong Liu
Chili peppers exhibit anti-obesity, anti-cancer, anti-diabetic, and pain- and itchiness-relieving effects on animals and humans; these effects are due to capsaicin, which is the main pungent and biologically active component of pepper. Capsiate, a nonpungent capsaicin analogue and is similar to capsaicin in terms of structure and biological activity. In this study, we investigated whether capsaicin and capsiate exhibit the same hypoglycemic effects on rats with type 1 diabetes (T1D). Experimental rats were categorized into four groups: control, model, capsaicin, and capsiate groups...
February 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28229980/acupuncture-improves-intestinal-absorption-of-iron-in-iron-deficient-obese-patients-a-randomized-controlled-preliminary-trial
#17
Xin-Cai Xie, Yan-Qiang Cao, Qian Gao, Chen Wang, Man Li, Shou-Gang Wei
BACKGROUND: Obesity has an adverse effect on iron status. Hepcidin-mediated inhibition of iron absorption in the duodenum is a potential mechanism. Iron-deficient obese patients have diminished response to oral iron therapy. This study was designed to assess whether acupuncture could promote the efficacy of oral iron supplementation for the treatment of obesity-related iron deficiency (ID). METHODS: Sixty ID or ID anemia (IDA) patients with obesity were screened at Beijing Hospital of Traditional Chinese Medicine and were randomly allocated to receive either oral iron replacement allied with acupuncture weight loss treatment (acupuncture group, n = 30) or oral iron combined with sham-acupuncture treatment (control group, n = 30)...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28229828/successful-treatment-of-a-refractory-dysbiotic-intestinal-pseudo-obstruction-in-a-patient-with-systemic-sclerosis-polymyositis-overlap-syndrome-by-intravenous-immunoglobulin-administration-possibly-related-to-gut-flora-normalisation
#18
Risa Kamei, Toshifumi Yamaoka, Kuniko Ikinaga, Hiroyuki Murota, Kentaro Shimizu, Ichiro Katayama
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January 31, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28229609/laparoscopic-treatment-of-hemorrhagic-meckel-diverticulum-after-diagnosis-with-wireless-capsule-endoscopy-and-double-balloon-enteroscopy
#19
Haibo Yu, Hongliang Song, Jing Cai
Meckel diverticulum (MD) is a common small intestinal malformation. The difficulty of MD with hemorrhage treatment lies in preoperative diagnosis. Wireless capsule endoscopy (WCE) and double-balloon enteroscopy (DBE) have been widely used to diagnose and treat diseases of the small intestine, but only rarely have they been used in combination to diagnose and treat bleeding MD. We successfully diagnosed and treated a patient with MD with hemorrhage with a combination of WCE, DBE, and laparoscopy. A 17-year-old man presented to the emergency room with hematochezia and was admitted for testing...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28229527/melanotransferrin-new-homolog-genes-and-their-differential-expression-during-intestinal-regeneration-in-the-sea-cucumber-holothuria-glaberrima
#20
Josué Hernández-Pasos, Griselle Valentín-Tirado, José E García-Arrarás
Melanotransferrin (MTf) is a protein associated with oncogenetic, developmental, and immune processes which function remains unclear. The MTf gene has been reported in numerous vertebrate and invertebrate species, including echinoderms. We now report the finding of four different MTfs in the transcriptome of the sea cucumber Holothuria glaberrima. Sequence studies and phylogenetic analyses were done to ascertain the similarities among the putative proteins and their relationship with other transferrin family members...
February 23, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
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