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Keloideal scars

Jonathan Zelken, Jung-Ju Huang, Chih-Wei Wu, Yi-Ling Lin, Ming-Huei Cheng
The periareolar approach is limited by areolar diameter. Asian women typically have smaller areolae than Western women. Voluminous and form-stable silicone implants demand larger incisions. Zigzag transareolar approaches closely approximate the nipple and improve exposure, but scar appearance remains problematic, and there is a risk of ductal injury and capsular contracture. We prefer a zigzag incision that straddles the areolar border. Between 2013 and 2015, 11 augmentation mammoplasties (20 incisions) were performed through a transareolar-periareolar (TAPA) incision...
September 2016: Plastic and Reconstructive Surgery. Global Open
Neha Jariwala, Jules B Lipoff
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
Clara Ferreira, Daniel Johnson, Karl Rasmussen, Clinton Leinweber, Salahuddin Ahmad, Jae Won Jung
PURPOSE: To develop a novel conformal superficial brachytherapy (CSBT) device as a treatment option for the patient-specific radiation therapy of conditions including superficial lesions, postsurgical positive margins, Dupuytren's contractures, keloid scars, and complex anatomic sites (eyelids, nose, ears, etc.). METHODS AND MATERIALS: A preliminary CSBT device prototype was designed, built, and tested using readily available radioactive seeds. Iodine-125 ((125)I) seeds were independently guided to the treatment surface to conform to the target...
October 3, 2016: Brachytherapy
Jie Zhang, Cai Yue Liu, Yun Wan, Li Peng, Wen Fang Li, Jia Xuan Qiu
The expression of the long non-coding RNA (lncRNA) H19 is associated with proliferation in tumors. In order to investigate whether H19 may additionally mediate the proliferation of fibroblasts in human keloid disease, the present study collected samples from 24 subjects, including 8 with keloids, 8 with normal scars and 8 normal skin controls. Reverse transcription-polymerase chain reaction revealed that H19 levels were markedly increased in human keloids compared with normal scars and normal skin controls (P=0...
October 2016: Oncology Letters
Shifeng Li, Wei Liu, Ying Lei, Jianhong Long
Keloid scarring is an abnormal pathological scar characterized by excessive fibro proliferation and extracellular matrix deposition. Electronic beam irradiation is commonly used with surgical removal to control high recurrence rates of keloid scarring; however, the mechanism remains unknown. In this study, we used keloid-derived primary fibroblasts (KF) as the cell model. A dose of 15Gy energy was used on the cells, followed by quantitative PCR (Q-PCR), Western blotting and gene overexpression/knock down techniques to reveal the molecular mechanisms affected by electronic beam irradiation...
September 30, 2016: Biology Open
Masayo Aoki, Satoshi Akaishi, Junichi Nakao, Teruyuki Dohi, Hiko Hyakusoku, Rei Ogawa
BACKGROUND: Keloids are characterized by the formation of excessive scar tissue that extends beyond the area of the initial wound. Keloid redness is due to angiogenesis and chronic inflammation and is an important indicator of the severity of the lesion and the effectiveness of treatment. METHODS: The color of 33 untreated keloids from 30 patients was measured with a narrow-band reflectance colorimeter. The erythema and melanin levels in the keloids (Ek and Mk, respectively) were recorded with control data obtained from the flexor aspect of the forearm (Ec and Mc, respectively)...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Biswanath Behera, Rashmi Kumari, Devinder Mohan Thappa, Munisamy Malathi
BACKGROUND: Keloids are difficult to treat due to their poor response and high recurrence rate. OBJECTIVE: We conducted a randomized controlled trial to compare the therapeutic efficacy of intralesional triamcinolone acetonide (ILTA) in combination with carbon dioxide laser (Group 1) versus in combination with cryotherapy (Group 2) in the treatment of keloids. MATERIALS AND METHODS: Sixty patients with 101 keloids were randomized into 2 groups...
October 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Gang An, Shuzeng Liang, Chunhong Sheng, Yan Liu, Wei Yao
Keloid is one of the most frustrating problems related to wounding healing and presents a great challenge in clinic. MicroRNAs (miRs) have shown their potential as a novel therapy for the prevention and treatment of keloid. Vascular endothelial growth factor (VEGF) plays a critical role in the regulation of scar development. In the current study, it was hypothesized that miR-205-5p was capable of suppressing keloid formation by inhibiting the VEGF-mediated wound healing cascade. The expression statuses of miR-205-5p and VEGF in clinical keloid tissues and keloid cell line human keloid fibroblasts (HKF) were detected...
September 19, 2016: Experimental Biology and Medicine
Abeer Shaheen, Jamal Khaddam, Fadi Kesh
BACKGROUND: Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals. It is a result of irregular wound healing, but the exact mechanism is unknown. However, several factors may play a role in keloid formation. To date, there are no studies of keloids in Syria, and limited studies on Caucasians, so we have investigated the risk factors of keloids in Syrians (Caucasians), and this is the main objective of this study. METHODS: Diagnosis of keloids was clinically made after an interview and physical examination...
2016: BMC Dermatology
O J Nelson, J Ward, A L Forde, N Ojeh
Keloids are characterised by scar tissue overgrowth on the skin beyond the borders of the original wound following an abnormal wound healing process and tend not to regress. These disfiguring scars can cause pain, itching and inflammation for the patient leading to an emotional and psychological impact and a sub-standard quality of life. A variety of treatments using surgical and non-surgical approaches exists that have been reported to be beneficial. However, no one treatment currently stands out as the most optimal due to a number of factors including different keloid subtypes...
March 10, 2016: West Indian Medical Journal
Nadja Zöller, Anke König, Manuel Butting, Roland Kaufmann, August Bernd, Eva Valesky, Stefan Kippenberger
Hypertrophic scar development is associated to impaired wound healing, imbalanced fibroblast proliferation and extracellular matrix synthesis. Stigmatization, physical restrictions and high recurrence rates are only some aspects that illustrate the severe influence impaired wound healing can have on patients' life. The treatment of hypertrophic scars especially keloids is still a challenge. In recent years water-filtered near-infrared irradiation (wIRA) composed of near-infrared (NIR) and a thermal component is applied for an increasing penal of clinical purposes...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
Xiao Long, Mingzi Zhang, Yang Wang, Ru Zhao, Youbin Wang, Xiaojun Wang
Keloids are common in the Asian population. Multiple or huge keloids can appear on the chest wall because of its tendency to develop acne, sebaceous cyst, etc. It is difficult to find an ideal treatment for keloids in this area due to the limit of local soft tissues and higher recurrence rate. This study aims at establishing an individualized protocol that could be easily applied according to the size and number of chest wall keloids.A total of 445 patients received various methods (4 protocols) of treatment in our department from September 2006 to September 2012 according to the size and number of their chest wall keloids...
August 2016: Medicine (Baltimore)
Jennifer M Hahn, Kevin L McFarland, Kelly A Combs, Dorothy M Supp
BACKGROUND: Keloids are an extreme form of abnormal scarring that result from a pathological fibroproliferative wound healing process. The molecular mechanisms driving keloid pathology remain incompletely understood, hindering development of targeted, effective therapies. Recent studies in our laboratory demonstrated that keloid keratinocytes exhibit adhesion abnormalities and display a transcriptional signature reminiscent of cells undergoing epithelial-mesenchymal transition (EMT), suggesting a role for EMT in keloid pathology...
2016: Burns and trauma
Zhensen Zhu, Jie Ding, Edward E Tredget
Hypertrophic scars (HTS) are caused by dermal injuries such as trauma and burns to the deep dermis, which are red, raised, itchy and painful. They can cause cosmetic disfigurement or contractures if craniofacial areas or mobile region of the skin are affected. Abnormal wound healing with more extracellular matrix deposition than degradation will result in HTS formation. This review will introduce the physiology of wound healing, dermal HTS formation, treatment and difference with keloids in the skin, and it also review the current advance of molecular basis of HTS including the involvement of cytokines, growth factors, and macrophages via chemokine pathway, to bring insights for future prevention and treatment of HTS...
2016: Burns and trauma
Arianna DI Stadio
BACKGROUND: Several treatments are available to treat the keloid scar. Keloids have the tendency to recur after surgical removal and new treatments for keloid scars include radiotherapy, cryotherapy or compressive therapy. Topical treatments have been also used to treat this pathology, such as injections or medical device applications. CASE REPORT: A 33-year-old man came to our attention and we treated him for a keloid scar located between the ear's helical tubercle and the ante-helix upper root of the left ear...
September 2016: In Vivo
Lele Lu, Linlin Chai, Wenping Wang, Xi Yuan, Shirong Li, Chuan Cao
Keloids are fibroproliferative disorders characterized by the overabundant deposition of extracellular matrix (ECM), especially collagen and overgrowth of scar tissue in response to cutaneous injury. In this study, we isolated a selenium (Se)-containing polysaccharide (Se-ZGTP-I) from Ziyang green tea and explored its potential therapeutic effects on keloid fibroblasts formation. 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and annexin V/propidium iodide (PI) staining assays demonstrated that Se-ZGTP-I or neuron-glia 2 (NG2) short hairpin RNA (shRNA) significantly inhibited proliferation of human keloid fibroblasts via induction of apoptosis...
August 27, 2016: Biological Trace Element Research
Ibrahim Khansa, Bridget Harrison, Jeffrey E Janis
BACKGROUND: Scars represent the visible sequelae of trauma, injury, burn, or surgery. They may induce distress in the patient because of their aesthetically unpleasant appearance, especially if they are excessively raised, depressed, wide, or erythematous. They may also cause the patient symptoms of pain, tightness, and pruritus. Numerous products are marketed for scar prevention or improvement, but their efficacy is unclear. METHODS: A literature review of high-level studies analyzing methods to prevent or improve hypertrophic scars, keloids, and striae distensae was performed...
September 2016: Plastic and Reconstructive Surgery
Ying Liu, Yue Li, Ning Li, Wen Teng, Min Wang, Yingbo Zhang, Zhibo Xiao
TGF-β1, upregulated in keloid tissue, promotes the proliferation, collagen formation and differentiation of dermal fibroblasts. miR-21 is one of microRNAs first found in human genome. The aim of our study is to explore the mechanisms of miR-21 in TGF-β1-induced scar fibroblasts proliferation and transdifferentiation. In the present study, first we found that TGF-β1 promoted scar fibroblasts proliferation and transdifferentiation via up-regulating miR-21 expression, which could be attenuated when miR-21 was inhibited...
2016: Scientific Reports
Gabriella Fabbrocini, Claudio Marasca, Sadia Ammad, Benedetta Brazzini, Rosanna Izzo, Marianna Donnarumma, Giuseppe Monfrecola
OBJECTIVE: To evaluate the individual effectiveness of needling therapy using the Dermapen (Dermapen, Salt Lake City, Utah) and topical therapy with silicone gel (Kelo-cote, Sinclair Pharma, London, England), and their combined effectiveness for the treatment of linear surgical scars, hypertrophic scars, and keloids. MATERIALS AND METHODS: Twenty patients were randomly selected and equally divided into 2 groups (A and B), with each group of 10 including 6 patients with keloids and 4 with hypertrophic scars...
September 2016: Advances in Skin & Wound Care
Maya Goder, Rachel Kornhaber, Daniele Bordoni, Eyal Winkler, Josef Haik, Ariel Tessone
Basal cell carcinomas (BCCs) are one of the most frequent cutaneous malignancies. The majority of BCCs are reported to occur on the auricular helix and periauricular region due to ultraviolet light exposure. Despite the frequency of BCCs, those that develop within scar tissue are rare, and the phenomenon of keloid BCCs has rarely been reported in the literature. Keloid collagen within BCCs is associated with morphoeiform characteristics, ulceration, or necrosis. Extensive keloid collagen is often seen in BCCs of the ear region, a site prone to keloid scarring...
2016: OncoTargets and Therapy
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