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https://www.readbyqxmd.com/read/27909731/hypoxia-drives-the-transition-of-human-dermal-fibroblasts-to-a-myofibroblast-like-phenotype-via-the-tgf-%C3%AE-1-smad3-pathway
#1
Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu
Keloids, partially considered as benign tumors, are characterized by the overgrowth of fibrosis beyond the boundaries of the wound and are regulated mainly by transforming growth factor (TGF)-β1, which induces the transition of fibroblasts to myofibroblasts. Hypoxia is an important driving force in the development of lung and liver fibrosis by activating hypoxia inducible factor-1α and stimulating epithelial‑mesenchymal transition. However, it is unknown whether and hypoxia can influence human dermal scarring...
December 1, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27892645/endothelial-cell-derived-endothelin-1-is-involved-in-abnormal-scar-formation-by-dermal-fibroblasts-through-rhoa-rho-kinase-pathway
#2
Koichiro Kiya, Tateki Kubo, Kenichiro Kawai, Shinsuke Matsuzaki, Rieko Muramatsu, Daisuke Maeda, Toshihiro Fujiwara, Akimitsu Nishibayashi, Shigeyuki Kanazawa, Kenji Yano, Genki Amano, Taiichi Katayama, Ko Hosokawa
Hypertrophic scars and keloids are characterized by excessive dermal deposition of extracellular matrix due to fibroblast-to-myofibroblast differentiation. Endothelin-1 (ET-1) is primarily produced by vascular endothelial cells, and plays multiple roles in the wound-healing response and organ fibrogenesis. In this study, we investigated the pathophysiological significance of ET-1 and involvement of RhoA, a member of the Rho GTPases, in hypertrophic scar/keloid formation. We found that ET-1 expression on dermal microvascular endothelial cells (ECs) in hypertrophic scars and keloids was higher than that in normal skin and mature scars...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27888895/treating-scars-in-the-auricle-region
#3
REVIEW
Deborah Watson, Bharat Panuganti
This article provides a review of the surgical and nonsurgical options available to manage a variety of auricular scars. The basics of wound healing are discussed in addition to the etiology of keloids and the cauliflower ear. Many auricular scars can be revised with scar excision techniques, but separate discussions for the treatment of keloids and the cauliflower ear are provided. The management plan for auricular scarring requires appropriate patient counseling regarding the risk of recurrence in keloids, regrowth of scar tissue in cauliflower ears, scar hypertrophy at the line of closure, widening of the scar, and persisting ear contour deformities...
February 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27888448/a-randomized-single-blind-trial-of-clobetasol-propionate-0-05-cream-under-silicone-dressing-occlusion-versus-intra-lesional-triamcinolone-for-treatment-of-keloid
#4
Norazirah Md Nor, Rasimah Ismail, Adawiyah Jamil, Shamsul Azhar Shah, Farah Hani Imran
BACKGROUND AND OBJECTIVE: Keloid is conventionally treated with intra-lesional (IL) triamcinolone, which is highly operator dependent and has its own adverse effects. Topical steroid and silicone dressings are a patient friendly and non-invasive treatment alternative. We therefore sought to determine the efficacy and safety of topical clobetasol propionate (Dermovate(®)) 0.05% cream under occlusion with Mepiform(®) silicone dressing compared to IL triamcinolone in the treatment of keloid...
November 25, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27877046/comparative-effect-and-safety-of-verapamil-in-keloid-and-hypertrophic-scar-treatment-a-meta-analysis
#5
Zhouna Li, Zhehu Jin
BACKGROUND: Keloids and hypertrophic scars are the most common types of pathological scarring. Traditionally, keloids have been considered as a result of aberrant wound healing, involving excessive fibroblast participation that is characterized by hyalinized collagen bundles. However, the usefulness of this characterization has been questioned. In recent years, studies have reported the appropriate use of verapamil for keloids and hypertrophic scars. METHODS: Searches were conducted on the databases Medline, Embase, Cochrane, PubMed, and China National Knowledge Infrastructure from 2006 to July 2016...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27866969/overexpression-of-cd109-in-the-epidermis-differentially-regulates-alk1-versus-alk5-signaling-and-modulates-extracellular-matrix-synthesis-in-the-skin
#6
Joshua Vorstenbosch, Christopher M Nguyen, Shufeng Zhou, You Jung Seo, Aya Siblini, Kenneth W Finnson, Albane A Bizet, Simon D Tran, Anie Philip
Transforming growth factor-beta (TGF-β) is a multifunctional growth factor involved in many physiological processes including wound healing and inflammation. Excessive TGF-β signaling in the skin has been implicated in fibrotic skin disorders such as keloids and scleroderma. We have previously identified CD109 as a TGF- β co-receptor and inhibitor of TGF-ß signaling, and have shown that transgenic mice overexpressing CD109 in the epidermis display decreased scarring. In certain cell types, in addition to the canonical type I receptor, ALK5 which activates Smad2/3, TGF-β can signal through another type I receptor ALK1 which activates Smad1/5...
November 17, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27855376/growth-differentiation-factor-9-promotes-fibroblast-proliferation-and-migration-in-keloids-through-the-smad2-3-pathway
#7
Zhaohua Jiang, Qingxiong Yu, Lingling Xia, Yi Zhang, Xiuxia Wang, Xiaoli Wu, Zhen Gao
BACKGROUND: Keloids are fibroproliferative scars that develop as a result of a dysregulated wound healing process; however, the molecular mechanisms of keloid pathogenesis remain unclear. Keloids are characterized by the ability to spread beyond the original boundary of the wound, and they represent a significant clinical challenge. Previous work from our group suggested that growth differentiation factor (GDF)-9 plays a role in the invasive behavior of keloids. Here, we examined the involvement of GDF-9 in keloid formation and spread and elucidated a potential underlying mechanism...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27847546/topical-silicone-sheet-application-in-the-treatment-of-hypertrophic-scars-and-keloids
#8
Iris Westra, Frank B Niessen
Objective: Since the early 1980s, topical silicone sheets have been used in the treatment of hypertrophic scars and keloids.This study aimed to determine the optimal duration and application of these sheets. Design: multi-centered therapeutic study. Setting and participants: A total of 224 patients were included in this study; 205 patients with hypertrophic scars and 19 patients with keloids. Patients received treatment with a topical silicone sheet. Treated scars varied in age, ranging from two weeks to 62 years and treatment time ranged from one month to 16 months...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27812490/comparing-two-methods-of-cryotherapy-and-intense-pulsed-light-with-triamcinolone-injection-in-the-treatment-of-keloid-and-hypertrophic-scars-a-clinical-trial
#9
Simin Shamsi Meymandi, Mahmood Moosazadeh, Azadeh Rezazadeh
OBJECTIVES: Keloid and hypertrophic scars are abnormal manifestations of wounds that occur following skin injuries in the form of local proliferation of fibroblasts and increased production of collagen. There are several ways to cure these scars; treatment must be selected based on the nature of the scars. In this clinical trial, two methods-cryotherapy and intense pulsed light (IPL)-are compared in the treatment of scars, and the results are presented in terms of improvement level, complications, and patient satisfaction...
October 2016: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/27796064/measurements-of-scar-properties-by-skinfibrometer-%C3%A2-skinglossmeter-%C3%A2-and-mexameter-%C3%A2-and-comparison-with-vancouver-scar-scale
#10
S R Seo, N O Kang, M S Yoon, H J Lee, D H Kim
BACKGROUND: An objective measurement of scar is important for evaluating treatment outcomes. However, to date, there is no 'gold standard' for quantitative measurement of properties of hypertrophic scar. Existing objective modalities are neither portable nor easy to use. OBJECTIVE: This study aims to validate the correlation between objective measurements with SkinFibrometer(®) , SkinGlossMeter(®) , and Mexameter(®) and subjective assessment with Vancouver Scar Scale (VSS) of keloid and hypertrophic scar...
October 30, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27784253/the-effectiveness-of-topical-anti-scarring-agents-and-a-novel-combined-process-on-cutaneous-scar-management
#11
Qing-Qing Fang, Chun- Ye Chen, Min-Xia Zhang, Chun-Lan Huang, Xiao-Wei Wang, Ji-Hua Xu, Li-Hong Wu, Li-Yun Zhang, Wei-Qiang Tan
Cutaneous scars (particularly hypertrophic and keloid scars), always follow after a dermal injury to the skin cutaneous scars leave a negative impact on people, both physically and mentally. Comparing to other surgical treatments, patients who do not opt for or can't opt for invasion therapy are more eligible for using the topical anti-scarring agents. In this mini-review, we have researched for and collected the data between October 2005 and October 2015, in PubMed and Web of Science, and identified those agents including silicone-based products, imiquimod, corticosteroids, 5- fluorouracil, bleomycin, mitomycin, and plant extracts such as onion extract, asiaticoside, aloe vera, vitamin E, and so on...
October 25, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27775986/treatment-of-keloids-with-excision-and-adjuvant-radiation-a-single-center-experience-and-review-of-the-literature
#12
Katelyn G Bennett, Theodore A Kung, James A Hayman, David L Brown
BACKGROUND: Management of keloids has remained a conundrum, because an optimum treatment regimen has yet to be elucidated. Currently, treatment varies widely between more conservative measures, such as steroid injections, topical medications, and silicone sheeting, to more aggressive options, such as surgery and postoperative radiation. The latter combination has been touted to have superior results, with the lowest rates of pathologic scar recurrence. METHODS: We performed a retrospective review to critically evaluate the effectiveness of surgical excision and radiation treatment in patients with keloids...
October 19, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27757340/the-transareolar-periareolar-approach
#13
Jonathan Zelken, Jung-Ju Huang, Chih-Wei Wu, Yi-Ling Lin, Ming-Huei Cheng
The periareolar approach is limited by areolar diameter. Asian women typically have smaller areolae than Western women. Voluminous and form-stable silicone implants demand larger incisions. Zigzag transareolar approaches closely approximate the nipple and improve exposure, but scar appearance remains problematic, and there is a risk of ductal injury and capsular contracture. We prefer a zigzag incision that straddles the areolar border. Between 2013 and 2015, 11 augmentation mammoplasties (20 incisions) were performed through a transareolar-periareolar (TAPA) incision...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27732732/the-keloid-scars-of-slavery
#14
Neha Jariwala, Jules B Lipoff
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27720205/a-novel-conformal-superficial-high-dose-rate-brachytherapy-device-for-the-treatment-of-nonmelanoma-skin-cancer-and-keloids
#15
Clara Ferreira, Daniel Johnson, Karl Rasmussen, Clinton Leinweber, Salahuddin Ahmad, Jae Won Jung
PURPOSE: To develop a novel conformal superficial brachytherapy (CSBT) device as a treatment option for the patient-specific radiation therapy of conditions including superficial lesions, postsurgical positive margins, Dupuytren's contractures, keloid scars, and complex anatomic sites (eyelids, nose, ears, etc.). METHODS AND MATERIALS: A preliminary CSBT device prototype was designed, built, and tested using readily available radioactive seeds. Iodine-125 ((125)I) seeds were independently guided to the treatment surface to conform to the target...
October 3, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27698867/long-non-coding-rna-h19-promotes-the-proliferation-of-fibroblasts-in-keloid-scarring
#16
Jie Zhang, Cai Yue Liu, Yun Wan, Li Peng, Wen Fang Li, Jia Xuan Qiu
The expression of the long non-coding RNA (lncRNA) H19 is associated with proliferation in tumors. In order to investigate whether H19 may additionally mediate the proliferation of fibroblasts in human keloid disease, the present study collected samples from 24 subjects, including 8 with keloids, 8 with normal scars and 8 normal skin controls. Reverse transcription-polymerase chain reaction revealed that H19 levels were markedly increased in human keloids compared with normal scars and normal skin controls (P=0...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27694104/regulatory-effects-of-electronic-beam-irradiation-on-mir-21-smad7-mediated-collagen-i-synthesis-in-keloid-derived-fibroblasts
#17
Shifeng Li, Wei Liu, Ying Lei, Jianhong Long
Keloid scarring is an abnormal pathological scar characterized by excessive fibro proliferation and extracellular matrix deposition. Electronic beam irradiation is commonly used with surgical removal to control high recurrence rates of keloid scarring; however, the mechanism remains unknown. In this study, we used keloid-derived primary fibroblasts (KF) as the cell model, and a dose of 15 Gy energy, followed by quantitative PCR (qPCR), western blotting and gene overexpression/knock down techniques were used to reveal the molecular mechanisms affected by electronic beam irradiation...
November 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27680482/objective-spectrometric-measurement-of-keloid-color-in-the-east-asian-population-pitfalls-of-subjective-color-measurements
#18
Masayo Aoki, Satoshi Akaishi, Junichi Nakao, Teruyuki Dohi, Hiko Hyakusoku, Rei Ogawa
BACKGROUND: Keloids are characterized by the formation of excessive scar tissue that extends beyond the area of the initial wound. Keloid redness is due to angiogenesis and chronic inflammation and is an important indicator of the severity of the lesion and the effectiveness of treatment. METHODS: The color of 33 untreated keloids from 30 patients was measured with a narrow-band reflectance colorimeter. The erythema and melanin levels in the keloids (Ek and Mk, respectively) were recorded with control data obtained from the flexor aspect of the forearm (Ec and Mc, respectively)...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27661432/therapeutic-efficacy-of-intralesional-steroid-with-carbon-dioxide-laser-versus-with-cryotherapy-in-treatment-of-keloids-a-randomized-controlled-trial
#19
Biswanath Behera, Rashmi Kumari, Devinder Mohan Thappa, Munisamy Malathi
BACKGROUND: Keloids are difficult to treat due to their poor response and high recurrence rate. OBJECTIVE: We conducted a randomized controlled trial to compare the therapeutic efficacy of intralesional triamcinolone acetonide (ILTA) in combination with carbon dioxide laser (Group 1) versus in combination with cryotherapy (Group 2) in the treatment of keloids. MATERIALS AND METHODS: Sixty patients with 101 keloids were randomized into 2 groups...
October 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27651436/upregulation-of-microrna-205-suppresses-vascular-endothelial-growth-factor-expression-mediated-pi3k-akt-signaling-transduction-in-human-keloid-fibroblasts
#20
Gang An, Shuzeng Liang, Chunhong Sheng, Yan Liu, Wei Yao
Keloid is one of the most frustrating problems related to wounding healing and presents a great challenge in clinic. MicroRNAs (miRs) have shown their potential as a novel therapy for the prevention and treatment of keloid. Vascular endothelial growth factor (VEGF) plays a critical role in the regulation of scar development. In the current study, it was hypothesized that miR-205-5p was capable of suppressing keloid formation by inhibiting the VEGF-mediated wound healing cascade. The expression statuses of miR-205-5p and VEGF in clinical keloid tissues and keloid cell line human keloid fibroblasts (HKF) were detected...
September 19, 2016: Experimental Biology and Medicine
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