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Keloideal scars

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https://www.readbyqxmd.com/read/29330940/extracorporeal-shockwave-therapy-for-treatment-of-keloid-scars
#1
Ching-Jen Wang, Jih-Yang Ko, Wen-Yi Chou, Jai-Hong Cheng, Yur-Ren Kuo
The purpose of this investigation was to study the effectiveness of extracorporeal shockwave therapy (ESWT) for the treatment of keloid scars, and compared the results with intralesional steroid injection. Thirty-nine patients were randomly divided into 22 in ESWT group and 17 in steroid group. The ESWT group received 3 ESWT treatments in 6 weeks. The steroid group received 3 intra-lesional triamcinolone injections in 6 weeks. The evaluations included gross morphology, functional outcome, local blood flow perfusion, biopsy for histopathological examination and immunohistochemical analysis...
January 13, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29328420/ginsenoside-rg3-inhibits-keloid-fibroblast-proliferation-angiogenesis-and-collagen-synthesis-in-vitro-via-the-tgf%C3%A2-%C3%AE-smad-and-erk-signaling-pathways
#2
Mengyao Tang, Weiwei Bian, Liying Cheng, Lu Zhang, Rong Jin, Wenbo Wang, Yuguang Zhang
A wide range of therapeutic options exists for the treatment of keloids, all of which have their own strengths; however, a high risk of side‑effects and frequent recurrence remains. Therefore, the present study aimed to identify improved therapeutic approaches or drugs for the treatment of keloids. Ginsenoside Rg3 (Rg3) has been reported to exert numerous antitumor effects, thus indicating that Rg3 may be a potential therapeutic agent that targets keloids. The present study determined the effects of Rg3 on human keloid fibroblasts (KFs) in vitro, and further explored the associated molecular and cellular mechanisms...
January 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29316083/near-infrared-fluorescent-molecular-probe-for-sensitive-imaging-of-keloid
#3
Qingqing Miao, David C Yeo, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu, Kanyi Pu
Early detection of skin diseases is imperative for their effective treatment. However, fluorescence molecular probes that allow this are rare. The first activatable near-infrared (NIR) fluorescent molecular probe is reported for sensitive imaging of keloid cells, skin cells from abnormal scar fibrous lesions. As keloid cells have high expression levels of fibroblast activation protein-alpha (FAPα), the probe (FNP1) is designed to have a caged NIR dye and a FAPα-cleavable peptide substrate linked by a self-immolative segment...
January 5, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29316036/inhibition-of-ire1-results-in-decreased-scar-formation
#4
Tatiana V Boyko, Rakesh Bam, Dadi Jiang, Zhen Wang, Namrata Bhatia, Misha C Tran, Michael T Longaker, Albert C Koong, George P Yang
Wound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis. One of the main components of the UPR is IRE1, an ER transmembrane protein with endonuclease activity that produces the activated form of the transcription factor XBP1. Using luciferase reporter mice for Xbp1 splicing, we showed that IRE1 was up-regulated during excisional wound healing at the time in wound healing consistent with that of the proliferative phase, when the majority of protein synthesis for cellular proliferation and matrix deposition occurs...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29313035/peptide-delivery-with-poly-ethylene-glycol-diacrylate-microneedles-through-swelling-effect
#5
Shiying Liu, David C Yeo, Christian Wiraja, Hong Liang Tey, Milan Mrksich, Chenjie Xu
Transdermal delivery of therapeutic biomolecules (including peptides) can avoid enzymatic digestion that occurs in the oral route. (Polyethylene glycol) diacrylate (PEGDA)-based microneedles, with good biocompatibility, are easily fabricated through photo-polymerization with a precisely controlled structure. It has successfully been used for the transdermal delivery of small molecule drugs such as 5-fluorouracil. However, the delivery of peptide-based therapeutics using this platform is seldom reported. This is because of the potential damage to the peptide during the photo-polymerization process of PEGDA...
September 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29305151/efficacy-and-the-toxicity-of-the-interstitial-high-dose-rate-brachytherapy-in-the-management-of-recurrent-keloids-5-year-outcomes
#6
Ping Jiang, Matthias Geenen, Frank-André Siebert, Julia Bertolini, Bjoern Poppe, Ulf Luetzen, Juergen Dunst, Daniel Druecke
PURPOSE: Recurring keloids are a clinical challenge. Interdisciplinary treatments are required in most cases. Owing to the wide variety of concepts, the optimal treatment regime remains unclear. Our clinic established a protocol of perioperative interstitial high-dose-rate brachytherapy with three fractions of 6 Gy and achieved an excellent 2-year local control rate of 94% (In search of the optimal treatment of keloids: Report of a series and a review of the literature). This report is an update on our long-term results of prospective study...
January 2, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29285054/gene-expression-profiling-analysis-of-keloids-with-and-without-hydrocortisone-treatment
#7
Hongyi Wang, Liangliang Quan, Jiulong Liang, Jie Shi, Tao Qiu, Ye Zhang, Yang Wang, Qiang Hui, Yu Zhang, Kai Tao
The present study aimed to investigate the genetic effects of hydrocortisone (HC) treatment on keloids and screen medicines to be used in a combination therapy of keloids with HC. The dataset GSE7890 was downloaded from Gene Expression Omnibus. It contained data regarding 4 fibroblast samples from normal scar tissue and 5 samples from keloid tissue with HC treatment, as well as 5 samples from normal scar and 5 samples from keloids without HC treatment. Following the identification of differentially expressed genes (DEGs), the functions of these DEGs were analyzed by Gene Ontology (GO) and pathway enrichment analyses...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29283384/high-mobility-group-box-1-mediates-fibroblast-activity-via-rage-mapk-and-nf-%C3%AE%C2%BAb-signaling-in-keloid-scar-formation
#8
Jihee Kim, Jong-Chul Park, Mi Hee Lee, Chae Eun Yang, Ju Hee Lee, Won Jai Lee
Emerging studies have revealed the involvement of high-mobility group box 1 (HMGB1) in systemic fibrotic diseases, yet its role in the cutaneous scarring process has not yet been investigated. We hypothesized that HMGB1 may promote fibroblast activity to cause abnormal cutaneous scarring. In vitro wound healing assay with normal and keloid fibroblasts demonstrated that HMGB1 administration promoted the migration of both fibroblasts with increased speed and a greater traveling distance. Treatment of the HMGB1 inhibitor glycyrrhizic acid (GA) showed an opposing effect on both activities...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29282183/techniques-for-optimizing-surgical-scars-part-2-hypertrophic-scars-and-keloids
#9
Kathryn Potter, Sailesh Konda, Vicky Zhen Ren, Apphia Lihan Wang, Aditya Srinivasan, Suneel Chilukuri
Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 2 focuses on scar revision for hypertrophic and keloids scars. Scar revision options for hypertrophic and keloid scars include corticosteroids, bleomycin, fluorouracil, verapamil, avotermin, hydrogel scaffold, nonablative fractional lasers, ablative and fractional ablative lasers, pulsed dye laser (PDL), flurandrenolide tape, imiquimod, onion extract, silicone, and scar massage...
2017: Skinmed
https://www.readbyqxmd.com/read/29240593/insights-into-the-pathophysiology-of-hypertrophic-scars-and-keloids-how-do-they-differ
#10
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240586/insights-into-the-pathophysiology-of-hypertrophic-scars-and-keloids-how-do-they-differ
#11
Feras M Ghazawi, Ramin Zargham, Mirko S Gilardino, Denis Sasseville, Fatemeh Jafarian
GENERAL PURPOSE: To provide information about the clinical presentation of hypertrophic scars and keloids based on their varied structural components. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that manifest when the cicatrix fails to properly heal...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240273/endothelial-dysfunction-may-promote-keloid-growth
#12
Chikage Noishiki, Gen Takagi, Yoshiaki Kubota, Rei Ogawa
Keloid is a cutaneous fibroproliferative disorder. It results from impaired wound healing that generates persistent inflammation and extensive deposition of collagen fibers in the wound/scar. Keloids tend to be worse in hypertensive patients. The present prospective cross-sectional study assessed whether endothelial dysfunction, which occurs in hypertension, associates with keloid formation and progression. This study included randomly-selected patients with keloids who were assessed for surgical keloid treatment in 2013-2014...
December 14, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29224036/laser-advances-in-the-treatment-of-burn-and-traumatic-scars
#13
Shilpi Khetarpal, Urvashi Kaw, Jeffrey S Dover, Kenneth A Arndt
The realm of scar management is constantly changing. Many factors need to be considered when developing a comprehensive treatment plan, including the nature of the scar and the patient. Scar characteristics can be divided by color, scar type and thickness, and body location. Topical and intralesional agents and light- and laserbased treatments can be used to revitalize and restore damaged skin in atrophic and hypertrophic scars. The most commonly used lasers are the pulsed-dye laser (PDL) and fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29218275/outcomes-of-surgical-excision-and-brachytherapy-in-intractable-keloids
#14
Ahmadreza Taheri, Hojjat Molaei, Mehdi Aghili, Naser Rahmanpanah, Atefeh Mirmohseni
BACKGROUND: Keloids as unusual scars are injury remnants characterized by bizarre cosmetics and painful itching. This study assessed outcomes of surgical excision and brachytherapy in intractable keloids. METHODS: Six patients with 10 keloid lesions were followed up. Surgical excision was done with 1-2 mm margin, and then radiotherapy was undertaken in 3 divided fractions on days 0, 1 and 2 after surgery. Scar improvement was evaluated by patients and observer with scar assessment scale (POSAS)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29194570/characterization-of-cd45ro-memory-t-lymphocytes-in-keloid-disease
#15
Z Chen, L Zhou, T Won, Z Gao, X Wu, L Lu
BACKGROUND: Memory T cells, a highly effective subset of T lymphocytes, have been reported to be involved in many inflammatory skin disorders. However, the potential role of memory T cells in keloid disease (KD) remains unclear. OBJECTIVES: Due to their important role in regulating inflammation, we investigated the characteristics of CD45RO+ memory T cells (mT) in KD. METHODS: Primary cutaneous cells were isolated from keloid scars and normal skin by enzymic digestion...
December 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29169897/wound-healing
#16
REVIEW
Peng-Hui Wang, Ben-Shian Huang, Huann-Cheng Horng, Chang-Ching Yeh, Yi-Jen Chen
Wound healing is an important physiological process to maintain the integrity of skin after trauma, either by accident or by intent procedure. The normal wound healing involves three successive but overlapping phases, including hemostasis/inflammatory phase, proliferative phase, and remodeling phase. Aberration of wound healing, such as excessive wound healing (hypertrophic scar and keloid) or chronic wound (ulcer) impairs the normal physical function. A large number of sophisticated experimental studies have provided insights into wound healing...
November 21, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29163221/the-superficial-dermis-may-initiate-keloid-formation-histological-analysis-of-the-keloid-dermis-at-different-depths
#17
Hu Jiao, Tiran Zhang, Jincai Fan, Ran Xiao
Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Samples were studied by light microscopy using routine hematoxylin and eosin histochemical staining, and immunohistochemistry to detect CD20-positive B-lymphocytes and CD3-positive T-lymphocytes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29152302/surgical-management-of-extensive-hypertrophic-scarring-of-the-halluces-secondary-to-a-decade-of-untreated-onychocryptosis-an-illustrative-case-report
#18
Dean J Samaras, Andrew C Kingsford
Extensive hypertrophic scarring of the halluces secondary to chronic onychocryptosis is a rare condition, which causes significant physical and psychosocial effects. In this case, a 31-year-old male developed large lesions on both great toes after he delayed treatment of chronic hallucal onychocryptosis for over a decade. Current treatment options for hypertrophic and keloid lesions in the foot and ankle vary considerably and differentiation is critical for appropriate treatment planning. In this case, surgical excision with total matrixectomy (modified Zadik-Syme) was considered optimal management...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29142785/role-of-cord-blood-and-bone-marrow-mesenchymal-stem-cells-in-recent-deep-burn-a-case-control-prospective-study
#19
Wael Abo-Elkheir, Fawzy Hamza, Ahmed M Elmofty, Atef Emam, Magdy Abdl-Moktader, Sameh Elsherefy, Hala Gabr
RATIONALE: Burn injuries represent one of the major worldwide public health problems causing more severe physiological stress than other traumas. Effective treatment of burn injuries is mandatory to prevent the numerous life-threatening complications and possible disabilities. Stem cells, a population of multipotent cells retaining the properties of self-renewal and differentiation, are the main player in tissue regeneration after major trauma. Thus, they are thought to play a key role in wound healing inducing efficient and physiological skin regeneration...
2017: American Journal of Stem Cells
https://www.readbyqxmd.com/read/29132871/the-role-of-tgf%C3%AE-in-wound-healing-pathologies
#20
REVIEW
Dimitra Kiritsi, Alexander Nyström
Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Chronic wounds are defined as barrier defects that have not proceeded through orderly and timely reparation to regain structural and functional integrity...
November 10, 2017: Mechanisms of Ageing and Development
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