keyword
Keywords Tumor regression grading in re...

Tumor regression grading in rectal cancer

https://read.qxmd.com/read/38010745/predicting-the-response-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer-using-soluble-immune-checkpoints
#21
JOURNAL ARTICLE
Aziz Ari, Husnu Sevik, Mert Mahsuni Sevinc, Cihad Tatar, Kenan Buyukasik, Aziz Ahmet Surel, Ufuk Oguz Idiz
Introduction: Personalizing neoadjuvant therapy for locally advanced rectal cancer (LARC) requires identifying biomarkers that predict treatment response. This study aims to evaluate soluble immune checkpoints (sICPs) as predictive markers for neoadjuvant treatment response in LARC patients located in the middle and lower rectum. Materials and Methods: This prospective study included patients diagnosed with clinical stage T3 or T4 rectal cancer (RC) based on pelvic magnetic resonance imaging, with or without pelvic lymph node involvement...
November 20, 2023: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/37999742/do-treated-rectal-tumors-appear-differently-on-mri-after-chemotherapy-versus-chemoradiotherapy
#22
JOURNAL ARTICLE
Yu Shen, Yanqiong Wen, Liang Bi, Xuyang Yang, Xiaoling Gong, Xiangbing Deng, Wenjian Meng, Ziqiang Wang
PURPOSE: Increasing studies have focused on neoadjuvant chemotherapy (NCT) in rectal cancer. However, few studies explored the differences in radiographic variation between patients treated with NCT and neoadjuvant chemoradiotherapy (NCRT). METHODS: Stage II/III rectal cancer patients from March 2016 to December 2019 meeting the criteria treated with NCRT or NCT were included. MRI features, including tumor location, longitudinal length, DWI signal, MRI tumor regression grade (mrTRG), and radiomic texture features, before and after neoadjuvant treatments were reviewed...
November 24, 2023: Abdominal Radiology
https://read.qxmd.com/read/37932062/value-of-pretreatment-inflammation-nutrition-score-to-predict-non-response-to-neoadjuvant-chemotherapy-in-locally-advanced-rectal-cancer
#23
JOURNAL ARTICLE
Guo Chao Zhang, Yan Yan Xu, Ying Chao Wu, Nuo Cheng, Rui Lian, Xin Wang
OBJECTIVE: To investigate the value of pretreatment inflammatory-nutritional biomarkers in predicting the pathological response of locally advanced rectal cancer (LARC) after neoadjuvant chemotherapy (nCT). METHODS: This retrospective study included eligible participants who underwent nCT followed by radical surgery. Pretreatment inflammatory nutritional biomarkers were calculated within one week prior to nCT. Correlations between biomarkers and pathological responses were analyzed...
October 20, 2023: Biomedical and Environmental Sciences: BES
https://read.qxmd.com/read/37901402/treatment-for-t1-colorectal-cancers-substratified-by-site-and-size-horses-for-courses
#24
JOURNAL ARTICLE
Kexin Shi, Zhen Yang, Kaiming Leng
BACKGROUND: Owing to advances in diagnostic technology, the diagnosis of T1 colorectal cancers (CRCs) continues to increase. However, the optimal management of T1 CRCs in the Western Hemisphere remains unclear due to limited population-based data directly comparing the efficacy of endoscopic therapy (ET) and surgical resection (SR). The purpose of this study was to report outcome data from a large Western cohort of patients who underwent ET or SR for early CRCs. METHODS: The SEER-18 database was used to identify patients with T1 CRCs diagnosed from 2004 to 2018 treated with ET or SR...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37893461/evaluation-of-changes-in-circulating-cell-free-dna-as-an-early-predictor-of-response-to-chemoradiation-in-rectal-cancer-a-pilot-study
#25
JOURNAL ARTICLE
Wee Liam Ong, Sorinel Lunca, Stefan Morarasu, Ana-Maria Musina, Alina Puscasu, Stefan Iacob, Irina Iftincai, Andreea Marinca, Iuliu Ivanov, Cristian Ena Roata, Natalia Velenciuc, Gabriel Dimofte
Background and Objectives: The objective of this study was to investigate quantitative changes in cell-free DNA (cfDNA) found in the bloodstream of patients with locally advanced rectal cancer who received neoadjuvant long-course chemoradiation, assuming a change in DNA fragments release during therapeutic stress. Materials and Methods: This was a prospective observational study that involved 49 patients who had three distinct pathologies requiring neoadjuvant chemoradiation: 18 patients with breast cancer, 18 patients with cervical cancer, and 13 patients with rectal cancer...
September 28, 2023: Medicina
https://read.qxmd.com/read/37892047/mri-tumor-regression-grade-combined-with-t2-weighted-volumetry-may-predict-histopathological-response-in-locally-advanced-rectal-cancer-following-neoadjuvant-chemoradiotherapy-a-new-scoring-system-proposal
#26
JOURNAL ARTICLE
Aleksandra Jankovic, Jelena Djokic Kovac, Marko Dakovic, Milica Mitrovic, Dusan Saponjski, Ognjen Milicevic, Aleksandra Djuric-Stefanovic, Goran Barisic
Modern studies focus on the discovery of innovative methods to improve the value of post-treatment magnetic resonance imaging (MRI) in the prediction of pathological responses to preoperative neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) . The aim of this study was to assess the potential benefits of combining magnetic resonance tumor regression grade (mrTRG) with T2-weighted volumetry in the prediction of pathological responses to nCRT in LARC. This was a cohort study conducted on patients with histopathologically confirmed LARC in a period from 2020 to 2022...
October 17, 2023: Diagnostics
https://read.qxmd.com/read/37891611/attention-mechanism-based-multi-sequence-mri-fusion-improves-prediction-of-response-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#27
JOURNAL ARTICLE
Xuezhi Zhou, Yi Yu, Yanru Feng, Guojun Ding, Peng Liu, Luying Liu, Wenjie Ren, Yuan Zhu, Wuteng Cao
BACKGROUND: Accurate prediction of response to neoadjuvant chemoradiotherapy (nCRT) is very important for treatment plan decision in locally advanced rectal cancer (LARC). The aim of this study was to investigate whether self-attention mechanism based multi-sequence fusion strategy applied to multiparametric magnetic resonance imaging (MRI) based deep learning or hand-crafted radiomics model construction can improve prediction of response to nCRT in LARC. METHODS: This retrospective analysis enrolled 422 consecutive patients with LARC who received nCRT before surgery at two hospitals...
October 27, 2023: Radiation Oncology
https://read.qxmd.com/read/37840101/mri-detected-tumor-deposits-in-ct3-and-ct4-rectal-cancer-following-neoadjuvant-chemoradiotherapy
#28
JOURNAL ARTICLE
Yu-Tao Que, Yan Chen, Xin-Yue Yang, Yu-Ru Ma, Yi-Yan Liu, Zi-Qiang Wen, Bao-Lan Lu, Xue-Han Wu, Zhi-Wen Zhang, Yun-Zhu Wu, Shen-Ping Yu, Jian-Peng Yuan
OBJECTIVES: To evaluate the identification of tumor deposits (TDs) and the prognostic significance of an MRI tumor regression grade for TDs in patients with rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT). METHODS: Ninety-one patients with cT3 or cT4 rectal cancer who underwent surgery following nCRT between August 2014 and June 2020 were retrospectively analyzed. Changes in pre-nCRT MRI-detected TDs (mrTDs) were described as mrTD regression grade...
October 16, 2023: European Radiology
https://read.qxmd.com/read/37807729/predictive-value-of-the-neutrophil-lymphocyte-ratio-for-tumor-regression-grade-and-prognosis-of-local-advanced-rectal-cancer-patients-undergoing-neoadjuvant-chemoradiotherapy
#29
JOURNAL ARTICLE
Shuofeng Li, Dingyuan Wang, Ran Wei, Guanhua Yu, Xishan Wang, Zheng Jiang
PURPOSE: Numerous indicators can be used to predict tumor patients' prognosis and tumor regression grade (TRG). The role of the neutrophil-lymphocyte ratio (NLR) among individuals with locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy (nCRT) hasn't been studied, nevertheless. This study aims to explore the predictive value of the NLR before nCRT (pre-NLR) in TRG and prognosis of LARC patients undergoing nCRT.. METHODS: In this retrospective investigation, 326 LARC patients receiving nCRT in total were included...
2023: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/37803322/theragnostic-utilities-for-neoplastic-diseases-of-the-rectum-by-mri-guided-radiotherapy-thunder-2-phase-ii-trial-interim-safety-analysis
#30
JOURNAL ARTICLE
Giuditta Chiloiro, Angela Romano, Davide Cusumano, Luca Boldrini, Giulia Panza, Lorenzo Placidi, Elisa Meldolesi, Matteo Nardini, Guenda Meffe, Gianluca Nicolini, Claudio Votta, Luca Indovina, Maria Antonietta Gambacorta
BACKGROUND: The THUNDER-2 phase II single institutional trial investigates the benefits of MRI-guided radiotherapy (MRIgRT) in treating locally advanced rectal cancer (LARC). This study focuses on evaluating the impact of escalating radiation therapy dose in non-responder patients using the Early Tumour Regression Index (ERI) for predicting complete response (CR). The trial's primary endpoint is to increase the CR rate in non-responders by 10% and assess the feasibility of the delta radiomics-based MRIgRT predictive model...
October 6, 2023: Radiation Oncology
https://read.qxmd.com/read/37795221/stereotactic-mr-guided-adaptive-radiotherapy-smart-for-primary-rectal-cancer-evaluation-of-early-toxicity-and-pathological-response
#31
JOURNAL ARTICLE
Alessandra Castelluccia, Domenico Marchesano, Gianmarco Grimaldi, Ivan Annessi, Federico Bianciardi, Cristian Borrazzo, Annamaria Dipalma, Randa El Gawhary, Marica Masi, Maria Rago, Maria Valentino, Laura Verna, Maurizio Portaluri, PierCarlo Gentile
BACKGROUND: The purpose of this study is to measure the effects of stereotactic MR-guided adaptive radiotherapy (SMART) for rectal cancer patients in terms of early toxicity and pathological response. MATERIALS AND METHODS: For this prospective pilot study, patients diagnosed with locally advanced rectal cancer (LARC) with positive lymph node clinical staging underwent SMART on rectal lesion and mesorectum using hybrid MR-Linac (MRIdian ViewRay). Dose prescription at 80% isodose for the rectal lesion and mesorectum was 40 Gy (8 Gy/fr) and 25 Gy (5 Gy/fr), respectively, delivered on 5 days (3 fr/week)...
2023: Reports of Practical Oncology and Radiotherapy
https://read.qxmd.com/read/37785184/modeling-acute-chemoradiotherapy-crt-diarrhea-severity-using-automatically-contoured-small-bowel
#32
JOURNAL ARTICLE
Z Shen, D Brand, Y Zhang, M Simard, A Lopes, E Miles, A Gilbert, N West, A Blake, G Royle, A Appelt, T S Maughan, D Sebag-Montefiore, C A Collins-Fekete, M A Hawkins
PURPOSE/OBJECTIVE(S): Acute severe diarrhea is a common toxicity in rectal cancer patients receiving CRT. A better understanding of the radiation tolerance of the small bowel is needed especially for novel radiation drug combinations. We investigate the dose impact by providing auto-contoured small bowel, using data from the ARISTOTLE phase III trial ISRCTN: 09351447. MATERIALS/METHODS: A subset of participants (n = 93/564) with locally advanced rectal cancer in the ARISTOTLE trial testing the addition of concurrent irinotecan (n = 48) to neoadjuvant capecitabine (n = 45) CRT (45/25 Gy/fx), in an MRI defined high risk of loco-regional failure...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37785164/a-phase-1-trial-of-the-safety-tolerability-and-biological-effects-of-intravenous-enadenotucirev-enad-a-novel-oncolytic-virus-in-combination-with-chemoradiotherapy-in-locally-advanced-rectal-cancer-cedar
#33
JOURNAL ARTICLE
S M O'Cathail, M Qiao, R Muirhead, R Adams, S Rao, K Fisher, L Seymour, R Brown, T Lille, A Ooms, T S Maughan, M A Hawkins
PURPOSE/OBJECTIVE(S): Novel treatment combinations are required to increase response rates in rectal cancer. EnAd is an intravenous, tumor selective, oncolytic adenovirus with high affinity for malignant colorectal epithelial cells. Pre-clinical evidence of synergy with radiation warranted further clinical evaluation and assessment of safety in combination with chemoradiation (CRT), 25 × 2Gy and concurrent capecitabine. MATERIALS/METHODS: EnAd was escalated using 2 dose levels of viral particles (1 × 1012 , 3 × 1012 ), given Monday, Wednesday, Friday over 3 schedules (pre-CRT, pre & post CRT)...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37785100/effect-of-anemia-on-tumor-response-to-preoperative-neoadjuvant-chemoradiotherapy-for-locally-advanced-rectal-cancer
#34
JOURNAL ARTICLE
L He, J Yang, R Li, B Liu, L Pan, L Sun, Q Peng
PURPOSE/OBJECTIVE(S): Preoperative neoadjuvant chemoradiotherapy (nCRT) and total rectal mesenteric resection (TME) are the primary treatment options for locally advanced rectal cancer (LARC), but their efficacy varies. This study aimed to investigate the impact of anemia on the tumor response of patients with LARC receiving preoperative neoadjuvant chemoradiotherapy. MATERIALS/METHODS: This study was a retrospective analysis of clinical and pathological data from patients with LARC who underwent nCRT and TME from January 2019 to May 2022 at a single institution...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37785099/correlation-between-lymph-node-regression-grading-and-tumor-regression-grading-after-neoadjuvant-chemoradiotherapy-for-locally-advanced-rectal-cancer
#35
JOURNAL ARTICLE
L He, L Sun, J Yang, B Song, C Liu, J Yan, Q Peng
PURPOSE/OBJECTIVE(S): This study aimed to determine the relationship between tumor regression grading (TRG) and lymph node regression grading (LRG) after neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC). MATERIALS/METHODS: The study was a retrospective analysis of the clinical data of LARC patients who underwent preoperative nCRT at one institution. A total of 101 rectal cancer patients who received nCRT and underwent total rectal mesenteric excision (TME) were included...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784278/relationships-between-microbiome-and-response-to-neoadjuvant-chemoradiotherapy-in-rectal-cancer
#36
JOURNAL ARTICLE
H I Lee, B S Jang, T H Lee, J H Park, J H Chang, E K Chie
PURPOSE/OBJECTIVE(S): Gut microbiome is known to be involved in antitumor immunotherapy and chemotherapy responses; however, few research has focused on the role of gut microbiome in the setting of concurrent chemoradiotherapy (CCRT). In this study, we investigated the tumor microbiome dynamics in patients undergoing neoadjuvant CCRT for locally advanced rectal cancer and sought to determine whether the diversity and composition of microbiome affect treatment response. MATERIALS/METHODS: A total of 103 samples from 26 patients with locally advanced rectal cancer were collected and 16S ribosomal RNA amplicon sequencing was performed...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37762904/low-anterior-resection-syndrome-lars-after-surgery-for-rectal-cancer-an-inevitable-price-to-pay-for-survival-or-a-preventable-complication
#37
JOURNAL ARTICLE
Edoardo Maria Muttillo, Alice La Franca, Alessandro Coppola, Francesco Saverio Li Causi, Marzia Checchelani, Alice Ceccacci, Giorgio Castagnola, Giovanni Maria Garbarino, Mattia Falchetto Osti, Genoveffa Balducci, Paolo Mercantini
BACKGROUND: Rectal cancer is frequent and often treated with sphincter-saving procedures that may cause LARS, a syndrome characterized by symptoms of bowel disfunction that may severely affect quality of life. LARS is common, but its pathogenesis is mostly unknown. The aim of this study is to assess the incidence of LARS and to identify potential risk factors. METHODS: We performed an observational retrospective single center analysis. The following data were collected and analyzed for each patient: demographics, tumor-related data, and intra- and peri-operative data...
September 14, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37736547/size-and-depth-of-residual-tumor-after-neoadjuvant-chemoradiotherapy-in-rectal-cancer-implications-for-the-development-of-new-imaging-modalities-for-response-assessment
#38
JOURNAL ARTICLE
Stefan D van der Stel, Jose G van den Berg, Petur Snaebjornsson, Iris M Seignette, Mark Witteveen, Brechtje A Grotenhuis, Geerard L Beets, Anouk L Post, Theo J M Ruers
With the shift towards organ preserving treatment strategies in rectal cancer it has become increasingly important to accurately discriminate between a complete and good clinical response after neoadjuvant chemoradiotherapy (CRT). Standard of care imaging techniques such as CT and MRI are well equipped for initial staging of rectal tumors, but discrimination between a good clinical and complete response remains difficult due to their limited ability to detect small residual vital tumor fragments. To identify new promising imaging techniques that could fill this gap, it is crucial to know the size and invasion depth of residual vital tumor tissue since this determines the requirements with regard to the resolution and imaging depth of potential new optical imaging techniques...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37719698/exploring-novel-genetic-and-hematological-predictors-of-response-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#39
JOURNAL ARTICLE
Mladen Marinkovic, Suzana Stojanovic-Rundic, Aleksandra Stanojevic, Marija Ostojic, Dusica Gavrilovic, Radmila Jankovic, Natasa Maksimovic, Rafael Stroggilos, Jerome Zoidakis, Sergi CastellvĂ­-Bel, Remond J A Fijneman, Milena Cavic
Introduction: The standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (nCRT). To select patients who would benefit the most from nCRT, there is a need for predictive biomarkers. The aim of this study was to evaluate the role of clinical, pathological, radiological, inflammation-related genetic, and hematological parameters in the prediction of post-nCRT response. Materials and methods: In silico analysis of published transcriptomics datasets was conducted to identify candidate genes, whose expression will be measured using quantitative Real Time PCR (qRT-PCR) in pretreatment formaline-fixed paraffin-embedded (FFPE) samples...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37700015/multicenter-phase-ii-trial-of-transanal-total-mesorectal-excision-for-rectal-cancer-preliminary-results
#40
MULTICENTER STUDY
Patricia Sylla, Dana Sands, Alison Ricardo, Antoinette Bonaccorso, Alexandros Polydorides, Mariana Berho, John Marks, Justin Maykel, Karim Alavi, Karen Zaghiyan, Mark Whiteford, Elisabeth Mclemore, Sami Chadi, Sherief F Shawki, Scott Steele, Alessio Pigazzi, Matthew Albert, Teresa DeBeche-Adams, Erin Moshier, Steven D Wexner
BACKGROUND: Transanal TME (taTME) combines abdominal and transanal dissection to facilitate sphincter preservation in patients with low rectal tumors. Few phase II/III trials report long-term oncologic and functional results. We report early results from a North American prospective multicenter phase II trial of taTME (NCT03144765). METHODS: 100 patients with stage I-III rectal adenocarcinoma located ≤ 10 cm from the anal verge (AV) were enrolled across 11 centers...
December 2023: Surgical Endoscopy
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