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Tumor regression grading in rectal cancer

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https://www.readbyqxmd.com/read/28628734/effect-of-abdominopelvic-sepsis-on-cancer-outcome-in-patients-undergoing-sphincter-saving-surgery-for-rectal-cancer
#1
Dirk Van de Putte, Elke Van Daele, Wouter Willaert, Piet Pattyn, Wim Ceelen, Yves Van Nieuwenhove
BACKGROUND: In rectal cancer, the significance of abdominopelvic sepsis (APS) on metastatic tumor growth remains uncertain. We aimed to analyze the effect of abdominopelvic sepsis on long-term survival in patients undergoing restorative rectal cancer surgery. METHODS: Data were used from the Belgian PROCARE rectal cancer registry. The effect of abdominopelvic infection on survival was assessed in uni- and multivariable Cox regression models. The effect of clinical and pathological covariates was controlled by propensity score-based matching of cases with controls...
June 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28621318/natural-killer-like-signature-observed-post-therapy-in-locally-advanced-rectal-cancer-is-a-determinant-of-pathological-response-and-improved-survival
#2
Matthew Alderdice, Philip D Dunne, Aidan J Cole, Paul G O'Reilly, Darragh G McArt, Vicky Bingham, Marc-Aurel Fuchs, Stephen McQuaid, Maurice B Loughrey, Graeme I Murray, Leslie M Samuel, Mark Lawler, Richard H Wilson, Manuel Salto-Tellez, Vicky M Coyle
Around 12-15% of patients with locally advanced rectal cancer undergo a pathologically complete response (tumor regression grade 4) to long-course preoperative chemoradiotherapy; the remainder exhibit a spectrum of tumor regression (tumor regression grade 1-3). Understanding therapy-related transcriptional alterations may enable better prediction of response as measured by progression-free and overall survival, in addition to aiding the development of improved strategies based on the underlying biology of the disease...
June 16, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28608017/relationship-between-expression-of-proteins-ercc1-ercc2-and-xrcc1-and-clinical-outcomes-in-patients-with-rectal-cancer-treated-with-folfox-based-preoperative-chemoradiotherapy
#3
Ming-Yii Huang, Joh-Jong Huang, Chun-Ming Huang, Chih-Hung Lin, Hsiang-Lin Tsai, Ching-Wen Huang, Chee-Yin Chai, Chia-Yang Lin, Jaw-Yuan Wang
BACKGROUND: Platinum resistance enhances DNA damage repair through nucleotide excision repair mechanisms involving the excision repair cross-complementing group 1 (ERCC1), X-ray cross-complementing group 1 (XRCC1), and excision repair cross-complementing group 2 (ERCC2). We evaluated the correlation between the expression of these three DNA repair genes and clinical outcomes in patients with rectal cancer receiving FOLFOX-based preoperative chemoradiotherapy (CRT). METHODS: Using immunohistochemistry, we examined the expression of ERCC1, ERCC2, and XRCC1 in pre-CRT cancer tissues from 86 patients with rectal cancer who had undergone curative resection and preoperative CRT with FOLFOX-4 to identify potential predictors of clinical outcomes...
June 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28534328/-predictive-value-of-serum-carcinoembryonic-antigen-level-in-efficacy-and-prognosis-for-patients-with-rectal-cancer-following-preoperative-radiochemotherapy
#4
Dakui Zhang, Tiancheng Zhan, Ming Li, Jin Gu
OBJECTIVE: To examine the association of preoperative carcinoembryonic antigen (CEA) level with the efficacy of neoadjuvant radiochemotherapy and postoperative metastasis and relapse in patients with rectal cancer. METHODS: Between January 2011 and January 2014, 325 patients with local advanced rectal cancer underwent preoperative radiochemotherapy and radical operation in Department of Colorectal Cancer Surgery, Beijing University Cancer Hospital, including 194 males and 131 females...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28534322/-value-of-functional-magnetic-resonance-imaging-in-predicting-outcomes-of-neoadjuvant-chemoradiotherapy-in-rectal-cancer
#5
Yishan Yu, Jinbo Yue, Jinming Yu
Rectal cancer is one of the common cancers which poses a threat to the health of mankind. In recent years. Multi-modality treatment strategies for locally advanced rectal cancer improve the treatment efficiency. Accurate prediction of the treatment response after the neoadjuvant chemoradiotherapy (CRT) can guide more suitable treatment strategy. MERCURY study proved the prognostic value of post-CRT standard morphologic MRI(T2-weighted) assessment of tumor regression grade(TRG), and MRI assessment of circumferential resection margin can guide the definitive surgery...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28534080/pathologic-complete-response-rates-after-neoadjuvant-treatment-in-rectal-cancer-an-analysis-of-the-national-cancer-database
#6
Patrick D Lorimer, Benjamin M Motz, Russell C Kirks, Danielle M Boselli, Kendall K Walsh, Roshan S Prabhu, Joshua S Hill, Jonathan C Salo
BACKGROUND: Pathologic complete response (pCR) of rectal cancer following neoadjuvant therapy is associated with decreased local recurrence and increased overall survival. This study utilizes a national dataset to identify predictors of pCR in patients with rectal cancer. METHODS: The National Cancer Database was queried for patients with nonmetastatic rectal cancer (2004-2014) who underwent neoadjuvant therapy and surgical resection. Unadjusted associations were assessed using rank-sum tests and χ (2) tests where appropriate...
May 22, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28493008/role-of-family-history-and-tumor-location-on-prognosis-of-patients-with-colorectal-cancer-and-synchronous-metastases
#7
Colloca Giuseppe, Venturino Antonella
BACKGROUND/AIMS: Family history of colorectal cancer and tumor location along colon-rectum have been reported as prognostic factors. The aim of the current study is to analyze the role of both on overall survival in a series of patients with metastatic colorectal cancer with synchronous metastases. METHODS: A retrospective mono-institutional analysis has been performed on patients, who received chemotherapy from 2004 to 2008. A Cox proportional-hazards regression was used to calculate hazard ratio (HR) for death, after adjustment for other variables (tumor metastasectomy, number of organs involved with metastases, number of anti-neoplastic drugs, age, sex, tumor grade, baseline CEA)...
May 10, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28488380/addition-of-oxaliplatin-to-neoadjuvant-radiochemotherapy-in-mri-defined-t3-t4-or-n-rectal-cancer-a-randomized-clinical-trial
#8
Peiman Haddad, Monir Miraie, Farshid Farhan, Mohammad-Sadegh Fazeli, Afsaneh Alikhassi, Afsaneh Maddah-Safaei, Mahdi Aghili, Bita Kalaghchi, Mohammad Babaei
BACKGROUND: Clinical trials investigating the effects of addition of oxaliplatin to neoadjuvant radiochemotherapy in locally advanced rectal cancers (LARCs) have brought controversial results for pathologic complete response as an endpoint. This randomized clinical trial investigated downstaging as a short-term surrogate for progression-free survival (PFS). METHODS: Patients with magnetic resonance imaging (MRI) defined T3, T4 or N+ histologically proven adenocarcinoma of rectum within 15 cm from anal verge were randomly assigned to receive 50-50...
May 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28485348/the-role-of-cox-2-and-ki-67-over-expression-in-the-prediction-of-pathologic-response-of-rectal-cancer-to-neoadjuvant-chemoradiation-therapy
#9
A H Jafarian, A Taghizadeh Kermani, J Esmaeili, N M Roshan, M Seilanian-Toosi, A A Omidi, M Karimi Shahri
BACKGROUND: The response to neoadjuvant chemoradiotherapy (CRT) is not the same among all cases with advanced rectal cancer. AIMS: This study investigated the association between over-expression of the two molecular markers (Cyclooxygenase-2 [COX-2] and Ki-67) and tumor response to neoadjuvant therapy. MATERIALS AND METHODS: In a retrospective cohort study, 55 patients with stage II-III rectal carcinoma were enrolled. All patients were treated with neoadjuvant therapy (45-50...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28485342/preoperative-long-course-chemoradiation-for-localized-rectal-cancer-a-retrospective-comparison-of-response-and-outcome-between-5-fluorouracil-leucovorin-versus-capecitabine
#10
B Kunheri, B Gurram, R Madhavan, D Makuny
BACKGROUND: Preoperative concurrent chemoradiation therapy (CRT) with either capecitabine or 5-florouracil/leucovorin (5 FU/LV) is the standard of care in locally advanced rectal cancer (LARC). Literature comparing the toxicity and response of these two regimens in Indian patients is sparse. Our objective was to compare the pathological response (PR) and clinical outcome of capecitabine versus 5 FU/LV in CRT for LARC. MATERIALS AND METHODS: Sixty patients with LARC treated with preoperative CRT with capecitabine or 5FU/LV from January 2009 to May 2014 were analyzed...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28466686/pre-operative-hyperfractionated-concurrent-radiochemotherapy-for-locally-advanced-rectal-cancers-a-phase-ii-clinical-study
#11
Adam Idasiak, Katarzyna Galwas-Kliber, Katarzyna Behrendt, Iwona Wziętek, Mariusz Kryj, Ewa Stobiecka, Ewa Chmielik, Rafał Suwiński
OBJECTIVE: The study was prospectively designed as a single-arm, single-institution prospective trial of pre-operative concomitant hyperfractionated radiotherapy (HART) with co-administration of chemotherapy based on 5-fluorouracil (5FU) in patients with T2/N+ or T3/any N resectable mid-low primary rectal cancer. The aim of the study was to assess the safety and efficacy of accelerated HART with concurrent 5FU-based chemotherapy in patients with locally advanced rectal cancer. METHODS: Patients with resectable locally advanced (≥T3 or N+) rectal cancer were eligible...
June 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28456481/significance-of-anemia-in-outcomes-after-neoadjuvant-chemoradiotherapy-for-locally-advanced-rectal-cancer
#12
John M McGrane, David J Humes, Austin G Acheson, Fiona Minear, James M D Wheeler, Catherine J Walter
BACKGROUND: Approximately one quarter of patients receiving neoadjuvant chemoradiotherapy (NCRT) for locally advanced rectal cancer will be anemic at presentation. The outcomes of these anemic patients have historically been less favorable. We assessed the potential of anemia to act as an independent biomarker for a poor prognosis in patients with locally advanced rectal cancer. MATERIALS AND METHODS: We performed a retrospective, observational study of consecutive patients with locally advanced rectal adenocarcinoma who underwent NCRT from 2004 to 2009 at 3 English National Health Service trusts...
March 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28427174/association-of-immunologic-markers-from-complete-blood-counts-with-the-response-to-preoperative-chemoradiotherapy-and-prognosis-in-locally-advanced-rectal-cancer
#13
Sung Woo Jung, In Ja Park, Se Heon Oh, Seung-Seop Yeom, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Jung Bok Lee, Chang Sik Yu, Jin Cheon Kim
We investigated retrospectively whether immunologic markers from a complete blood count (CBC) are associated with the responsiveness to preoperative chemoradiotherapy (PCRT) and oncologic outcomes in 984 patients with locally advanced rectal cancer (LARC) who also underwent radical surgery from 2005 to 2013. CBC parameters including the neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) were recorded. Pathologic responses to PCRT were evaluated in the resected specimens using the tumor regression grade system...
February 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28425130/histological-grading-based-on-poorly-differentiated-clusters-pdc-is-predictive-of-tumor-response-and-clinical-outcome-in-rectal-carcinoma-treated-with-neo-adjuvant-chemo-radiotherapy
#14
Luca Reggiani Bonetti, Simona Lionti, Federica Domati, Giuliana Pagliani, Elisabetta Mattioli, Valeria Barresi
AIMS: The clinical outcome of patients with locally advanced rectal cancer submitted to neo-adjuvant chemo-radiotherapy (CRT) is influenced by tumour response to treatment, which is reflected by tumour regression grade (TRG) and post-treatment (y) TNM stage. Little is known on the prognostic value of pre-treatment histopathological features of the tumour which may be useful to discriminate potential non-responders and to design tailored therapeutic strategies. In this study, we aimed to investigate the prognostic role of poorly differentiated clusters (PDC) of neoplastic cells in pre-treatment biopsies of rectal cancer submitted to neo-adjuvant CRT...
April 20, 2017: Histopathology
https://www.readbyqxmd.com/read/28423701/identification-of-protein-clusters-predictive-of-tumor-response-in-rectal-cancer-patients-receiving-neoadjuvant-chemo-radiotherapy
#15
Ombretta Repetto, Valli De Re, Antonino De Paoli, Claudio Belluco, Lara Alessandrini, Vincenzo Canzonieri, Renato Cannizzaro
Preoperative neoadjuvant chemoradiotherapy (nCRT) is the gold standard in locally advanced rectal cancer, only 10-30% of patients achieving benefits. Currently, there is a need of a reliable selection of markers for the identification of poor or non-responders prior to therapy. In this work, we compared protein profiles before therapy of patients differing in their responses to nCRT to find novel predictive markers of response to therapy. Patients were grouped into 3 groups according to their tumor regression grading (TRG) after surgery: 'TRG 1-2', good responders, 'TRG 3' and 'TRG 4', poor responders...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420585/adjuvant-chemotherapy-is-associated-with-improved-overall-survival-in-locally-advanced-rectal-cancer-after-achievement-of-a-pathologic-complete-response-to-chemoradiation
#16
Danish Shahab, Emmanuel Gabriel, Kristopher Attwood, Wen Wee Ma, Valerie Francescutti, Steven Nurkin, Patrick M Boland
BACKGROUND: In locally advanced rectal adenocarcinoma, 15% to 20% of patients treated with neoadjuvant chemoradiation (nCRT) achieve a pathologic complete response (pCR). The benefit of adjuvant chemotherapy is controversial in rectal cancer. Our objective was to evaluate the effect of clinical risk factors and adjuvant chemotherapy usage on the outcomes of the pCR patient population. PATIENTS AND METHODS: We performed a retrospective study using the National Cancer Data Base from 2006 to 2013...
March 18, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28417167/gene-expression-levels-of-gamma-glutamyl-hydrolase-in-tumor-tissues-may-be-a-useful-biomarker-for-the-proper-use-of-s-1-and-tegafur-uracil-leucovorin-in-preoperative-chemoradiotherapy-for-patients-with-rectal-cancer
#17
Sotaro Sadahiro, T Suzuki, A Tanaka, K Okada, G Saito, H Miyakita, T Ogimi, H Nagase
PURPOSE: Preoperative chemoradiotherapy (CRT) using 5-fluorouracil (5-FU)-based chemotherapy is the standard of care for rectal cancer. The effect of additional chemotherapy during the period between the completion of radiotherapy and surgery remains unclear. Predictive factors for CRT may differ between combination chemotherapy with S-1 and with tegafur-uracil/leucovorin (UFT/LV). METHODS: The subjects were 54 patients with locally advanced rectal cancer who received preoperative CRT with S-1 or UFT/LV...
June 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28410832/a-dose-finding-and-biomarker-evaluation-phase-ib-study-of-everolimus-in-association-with-5-fluorouracil-and-pelvic-radiotherapy-as-neoadjuvant-treatment-of-locally-advanced-rectal-cancer-e-larc-study
#18
Fabio Gelsomino, Federica Bertolini, Gabriele Luppi, Andrea Spallanzani, Elisa Pettorelli, Luca Reggiani Bonetti, Bruno Meduri, Gianrocco Manco, Pierfranco Conte, Stefano Cascinu
BACKGROUND: During the past 20 years, considerable improvement has occurred in the treatment of patients with locally advanced rectal cancer (LARC). With the introduction of multimodal treatment, refinements in preclinical staging and improvements in surgical skills, local relapse is no longer the major problem for patients with LARC. However, many patients die of metastatic disease. The present phase Ib study aimed to establish the maximum tolerated dose of everolimus combined with 5-fluorouracil and radiotherapy in patients with LARC...
March 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28347525/tumor-regression-grade-and-survival-after-neoadjuvant-treatment-in-gastro-esophageal-cancer-a-meta-analysis-of-17-published-studies
#19
REVIEW
G Tomasello, F Petrelli, M Ghidini, E Pezzica, R Passalacqua, F Steccanella, L Turati, G Sgroi, S Barni
INTRODUCTION: Major pathologic regression after neoadjuvant therapy is a strong and favorable prognostic factor in several types of cancer (breast, rectal and bladder). This information is less clear and has yet to be systematically evaluated in upper gastrointestinal tumors. We performed a meta-analysis to evaluate the prognostic impact of tumor regression after preoperative therapy on disease-free survival (DFS) and overall survival (OS) in gastro-esophageal cancer patients. METHODS: we searched for relevant articles in PubMed, SCOPUS, Web of Science, CINAHL, LILACS, Ovid, Cochrane Library, Google Scholar and Embase up to June 2, 2016...
March 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28342240/combination-of-growth-pattern-and-tumor-regression-identifies-a-high-risk-group-in-neoadjuvant-treated-rectal-cancer-patients
#20
Jonas Jessberger, Katharina Erlenbach-Wünsch, Rebecca Posselt, Marlen Haderlein, Abbas Agaimy, Rainer Fietkau, Arndt Hartmann, Luitpold Distel
AIM: In this study we analyzed the prognostic effect of E-Cadherin expression, the growth pattern of the tumor and the regression grade in a rectal cancer cohort treated with neoadjuvant radiochemotherapy. METHOD: 223 patients with rectal cancer treated with neoadjuvant radiochemotherapy followed by surgery were included. 88 biopsies prior to radiochemotherapy and 213 tumor resections with an average of 55 days post-RCT were investigated. Protein expression of E-cadherin and tumor growth pattern (solid-glandular vs...
March 25, 2017: Journal of Digestive Diseases
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