keyword
MENU ▼
Read by QxMD icon Read
search

Tumor regression grading in rectal cancer

keyword
https://www.readbyqxmd.com/read/29767284/diagnostic-accuracy-of-mri-in-assessing-tumor-regression-and-identifying-complete-response-in-patients-with-locally-advanced-rectal-cancer-after-neoadjuvant-treatment
#1
Medhat Aker, Darren Boone, Anuradha Chandramohan, Bruce Sizer, Roger Motson, Tan Arulampalam
BACKGROUND: The diagnostic accuracy of Magnetic Resonance Imaging (MRI) in restaging locally advanced rectal cancers (LARC) after neoadjuvant chemo-radio therapy (NCRT) has been under recent scrutiny. There is limited data on the accuracy of MRI and its timing in assessing tumor regression grade (TRG) and in identifying patients with complete response (CR). NCRT seems to cause tissue inflammation and oedema which renders reading the scans difficult for radiologist. AIM: This study aims to assess the accuracy of MRI at different time intervals after NCRT in staging TRG and in identifying CR...
May 16, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29743887/mean-corpuscular-volume-as-a-predictive-factor-of-response-to-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#2
Wen-Yi Zhang, Xing-Xing Chen, Wen-Hao Chen, Hui Zhang, Chang-Lin Zou
Background: The aim of this study was to identify if blood routine parameters and serum tumor marker are potential predictive factors for tumor response to preoperative chemoradiotherapy (CRT) in locally advanced rectal cancer. Materials and Methods: 55 locally advanced rectal cancer patients were treated with preoperative CRT in this study. The total dose of preoperative radiotherapy was 45 Gy in 25 fractions of 1.8 in 5 weeks. All patients concurrently received 825 mg/m2 capecitabine orally twice daily on days 1 to 14 and 22 to 35...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29587797/comparison-of-efficacy-and-safety-of-preoperative-chemoradiotherapy-in-locally-advanced-upper-and-middle-lower-rectal-cancer
#3
Ming-Yii Huang, Hsin-Hua Lee, Hsiang-Lin Tsai, Ching-Wen Huang, Yung-Sung Yeh, Cheng-Jen Ma, Chun-Ming Huang, Chiao-Yun Chen, Joh-Jong Huang, Jaw-Yuan Wang
BACKGROUND: We aimed to explore the efficacy and safety profile of preoperative neoadjuvant chemoradiation (NACRT) in locally advanced rectal cancer (LARC) in upper rectum versus middle/lower rectum. METHODS: The study included 173 patients with stage II or III (T2-4b, N0-2b) LARC who underwent NACRT followed by total mesorectal excision (TME) between January 2011 and October 2016. Cox regression, log-rank test, and Kaplan-Meier curves were calculated. RESULTS: Among the 173 patients, 58 had lesions in the upper rectum and 115 patients had lesions in middle/lower rectum...
March 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29580675/evaluating-the-current-status-of-rectal-cancer-care-in-the-us-where-we-stand-at-the-start-of-the-commission-on-cancer-s-national-accreditation-program-for-rectal-cancer
#4
Justin T Brady, Zhaomin Xu, Kelly B Scarberry, Amin Saad, Fergal J Fleming, Feza H Remzi, Steven D Wexner, David P Winchester, John R T Monson, Lawrence Lee, David W Dietz
BACKGROUND: In an effort to improve the quality of rectal cancer care in the US, the American College of Surgeons Commission on Cancer has developed the National Accreditation Program for Rectal Cancer (NAPRC). We aimed to describe the current status of rectal cancer care before implementation of the NAPRC. STUDY DESIGN: The 2011-2014 National Cancer Database was queried for non-metastatic rectal cancer patients who underwent proctectomy. The NAPRC process measures evaluated included clinical staging completion, treatment starting fewer than 60 days from diagnosis, CEA level drawn before treatment, tumor regression grading, and margin assessment...
March 22, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29558294/mr-imaging-with-apparent-diffusion-coefficient-histogram-analysis-evaluation-of-locally-advanced-rectal-cancer-after-chemotherapy-and-radiation-therapy
#5
Nandin-Erdene Enkhbaatar, Shigeaki Inoue, Hiroshi Yamamuro, Shuichi Kawada, Masashi Miyaoka, Naoya Nakamura, Sotaro Sadahiro, Yutaka Imai
Purpose To determine response to neoadjuvant chemotherapy and radiation therapy in patients with locally advanced rectal cancer (LARC) by using magnetic resonance (MR) apparent diffusion coefficient (ADC) histogram analysis. Materials and Methods Ninety-two patients with LARC underwent MR imaging with rectal barium before and after chemotherapy and radiation therapy (CRT). Rectal expansion with barium expanded the lumen, provided similar imaging geometry before and after CRT, and eliminated fecal matter, air, and residual fluid...
March 20, 2018: Radiology
https://www.readbyqxmd.com/read/29552288/mri-texture-analysis-in-predicting-treatment-response-to-neoadjuvant-chemoradiotherapy-in-rectal-cancer
#6
Yankai Meng, Chongda Zhang, Shuangmei Zou, Xinming Zhao, Kai Xu, Hongmei Zhang, Chunwu Zhou
To evaluate the importance of MRI texture analysis in prediction and early assessment of treatment response before and early neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC). This retrospective study comprised of 59 patients. The tumoral texture parameters were compared between pre- and early nCRT. Area Under receiver operating characteristic (ROC) Curves [AUCs] were used to compare the diagnostic performance of statistically significant difference parameters and logistic regression analysis predicted probabilities for discriminating responders and nonresponders...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29388280/area-of-residual-tumor-is-a-robust-prognostic-marker-for-patients-with-rectal-cancer-undergoing-preoperative-therapy
#7
COMPARATIVE STUDY
Naoki Sakuyama, Motohiro Kojima, Shingo Kawano, Yoko Matsuda, Mari Mino-Kenudson, Atsushi Ochiai, Masaaki Ito
The aim of this study was to elucidate differences in the histological features of rectal cancer between patients treated with preoperative chemoradiotherapy and those treated with preoperative chemotherapy. Area of residual tumor (ART) was also evaluated for its utility as a potential prognostic marker between them. Sixty-eight patients with rectal cancer who underwent sphincter-saving surgery were enrolled in this study. Of these, 39 patients received preoperative chemoradiotherapy (CRT group) and 29 patients received preoperative (neoadjuvant) chemotherapy (NAC group)...
March 2018: Cancer Science
https://www.readbyqxmd.com/read/29383117/magnetic-resonance-tumor-regression-grade-mr-trg-to-assess-pathological-complete-response-following-neoadjuvant-radiochemotherapy-in-locally-advanced-rectal-cancer
#8
Marco Rengo, Simona Picchia, Simona Marzi, Davide Bellini, Damiano Caruso, Mauro Caterino, Maria Ciolina, Domenico De Santis, Daniela Musio, Vincenzo Tombolini, Andrea Laghi
This study aims to evaluate the feasibility of a magnetic resonance (MR) automatic method for quantitative assessment of the percentage of fibrosis developed within locally advanced rectal cancers (LARC) after neoadjuvant radiochemotherapy (RCT). A total of 65 patients were enrolled in the study and MR studies were performed on 3.0 Tesla scanner; patients were followed-up for 30 months. The percentage of fibrosis was quantified on T2-weighted images, using automatic K-Means clustering algorithm. According to the percentage of fibrosis, an optimal cut-off point for separating patients into favorable and unfavorable pathologic response groups was identified by ROC analysis and tumor regression grade (MR-TRG) classes were determined and compared to histopathologic TRG...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29374729/image-quality-assessment-of-2d-versus-3d-t2wi-and-evaluation-of-ultra-high-b-value-b-2-000-mm-s-2-dwi-for-response-assessment-in-rectal-cancer
#9
Daniel Hausmann, Jing Liu, Johannes Budjan, Miriam Reichert, Melissa Ong, Mathias Meyer, Arman Smakic, Robert Grimm, Ralph Strecker, Stefan O Schoenberg, Xiaoying Wang, Ulrike I Attenberger
AIM: The purpose of this IRB-approved, retrospective study was to compare image quality between 2D and high-resolution 3D, T2-weighted (T2WI) magnetic resonance imaging (MRI) sequences and to investigate the additional value of ultra-high b-value diffusion-weighted imaging (DWI; b=2,000 mm/s2 ) for both rectal cancer staging and evaluating treatment response. MATERIALS AND METHODS: From 12 February to 24 August 2016, 26 consecutive patients (22 males, four females; mean age: 61...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29354903/-the-value-of-mri-with-cube-sequence-in-early-evaluation-of-the-efficacy-of-neoadjuvant-therapy-for-locally-advanced-rectal-cancer
#10
Xinhua Wang, Wuteng Cao, Dechao Liu, Fangqian Li, Wenli Li, Liang Kang, Yanhong Deng, Zhiyang Zhou
OBJECTIVE: To investigate the value of MRI with CUBE sequence in early evaluation of the efficacy of neoadjuvant therapy (NAT) for locally advanced rectal cancer. METHODS: Inclusion criteria: (1) rectal cancer proven by biopsy; (2) locally advanced rectal cancer (T3-4 or positive lymph nodes) with distance from lower edge of tumor to anal verge within 12 cm diagnosed by MRI before NAT; (3) acceptance of NAT treatment regulations and completion of NAT; (4) completion of routine MRI scan and CUBE scan before and after 2-course NAT chemotherapy (including new neoadjuvant chemotherapy and chemoradiotherapy); (5) completion of surgery 6-8 weeks after NAT; (6) exclusion of any previous NAT due to rectal malignant tumor or other tumors; (7) exclusion of poor image quality of preoperative routine MRI insufficient for rectal cancer staging or of CUBE image insufficient for tumor volume measurement...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29332339/p21-does-but-p53-does-not-predict-pathological-response-to-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#11
Suzana Stojanovic-Rundic, Radmila Jankovic, Marjan Micev, Vladimir Nikolic, Ivan Popov, Dusica Gavrilovic, Vesna Plesinac-Karapandzic, Aleksandra Djuric-Stefanovic, Zoran Krivokapic, Sinisa Radulovic
PURPOSE: Preoperative chemoradiotherapy (CRT) is the standard treatment option in locally advanced rectal cancer. The tumor response is assessed through tumor and nodal downstaging and the tumor regression grade. Currently, there is no method to predict a tumor response to CRT. We aimed to evaluate whether p21 and p53 expressions could be a reliable predictors of pathological response to CRT. METHODS: Fifty patients with locally advanced rectal cancer were treated with preoperative radiotherapy combined with mitomycin C and capecitabine...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332248/performance-of-diffusion-weighted-magnetic-resonance-imaging-at-3-0t-for-early-assessment-of-tumor-response-in-locally-advanced-rectal-cancer-treated-with-preoperative-chemoradiation-therapy
#12
Andrea Delli Pizzi, Roberta Cianci, Domenico Genovesi, Gianluigi Esposito, Mauro Timpani, Alessandra Tavoletta, Pierluigi Pulsone, Raffaella Basilico, Daniela Gabrielli, Consuelo Rosa, Luciana Caravatta, Monica Di Tommaso, Massimo Caulo, Antonella Filippone
PURPOSE: The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopathologic response. METHODS: Forty-three patients receiving CRT for LARC and 3.0T magnetic resonance imaging with diffusion-weighted sequences before treatment, 2 weeks during, and 8 weeks post the completion of CRT were included...
January 13, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29250176/leucine-rich-repeat-containing-g-protein-coupled-receptor-5-and-cd133-expression-is-associated-with-tumor-progression-and-resistance-to-preoperative-chemoradiotherapy-in-low-rectal-cancer
#13
Yuzo Harada, Shinsuke Kazama, Teppei Morikawa, Koji Murono, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hiroaki Nozawa, Hironori Yamaguchi, Soichiro Ishihara, Toshiaki Watanabe
Preoperative chemoradiotherapy has been performed as a standard therapy for advanced low rectal cancer. Cancer stem cells (CSCs) have been reported to contribute to resistance to treatment and patient prognosis. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) and cluster of differentiation (CD133) are putative markers for CSCs. However, their prognostic ability remains unknown, and evaluation of a single marker can be insufficient due to the heterogeneity of cancer. LGR5 and CD133 expression was immunohistochemically evaluated in surgical specimens of 56 patients who received curative resection following chemoradiotherapy for advanced low rectal cancer...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29245968/associations-of-tumor-regression-grade-with-outcomes-in-patients-with-locally-advanced-rectal-cancer-treated-with-preoperative-two-week-course-of-radiotherapy
#14
Yong-Heng Li, Jin-Luan Li, Xiang-Gao Zhu, Jun-Yan He, Li-Mei Lin, Xiao-Yi Lin, Li-Rui Tang, Yong Cai
Purpose: Studies concerning tumor regression grade (TRG) after two-week course of radiotherapy (RT) are limited. We tried to assess associations of TRG and outcomes in patients with locally advanced rectal cancer (LARC) treated with preoperative two-week course of RT. Methods: 356 consecutive LARC patients were retrospectively assessed. Patients with complete/intermediate (TRG1-3) and poor (TRG4-5) regressions were compared for overall survival (OS), disease-free survival (DFS) and metastasis-free survival (MFS)...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228455/prognostic-significance-of-neoadjuvant-rectal-score-in-locally-advanced-rectal-cancer-after-neoadjuvant-chemoradiotherapy-and-construction-of-a-prediction-model
#15
Yanwu Sun, Yiyi Zhang, Xuejing Wu, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Xiaojie Wang, Pan Chi
AIM: To evaluate the prognostic significance of neoadjuvant rectal (NAR) score after neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC), and to develop a nomogram predicting disease-free survival (DFS). METHOD: A total of 522 LARC patients undergoing nCRT and surgery were included. NAR scores were calculated using the equation [5pN-3(cT-pT) + 12]^2/9.61, and classified as low (<8), intermediate (8-16), and high (>16). Clinicopathological and survival outcomes were compared...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29206996/tumor-regression-grading-after-preoperative-chemoradiotherapy-as-a-prognostic-factor-and-individual-level-surrogate-for-disease-free-survival-in-rectal-cancer
#16
RANDOMIZED CONTROLLED TRIAL
Emmanouil Fokas, Philipp Ströbel, Rainer Fietkau, Michael Ghadimi, Torsten Liersch, Gerhard G Grabenbauer, Arndt Hartmann, Marco Kaufmann, Rolf Sauer, Ullrich Graeven, Hans Hoffmanns, Hans-Rudolf Raab, Torsten Hothorn, Christian Wittekind, Claus Rödel
Background: We investigated tumor regression grading (TRG) as a prognostic marker and individual-level surrogate for disease-free survival (DFS) in patients with rectal carcinoma treated within the Chirurgische Arbeitsgemeinschaft fur Onkologie/Arbeitsgemeinschaft Radiologische Onkologie/Arbeitsgemeinschaft Internistische Onkologie (CAO/ARO/AIO)-04 randomized trial. Methods: TRG was recorded prospectively using the Dworak classification in 1179 patients after preoperative fluorouracil-based chemoradiotherapy (CRT) with or without oxaliplatin...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29151142/mr-imaging-perfusion-and-diffusion-analysis-to-assess-preoperative-short-course-radiotherapy-response-in-locally-advanced-rectal-cancer-standardized-index-of-shape-by-dce-mri-and-intravoxel-incoherent-motion-derived-parameters-by-dw-mri
#17
Antonella Petrillo, Roberta Fusco, Vincenza Granata, Sergio Venanzio Setola, Mario Sansone, Daniela Rega, Paolo Delrio, Francesco Bianco, Giovanni Maria Romano, Fabiana Tatangelo, Antonio Avallone, Biagio Pecori
Our aim is to assess preoperative Short Course Radiotherapy (SCR) tumor response in locally advanced rectal cancer (LARC) through Standardized Index of Shape (SIS) by DCE-MRI, apparent diffusion coefficient (ADC) and intravoxel incoherent motion-derived parameters by DW-MRI. 35 patients with LARC underwent MR scan before and after SCR followed by delayed surgery, retrospectively, were enrolled. SIS, ADC, tissue diffusion (Dt ), pseudodiffusion (Dp ), and perfusion fraction (f) were extracted by MRI for each patient before and after SCR...
November 18, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29136732/-prognosis-factors-for-the-perineal-incision-complications-after-abdominoperineal-resection-for-low-rectal-cancer
#18
S Luo, J W Liang, H T Zhou, W Pei, Z X Zhou, Q Liu, X S Wang
Objective: To evaluate the prognosis factors affecting perineal incision complications after abdominoperineal resection (APR) for the low rectal cancer. Methods: This was a retrospective analysis of 151 consecutive patients with low rectal cancer undergoing APR between January and December 2013 at Department of Colorectal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. The patients were comprised of 95 males and 56 females. The mean age of the patients was (57...
November 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29121143/mismatch-repair-deficiency-testing-in-patients-with-colorectal-cancer-and-nonadherence-to-testing-guidelines-in-young-adults
#19
Talha Shaikh, Elizabeth A Handorf, Joshua E Meyer, Michael J Hall, Nestor F Esnaola
Importance: Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which has a higher incidence in young adults (age, <50 years) with CRC. Mismatch repair deficiency can be due to germline mutations or epigenetic inactivation, affects prognosis and response to systemic therapy, and results in unrepaired repetitive DNA sequences, which increases the risk of multiple malignant tumors...
February 8, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29113665/endoscopic-assessment-of-tumor-regression-after-preoperative-chemoradiotherapy-as-a-prognostic-marker-in-locally-advanced-rectal-cancer
#20
Dae Kyung Sohn, Kyung Su Han, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Ji Yeon Baek, Min Ju Kim, Sung Chan Park, Jae Hwan Oh, Dae Yong Kim
PURPOSE: This study was designed to evaluate tumor regression endoscopic criteria for predicting the post-chemoradiotherapy (CRT) prognosis of patients with locally advanced rectal cancer. MATERIAL AND METHODS: A total of 425 patients with rectal cancer who received radical surgery after CRT were included in this study. All patients were divided into two groups according to post-CRT preoperative endoscopic findings: 1) good response (E-GR): scar, telangiectasia, or erythema; 2) minimal or no response (E-MR): nodules, ulcers, strictures, or remnant tumor...
December 2017: Surgical Oncology
keyword
keyword
64589
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"