keyword
Keywords Tumor regression grading in re...

Tumor regression grading in rectal cancer

https://read.qxmd.com/read/38462629/efficacy-and-safety-of-pd-1-blockade-plus-long-course-chemoradiotherapy-in-locally-advanced-rectal-cancer-nectar-a-multi-center-phase-2-study
#1
JOURNAL ARTICLE
Zhengyang Yang, Jiale Gao, Jianyong Zheng, Jiagang Han, Ang Li, Gang Liu, Yi Sun, Jie Zhang, Guangyong Chen, Rui Xu, Xiao Zhang, Yishan Liu, Zhigang Bai, Wei Deng, Wei He, Hongwei Yao, Zhongtao Zhang
Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer (LARC) patients with microsatellite stable (MSS) / mismatch repair-proficient (pMMR) tumors is an attractive, but debatable strategy. This phase 2, multicenter, prospective, single-arm study enrolled patients from 6 centers from June 2021 to November 2022. Locally advanced rectal cancer (LARC, cT3-4a N0 M0 and cT1-4a N1-2 M0 ) patients aged ≥18 years with the distance from distal border of tumor to anal verge ≤10 cm (identified by Magnetic Resonance Imaging) were qualified for inclusion...
March 11, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38460248/negative-prognostic-impact-of-co-mutations-in-tgf%C3%AE-and-tp53-pathways-in-surgically-resected-rectal-tumors-following-neoadjuvant-chemoradiotherapy
#2
JOURNAL ARTICLE
Chengyuan Qian, Weina Yang, Mengxia Li, Yan Feng, Nan Dai, Hao Luo, Dan Jian, Xuemei Li, Yuxin Yang, Yue He, Dong Wang, Chunxue Li, He Xiao
BACKGROUND: Preoperative neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is a common approach for treating patients with locally advanced rectal cancer. Nevertheless, the mutational profile and its prognostic impact in surgically resected tumor specimens after nCRT remains to be clarified. METHODS: The comprehensive analysis of mutational landscape was retrospectively conducted by target regions sequencing approach that covered 150 tumor-related genes...
March 6, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38454349/fully-semantic-segmentation-for-rectal-cancer-based-on-post-ncrt-mrl-modality-and-deep-learning-framework
#3
JOURNAL ARTICLE
Shaojun Xia, Qingyang Li, Hai-Tao Zhu, Xiao-Yan Zhang, Yan-Jie Shi, Ding Yang, Jiaqi Wu, Zhen Guan, Qiaoyuan Lu, Xiao-Ting Li, Ying-Shi Sun
PURPOSE: Rectal tumor segmentation on post neoadjuvant chemoradiotherapy (nCRT) magnetic resonance imaging (MRI) has great significance for tumor measurement, radiomics analysis, treatment planning, and operative strategy. In this study, we developed and evaluated segmentation potential exclusively on post-chemoradiation T2-weighted MRI using convolutional neural networks, with the aim of reducing the detection workload for radiologists and clinicians. METHODS: A total of 372 consecutive patients with LARC were retrospectively enrolled from October 2015 to December 2017...
March 7, 2024: BMC Cancer
https://read.qxmd.com/read/38449411/-three-cases-of-preoperative-chemotherapy-folfoxiri-plus-bevacizumab-for-locally-advanced-colorectal-cancer-with-urinary-bladder-invasion
#4
JOURNAL ARTICLE
Hiroto Saito, Mari Shimada, Toshikatsu Tsuji, Koichi Okamoto, Hideki Moriyama, Jun Kinoshita, Keishi Nakamura, Noriyuki Inaki
Radical cystectomy for locally advanced colorectal cancer with urinary bladder invasion significantly reduces the quality of life in exchange for a cure. We performed preoperative chemotherapy with FOLFOXIRI plus bevacizumab for 3 patients with locally advanced colorectal cancer with urinary bladder invasion to avoid radical cystectomy and to achieve local control for urinary bladder preservation. Grade 3 neutropenia was observed in 2 patients as an adverse reaction to the preoperative chemotherapy, but all 3 patients showed good tumor regression...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38418345/photon-counting-computed-tomography-in-rectal-cancer-associations-between-iodine-concentration-histopathology-and-treatment-response-a-pilot-study
#5
JOURNAL ARTICLE
Alexey Surov, Raihanatou Diallo-Danebrock, Amin Radi, Jan Robert Kröger, Julius Henning Niehoff, Arwed Elias Michael, Berthold Gerdes, Saleem Elhabash, Andreas Wienke, Jan Borggrefe
RATIONALE AND OBJECTIVES: Common computed tomography (CT) investigation plays a limited role in characterizing and assessing the response of rectal cancer (RC) to neoadjuvant radiochemotherapy (NARC). Photon counting computed tomography (PCCT) improves the imaging quality and can provide multiparametric spectral image information including iodine concentration (IC). Our purpose was to analyze associations between IC and histopathology in RC and to evaluate the role of IC in response prediction to NARC...
February 27, 2024: Academic Radiology
https://read.qxmd.com/read/38397430/effect-of-5-alpha-reductase-inhibitors-on-magnetic-resonance-imaging-and-prostate-cancer-detection
#6
JOURNAL ARTICLE
Juan Morote, Natàlia Picola, Jesús Muñoz-Rodriguez, Nahuel Paesano, Xavier Ruiz-Plazas, Marta V Muñoz-Rivero, Ana Celma, Gemma García-de Manuel, Berta Miró, Pol Servian, José M Abascal
Concerns exist regarding the effects of 5-alpha reductase inhibitors (5-ARIs) on multipa-rametric magnetic resonance imaging (mpMRI) and clinically significant prostate cancer (csPCa) detection. Our objective is to analyze the effect of 5-ARI on the prostate imaging-reporting and data system (PI-RADS) distribution and csPCa and insignificant PCa (iPCa) detection. Among 2212 men with serum prostate-specific antigen levels of >3.0 ng/mL and/or suspicious digital rectal examinations who underwent mpMRI and targeted and/or systematic biopsies, 120 individuals exposed to 5-ARI treatment for over a year were identified...
February 5, 2024: Biomolecules
https://read.qxmd.com/read/38303295/-a-case-of-double-cancer-of-squamous-cell-carcinoma-of-the-rectum-and-adenocarcinoma-of-the-sigmoid-colon
#7
JOURNAL ARTICLE
Shinji Tsutsumi, Hirokazu Ogasawara, Satoko Umetsu, Akiko Suto, Harue Akasaka, Shigeru Shibata
A 72-year-old male was transported to our hospital with complaints of heart palpitations and dyspnea since a month earlier and was immobile. Blood examination showed severe anemia, and colonoscopy revealed circumferential tumors in the rectum and the sigmoid colon. Histopathologic examination revealed the tumors as squamous cell carcinoma of the rectum and adenocarcinoma of the sigmoid colon. Therefore, they were diagnosed as double colorectal cancers. CT and MRI showed that rectal cancer invaded the seminal vesicles and the prostate; therefore, the patient underwent neoadjuvant chemoradiotherapy(oral capecitabine and concomitant radiation therapy: a total dose of 50...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38289485/findings-in-magnetic-resonance-imaging-for-restaging-locally-advanced-rectal-cancer
#8
JOURNAL ARTICLE
Suvi Marjasuo, Laura Koskenvuo, Anna Lepistö
PURPOSE: We aimed to assess the prognostic value of restaging magnetic resonance imaging (MRI) in rectal cancer after neoadjuvant therapy and compare long-course chemoradiotherapy (LC-CRT) to short-course radiotherapy with delayed surgery (SCRT-delay). METHODS: This retrospective study included 267 patients with locally advanced rectal cancer (LARC) operated on between January 2016 and April 2019, all of whom received either LC-CRT or SCRT-delay in the neoadjuvant setting...
January 30, 2024: International Journal of Colorectal Disease
https://read.qxmd.com/read/38255799/p21-as-a-predictor-and-prognostic-indicator-of-clinical-outcome-in-rectal-cancer-patients
#9
JOURNAL ARTICLE
Li Ching Ooi, Vincent Ho, Jing Zhou Zhu, Stephanie Lim, Liping Chung, Askar Abubakar, Tristan Rutland, Wei Chua, Weng Ng, Mark Lee, Matthew Morgan, Scott MacKenzie, Cheok Soon Lee
The cell cycle plays a key and complex role in the development of human cancers. p21 is a potent cyclin-dependent kinase inhibitor (CDKI) involved in the promotion of cell cycle arrest and the regulation of cellular senescence. Altered p21 expression in rectal cancer cells may affect tumor cells' behavior and resistance to neoadjuvant and adjuvant therapy. Our study aimed to ascertain the relationship between the differential expression of p21 in rectal cancer and patient survival outcomes. Using tissue microarrays, 266 rectal cancer specimens were immunohistochemically stained for p21...
January 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38248122/artemis-as-predictive-biomarker-of-responsiveness-to-preoperative-chemoradiotherapy-in-patients-with-locally-advanced-rectal-cancer
#10
JOURNAL ARTICLE
Hai Liu, Runying Huang, Jingjing Shan, Xuyun Xie, Chongwei Wang, Peng Hu, Xiaonan Sun
The aim of this study was to identify Artemis as a predictive biomarker for guiding preoperative chemoradiotherapy in locally advanced rectal cancer. The resection specimens were collected from 50 patients with rectal cancer who underwent preoperative chemoradiotherapy. Artemis expression in biopsy tissues was evaluated using immunohistochemical staining according to the percentage of positively stained cells combined with staining intensity. Among the 50 patients, 36 (72%) had a weakly positive Artemis protein expression, 10 (20%) had a moderately positive expression, and 4 (8%) showed a strongly positive expression...
January 18, 2024: Current Oncology
https://read.qxmd.com/read/38221655/impact-of-neoadjuvant-therapy-on-nodal-harvest-in-clinical-stage-iii-rectal-cancer-establishing-optimum-cut-offs-by-disease-response
#11
JOURNAL ARTICLE
Chase J Wehrle, Kimberly Woo, Jenny Chang, Maysoon Gamaleldin, Reece DeHaan, Fadi Dahdaleh, Seth Felder, David R Rosen, Bradley Champagne, Scott R Steele, Samer A Naffouje
INTRODUCTION: A minimum lymph node harvest (LNH) of 12 is the current standard for appropriate nodal staging in resectable rectal cancer. However, the rise of neoadjuvant chemoradiation (NCRT) and total neoadjuvant therapy (TNT) has been associated with decreasing number of LNH. We hypothesize that as tumor response to neoadjuvant therapy increases, the optimum for LNH to achieve appropriate nodal staging should decrease. METHODS: Patients with clinical stage III rectal adenocarcinoma who underwent NCRT/TNT followed by resection were identified from the National Cancer Database...
January 14, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38157991/digitally-assessed-lymphocyte-infiltration-in-rectal-cancer-biopsies-is-associated-with-pathological-response-to-neoadjuvant-therapy
#12
JOURNAL ARTICLE
Dea Natalie Munch Jepsen, Henrik Høeg, Michael Bzorek, Adile Orhan, Jens Ole Eriksen, Ismail Gögenur, Björn Reiss, Anne-Marie Kanstrup Fiehn
A frequently used treatment strategy in locally advanced rectal cancer (RC) is neoadjuvant therapy followed by surgery. Patients treated with neoadjuvant therapy achieve varying pathological response, and currently, predicting the degree of response is challenging. This study examined the association between digitally assessed histopathological features in the diagnostic biopsies and pathological response to neoadjuvant therapy, aiming to find potential predictive biomarkers. 50 patients with RC treated with neoadjuvant chemotherapy and/or radiotherapy followed by surgery were included...
December 27, 2023: Human Pathology
https://read.qxmd.com/read/38147435/pathological-features-modified-tnm-staging-system-improves-prognostic-accuracy-for-rectal-cancer
#13
JOURNAL ARTICLE
Yuesheng Yang, Zifeng Yang, Zejian Lyu, Kaibo Ouyang, Junjiang Wang, Deqing Wu, Yong Li
BACKGROUND: Variations in survival outcomes are observed in the American Joint Committee on Cancer's 8th edition TNM staging system. OBJECTIVE: Machine learning ensemble methods were used to develop and evaluate the effectiveness of a pathological-features-modified tumor node metastasis staging system in predicting survival for patients with rectal cancer by using commonly reported pathological features, such as histological grade, tumor deposits, and perineural invasion, to improve the prognostic accuracy...
December 26, 2023: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38138297/prognostic-value-of-tumor-volume-tumor-volume-reduction-rate-and-magnetic-resonance-tumor-regression-grade-in-rectal-cancer
#14
JOURNAL ARTICLE
Ingrida Pikūnienė, Vestina Strakšytė, Algidas Basevičius, Justas Žilinskas, Rita Ambrazienė, Rasa Jančiauskienė, Žilvinas Saladžinskas
Background and Objectives : Rectal cancer poses significant treatment challenges, especially in advanced stages. Radiologic assessment, particularly with MRI, is critical for surgeons and oncologists to understand tumor dynamics and tailor treatment strategies to improve patient outcomes. The purpose of this study was to correlate MRI-based tumor volumetric and tumor regression grade analysis in patients with advanced rectal cancer, assessing the impact of preoperative chemotherapy (CT) alone or chemoradiotherapy (CRT) on surgical technique choices...
December 18, 2023: Medicina
https://read.qxmd.com/read/38137759/predictive-value-of-the-interaction-between-cea-and-hemoglobin-in-neoadjuvant-ccrt-outcomes-in-rectal-cancer-patients
#15
JOURNAL ARTICLE
Yi-Hsuan Lai, Yu-Tien Chang, Yu-Jia Chang, Jo-Ting Tsai, Ming-Hsien Li, Jang-Chun Lin
The adoption of neoadjuvant concurrent chemoradiotherapy (CCRT) has reshaped the therapeutic landscape, but response prediction remains challenging. This study investigates the interaction between pre-CCRT carcinoembryonic antigen (CEA) and post-CCRT hemoglobin (Hb) levels in predicting the response of locally advanced rectal cancer (LARC) to CCRT. Retrospective data from 93 rectal cancer patients receiving neoadjuvant CCRT were analyzed. Univariate analyses assessed clinical factors associated with tumor regression grade (TRG) and T-stage outcomes...
December 14, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38135624/preoperative-noninvasive-evaluation-of-tumor-budding-in-rectal-cancer-using-multiparameter-mri-radiomics
#16
JOURNAL ARTICLE
Lin Peng, Dongqing Wang, Zijian Zhuang, Xingchi Chen, Jing Xue, Haitao Zhu, Lirong Zhang
RATIONALE AND OBJECTIVES: To assess the value of a multiparametric magnetic resonance imaging (MRI)-based model integrating radiomics features with clinical and MRI semantic features for preoperative evaluation of tumor budding (TB) in rectal cancer. MATERIALS AND METHODS: A total of 120 patients with pathologically confirmed rectal cancer were retrospectively analyzed. The patients were randomized into training and validation cohorts in a 6:4 ratio. Radiomics features were extracted and selected from preoperative T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast-enhanced T1-weighted imaging (T1CE) sequences, after which the corresponding radiomics score (RS) was calculated, and the radiomics models (T2WI model, DWI model, and T1CE model) were constructed...
December 21, 2023: Academic Radiology
https://read.qxmd.com/read/38106864/predicting-positive-radial-margin-on-restaging-mri-of-patients-with-low-rectal-cancer-can-we-do-better
#17
JOURNAL ARTICLE
Anurima Patra, Aisha Lakhani, Antony Augustine, Priyanka Mohapatra, Anu Eapen, Ashish Singh, Dipti Masih, Thomas S Ram, Mark R Jesudason, Rohin Mittal, Anuradha Chandramohan
Objective  The aim of this study was to characterize the tissue involving the margin and study if this information will affect margin prediction on restaging magnetic resonance imaging (MRI) in low rectal adenocarcinoma (LRC) patients treated with neoadjuvant long-course chemoradiotherapy (LCCRT). Methods  In this retrospective study of nonmetastatic LRC (distal margin <5 cm from the anal verge) treated with LCCRT followed by surgery, a radiologist blinded to outcome reread the restaging MRI and documented if the radial margin was involved by tumor, fibrosis, or mucin reaction using T2 high-resolution (HR) and diffusion-weighted imaging (DWI)...
January 2024: Indian Journal of Radiology & Imaging
https://read.qxmd.com/read/38106857/evaluation-of-an-objective-mri-based-tumor-regression-grade-mrtrg-score-and-a-subjective-likert-score-for-assessing-treatment-response-in-locally-advanced-rectal-cancers-a-retrospective-study
#18
JOURNAL ARTICLE
Aparna N Katdare, Akshay D Baheti, Sayali Y Pangarkar, Kunal A Mistry, Suman K Ankathi, Purvi D Haria, Amit J Choudhari, Amrita Guha, Kunal Gala, Nitin Shetty, Suyash Kulkarni, Mukta Ramadwar, Munita Bal
Purpose:  Magnetic resonance imaging (MRI) with the help of MRI-based tumor regression grade (mrTRG) score has been used as a tool to predict pathological tumor regression grade (pTRG) in patients of rectal cancer post-neoadjuvant chemoradiation. Our study aims to evaluate the ability of MRI in assessing treatment response comparing an objective mrTRG score and a subjective Likert score, with a focus on the ability to predict pathologic complete response (pCR). Methods:  Post-treatment MRI studies were retrospectively reviewed for 170 consecutive cases of histopathologically proven rectal cancer after receiving neoadjuvant chemoradiation and prior to surgery by two oncoradiologists blinded to the eventual postoperative histopathology findings...
January 2024: Indian Journal of Radiology & Imaging
https://read.qxmd.com/read/38074647/body-composition-parameters-combined-with-blood-biomarkers-and-magnetic-resonance-imaging-predict-responses-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#19
JOURNAL ARTICLE
Jianguo Yang, Qican Deng, Zhenzhou Chen, Yajun Chen, Zhongxue Fu
AIM: To investigate whether body composition parameters combined with systemic inflammatory markers and magnetic resonance imaging (MRI) can predict the pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT) in locally advanced rectal cancer (LARC). METHODS: A retrospective analysis of data on LARC patients treated with NCTR and radical surgery between January 2013 and May 2023 was performed. Body composition parameters were assessed by measuring the skeletal muscle index (SMI), subcutaneous adipose index (SAI), and visceral adipose index (VAI) at the third lumbar vertebra level by computed tomography (CT)...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38051436/the-ypt-may-better-predict-the-efficacy-of-neoadjuvant-chemoradiotherapy-than-tumor-regression-grade-in-locally-advanced-rectal-cancer-patients-diagnosed-ypt1-4n0
#20
JOURNAL ARTICLE
Yujun Cui, Xinzhi Liu, Shuai Li, Hongzhi Wang, Yirong Xiang, Yangzi Zhang, Maxiaowei Song, Jianhao Geng, Zhiyan Liu, Huajing Teng, Xianggao Zhu, Yong Cai, Yongheng Li, Weihu Wang
PURPOSE: This study aimed to assess the impact of ypT stage and tumor regression grade (TRG) on the long-term prognosis of patients with locally advanced rectal cancer (LARC) stage ypT1-4N0 after neoadjuvant chemoradiotherapy (NCRT). METHODS: We retrospectively analyzed 585 patients with histologically diagnosed middle-low LARC (cT3-4 or cN + by pelvic MRI) from 2014 to 2019. All patients underwent NCRT, followed by total mesorectal excision. Disease-free survival (DFS) rates were compared among patients with different ypT stages and TRGs by Kaplan-Meier survival analysis...
December 5, 2023: Clinical & Translational Oncology
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