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https://www.readbyqxmd.com/read/27924979/the-mechanism-of-selective-catalytic-reduction-of-nox-on-cu-ssz-13-a-computational-study
#1
Douglas W Crandell, Haiyang Zhu, Xiaofan Yang, John Hochmuth, Mu-Hyun Baik
The copper-exchanged aluminosilicate zeolite SSZ-13 is a leading catalyst for the selective catalytic reduction of NO. Density functional theory calculations are used to construct a complete catalytic cycle of this process paying special attention to the coordination geometries and redox states of copper. N2 can be produced in the reduction half-cycle via a nitrosamine intermediate generated from the reaction of the additive reductant NH3 with a NO(+) intermediate stabilized by the zeolite lattice. The decomposition of this nitrosamine species can be assisted by incipient Brønsted acid sites generated during catalysis...
December 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27924705/long-term-air-pollution-and-traffic-noise-exposures-and-cognitive-function-a-cross-sectional-analysis-of-the-heinz-nixdorf-recall-study
#2
Lilian Tzivian, Martha Dlugaj, Angela Winkler, Frauke Hennig, Kateryna Fuks, Dorothee Sugiri, Tamara Schikowski, Hermann Jakobs, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Barbara Hoffmann, Christian Weimar
Investigations of adverse effects of air pollution (AP) and ambient noise on cognitive functions are apparently scarce, and findings seem to be inconsistent. The aim of this study was to examine the associations of long-term exposure to AP and traffic noise with cognitive performance. At the second examination of the population-based Heinz Nixdorf Recall study (2006-2008), cognitive performance was evaluated in 4086 participants. Long-term residential exposure to size-specific particulate matter (PM) and nitrogen oxides (NOx) with land use regression, to and traffic noise (weighted 24-h (LDEN) and nighttime (LNIGHT) means), was assessed according to the European Union (EU) Directive 2002/49/EC...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27924617/cxcl12-sdf-1-dependent-retinal-migration-of-endogenous-bone-marrow-derived-stem-cells-improves-visual-function-after-pharmacologically-induced-retinal-degeneration
#3
Volker Enzmann, Stéphanie Lecaudé, Anna Kruschinski, Axel Vater
Mobilized bone marrow-derived stem cells (BMSC) have been discussed as an alternative strategy for endogenous repair. Thereby, different approaches for BMSC mobilization have been pursued. Herein, the role of a newly discovered oligonucleotide for retinal homing and regeneration capability of BMSCs was investigated in the sodium iodate (NaIO3) model of retinal degeneration. Mobilization was achieved in GFP-chimera with NOX-A12, a CXC-motif chemokine ligand 12 (CXCL12)/stromal cell-derived factor 1 (SDF-1)-neutralizing L-aptamer...
December 6, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27924425/inhibition-of-nlrp3-inflammasome-prevents-lps-induced-inflammatory-hyperalgesia-in-mice-contribution-of-nf-%C3%AE%C2%BAb-caspase-1-11-asc-nox-and-nos-isoforms
#4
Abdurrahman Dolunay, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Demet Sinem Guden, Ayse Nihal Sari, Seyhan Sahan-Firat, Bahar Tunctan
The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), an intracellular signaling molecule that senses many environmental- and pathogen/host-derived factors, has been implicated in the pathogenesis of several diseases associated with inflammation. It has been suggested that NLRP3 inflammasome inhibitors may have a therapeutic potential in the treatment of NLRP3-related inflammatory diseases. The aim of this study was to determine whether inhibition of NLRP3 inflammasome prevents inflammatory hyperalgesia induced by lipopolysaccharide (LPS) in mice as well as changes in expression/activity of nuclear factor κB (NF-κB), caspase-1/11, nicotinamide adenine dinucleotide phosphate oxidase (NOX), and endothelial/neuronal/inducible nitric oxide synthase (eNOS/nNOS/iNOS) that may regulate NLRP3/apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)/pro-caspase-1 inflammasome formation and activity by using a selective NLRP3 inflammasome inhibitor, MCC950...
December 6, 2016: Inflammation
https://www.readbyqxmd.com/read/27924150/increasing-n-butanol-production-with-saccharomyces-cerevisiae-by-optimizing-acetyl-coa-synthesis-nadh-levels-and-trans-2-enoyl-coa-reductase-expression
#5
Virginia Schadeweg, Eckhard Boles
BACKGROUND: n-Butanol can serve as an excellent gasoline substitute. Naturally, it is produced by some Clostridia species which, however, exhibit only limited suitability for industrial n-butanol production. The yeast Saccharomyces cerevisiae would be an ideal host due to its high robustness in fermentation processes. Nevertheless, n-butanol yields and titers obtained so far with genetically engineered yeast strains are only low. RESULTS: In our recent work, we showed that n-butanol production via a clostridial acetoacetyl-CoA-derived pathway in engineered yeast was limited by the availability of coenzyme A (CoA) and cytosolic acetyl-CoA...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27916493/free-amino-acid-concentrations-and-nitrogen-isotope-signatures-in-pinus-massoniana-lamb-needles-of-different-ages-for-indicating-atmospheric-nitrogen-deposition
#6
Yu Xu, Huayun Xiao
Free amino acid concentrations and nitrogen (N) isotopic composition in new current-year (new), mature current-year (middle-aged) and previous-year (old) Masson pine (Pinus massoniana Lamb.) needles were determined to indicate atmospheric N deposition in Guiyang (SW China). In different areas, free amino acids (especially arginine) concentrations in new and middle-aged needles were higher than in old needles, and the variation of free amino acids (especially arginine) concentrations in new and middle-aged needles was also greater than in old needles...
December 1, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27916311/land-use-regression-modeling-of-ultrafine-particles-ozone-nitrogen-oxides-and-markers-of-particulate-matter-pollution-in-augsburg-germany
#7
Kathrin Wolf, Josef Cyrys, Tatiana Harciníková, Jianwei Gu, Thomas Kusch, Regina Hampel, Alexandra Schneider, Annette Peters
Important health relevance has been suggested for ultrafine particles (UFP) and ozone, but studies on long-term effects are scarce, mainly due to the lack of appropriate spatial exposure models. We designed a measurement campaign to develop land use regression (LUR) models to predict the spatial variability focusing on particle number concentration (PNC) as indicator for UFP, ozone and several other air pollutants in the Augsburg region, Southern Germany. Three bi-weekly measurements of PNC, ozone, particulate matter (PM10, PM2...
December 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27916309/optical-properties-of-secondary-organic-aerosols-derived-from-long-chain-alkanes-under-various-nox-and-seed-conditions
#8
Junling Li, Kun Li, Weigang Wang, Jing Wang, Chao Peng, Maofa Ge
Long-chain alkanes are a type of important intermediate-volatile organic compounds (IVOCs) in the atmosphere, which contribute to a large proportion of secondary organic aerosol (SOA). However, the optical properties of SOA derived from long-chain alkanes remain poorly understood. Here, we investigate the refractive index (RI) of SOA derived from photo-oxidation of dodecane (C12), pentadecane (C15) and heptadecane (C17) under low-NOx and high-NOx conditions with the absence or presence of inorganic aerosol seeds...
December 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27916307/summertime-ambient-ammonia-and-its-effects-on-ammonium-aerosol-in-urban-beijing-china
#9
Zhaoyang Meng, Weili Lin, Renjian Zhang, Zhiwei Han, Xiaofang Jia
To improve the understanding of NH3 variation in urban Beijing, high temporal resolution (1-min averaged) NH3 data derived during the summer of 2009 were analyzed. The results indicated that after rain there was generally an increase in NH3 concentration. The analysis of the 1-min data revealed that a weak but significant linear correlation existed between NH3 and NOx in August, indicating a connection between NH3 concentrations and traffic levels during summer. This was further supported by peak NH3 levels approximately coinciding with morning rush hours...
December 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27915400/the-pathophysiological-role-of-nox2-in-hypertension-and-organ-damage
#10
REVIEW
Maurizio Forte, Cristina Nocella, Elena De Falco, Silvia Palmerio, Leonardo Schirone, Valentina Valenti, Giacomo Frati, Roberto Carnevale, Sebastiano Sciarretta
NADPH oxidases (NOXs) represent one of the major sources of reactive oxygen species in the vascular district. Reactive oxygen species are responsible for vascular damage that leads to several cardiovascular pathological conditions. Among NOX isoforms, NOX2 is widely expressed in many cells types, such as cardiomyocytes, endothelial cells, and vascular smooth muscle cells, confirming its pivotal role in vascular pathophysiology. Studies in mice models with systemic deletion of NOX2, as well as in transgenic mice overexpressing NOX2, have demonstrated the undeniable involvement of NOX2 in the development of hypertension, atherosclerosis, diabetes mellitus, cardiac hypertrophy, platelet aggregation, and aging...
December 3, 2016: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/27913300/suppression-of-nadph-oxidase-attenuates-hypoxia-induced-dysfunctions-of-endothelial-progenitor-cells
#11
Bin Liu, Kai-Di Ren, Jing-Jie Peng, Tao Li, Xiu-Ju Luo, Chengming Fan, Jin-Fu Yang, Jun Peng
NADPH oxidases (NOX) - derived reactive oxygen species (ROS) contribute to oxidative injury in hypoxia-induced pulmonary arterial hypertension. This study aims to evaluate the status of NOX in endothelial progenitor cells (EPCs) under hypoxic condition and to determine whether NOX inhibitors could attenuate hypoxia-induced dysfunctions of EPCs. EPCs were isolated from peripheral blood of SD rats and subjected to hypoxia (O2/N2/CO2, 1/94/5) for 24 h. The cells were collected for β-galactosidase or Hoechst staining, or for functional analysis (migration, adhesion and tube formation)...
November 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27913188/fructose-suppresses-uric-acid-excretion-to-the-intestinal-lumen-as-a-result-of-the-induction-of-oxidative-stress-by-nadph-oxidase-activation
#12
Chihiro Kaneko, Jiro Ogura, Shunichi Sasaki, Keisuke Okamoto, Masaki Kobayashi, Kaori Kuwayama, Katsuya Narumi, Ken Iseki
BACKGROUND: A high intake of fructose increases the risk for hyperuricemia. It has been reported that long-term fructose consumption suppressed renal uric acid excretion and increased serum uric acid level. However, the effect of single administration of fructose on excretion of uric acid has not been clarified. METHODS: We used male Wistar rats, which were orally administered fructose (5g/kg). Those rats were used in each experiment at 12h after administration...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27912197/rac1-nadph-oxidase-signaling-promotes-cd36-activation-under-glucotoxic-conditions-in-pancreatic-beta-cells
#13
Suma Elumalai, Udayakumar Karunakaran, In Kyu Lee, Jun Sung Moon, Kyu Chang Won
We recently reported that cluster determinant 36 (CD36), a fatty acid transporter, plays a pivotal role in glucotoxicity-induced β-cell dysfunction. However, little is known about how glucotoxicity influences CD36 expression. Emerging evidence suggests that the small GTPase Rac1 is involved in the pathogenesis of beta cell dysfunction in type 2 diabetes (T2D). The primary objective of the current study was to determine the role of Rac1 in CD36 activation and its impact on β-cell dysfunction in diabetes mellitus...
November 23, 2016: Redox Biology
https://www.readbyqxmd.com/read/27912196/nox-isoforms-in-the-development-of-abdominal-aortic-aneurysm
#14
Kin Lung Siu, Qiang Li, Yixuan Zhang, Jun Guo, Ji Youn Youn, Jie Du, Hua Cai
Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal role of uncoupled eNOS in this severe human disease. We have also shown that activation of NADPH oxidase (NOX) lies upstream of uncoupled eNOS. Therefore, identification of the specific NOX isoforms that are required for eNOS uncoupling and AAA formation would ultimately lead to novel therapies for AAA. In the present study, we used the Ang II infused hph-1 mice to examine the roles of NOX isoforms in the development of AAA...
November 19, 2016: Redox Biology
https://www.readbyqxmd.com/read/27912150/calea-uniflora-less-attenuates-the-inflammatory-response-to-carrageenan-induced-pleurisy-in-mice
#15
Julia Salvan da Rosa, Silvana Virginia Gagliotti Vigil de Mello, Geison Vicente, Yeo Jim K Moon, Felipe Perozzo Daltoé, Tamires Cardoso Lima, Rafaela de Jesus Souza, Maique Weber Biavatti, Tânia Silvia Fröde
Calea uniflora Less. (family Asteraceae), also named "arnica" and "erva-de-lagarto", is a native plant to the South and Southeast of Brazil. This species was used to treat rheumatism, respiratory diseases, and digestive problems in Brazilian folk medicine. In vitro studies have shown the important biological effects of C. uniflora. However no studies have focused on the mechanism of action of anti-inflammatory activity of C. uniflora. The aim of this study was to evaluate the anti-inflammatory effects of the crude extract, its fractions, and isolated compounds obtained from of C...
November 29, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27910195/mulberrofuran-g-protects-ischemic-injury-induced-cell-death-via-inhibition-of-nox4-mediated-ros-generation-and-er-stress
#16
Sungeun Hong, Jaeyoung Kwon, Dong-Woo Kim, Hak Ju Lee, Dongho Lee, Woongchon Mar
The aim of this study was to investigate the neuroprotective effect of mulberrofuran G (MG) in in vitro and in vivo models of cerebral ischemia. MG was isolated from the root bark of Morus bombycis. MG inhibited nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzyme activity and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced NOX4 protein expression in SH-SY5Y cells. MG inhibited the expression of activated caspase-3 and caspase-9 and cleaved poly adenine dinucleotide phosphate-ribose polymerase in OGD/R-induced SH-SY5Y cells...
December 2, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27903507/hydroxychloroquine-inhibits-proinflammatory-signalling-pathways-by-targeting-endosomal-nadph-oxidase
#17
Nadine Müller-Calleja, Davit Manukyan, Antje Canisius, Dennis Strand, Karl J Lackner
OBJECTIVES: Hydroxychloroquine (HCQ) has been used for decades to treat patients with rheumatic diseases, for example, systemic lupus erythematosus (SLE), rheumatoid arthritis or the antiphospholipid syndrome (APS). We hypothesise that HCQ might target endosomal NADPH oxidase (NOX), which is involved in the signal transduction of cytokines as well as antiphospholipid antibodies (aPL). METHODS: For in vitro experiments, monocytic cells were stimulated with tumour necrosis factor α (TNFα), interleukin-1β (IL-1β) or a human monoclonal aPL and the activity of NOX was determined by flow cytometry...
November 30, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27903268/long-term-outdoor-air-pollution-and-dna-methylation-in-circulating-monocytes-results-from-the-multi-ethnic-study-of-atherosclerosis-mesa
#18
Gloria C Chi, Yongmei Liu, James W MacDonald, R Graham Barr, Kathleen M Donohue, Mark D Hensley, Lifang Hou, Charles E McCall, Lindsay M Reynolds, David S Siscovick, Joel D Kaufman
BACKGROUND: DNA methylation may mediate effects of air pollution on cardiovascular disease. The association between long-term air pollution exposure and DNA methylation in monocytes, which are central to atherosclerosis, has not been studied. We investigated the association between long-term ambient air pollution exposure and DNA methylation (candidate sites and global) in monocytes of adults (aged ≥55). METHODS: One-year average ambient fine particulate matter (PM2...
December 1, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27899246/pilot-scale-evaluation-of-a-novel-tio2-supported-v2o5-catalyst-for-denox-at-low-temperatures-at-a-waste-incinerator
#19
Hyounduk Jung, Eunseuk Park, Minsu Kim, Jongsoo Jurng
The removal of NOx by catalytic technology at low temperatures is significant for treatment of flue gas in waste incineration plants, especially at temperatures below 200°C. A novel highly active TiO2-supported vanadium oxide catalyst at low temperatures (200-250°C) has been developed for the selective catalytic reduction (SCR) de-NOx process with ammonia. The catalyst was evaluated in a pilot-scale equipment, and the results were compared with those obtained in our previous work using laboratory scale (small volume test) equipment as well as bench-scale laboratory equipment...
November 26, 2016: Waste Management
https://www.readbyqxmd.com/read/27898285/comparative-proteomics-reveals-the-potential-targets-of-bcnoxr-a-putative-regulatory-subunit-of-nadph-oxidase-of-bortytis-cinerea
#20
Hua Li, Zhanquan Zhang, Chang He, Guozheng Qin, Shiping Tian
The NADPH oxidase complex (NOX) has been shown to play a crucial role in stress response and in the virulence of various fungal pathogens. The underlying molecular mechanisms of NOX, however, remain largely unknown. In the present study, a comparative proteomic analysis compared changes in protein abundance in wild-type Botrytis cinerea and ΔbcnoxR mutants in which the regulatory subunit of NOX was deleted. The ΔbcnoxR mutants exhibited reduced growth, sporulation, and impaired virulence. A total of 60 proteins, representing 49 individual genes, were identified in ΔbcnoxR mutants that exhibited significant differences in abundance relative to wild-type...
November 29, 2016: Molecular Plant-microbe Interactions: MPMI
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