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Treg HBV virus

Soheil Tavakolpour, Seyed Moayed Alavian, Shahnaz Sali
BACKGROUND: Identification of effective treatments in hepatitis B virus (HBV) infection remains a controversial topic. Although the currently approved drugs for HBV control the disease's progression and also limit associated outcomes, these drugs may not fully eradicate HBV infection. In addition to better managing patients with chronic hepatitis B (CHB) infection, the induction of seroclearance by these drugs has been a commonly discussed topic in recent years. OBJECTIVES: In this study, we focused on treating CHB infection via the manipulation of T cells' responses to identify possible approaches to cure CHB...
June 2016: Hepatitis Monthly
Joselyn Rojas, Guillermo Teran-Angel, Luisa Barbosa, Darrell L Peterson, Lisbeth Berrueta, Siham Salmen
Foxp3 is considered to be the master regulator for the development and function of regulatory T cells (Treg). Recently Foxp3, has been detected in extra lymphoid tissue, and in hepatocytes and has been associated with hepatocellular carcinoma (HCC), although its role has not been defined. Since it is expected that there is a relationship between protein localization, activity and cellular function, the aim of this study was to explore the subcellular localization of Foxp3 in resting and stimulated human hepatocytes...
May 1, 2016: Experimental Cell Research
Kirsten K Dietze, Simone Schimmer, Freya Kretzmer, Junzhong Wang, Yong Lin, Xuan Huang, Weimin Wu, Baoju Wang, Mengji Lu, Ulf Dittmer, Dongliang Yang, Jia Liu
Regulatory T cells (Tregs) play an important role in counter-regulating effector T cell responses in many infectious diseases. However, they can also contribute to the development of T cell dysfunction and pathogen persistence in chronic infections. Tregs have been reported to suppress virus-specific T cell responses in hepatitis B virus (HBV) infection of human patients as well as in HBV animal models. However, the phenotype and expansion of Tregs has so far only been investigated in other infections, but not in HBV...
2016: PloS One
Yun Liu, Li-Sha Cheng, Sheng-di Wu, Si-Qi Wang, Lei Li, Wei-Min She, Jing Li, Ji-Yao Wang, Wei Jiang
Non-specific immune responses to antigens have been demonstrated as being enhanced during chronic hepatitis B virus (HBV) infection. Here, we evaluated the role of interleukin-10 (IL-10)-producing regulatory B-cells (Bregs) in the pathogenesis of HBV-related liver fibrosis (HBV-LF) and assessed their immunoregulatory effects. Sixty-seven patients diagnosed with chronic hepatitis B (CHB) were enrolled in this study. Numbers and frequencies of peripheral B-cells (memory CD19(+)CD24(hi)CD27(+) cells, immature/transitional CD19(+)CD24(hi)CD38(hi) cells, mature CD19(+)CD24(int)CD38(int) cells) were tested and analysed...
June 1, 2016: Clinical Science (1979-)
Jiezuan Yang, Guoping Sheng, Dangsheng Xiao, Haiyan Shi, Wei Wu, Haifeng Lu, Hongcui Cao, Lanjuan Li
The frequency and T-cell receptor beta-chain variable (TCRBV) patterns of peripheral CD4(+)CD25(+) regulatory T-cells (Tregs) are ambiguously altered in chronic hepatitis B (CHB) patients following tenofovir disoproxil fumarate (TDF) treatment. Moreover, the clinical significance of these parameters in relation to hepatitis B e antigen (HBeAg) seroconversion (SC) is largely unknown. In this study, the circulation of Tregs in HBeAg-positive CHB patients was determined by flow cytometry, and the molecular profiles of frequent TCRBV patterns of Tregs were analyzed using a gene melting spectral pattern...
September 2016: Cellular & Molecular Immunology
Zhan-Fei Tian, Zhong-Lan You, Hong Yi, Xue-Mei Kuang, Yu-Ming Wang
UNLABELLED:  Background and aims. CD4+ T cells play an important role in response to hepatitis B virus (HBV) infection. We investigated the change in CD4+ T-cell subpopulations and viral load in patients with chronic HBV infection who were treated with entecavir. MATERIAL AND METHODS: Thirty patients with chronic HBV infection were enrolled according to the criteria recommended by the Chinese Society of Infectious Diseases and the Chinese Society of Hepatology...
March 2016: Annals of Hepatology
G Zhang, W Wang, S Li, H Yang, M Zhang, P Zhang, Y Wen, A Wu, L Yang, B Zhou, X Chen
Interleukin-6 (IL-6) has an important role in the pathogenesis of chronic viral hepatitis and related liver diseases. Although host genetics associated with the response to anti-viral treatment have been reported, little is known about the relationship between IL6 genetic polymorphisms and the outcome of hepatitis B virus (HBV) infection. In this study, we determined the genotype distribution of rs1800796 polymorphism in healthy controls and cases including chronic HBV (CHB), hepatitis C virus and HIV infection...
December 2015: Genes and Immunity
Yinjie Gao, Min Zhang, Jin Li, Mei Yang, Yuan Liu, Xiaodong Guo, Hanwei Li, Zhenwen Liu, Jingmin Zhao
OBJECTIVE: To longitudinally investigate the role of FoxP3+ Regulatory T cells (Treg) and interleukin17-producing T helper 17 cells (Th17) in De Novo Hepatitis B Virus infection after orthotopic Liver Transplantation (DNHB-OLT), and analyze the possible correlation between these cells and HBV clearance of the disease. METHODS: We enrolled 12 control cases after orthotopic Liver Transplantation (OLT) and 24 patients, including 12 diagnosed with DNHB-OLT and 12 diagnosed with Acute Hepatitis B Virus infection (AHB), into the study from the liver transplantation and research center at Beijing 302 Hospital...
2015: PloS One
Hao Feng, Jie Yin, Ya-Ping Han, Xiao-Ying Zhou, Su Chen, Li Yang, Jin-Rui Yan, Guo-Xin Zhang
Hepatitis B is a worldwide infectious disease caused by hepatitis B virus (HBV), it leaded to millions of deaths every year, HBV mainly through immune response to damage liver cells. The purpose of this study was to judge the value of Regulatory T cells (Treg) and IL-17(+) T helper cells (Th17) in different chronic HBV infection stages. 96 patients with chronic HBV infection were enrolled and selected 33 healthy adults as control. Detected the expression of Treg and Th17 cells in peripheral blood by flow cytometry and assayed liver function simultaneously...
2015: International Journal of Clinical and Experimental Medicine
Chao Feng, Li-Juan Cao, Hua-Feng Song, Ping Xu, Hui Chen, Jun-Chi Xu, Xiao-Yan Zhu, Xue-Guang Zhang, Xue-Feng Wang
Regulatory T cells (Tregs) play a pivotal role in suppressing specific antiviral immune responses during the progression of chronic hepatitis B virus infection (CHB) as well as tumorigenesis. Programmed death-1 ligand-1 (PD-L1) expressed on Tregs can transduce an inhibitory signal into effector T cells through interacting with programmed death-1 (PD-1). However, in CHB patients, the clinical significance of PD-L1 expression on Tregs has not been clearly described. This study investigated the frequency of circulating Tregs and PD-L1 expression on Tregs and analyzed their correlations with clinical parameters...
October 2015: Viral Immunology
Hao Feng, Jie Yin, Ya-Ping Han, Xiao-Ying Zhou, Su Chen, Li Yang, Jin-Rui Yan, Guo-Xin Zhang
Chronic hepatitis B (CHB) is a worldwide infectious disease caused by hepatitis B virus (HBV). HBV mainly damages liver cells through immune response. The purpose of this study was to determine whether there were dynamic changes of Treg and Th17 cells and to judge the value of these indicators to antiviral treatment. Twenty-two CHB patients and selected 30 healthy adults were enrolled. Results showed that the expression of Treg (5.72±0.46 vs. 4.42±0.17, p=0.0019) and Th17 (3.94±0.64 vs. 2.66±3.12, p=0.0436) cells was significantly increased in CHB patients, as well as the level of interleukin-17 (IL-17) (16...
October 2015: Viral Immunology
Yongyan Chen, Rui Sun, Xunyao Wu, Min Cheng, Haiming Wei, Zhigang Tian
CD4+CD25+ regulatory T cells (Tregs) are involved in the regulation of physiological and pathological hepatic immune responses, but the roles are not well explored in natural killer (NK) cell-mediated liver diseases. In this study, using the NK cell-mediated oversensitive liver injury model of hepatitis B virus transgenic (HBs-Tg) mice triggered by a low dose of concanavalin A, it was observed that an increased number of CD4+CD25+Foxp3+ Tregs were accumulated in the liver, along with the recovery of liver injury...
2016: Journal of Innate Immunity
Yuka Kowazaki, Yosuke Osawa, Jun Imamura, Kazuteru Ohashi, Hisashi Sakamaki, Kiminori Kimura
Patients with resolved hepatitis B virus (HBV) infection undergoing chemo- or immunosuppressive therapy are at potential risk for HBV reactivation. To determine whether the host immune response contributes to liver injury, we performed an immunological analysis of a patient with HBV reactivation. Consistent with the detection of HBV DNA in the sera, the number of polyclonal HBV-specific cytotoxic T lymphocytes (CTLs) gradually increased; however, the number of CD4(+)CD25(+) regulatory T cells (Treg) decreased...
2015: Internal Medicine
Maria Tagliamonte, Annacarmen Petrizzo, Maria Napolitano, Antonio Luciano, Claudio Arra, Piera Maiolino, Francesco Izzo, Maria Lina Tornesello, Luigi Aurisicchio, Gennaro Ciliberto, Franco M Buonaguro, Luigi Buonaguro
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and represents the third and the fifth leading cause of cancer-related death worldwide in men and women, respectively. Hepatitis B virus (HBV) and hepatitis C virus (HCV) chronic infections account for pathogenesis of more than 80 % of primary HCC. HCC prognosis greatly varies according to stage at beginning of treatment, but the overall 5-year survival rate is approximately 5-6 %. Given the limited number of effective therapeutic strategies available, immunotherapies and therapeutic cancer vaccines may help in improving the clinical outcome for HCC patients...
October 2015: Cancer Immunology, Immunotherapy: CII
Miao-Tzu Huang, Wei-Liang Liu, Chun-Wei Lu, Jian-Jhih Huang, Hsiao-Li Chuang, Yen-Te Huang, Jau-Haw Horng, Peng Liu, Dai-Shu Han, Bor-Luen Chiang, Chiaho Shih, Pei-Jer Chen, Ding-Shinn Chen
Hepatitis B virus (HBV) is known to cause age-dependent infection outcomes wherein most infections during young age result in chronicity. The mechanism underlying the differential outcome remains elusive. By using hydrodynamic injection of the replication-competent pAAV-HBV, we established a mouse model in which HBV persistence was generated in 4-5 w/o C57BL/6 young mice, but not in adult mice over 10 w/o. HBV-tolerant young mice expressed higher interferon (IFN)-α/β levels in hepatocytes and intrahepatic plasmacytoid DCs (pDCs) than adult mice after pAAV-HBV injection...
June 2015: European Journal of Immunology
Shreya Sharma, Ritu Khosla, Paul David, Archana Rastogi, Ashish Vyas, Dileep Singh, Ankit Bhardwaj, Amrish Sahney, Rakhi Maiwall, Shiv Kumar Sarin, Nirupma Trehanpati
BACKGROUND: Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide and hepatitis B is one of the commonest causes. T regulatory cells (Tregs) are strong immunomodulators and are likely to play a major role in HCC development. HBV infection is reported to induce expansion of Tregs. We investigated the CD4+CD25+CD127(-ve)FoxP3+ Tregs in HBV-related HCC as compared to non-HBV-HCC. PATIENTS AND METHODS: Whole blood immunophenotyping was analyzed by multicolor flow cytometry in patients with HBV-related HCC (HBV-HCC, n = 17), non-HBV-HCC (n = 22; NASH = 16, alcohol-related = 6), and chronic hepatitis B infection (CHBV; n = 10)...
2015: Frontiers in Immunology
Yasuteru Kondo, Tooru Shimosegawa
The adaptive immune system, including type1 helper T cells (Th1 cells), cytotoxic T lymphocytes (CTLs), and dendritic cells (DCs), plays an important role in the control of hepatitis B virus (HBV). On the other hand, regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) suppress the immune reaction in HBV and hepatocellular carcinoma (HCC). Excessive activation of immune suppressive cells could contribute to the persistent infection of HBV and the progression of HCC. The frequency and/or function of Tregs could affect the natural course in chronic hepatitis B patients and the treatment response...
2015: International Journal of Molecular Sciences
Yi Chen, Jiankai Fang, Xuzheng Chen, Chen Pan, Xiaolong Liu, Jingfeng Liu
The extent to which T-cell-mediated immunity is impaired in patients with hepatitis B virus (HBV) infection remains controversial. In addition, the role of T regulatory (Treg) and T helper 17 (Th17) cells and their associated cytokines in immunity is not clear. In the present study, peripheral blood samples were collected from 44 patients with chronic hepatitis B virus, 14 asymptomatic hepatitis B carriers, 19 patients with liver cirrhosis and 20 healthy individuals. Flow cytometry was used to detect the percentages of T cell subsets in the samples, including CD3(+), CD4(+) and CD8(+) T cells, Treg cells and Th17 cells...
February 2015: Experimental and Therapeutic Medicine
Xuefen Li, Xia Liu, Li Tian, Yu Chen
Hepatitis B virus (HBV) infection is a worldwide health problem, with approximately one third of populations have been infected, among which 3-5% of adults and more than 90% of children developed to chronic HBV infection. Host immune factors play essential roles in the outcome of HBV infection. Thus, ineffective immune response against HBV may result in persistent virus replications and liver necroinflammations, then lead to chronic HBV infection, liver cirrhosis, and even hepatocellular carcinoma. Cytokine balance was shown to be an important immune characteristic in the development and progression of hepatitis B, as well as in an effective antiviral immunity...
February 2016: Clinical Reviews in Allergy & Immunology
Xiao Gang Xiang, Qing Xie
Interleukin (IL)-35, a recently identified cytokine of the IL-12 family, is a potent immunosuppressive cytokine secreted by regulatory T (Treg) cells and the newly reported regulatory B (Breg) cells. IL-35 functions as a crucial immunosuppressive factor in immune-mediated diseases, and the predominant mechanism of suppression is its ability to suppress T cell proliferation and effector functions. The pathogenic processes of the non-cytopathic hepatitis B virus (HBV) infection-related liver diseases are immune-mediated, including liver damage and viral control...
January 2015: Journal of Digestive Diseases
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