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https://www.readbyqxmd.com/read/28399886/levels-of-hepatic-th17-cells-and-regulatory-t-cells-upregulated-by-hepatic-stellate-cells-in-advanced-hbv-related-liver-fibrosis
#1
Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li, Zhiliang Gao
BACKGROUND: Liver fibrosis which mainly occurs upon chronic hepatitis virus infection potentially leads to portal hypertension, hepatic failure and hepatocellular carcinoma. However, the immune status of Th17 and Treg cells in liver fibrosis is controversial and the exact mechanisms remain largely elusive. METHODS: Liver tissues and peripheral blood were obtained simultaneously from 32 hepatitis B virus infected patients undergoing surgery for hepatocellular carcinoma at the medical center of Sun Yat-sen University...
April 11, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28329297/association-of-mutations-in-toll-like-receptor-2-signaling-genes-with-fulminant-form-of-hepatitis-b-related-acute-liver-failure
#2
Yue Han, Leilei Gu, Jing Liu, Xinhua Li, Mingjie Wang, Qiming Gong, Demin Yu, Zhitao Yang, Donghua Zhang, Huijuan Yang, Zhongliang Shen, Hongguang Zhu, Youhua Xie, Xinxin Zhang
Background.: The fulminant form of hepatitis B-related acute liver failure (FHB-ALF) is a rare but highly fatal outcome of acute hepatitis B virus (HBV) infection. Its related host factors have not been studied to our knowledge. Methods.: To identify functionally relevant biological pathway(8) in FHB-ALF pathogenesis, pathway enrichment analysis was conducted on a data set of rare case-specific variants derived from exomic sequencing of 10 unrelated cases. Key variants in identified pathways were validated using 312 controls with HBV disease...
April 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28295453/low-hepatitis-b-virus-specific-t-cell-response-in-males-correlates-with-high-regulatory-t-cell-numbers-in-murine-models
#3
Anna D Kosinska, Leila Pishraft-Sabet, Weimin Wu, Zhong Fang, Marzena Lenart, Jieliang Chen, Kirsten K Dietze, Cong Wang, Thekla Kemper, Yong Lin, Shiou-Hwei Yeh, Jia Liu, Ulf Dittmer, Zhenghong Yuan, Michael Roggendorf, Mengji Lu
Hepatitis B virus (HBV) infection shows significant gender-related differences in pathogenesis, disease progression, and development of hepatocellular carcinoma. The gender-associated differences in HBV replication and viral protein levels may be associated with distinct HBV-specific immune responses in the host. In the present study, we examined the impact of gender on HBV-specific immune responses in two different mouse models representing transient and persistent hepadnaviral infection; hydrodynamic injection (HI) with the HBV genome mimicked acute HBV infection, whereas the efficacy of therapeutic vaccination was studied in the woodchuck hepatitis virus (WHV) transgenic (Tg) mouse model...
March 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28273209/influence-of-treg-cells-and-hbv-genotype-on-sustained-response-and-drug-resistance-in-the-treatment-with-nucleoside-drugs
#4
Y R Zhang, B Li, C X Wang, N Zhou, W Qi, X L Li, L Y Wu, S F Wei, Y D Zhang
We aimed to investigate the influence of regulatory T cells including CD4+CD25+, CD8+CD28- and hepatitis B virus (HBV) genotype on sustained virological response and tolerance of nucleoside drugs. One hundred and thirty-seven patients were enrolled. Lamivudine was administered to 84 patients. Entecavir was administered to the other 53 patients. Before treatment, biochemical tests, HBV DNA load, HBV serum level, HBV genotype, PB CD3+, CD4+, CD8+, CD4+CD25+/CD3+, and CD8+CD28-/CD3+ frequencies were measured. Based on HBV DNA loads after 4 weeks of therapy, patients were divided into response group and suboptimal response group...
March 2, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28272219/predictive-value-of-serum-alt-and-t-cell-receptor-beta-variable-chain-for-hbeag-seroconversion-in-chronic-hepatitis-b-patients-during-tenofovir-treatment
#5
Jiezuan Yang, Dong Yan, Renyong Guo, Jiajia Chen, Yongtao Li, Jun Fan, Xuyan Fu, Xinsheng Yao, Hongyan Diao, Lanjuan Li
Effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis B (CHB). Identification of serum indices, including hepatitis B e antigen (HBeAg) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in HBeAg-positive CHB patients. The biochemical, serological, virological parameters, and the frequency of circulating CD4CD25 regulatory T cell (Treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of tenofovir disoproxil fumarate (TDF) treatment...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28259000/th17-treg-imbalance-and-increased-interleukin-21-are-associated-with-liver-injury-in-patients-with-chronic-severe-hepatitis-b
#6
Bin Liu, Wei Gao, Li Zhang, Jing Wang, Min Chen, Mingli Peng, Hong Ren, Peng Hu
BACKGROUND: Th17/Treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. The aim of the current study was to assess the Treg/Th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepatitis B virus (HBV) infection. METHODS: The proportions of peripheral Th17, Treg and Th1 cells in 7 patients classified as asymptomatic hepatitis B virus carriers (AsCs), 38 patients with low or moderate grade chronic hepatitis B (CHB-LM), 20 patients with chronic severe hepatitis B (CSHB), and 10 healthy controls (HCs) were determined by flow cytometry...
March 1, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28169127/th17-treg-imbalance-is-an-indicator-of-liver-cirrhosis-process-and-a-risk-factor-for-hcc-occurrence-in-hbv-patients
#7
Kun Li, Huaie Liu, Tao Guo
OBJECTIVE: To determine the impact of T helper 17 cell (Th17)/regulatory T cell (Treg) ratio imbalance on the process and prognosis of hepatitis B virus (HBV)-related liver cirrhosis. METHODS: Patients with HBV who refused to accept any therapy from were recruited from 2009 to 2014 and followed-up to August 2016. Based on a liver stiffness measurement (LSM), the patients were divided into a low LSM group and a high LSM group. After propensity score matching, 150 patients were included...
February 3, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28109025/immune-regulation-by-t-regulatory-cells-in-hepatitis-b-virus-related-inflammation-and-cancer
#8
REVIEW
N Trehanpati, A K Vyas
Hepatocellular carcinoma (HCC) is the leading cause of cancer death, and hepatitis B virus (HBV) infection is one of the commonest causes in Asian countries. India has the second largest pool after China for hepatitis B-infected subjects. HBV clearance is T cell dependent, and one of the reasons for T cells hyporesponsiveness is due to mass production of regulatory T cells (Tregs) through activation of Notch signalling, which suppress CD4/CD8 T cells. Tregs are important to maintain cellular homoeostasis; however, during viral infection increase of Tregs is inversely proportional to HBV DNA titres...
March 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28035208/regulatory-t-cells-in-hepatitis-b-and-c-virus-infections
#9
REVIEW
Min Kyung Jung, Eui-Cheol Shin
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4(+)CD25(+)Foxp3(+) Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage...
December 2016: Immune Network
https://www.readbyqxmd.com/read/27630728/manipulation-of-regulatory-cells-responses-to-treatments-for-chronic-hepatitis-b-virus-infection
#10
Soheil Tavakolpour, Seyed Moayed Alavian, Shahnaz Sali
BACKGROUND: Identification of effective treatments in hepatitis B virus (HBV) infection remains a controversial topic. Although the currently approved drugs for HBV control the disease's progression and also limit associated outcomes, these drugs may not fully eradicate HBV infection. In addition to better managing patients with chronic hepatitis B (CHB) infection, the induction of seroclearance by these drugs has been a commonly discussed topic in recent years. OBJECTIVES: In this study, we focused on treating CHB infection via the manipulation of T cells' responses to identify possible approaches to cure CHB...
June 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27068374/activation-dependent-mitochondrial-translocation-of-foxp3-in-human-hepatocytes
#11
Joselyn Rojas, Guillermo Teran-Angel, Luisa Barbosa, Darrell L Peterson, Lisbeth Berrueta, Siham Salmen
Foxp3 is considered to be the master regulator for the development and function of regulatory T cells (Treg). Recently Foxp3, has been detected in extra lymphoid tissue, and in hepatocytes and has been associated with hepatocellular carcinoma (HCC), although its role has not been defined. Since it is expected that there is a relationship between protein localization, activity and cellular function, the aim of this study was to explore the subcellular localization of Foxp3 in resting and stimulated human hepatocytes...
May 1, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/26986976/characterization-of-the-treg-response-in-the-hepatitis-b-virus-hydrodynamic-injection-mouse-model
#12
Kirsten K Dietze, Simone Schimmer, Freya Kretzmer, Junzhong Wang, Yong Lin, Xuan Huang, Weimin Wu, Baoju Wang, Mengji Lu, Ulf Dittmer, Dongliang Yang, Jia Liu
Regulatory T cells (Tregs) play an important role in counter-regulating effector T cell responses in many infectious diseases. However, they can also contribute to the development of T cell dysfunction and pathogen persistence in chronic infections. Tregs have been reported to suppress virus-specific T cell responses in hepatitis B virus (HBV) infection of human patients as well as in HBV animal models. However, the phenotype and expansion of Tregs has so far only been investigated in other infections, but not in HBV...
2016: PloS One
https://www.readbyqxmd.com/read/26980345/il-10-producing-regulatory-b-cells-suppressed-effector-t-cells-but-enhanced-regulatory-t-cells-in-chronic-hbv-infection
#13
Yun Liu, Li-Sha Cheng, Sheng-di Wu, Si-Qi Wang, Lei Li, Wei-Min She, Jing Li, Ji-Yao Wang, Wei Jiang
Non-specific immune responses to antigens have been demonstrated as being enhanced during chronic hepatitis B virus (HBV) infection. Here, we evaluated the role of interleukin-10 (IL-10)-producing regulatory B-cells (Bregs) in the pathogenesis of HBV-related liver fibrosis (HBV-LF) and assessed their immunoregulatory effects. Sixty-seven patients diagnosed with chronic hepatitis B (CHB) were enrolled in this study. Numbers and frequencies of peripheral B-cells (memory CD19(+)CD24(hi)CD27(+) cells, immature/transitional CD19(+)CD24(hi)CD38(hi) cells, mature CD19(+)CD24(int)CD38(int) cells) were tested and analysed...
June 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/26899927/the-frequency-and-skewed-t-cell-receptor-beta-chain-variable-patterns-of-peripheral-cd4-cd25-regulatory-t-cells-are-associated-with-hepatitis-b-e-antigen-seroconversion-of-chronic-hepatitis-b-patients-during-antiviral-treatment
#14
Jiezuan Yang, Guoping Sheng, Dangsheng Xiao, Haiyan Shi, Wei Wu, Haifeng Lu, Hongcui Cao, Lanjuan Li
The frequency and T-cell receptor beta-chain variable (TCRBV) patterns of peripheral CD4(+)CD25(+) regulatory T-cells (Tregs) are ambiguously altered in chronic hepatitis B (CHB) patients following tenofovir disoproxil fumarate (TDF) treatment. Moreover, the clinical significance of these parameters in relation to hepatitis B e antigen (HBeAg) seroconversion (SC) is largely unknown. In this study, the circulation of Tregs in HBeAg-positive CHB patients was determined by flow cytometry, and the molecular profiles of frequent TCRBV patterns of Tregs were analyzed using a gene melting spectral pattern...
September 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/26845594/%C3%A2-effect-of-entecavir-on-cd4-t-cell-subpopulations-in-patients-with-chronic-hepatitis-b
#15
Zhan-Fei Tian, Zhong-Lan You, Hong Yi, Xue-Mei Kuang, Yu-Ming Wang
UNLABELLED:  Background and aims. CD4+ T cells play an important role in response to hepatitis B virus (HBV) infection. We investigated the change in CD4+ T-cell subpopulations and viral load in patients with chronic HBV infection who were treated with entecavir. MATERIAL AND METHODS: Thirty patients with chronic HBV infection were enrolled according to the criteria recommended by the Chinese Society of Infectious Diseases and the Chinese Society of Hepatology...
March 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/26447433/il6-gene-allele-specific-c-ebp%C3%AE-binding-activity-affects-the-development-of-hbv-infection-through-modulation-of-th17-treg-balance
#16
G Zhang, W Wang, S Li, H Yang, M Zhang, P Zhang, Y Wen, A Wu, L Yang, B Zhou, X Chen
Interleukin-6 (IL-6) has an important role in the pathogenesis of chronic viral hepatitis and related liver diseases. Although host genetics associated with the response to anti-viral treatment have been reported, little is known about the relationship between IL6 genetic polymorphisms and the outcome of hepatitis B virus (HBV) infection. In this study, we determined the genotype distribution of rs1800796 polymorphism in healthy controls and cases including chronic HBV (CHB), hepatitis C virus and HIV infection...
December 2015: Genes and Immunity
https://www.readbyqxmd.com/read/26367459/circulating-foxp3-regulatory-t-and-interleukin17-producing-th17-cells-actively-influence-hbv-clearance-in-de-novo-hepatitis-b-virus-infected-patients-after-orthotopic-liver-transplantation
#17
Yinjie Gao, Min Zhang, Jin Li, Mei Yang, Yuan Liu, Xiaodong Guo, Hanwei Li, Zhenwen Liu, Jingmin Zhao
OBJECTIVE: To longitudinally investigate the role of FoxP3+ Regulatory T cells (Treg) and interleukin17-producing T helper 17 cells (Th17) in De Novo Hepatitis B Virus infection after orthotopic Liver Transplantation (DNHB-OLT), and analyze the possible correlation between these cells and HBV clearance of the disease. METHODS: We enrolled 12 control cases after orthotopic Liver Transplantation (OLT) and 24 patients, including 12 diagnosed with DNHB-OLT and 12 diagnosed with Acute Hepatitis B Virus infection (AHB), into the study from the liver transplantation and research center at Beijing 302 Hospital...
2015: PloS One
https://www.readbyqxmd.com/read/26309519/regulatory-t-cells-and-il-17-t-helper-cells-enhanced-in-patients-with-chronic-hepatitis-b-virus-infection
#18
Hao Feng, Jie Yin, Ya-Ping Han, Xiao-Ying Zhou, Su Chen, Li Yang, Jin-Rui Yan, Guo-Xin Zhang
Hepatitis B is a worldwide infectious disease caused by hepatitis B virus (HBV), it leaded to millions of deaths every year, HBV mainly through immune response to damage liver cells. The purpose of this study was to judge the value of Regulatory T cells (Treg) and IL-17(+) T helper cells (Th17) in different chronic HBV infection stages. 96 patients with chronic HBV infection were enrolled and selected 33 healthy adults as control. Detected the expression of Treg and Th17 cells in peripheral blood by flow cytometry and assayed liver function simultaneously...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26266813/expression-of-pd-l1-on-cd4-cd25-foxp3-regulatory-t-cells-of-patients-with-chronic-hbv-infection-and-its-correlation-with-clinical-parameters
#19
Chao Feng, Li-Juan Cao, Hua-Feng Song, Ping Xu, Hui Chen, Jun-Chi Xu, Xiao-Yan Zhu, Xue-Guang Zhang, Xue-Feng Wang
Regulatory T cells (Tregs) play a pivotal role in suppressing specific antiviral immune responses during the progression of chronic hepatitis B virus infection (CHB) as well as tumorigenesis. Programmed death-1 ligand-1 (PD-L1) expressed on Tregs can transduce an inhibitory signal into effector T cells through interacting with programmed death-1 (PD-1). However, in CHB patients, the clinical significance of PD-L1 expression on Tregs has not been clearly described. This study investigated the frequency of circulating Tregs and PD-L1 expression on Tregs and analyzed their correlations with clinical parameters...
October 2015: Viral Immunology
https://www.readbyqxmd.com/read/26266573/sustained-changes-of-treg-and-th17-cells-during-interferon-%C3%AE-therapy-in-patients-with-chronic-hepatitis-b
#20
Hao Feng, Jie Yin, Ya-Ping Han, Xiao-Ying Zhou, Su Chen, Li Yang, Jin-Rui Yan, Guo-Xin Zhang
Chronic hepatitis B (CHB) is a worldwide infectious disease caused by hepatitis B virus (HBV). HBV mainly damages liver cells through immune response. The purpose of this study was to determine whether there were dynamic changes of Treg and Th17 cells and to judge the value of these indicators to antiviral treatment. Twenty-two CHB patients and selected 30 healthy adults were enrolled. Results showed that the expression of Treg (5.72±0.46 vs. 4.42±0.17, p=0.0019) and Th17 (3.94±0.64 vs. 2.66±3.12, p=0.0436) cells was significantly increased in CHB patients, as well as the level of interleukin-17 (IL-17) (16...
October 2015: Viral Immunology
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