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https://www.readbyqxmd.com/read/29148037/growth-performance-fatty-acid-composition-lipid-deposition-and-hepatic-lipid-metabolism-related-gene-expression-in-juvenile-pond-loach-misgurnus-anguillicaudatus-fed-diets-with-different-dietary-soybean-oil-levels
#1
Y Li, Z Jia, X Liang, D Matulic, M Hussein, J Gao
A 10 week feeding trial was conducted to evaluate the effects of different dietary soybean oil (SO) levels on growth performance, fatty-acid composition and lipid deposition in viscera, histology and histochemistry of liver, intestine and hepatic-lipid metabolism-related gene expressions in pond loach Misgurnus anguillicaudatus juveniles. Misgurnus anguillicaudatus (mean ± s.d. mass 0·40 ± 0·01 g) were fed five experimental diets containing SO at different concentrations: 0, 20, 32, 56 and 100% SO and a diet containing 100% fish oil (100% FO)...
November 17, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29136581/honokiol-exerts-dual-effects-on-browning-and-apoptosis-of-adipocytes
#2
Jameel Lone, Jong Won Yun
BACKGROUND: Induction of brown adipocyte-like phenotype (browning) in white adipocytes and promotion of apoptosis by dietary and pharmacological compounds is considered a novel strategy against obesity. Here, we show that honokiol exerts dual modulatory effects on adipocytes via induction of browning in 3T3-L1 white adipocytes and apoptosis as well as activation of HIB1B brown adipocytes combined with inhibition of apoptosis. METHODS: Honokiol-induced browning and apoptosis were investigated by determining expression levels of brown adipocyte-specific genes and proteins by RT-PCR and immunoblot analysis, respectively...
June 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29092796/ampk-activation-caused-by-reduced-liver-lactate-metabolism-protects-against-hepatic-steatosis-in-mct1-haploinsufficient-mice
#3
Lionel Carneiro, Mohamed Asrih, Cendrine Repond, Christine Sempoux, Jean-Christophe Stehle, Corinne Leloup, François R Jornayvaz, Luc Pellerin
OBJECTIVE: Hepatic steatosis is the first step leading to non-alcoholic fatty liver disease, which represents a major complication of obesity. Here, we show that MCT1 haploinsufficient mice resist to hepatic steatosis development when fed a high fat diet. They exhibit a reduced hepatic capacity to metabolize monocarboxylates such as lactate compared to wildtype mice. METHODS: To understand how this resistance to steatosis develops, we used HFD fed wildtype mice with hepatic steatosis and MCT1 haploinsufficient mice to study hepatic metabolism...
October 20, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29063809/thoracic-gamma-irradiation-induced-obesity-in-c57bl-6-female-mice
#4
Steven B Zhang, Shanmin Yang, Zhenhuan Zhang, Amy Zhang, Mei Zhang, Liangjie Yin, Katherine Casey-Sawicki, Steven Swarts, Sadasivan Vidyasagar, Lurong Zhang, Paul Okunieff
PURPOSE: To investigate the late effects of thoracic region irradiation (TRI) on mouse body weight. MATERIALS AND METHODS: Female C57BL/6 mice were divided into nonirradiated, 5 Gy total body irradiation, 9 Gy sub-total body irradiation, and 12.5 Gy thoracic region irradiation (TRI) groups. Changes in mouse weight were monitored every other week at similar time points for 12 months. The anatomical characteristics of abdominal visceral fat distribution were recorded, and mitochondrial DNA copy number in the hearts and livers and lipid metabolic signaling in the liver were analyzed...
October 24, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29042644/hiv-1-viral-protein-r-vpr-induces-fatty-liver-in-mice-via-lxr%C3%AE-and-ppar%C3%AE-dysregulation-implications-for-hiv-specific-pathogenesis-of-nafld
#5
Neeti Agarwal, Dinakar Iyer, Chiara Gabbi, Pradip Saha, Sanjeet G Patel, Qianxing Mo, Benny Chang, Biman Goswami, Ulrich Schubert, Jeffrey B Kopp, Dorothy E Lewis, Ashok Balasubramanyam
HIV patients develop hepatic steatosis. We investigated hepatic steatosis in transgenic mice expressing the HIV-1 accessory protein Vpr (Vpr-Tg) in liver and adipose tissues, and WT mice infused with synthetic Vpr. Vpr-Tg mice developed increased liver triglyceride content and elevated ALT, bilirubin and alkaline phosphatase due to three hepatic defects: 1.6-fold accelerated de novo lipogenesis (DNL), 45% slower fatty acid ß-oxidation, and 40% decreased VLDL-triglyceride export. Accelerated hepatic DNL was due to coactivation by Vpr of liver X receptor-α (LXRα) with increased expression of its lipogenic targets Srebp1c, Chrebp, Lpk, Dgat, Fasn and Scd1, and intranuclear SREBP1c and ChREBP...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038358/expression-of-genes-involved-in-carbohydrate-lipid-metabolism-in-muscle-and-fat-tissues-in-the-initial-stage-of-adult-age-obesity-in-fed-and-fasted-mice
#6
Nadezhda M Bazhan, Alexandr V Baklanov, Julia V Piskunova, Antonina J Kazantseva, Elena N Makarova
C57Bl mice exhibit impaired glucose metabolism by the late adult age under standard living conditions. The aim of this study was to evaluate white adipose tissue (WAT), brown adipose tissue (BAT), and skeletal muscle expression of genes involved in carbohydrate-lipid metabolism at postpubertal stages preceding the late adult age in C57Bl mice. Muscle mRNA levels of uncoupling protein 3 (Ucp3) and carnitine palmitoyltransferase 1 (Cpt1) (indicators of FFA oxidation), WAT mRNA levels of hormone-sensitive lipase (Lipe) and lipoprotein lipase (Lpl) (indicators of lipolysis and lipogenesis), muscle and WAT mRNA levels of the type 4 glucose transporter Slc2a4 (indicators of insulin-dependent glucose uptake), and BAT mRNA levels of uncoupling protein 1 (Ucp1) (indicator of thermogenesis) were measured in fed and 16 h-fasted mice in three age groups: 10-week-old (young), 15-week-old (early adult), and 30-week-old (late adult)...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29024108/changes-in-hepatic-glucose-and-lipid-metabolism-related-parameters-in-domestic-pigeon-columba-livia-during-incubation-and-chick-rearing
#7
X P Wan, P Xie, Z Bu, X T Zou
This study aimed to evaluate the hepatic glucose and lipid metabolism-related parameters of adult male and female White King pigeons (Columba livia) during incubation and chick rearing. At day 4 (I4), 10 (I10) and 17 (I17) of incubation and day 1 (R1), 7 (R7), 15 (R15) and 25 (R25) of chick rearing, livers were sampled from six pigeons for each sex. Glycogen and fat contents, activities of glycolytic enzymes (hexokinase, HK; 6-phosphofructokinase, 6-PFK), and genes expressions of key enzymes involved in glycolysis (pyruvate kinase, PK; glucokinase, GK), gluconeogenesis (phosphoenolpyruvate carboxykinase cytosolic, PCK1; fructose-1,6-bisphosphatase, FBP1; glucose-6-phosphatase, G6Pase), fatty acid synthesis (fatty acid synthase, FAS; acetyl-CoA carboxylase, ACC) and fatty acid β-oxidation (carnitine palmitoyltransferase 1, CPT1; acyl-CoA 1, ACO) were measured...
October 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28993954/obesity-alleviating-potential-of-asiatic-acid-and-its-effects-on-acc1-ucp2-and-cpt1-mrna-expression-in-high-fat-diet-induced-obese-sprague-dawley-rats
#8
P Rameshreddy, V V Sathibabu Uddandrao, Parim Brahmanaidu, S Vadivukkarasi, Ramavat Ravindarnaik, Pothani Suresh, K Swapna, A Kalaivani, Parimi Parvathi, P Tamilmani, Ganapathy Saravanan
The present study evaluated the effects of asiatic acid (AA), a pentacyclic triterpenoid from Centella asiatica on lipid metabolism parameters in a rat model of obesity induced using a high fat diet (HFD) for 42 days. AA (20 mg/kg body weight [BW]) was administered orally once daily for 42 days, and an orlistat-treated group of rats (10 mg/kg BW) was included for comparison. Changes in BW, blood glucose levels, insulin resistance and leptin, adiponectin, amylase, and lipase levels in the blood; lipid profiles of plasma; liver antioxidants levels; and acetyl CoA carboxylase(ACC), uncoupling protein-2 (UCP2), and carnitine palmitoyltransferase-1 (CPT1) mRNA expression were observed in the experimental rats...
October 9, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28982243/solanum-nigrum-polyphenol-extracts-inhibit-hepatic-inflammation-oxidative-stress-and-lipogenesis-in-high-fat-diet-treated-mice
#9
Ja-Jen Chang, Dai-Jung Chung, Yi-Ju Lee, Bo-Han Wen, Hsing-Yu Jao, Chau-Jong Wang
Patients with diabetes, obesity, and hyperlipidemia are all high-risk groups for fatty liver; however, the mechanism of fatty liver formation is not completely understood. Studies have indicated that abnormal fat metabolism, oxidative stress, and insulin resistance are positively correlated with peroxidation and abnormal cytokine production. Recent studies have revealed that Solanum nigrum extracts (SNE) possess anti-inflammatory, antioxidation, antihyperlipidemia, and liver protection abilities. Therefore, the present study investigated the in vivo and in vitro effects of an SNE on nonalcoholic fatty liver (NAFL)-induced hepatitis...
October 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28965027/l-carnitine-supplementation-during-vitrification-or-warming-of-in%C3%A2-vivo-produced-ovine-embryos-does-not-affect-embryonic-survival-rates-but-alters-crat-and-prdx1-expression
#10
Helena F R A Saraiva, Ribrio I T P Batista, Vivian A P Alfradique, Pedro H N Pinto, Lilian S Ribeiro, Clara S Oliveira, Joanna M G Souza-Fabjan, Luiz S A Camargo, Jeferson F Fonseca, Felipe Z Brandão
l-carnitine is an antioxidant and β-oxidation stimulator substance commonly used to improve metabolic performance of oocytes and embryos in in vitro systems. However, few studies have evaluated its beneficial effects in embryos produced in vivo. This study aimed to evaluate the effect of l-carnitine supplementation into vitrification or warming solutions on the post-warming character of day 6-7 in vivo-produced ovine embryos. l-carnitine (3.72 mM) was added to vitrification (Experiment 1) or warming solutions (Experiment 2)...
January 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/28933767/hemin-improves-insulin-sensitivity-and-lipid-metabolism-in-cultured-hepatocytes-and-mice-fed-a-high-fat-diet
#11
Yi Luan, Fang Zhang, Yalan Cheng, Jun Liu, Rui Huang, Menghong Yan, Yuangao Wang, Zhishui He, Hejin Lai, Hui Wang, Hao Ying, Feifan Guo, Qiwei Zhai
Hemin is a breakdown product of hemoglobin. It has been reported that the injection of hemin improves lipid metabolism and insulin sensitivity in various genetic models. However, the effect of hemin supplementation in food on lipid metabolism and insulin sensitivity is still unclear, and whether hemin directly affects cellular insulin sensitivity is yet to be elucidated. Here we show that hemin enhances insulin-induced phosphorylation of insulin receptors, Akt, Gsk3β, FoxO1 and cytoplasmic translocation of FoxO1 in cultured primary hepatocytes under insulin-resistant conditions...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28915573/lipid-catabolism-inhibition-sensitizes-prostate-cancer-cells-to-antiandrogen-blockade
#12
Thomas W Flaig, Maren Salzmann-Sullivan, Lih-Jen Su, Zhiyong Zhang, Molishree Joshi, Miguel A Gijón, Jihye Kim, John J Arcaroli, Adrie Van Bokhoven, M Scott Lucia, Francisco G La Rosa, Isabel R Schlaepfer
Prostate cancer (PCa) is the most common malignancy among Western men and the second leading-cause of cancer related deaths. For men who develop metastatic castration resistant PCa (mCRPC), survival is limited, making the identification of novel therapies for mCRPC critical. We have found that deficient lipid oxidation via carnitine palmitoyltransferase (CPT1) results in decreased growth and invasion, underscoring the role of lipid oxidation to fuel PCa growth. Using immunohistochemistry we have found that the CPT1A isoform is abundant in PCa compared to benign tissue (n=39, p<0...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28894292/partitioning-of-adipose-lipid-metabolism-by-altered-expression-and-function-of-ppar-isoforms-after-bariatric-surgery
#13
C Jahansouz, H Xu, A V Hertzel, S Kizy, K A Steen, R Foncea, F J Serrot, N Kvalheim, G Luthra, K Ewing, D B Leslie, S Ikramuddin, D A Bernlohr
BACKGROUND: Bariatric surgery remains the most effective treatment for reducing adiposity and eliminating type 2 diabetes; however, the mechanism(s) responsible have remained elusive. Peroxisome proliferator-activated receptors (PPAR) encompass a family of nuclear hormone receptors that upon activation exert control of lipid metabolism, glucose regulation and inflammation. Their role in adipose tissue following bariatric surgery remains undefined. MATERIALS AND METHODS: Subcutaneous adipose tissue biopsies and serum were obtained and evaluated from time of surgery and on postoperative day 7 in patients randomized to Roux-en-Y gastric bypass (n=13) or matched caloric restriction (n=14), as well as patients undergoing vertical sleeve gastrectomy (n=33)...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28888875/imazalil-exposure-induces-gut-microbiota-dysbiosis-and-hepatic-metabolism-disorder-in-zebrafish
#14
Cuiyuan Jin, Ting Luo, Zhihong Zhu, Zihong Pan, Jiajing Yang, Wenchao Wang, Zhengwei Fu, Yuanxiang Jin
The fungicide imazalil (IMZ) is used extensively to preserve freshness, prevent decay and control fungal infections in fruits, vegetables or other plants. Recently, some studies have reported that the real in aquatic systems have reached very high levels. Here, male adult zebrafish were exposed to 100 and 1000μg/L IMZ for 1, 7, 21days, and the gut microbiota and hepatic metabolism were evaluated. Exposure to a high concentration of IMZ for 21days decreased mucin secretion in the gut. Sequencing of the V3-V4 region of the bacterial 16S rRNA gene revealed a significant increase in the diversity of gut microbiota in male zebrafish...
November 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28883917/betaine-affects-muscle-lipid-metabolism-via-regulating-the-fatty-acid-uptake-and-oxidation-in-finishing-pig
#15
Sisi Li, Haichao Wang, Xinxia Wang, Yizhen Wang, Jie Feng
BACKGROUND: Betaine affects fat metabolism in animals, but the specific mechanism is still not clear. The purpose of this study was to investigate possible mechanisms of betaine in altering lipid metabolism in muscle tissue in finishing pigs. METHODS: A total of 120 crossbred gilts (Landrace × Yorkshire × Duroc) with an average initial body weight of 70.1 kg were randomly allotted to three dietary treatments. The treatments included a corn-soybean meal basal diet supplemented with 0, 1250 or 2500 mg/kg betaine...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28867797/flavonoid-rich-extract-of-paulownia-fortunei-flowers-attenuates-diet-induced-hyperlipidemia-hepatic-steatosis-and-insulin-resistance-in-obesity-mice-by-ampk-pathway
#16
Chanmin Liu, Jieqiong Ma, Jianmei Sun, Chao Cheng, Zhaojun Feng, Hong Jiang, Wei Yang
The flavonoid-rich extract from Paulownia fortunei flowers (EPF) has been reported to prevent obesity and other lipid metabolism disease. However, the mechanism of its protective effects is not yet clear. The objective of this study was to investigate molecular factors involved in the hypoglycemic and hypolipidemic effects of EPF in obese mice fed a high-fat diet (HFD). Male h ICR (Institute of Cancer Research) mice were fed a HFD containing or not containing the EPF (50 or 100 mg/kg) for eight weeks. EPF reduced body weight gain, lipid accumulation in livers and levels of lipid, glucose and insulin in plasma as well as reduced insulin resistance as compared with the HFD group...
August 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28760472/mitochondrial-dysfunction-in-atrial-tissue-of-patients-developing-postoperative-atrial-fibrillation
#17
COMPARATIVE STUDY
Jelliffe Jeganathan, Rabya Saraf, Feroze Mahmood, Anam Pal, Manoj K Bhasin, Thomas Huang, Aaron Mittel, Ziyad Knio, Russell Simons, Kamal Khabbaz, Venkatachalam Senthilnathan, David Liu, Frank Sellke, Robina Matyal
BACKGROUND: Mitochondria are the major site of cellular oxidation. Metabolism and oxidative stress have been implicated as possible mechanisms for postoperative atrial fibrillation (POAF) after cardiac operations. Establishing the precise nature of mitochondrial dysfunction as an etiologic factor for oxidative stress-related cell death and apoptosis could further the understanding of POAF. To establish this relationship, mitochondrial function was studied in patients undergoing cardiac operations that developed POAF and compared it with patients without POAF...
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28747869/effect-of-dietary-copper-addition-on-lipid-metabolism-in-rabbits
#18
Liu Lei, Sui Xiaoyi, Li Fuchang
The present study was conducted to investigate the effect of copper supplementation on lipid metabolism in rabbits. Our study showed dietary copper addition (5-45 mg/kg) increased body mass gain, but decreased fat and liver weights compared with those in the control group (P < 0.05). Copper (45 mg/kg) addition significantly increased the skeletal muscle weight, but inhibited cytoplasmic lipid accumulation in liver, skeletal muscle and adipose tissue (P < 0.05). Compared with the control group, dietary copper addition (45 mg/kg) significantly increased plasma triglyceride levels but decreased very low density lipoprotein levels (P < 0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28713989/effects-of-proton-beam-irradiation-on-mitochondrial-biogenesis-in-a-human-colorectal-adenocarcinoma-cell-line
#19
Byung Geun Ha, Sung Suk Jung, Yun Hee Shon
Proton beam therapy has recently been used to improve local control of tumor growth and reduce side-effects by decreasing the global dose to normal tissue. However, the regulatory mechanisms underlying the physiological role of proton beam radiation are not well understood, and many studies are still being conducted regarding these mechanisms. To determine the effects of proton beams on mitochondrial biogenesis, we investigated: mitochondrial DNA (mtDNA) mass; the gene expression of mitochondrial transcription factors, functional regulators, and dynamic-related regulators; and the phosphorylation of the signaling molecules that participate in mitochondrial biogenesis...
July 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28691342/dual-function-of-lactobacillus-kefiri-dh5-in-preventing-high-fat-diet-induced-obesity-direct-reduction-of-cholesterol-and-upregulation-of-ppar-%C3%AE-in-adipose-tissue
#20
Dong-Hyeon Kim, Dana Jeong, Il-Byeong Kang, Hyunsook Kim, Kwang-Young Song, Kun-Ho Seo
SCOPE: Kefir consumption inhibits the development of obesity and non-alcoholic fatty liver disease (NALFD) in mice fed 60% high-fat diet (HFD). To identify the key contributor of this effect, we isolated lactic acid bacteria (LAB) from kefir and examined their anti-obesity properties from in vitro screening and in vivo validation. METHODS AND RESULTS: Thirteen kefir LAB isolates were subjected to survivability test using artificial gastrointestinal environment and cholesterol-reducing assay...
July 10, 2017: Molecular Nutrition & Food Research
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