Bo Sun, Kelly A S da Costa, Aljawharah Alrubayyi, Jonida Kokici, Natasha Fisher-Pearson, Noshin Hussain, Stefano D'Anna, Lorenzo Piermatteo, Romina Salpini, Valentina Svicher, Stephanie Kucykowicz, Indrajit Ghosh, Fiona Burns, Sabine Kinloch, Pedro Simoes, Sanjay Bhagani, Patrick T F Kennedy, Mala K Maini, Rachael Bashford-Rogers, Upkar S Gill, Dimitra Peppa
BACKGROUND: HBV and HIV co-infection is a common occurrence globally, with significant morbidity and mortality. Both viruses lead to immune dysregulation including changes in NK cells, a key component of antiviral defense and a promising target for HBV cure strategies. Here we used high-throughput single cell analysis to explore the immune cell landscape in people with HBV mono-infection and HIV/HBV co-infection, on antiviral therapy, with emphasis on identifying the distinctive characteristics of NK cell subsets that can be therapeutically harnessed...
April 30, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases