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https://www.readbyqxmd.com/read/27919765/late-gadolinium-enhancement-in-brugada-syndrome-a-marker-for-subtle-underlying-cardiomyopathy
#1
Rachel Bastiaenen, Andrew T Cox, Silvia Castelletti, Yanushi D Wijeyeratne, Nicholas Colbeck, Nadia Pakroo, Hammad Ahmed, Nick Bunce, Lisa Anderson, James C Moon, Sanjay Prasad, Sanjay Sharma, Elijah R Behr
BACKGROUND: There is increasing evidence that the Brugada ECG pattern is a marker of subtle structural heart disease. OBJECTIVE: We characterised Brugada syndrome (BrS) patients using cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE). METHODS: BrS was diagnosed according to international guidelines. 26% BrS patients carried SCN5A mutations. CMR data from 78 BrS patients were compared with 78 healthy controls (44±15 vs 42±14 years; p=0...
December 2, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27913009/quantitative-changes-in-late-gadolinium-enhancement-at-cardiac-magnetic-resonance-in-the-early-phase-of-acute-myocarditis
#2
Enrico Ammirati, Francesco Moroni, Paola Sormani, Angelica Peritore, Angela Milazzo, Giuseppina Quattrocchi, Manlio Cipriani, Fabrizio Oliva, Cristina Giannattasio, Maria Frigerio, Alberto Roghi, Paolo G Camici, Patrizia Pedrotti
BACKGROUND: The presence of late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) has diagnostic and prognostic value in patients with acute myocarditis (AM). Aim of our study was to quantify the changes in LGE extension (LGE%) early after AM and evaluate its relations with biventricular function and morphology. METHODS: We investigated 76 consecutive patients with AM (acute onset of chest pain/heart failure/ventricular arrhythmias not explained by other causes, and raised troponin) that met CMR criteria based on myocardial oedema at T2-weighted images and LGE on post-contrast images at median time of 6days from onset of symptoms...
November 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27905543/rapid-functional-cardiac-imaging-after-gadolinium-injection-evaluation-of-a-highly-accelerated-sequence-with-sparse-data-sampling-and-iterative-reconstruction
#3
Johannes Budjan, Holger Haubenreisser, Thomas Henzler, Sonja Sudarski, Michaela Schmidt, Christina Doesch, Ibrahim Akin, Martin Borggrefe, Nadja M Meßner, Stefan O Schoenberg, Ulrike I Attenberger, Theano Papavassiliu
To generate a patient-friendly, time-efficient cardiac MRI examination protocol, a highly accelerated real-time CINE MR sequence (SSIR) was acquired in the idle time in between contrast injection and late gadolinium enhancement phase. 20 consecutive patients underwent a cardiac MRI examination including a multi-breath-hold sequence as gold standard (Ref) as well as SSIR sequences with (SSIR-BH) and without breath-hold (SSIR-nonBH). SSIR sequences were acquired 4 minutes after gadolinium injection. Right- (RV) and left-ventricular (LV) volumetric functional parameters were evaluated and compared between Ref and SSIR sequences...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905023/distinct-cortical-and-sub-cortical-neurogenic-domains-for-gabaergic-interneuron-precursor-transcription-factors-nkx2-1-olig2-and-coup-tfii-in-early-fetal-human-telencephalon
#4
Ayman Alzu'bi, Susan Lindsay, Janet Kerwin, Shi Jie Looi, Fareha Khalil, Gavin J Clowry
The extent of similarities and differences between cortical GABAergic interneuron generation in rodent and primate telencephalon remains contentious. We examined expression of three interneuron precursor transcription factors, alongside other markers, using immunohistochemistry on 8-12 post-conceptional weeks (PCW) human telencephalon sections. NKX2.1, OLIG2, and COUP-TFII expression occupied distinct (although overlapping) neurogenic domains which extended into the cortex and revealed three CGE compartments: lateral, medial, and ventral...
November 30, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27899132/cardiac-t1-mapping-and-extracellular-volume-ecv-in-clinical-practice-a-comprehensive-review
#5
REVIEW
Philip Haaf, Pankaj Garg, Daniel R Messroghli, David A Broadbent, John P Greenwood, Sven Plein
Cardiovascular Magnetic Resonance is increasingly used to differentiate the aetiology of cardiomyopathies. Late Gadolinium Enhancement (LGE) is the reference standard for non-invasive imaging of myocardial scar and focal fibrosis and is valuable in the differential diagnosis of ischaemic versus non-ischaemic cardiomyopathy. Diffuse fibrosis may go undetected on LGE imaging. Tissue characterisation with parametric mapping methods has the potential to detect and quantify both focal and diffuse alterations in myocardial structure not assessable by LGE...
November 30, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27889555/correlation-between-microvascular-dysfunction-and-b-type-natriuretic-peptide-levels-in-non-ischemic-heart-failure-patients-with-cardiac-fibrosis
#6
Kyoko Hirakawa, Megumi Yamamuro, Tomoaki Uemura, Seiji Takashio, Koichi Kaikita, Daisuke Utsunomiya, Mina Nakayama, Eiichiro Yamamoto, Yasuyuki Yamashita, Seiji Hokimoto, Kenichi Tsujita
BACKGROUNDS: The relationship between microvascular dysfunction and plasma B-type natriuretic peptide (BNP) levels remains unclear in heart failure (HF) patients with cardiac fibrosis. METHODS: This study evaluated 55 consecutive non-ischemic HF patients in an effort to determine the relationship between endothelial independent coronary microvascular dysfunction and plasma BNP levels, as well as whether each measure is correlated with myocardial fibrosis. We evaluated plasma BNP levels in patients with stable HF...
November 8, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27878700/performance-of-native-and-contrast-enhanced-t1-mapping-to-detect-myocardial-damage-in-patients-with-suspected-myocarditis-a-head-to-head-comparison-of-different-cardiovascular-magnetic-resonance-techniques
#7
Jonathan Nadjiri, Hanna Nieberler, Eva Hendrich, Andreas Greiser, Albrecht Will, Stefan Martinoff, Martin Hadamitzky
Myocardial T1 mapping is a novel technique that has proven to be superior to standard imaging for differentiation between healthy individuals in acute myocarditis. Aim of this study was comparison of T1 mapping with a clinical biomarker. We retrospectively investigated 171 patients undergoing cardiovascular magnetic resonance (CMR) examination with suspected myocarditis by performing native and contrast enhanced T1-mapping. Additionally, T2w and T1w images and late gadolinium enhancement sequences (LGE) were utilized for myocardial evaluation; Lake Louise Criteria comprise T1w, T2w and LGE imaging in a score...
November 23, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27870974/myocardial-perfusion-in-peripheral-raynaud-s-phenomenon-evaluation-using-stress-cardiovascular-magnetic-resonance
#8
Sophie Mavrogeni, Konstantinos Bratis, Loukia Koutsogeorgopoulou, Georgia Karabela, Efthymios Savropoulos, Gikas Katsifis, John Raftakis, George Markousis-Mavrogenis, Genovefa Kolovou
BACKGROUND: Peripheral Raynaud's phenomenon (RP) is either primary (PRP), without any coexisting disease or secondary (SRP), due to connective tissue diseases (CTD). We hypothesized that adenosine stress cardiovascular magnetic resonance (CMR) can assess myocardial perfusion in a population of PRP and SRP. PATIENTS-METHODS: Twenty CTDs, aged 30.6±7.5yrs., 16F/4M, including 9 systemic sclerosis (SSc), 4 systemic lupus erythematosus (SLE), 3 mixed connective tissue disease (MCTD), 2 polymyositis (PM) and 2 rheumatoid arthritis (RA), with SRP, under treatment with calcium blockers, were evaluated by stress CMR and compared with age-sex matched PRP and controls...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27865184/changes-of-left-ventricular-mechanics-after-trans-catheter-aortic-valve-implantation-and-surgical-aortic-valve-replacement-for-severe-aortic-stenosis-a-tissue-tracking-cardiac-magnetic-resonance-study
#9
Gaetano Nucifora, John-Paul Tantiongco, Gareth Crouch, Jayme Bennetts, Ajay Sinhal, Phillip J Tully, Craig Bradbrook, Robert A Baker, Joseph B Selvanayagam
BACKGROUND: Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). The aim of the present study was to assess their changes early and late after trans-catheter aortic valve implantation (TAVI) and surgical aortic valve replacement (AVR) using cardiac magnetic resonance (CMR) tissue-tracking imaging. METHODS: In 59 patients with severe AS undergoing either TAVI (n=35) or surgical AVR (n=24), CMR with late gadolinium enhancement (LGE) imaging was performed before and early post-procedure to evaluate LV function and mass, and presence/extent of LGE...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27855806/long-term-prognostic-value-of-cardiac%C3%A2-magnetic-resonance-in-left%C3%A2-ventricle-noncompaction-a-prospective-multicenter-study
#10
Daniele Andreini, Gianluca Pontone, Jan Bogaert, Alberto Roghi, Andrea Barison, Juerg Schwitter, Saima Mushtaq, Georgios Vovas, Paola Sormani, Giovanni D Aquaro, Pierre Monney, Chiara Segurini, Marco Guglielmo, Edoardo Conte, Laura Fusini, Antonio Dello Russo, Massimo Lombardi, Paola Gripari, Andrea Baggiano, Cesare Fiorentini, Federico Lombardi, Antonio L Bartorelli, Mauro Pepi, Pier Giorgio Masci
BACKGROUND: Cardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value. OBJECTIVES: The goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC. METHODS: A total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2...
November 15, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27852696/insights-into-cardiac-involvement-in-ankylosing-spondylitis-from-cardiovascular-magnetic-resonance
#11
P Stefan Biesbroek, Sjoerd C Heslinga, Thelma C Konings, Irene E van der Horst-Bruinsma, Mark B M Hofman, Peter M van de Ven, Otto Kamp, Vokko P van Halm, Mike J L Peters, Yvo M Smulders, Albert C van Rossum, Mike T Nurmohamed, Robin Nijveldt
OBJECTIVE: To evaluate cardiac involvement in patients with ankylosing spondylitis using cardiac magnetic resonance (CMR). METHODS: Patients with ankylosing spondylitis without cardiovascular symptoms or known cardiovascular disease were screened by transthoracic echocardiography (TTE) for participation in this exploratory CMR study. We prospectively enrolled 15 ankylosing spondylitis patients with an abnormal TTE for further tissue characterisation using late gadolinium enhancement (LGE) and T1 mapping...
November 16, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27826248/slow-conduction-in-the-border-zones-of-patchy-fibrosis-stabilizes-the-drivers-for-atrial-fibrillation-insights-from-multi-scale-human-atrial-modeling
#12
Ross Morgan, Michael A Colman, Henry Chubb, Gunnar Seemann, Oleg V Aslanidi
Introduction: The genesis of atrial fibrillation (AF) and success of AF ablation therapy have been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific distributions of fibrosis may determine the locations of electrical drivers (rotors) sustaining AF, but the underlying mechanisms are incompletely understood. This study aims to elucidate a missing mechanistic link between patient-specific fibrosis distributions and AF drivers. Methods: 3D atrial models integrated human atrial geometry, rule-based fiber orientation, region-specific electrophysiology, and AF-induced ionic remodeling...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27818475/sector-based-assessment-of-infarct-size-on-late-gadolinium-enhancement-mri-in-a-mouse-model-of-acute-myocardial-infarction
#13
Cheongsoo Park, Eun-Hye Park, Kiyuk Chang, Kwan Soo Hong
Scoring of myocardial infarction (MI) disease extent in cardiac magnetic resonance (CMR) images has been generally presented in terms of area-based infarct size. However, gradual thinning of the infarcted wall and compensatory hypertrophy of the noninfarcted remote wall during left ventricular (LV) remodeling after MI complicate the accuracy of infarct size measurement. In this study, we measured and compared infarct sizes in mice on late gadolinium enhancement (LGE) images using area-, length-, and radial sector-based methods...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27817748/dark-blood-late-enhancement-imaging
#14
Peter Kellman, Hui Xue, Laura J Olivieri, Russell R Cross, Elena K Grant, Marianna Fontana, Martin Ugander, James C Moon, Michael S Hansen
BACKGROUND: Bright blood late gadolinium enhancement (LGE) imaging typically achieves excellent contrast between infarcted and normal myocardium. However, the contrast between the myocardial infarction (MI) and the blood pool is frequently suboptimal. A large fraction of infarctions caused by coronary artery disease are sub-endocardial and thus adjacent to the blood pool. It is not infrequent that sub-endocardial MIs are difficult to detect or clearly delineate. METHODS: In this present work, an inversion recovery (IR) T2 preparation was combined with single shot steady state free precession imaging and respiratory motion corrected averaging to achieve dark blood LGE images with good signal to noise ratio while maintaining the desired spatial and temporal resolution...
November 7, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27816171/reliable-exclusion-of-prognostically-significant-coronary-disease-in-left-ventricular-dysfunction-by-cardiac-mri
#15
A C M Thompson, J G Crilley, D W Wilson, A P S Hungin, A Fuat, J J M Murphy
AIM: To assess the ability of cardiac magnetic resonance (CMR) to exclude prognostically significant coronary artery disease (CAD) in patients with left ventricular systolic dysfunction (LVSD). MATERIALS AND METHODS: A cohort of patients who underwent both X-ray angiography and CMR since 2006 was reviewed retrospectively. Records of those with European criteria for LVSD (left ventricular ejection fraction [LVEF] <50% or LV end-diastolic volume index [LVEDVI] ≥97 ml/m(2)) on CMR or transthoracic echo were analysed...
November 2, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27815793/cardiovascular-magnetic-resonance-in-patients-with-magnetic-resonance-conditional-pacemaker-systems-at-1-5%C3%A2-t-influence-of-pacemaker-related-artifacts-on-image-quality-including-first-pass-perfusion-aortic-and-mitral-valve-assessment-flow-measurement-short
#16
REVIEW
Oliver Klein-Wiele, Marietta Garmer, Martin Busch, Serban Mateiescu, Rhyan Urbien, Gianluca Barbone, Kaffer Kara, Michael Schulte-Hermes, Frauke Metz, Birgit Hailer, Dietrich Grönemeyer
There are only limited data on the impact of device-related artifacts on image quality in cardiovascular magnetic resonance imaging (CMR) in patients with pacemakers (PM). Adenosine stress perfusion, T1-weighted imaging and flow measurement as well as valve characterization have not been evaluated previously concerning artifact burden. We aimed to assess image quality in all routinely used CMR sequences. We analyzed 2623 myocardial segments in CMR scans of 61 patients with MR conditional PM (mean age 72.1 ± 11...
November 4, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27813364/magnetic-resonance-detected-myocardial-inflammation-and-fibrosis-in-rheumatoid-arthritis-associations-of-disease-characteristics-and-n-terminal-pro-brain-natriuretic-peptide-levels
#17
Hitomi Kobayshi, Yasuyuki Kobayashi, Isamu Yokoe, Yosikatsu Akashi, Masami Takei, Jon T Giles
Objective Myocardial dysfunction and heart failure (HF) are increased in rheumatoid arthritis (RA), yet there are few studies of the RA myocardium. Methods RA patients with no known heart disease or risk factors underwent gadolinium-enhanced cardiac magnetic resonance (cMR) imaging. Images were assessed for left-ventricular (LV) structure and functional parameters, and for myocardial late gadolinium enhancement (LGE: an indicator of myocardial fibrosis) and T2-weighted imaging (T2WI: an indicator of active inflammation)...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27804054/regional-myocardial-damage-and-active-inflammation-in-patients-with-cardiac-sarcoidosis-detected-by-non-invasive-multi-modal-imaging
#18
Shohei Kataoka, Mitsuru Momose, Kenji Fukushima, Naoki Serizawa, Atsushi Suzuki, Chisato Kondo, Koichiro Abe, Shuji Sakai, Nobuhisa Hagiwara
AIMS: Cardiac sarcoidosis (CS) can be diagnosed using (18)F-FDG-PET/CT (PET), cardiovascular magnetic resonance (CMR), and (123)I-BMIPP/(201)TlCl dual myocardial SPECT. This study aims to clarify the relationships among the three modalities with respect to CS. METHODS AND RESULTS: We evaluated 16 patients (male n = 11; age 55 ± 13 years) with confirmed CS who underwent PET, CMR, and dual SPECT with gated SPECT before starting steroid therapy. The left ventricular myocardium was divided into 17 segments to obtain SUVmax for PET images, defect scores from 0 to 4 (0 normal; 4 absent), and mismatch scores for dual SPECT (BMDS, TLDS, and MS) images and late gadolinium enhancement (LGE) scores (0 none; 1 partly positive; 2 homogeneous) on CMR images...
November 1, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27801994/clinical-evaluation-of-three-dimensional-late-enhancement-mri
#19
Konstantinos Bratis, Markus Henningsson, Chrisanthos Grigoratos, Matteo Dell' Omodarme, Konstantinos Chasapides, Rene Botnar, Eike Nagel
PURPOSE: To assess the diagnostic value of three-dimensional late enhancement (3D-LGE) for the detection of myocardial necrosis in a routine clinical setting. 3D-LGE has been proposed as a novel magnetic resonance (MR) technique for the accurate detection of myocardial scar in both the ventricles and atria. Its performance in clinical practice has been poorly examined. MATERIALS AND METHODS: Fifty-seven patients referred for cardiac MR examination including scar imaging were prospectively enrolled...
November 1, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27799316/longitudinal-strain-combined-with-delayed-enhancement-magnetic-resonance-improves-risk-stratification-in-patients-with-dilated-cardiomyopathy
#20
Misato Chimura, Tetsuari Onishi, Yasue Tsukishiro, Takahiro Sawada, Kunihiko Kiuchi, Akira Shimane, Katsunori Okajima, Shinichiro Yamada, Yasuyo Taniguchi, Yoshinori Yasaka, Hiroya Kawai
OBJECTIVE: Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging has been reported to be associated with unfavourable outcomes; however, few studies have addressed the prognostic value of left ventricular (LV) deformation parameter indicated by global longitudinal strain (GLS) in two-dimensional speckle-tracking (2DST) echocardiography in patients with non-ischaemic dilated cardiomyopathy (DCM). This study aims to investigate whether the combination of GLS and LGE is useful in stratifying the risk in patients with DCM...
October 31, 2016: Heart: Official Journal of the British Cardiac Society
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