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Ahmed S Fahmy, Ulf Neisius, Connie W Tsao, Sophie Berg, Elizabeth Goddu, Patrick Pierce, Tamer A Basha, Long Ngo, Warren J Manning, Reza Nezafat
BACKGROUND: Low scar-to-blood contrast in late gadolinium enhanced (LGE) MRI limits the visualization of scars adjacent to the blood pool. Nulling the blood signal improves scar detection but results in lack of contrast between myocardium and blood, which makes clinical evaluation of LGE images more difficult. METHODS: GB-LGE contrast is achieved through partial suppression of the blood signal using T2 magnetization preparation between the inversion pulse and acquisition...
March 22, 2018: Journal of Cardiovascular Magnetic Resonance
Henry Chubb, Rashed Karim, Sébastien Roujol, Marta Nuñez-Garcia, Steven E Williams, John Whitaker, James Harrison, Constantine Butakoff, Oscar Camara, Amedeo Chiribiri, Tobias Schaeffter, Matthew Wright, Mark O'Neill, Reza Razavi
BACKGROUND: Cardiovascular magnetic resonance (CMR) imaging has been used to visualise post-ablation atrial scar (PAAS), generally employing a three-dimensional (3D) late gadolinium enhancement (LGE) technique. However the reproducibility of PAAS imaging has not been determined. This cross-over study is the first to investigate the reproducibility of the technique, crucial for both future research design and clinical implementation. METHODS: Forty subjects undergoing first time ablation for atrial fibrillation (AF) had detailed CMR assessment of PAAS...
March 19, 2018: Journal of Cardiovascular Magnetic Resonance
Alessandro Zorzi, Angela Susana, Manuel De Lazzari, Federico Migliore, Giovanni Vescovo, Daniele Scarpa, Anna Baritussio, Giuseppe Tarantini, Luisa Cacciavillani, Benedetta Giorgi, Cristina Basso, Sabino Iliceto, Chiara Bucciarelli Ducci, Domenico Corrado, Martina Perazzolo Marra
BACKGROUND: In patients who survived out-of-hospital cardiac arrest (OHCA) it is crucial to establish the underlying cause and its potential reversibility. OBJECTIVE: We assessed the incremental diagnostic and prognostic role of early cardiac magnetic resonance (CMR) in survivors of OHCA. METHODS: Among 139 consecutive OHCA patients, we enrolled 44 (median age 43 years; 84% males) patients who underwent coronary angiography and CMR ≤7 days after admission...
March 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
H Fan, S Li, M Lu, G Yin, X Yang, T Lan, L Dai, X Chen, J Li, Y Zhang, A Sirajuddin, P Kellman, A E Arai, S Zhao
AIM: To evaluate the image quality and diagnostic agreement with a head-to-head comparison of late gadolinium enhancement (LGE) images acquired by the motion-corrected (MOCO) balanced steady-state free precession (bSSFP) phase sensitivity inversion recovery (PSIR) and conventional segmented fast low angle shot (FLASH) PSIR methods15,16 in a patient cohort with a wide spectrum of cardiovascular disease. MATERIALS AND METHODS: In 59 consecutive patients, signal-to-noise ratios (SNRs), contrast-to-noise ratios (CNRs) of the normal myocardium (NM), LGE, and blood pool (BP) were pair-wise compared between the two different sequences...
March 13, 2018: Clinical Radiology
Goran Abdula, Jannike Nickander, Peder Sörensson, Magnus Lundin, Peter Kellman, Andreas Sigfridsson, Martin Ugander
OBJECTIVES: Late gadolinium enhancement (LGE) is the in vivo reference standard for assessing focal myocardial fibrosis. Post-contrast T1-mapping by Modified Look-Locker Inversion recovery (MOLLI) can be used to generate synthetic late gadolinium enhancement (SynLGE) images with an image contrast similar to conventional LGE images. We hypothesized that SynLGE has an accuracy that approaches conventional LGE for diagnosing focal myocardial fibrosis. METHODS: Consecutive patients (n = 109, mean ± SD age 50 ± 16 years, 63% male) referred for clinical cardiac magnetic resonance imaging underwent LGE and post-contrast MOLLI starting 10-15 and 20-25 minutes post contrast, respectively...
March 16, 2018: Scandinavian Cardiovascular Journal: SCJ
Apostolos Kiaos, Ioannis Tziatzios, Stavros Hadjimiltiades, Charalambos Karvounis, Theodoros D Karamitsos
Stress perfusion cardiac magnetic resonance (CMR) has been proposed as an important gatekeeper for invasive coronary angiography (ICA) and percutaneous coronary interventions (PCI) in patients evaluated for possible coronary artery disease (CAD) (Fihn et al., 2012; Montalescot et al., 2013) [1], [2]. Several meta-analyses have evaluated the accuracy of stress perfusion CMR to diagnose CAD at the vessel level (Danad et al., 2017; Dai et al., 2016; Jiang et al., 2016; Takx et al., 2015; Li et al., 2015; Desai and Jha, 2013; Jaarsma et al...
February 2018: Data in Brief
Tarek Zghaib, Ashkan A Malayeri, Esra G Ipek, Mohammadali Habibi, Dong Huang, Muhammad A Balouch, David A Bluemke, Hugh Calkins, Saman Nazarian, Stefan L Zimmerman
BACKGROUND: Ablation-induced left atrial (LA) edema may result in procedural failure due to reversible pulmonary vein (PV) isolation. Conventional T2-weighted magnetic resonance edema imaging is limited by low spatial resolution. OBJECTIVE: In this pilot study, our goal was to 1) optimize and validate a 3D-SPACE sequence for quantification of T2-signal in the LA and 2) apply in recently ablated patients, comparing myocardial edema on T2-SPACE to tissue damage on late gadolinium-enhancement (LGE) imaging...
March 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Benedict T Costello, Dion Stub, James Hare, Andris H Ellims, Xinyu Wang, Karen Smith, Stephen Bernard, Ziad Nehme, Michael Stephenson, Janet E Bray, Peter Cameron, Bill Barger, Ian T Meredith, David M Kaye, Leah Iles, Andrew J Taylor
BACKGROUND: Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) is commonly assumed to represent myocardial fibrosis; however, comparative human histological data are limited, and there is no consensus on the most accurate method for LGE quantitation. We evaluated the relationship between CMR assessment of regional fibrosis and infarct size assessment using serial biomarkers after ST elevation acute myocardial infarction (STEMI). METHODS: Ninety-three patients treated for STEMI (59±10 years, 86% male) underwent CMR 6 months after infarction...
February 21, 2018: Heart, Lung & Circulation
John Whitaker, Cory M Tschabrunn, Jihye Jang, Eran Leshem, Mark O'Neill, Warren J Manning, Elad Anter, Reza Nezafat
BACKGROUND: Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias. PURPOSE: We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia-reperfusion-mediated MI. ANIMAL MODEL: Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia-reperfusion experimental model of MI...
March 9, 2018: Journal of Magnetic Resonance Imaging: JMRI
Tarek Zghaib, Ali Keramati, Jonathan Chrispin, Dong Huang, Muhammad A Balouch, Luisa Ciuffo, Ronald D Berger, Joseph E Marine, Hiroshi Ashikaga, Hugh Calkins, Saman Nazarian, David D Spragg
Background: Bipolar voltage mapping, as part of atrial fibrillation (AF) ablation, is traditionally performed in a point-by-point (PBP) approach using single-tip ablation catheters. Alternative techniques for fibrosis-delineation include fast-anatomical mapping (FAM) with multi-electrode circular catheters, and late gadolinium-enhanced magnetic-resonance imaging (LGE-MRI). The correlation between PBP, FAM, and LGE-MRI fibrosis assessment is unknown. Objective: In this study, we examined AF substrate using different modalities (PBP, FAM, and LGE-MRI mapping) in patients presenting for an AF ablation...
January 2018: JACC. Clinical Electrophysiology
Lei Wang, Yushu Chen, Bing Zhang, Wei Chen, Chunhua Wang, Li Song, Ziqian Xu, Jie Zheng, Fabao Gao
Objective: A failed electrocardiography (ECG)-trigger often leads to a long acquisition time (TA) and deterioration in image quality. The purpose of this study was to evaluate and optimize the technique of self-gated (SG) cardiovascular magnetic resonance (CMR) for cardiac late gadolinium enhancement (LGE) imaging of rats with myocardial infarction/reperfusion. Materials and Methods: Cardiovascular magnetic resonance images of 10 rats were obtained using SG-LGE or ECG with respiration double-gating (ECG-RESP-gating) method at 7T to compare differences in image interference and TA between the two methods...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
José A B Araujo-Filho, Antonildes N Assuncao, Marcelo D Tavares de Melo, Loïc Bière, Camila R Lima, Roberto N Dantas, Cesar H Nomura, Vera M C Salemi, Michael Jerosch-Herold, Jose R Parga
Aims: From pathophysiological mechanisms to risk stratification and management, much debate and discussion persist regarding left ventricular non-compaction cardiomyopathy (LVNC). This study aimed to characterize myocardial T1 mapping and extracellular volume (ECV) fraction by cardiovascular magnetic resonance (CMR), and investigate how these biomarkers relate to left ventricular ejection fraction (LVEF) and ventricular arrhythmias (VA) in LVNC. Methods and results: Patients with LVNC (n = 36) and healthy controls (n = 18) were enrolled to perform a CMR with T1 mapping...
March 6, 2018: European Heart Journal Cardiovascular Imaging
Li Wang, Min-Jie Lu, Lei Feng, Juan Wang, Wei Fang, Zuo-Xiang He, Ke-Fei Dou, Shi-Hua Zhao, Min-Fu Yang
BACKGROUND: The relationship between myocardial viability and angiographic collateral flow is not fully elucidated in ischemic cardiomyopathy (ICM) with coronary artery chronic total occlusion (CTO). We aimed to clarify the relationship between myocardial hibernation, myocardial scar, and angiographic collateral flow in these patients. METHODS AND RESULTS: Seventy-one consecutive ICM patients with 122 CTOs and 652 dysfunctional segments within CTO territories were retrospectively analyzed...
March 7, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Fumi Yanagisawa, Yasuo Amano, Masaki Tachi, Keisuke Inui, Kuniya Asai, Shinichiro Kumita
PURPOSE: We sought to use non-contrast-enhanced T1 mapping to determine the native T1 values required to identify myocardial fibrosis in patients with dilated cardiomyopathy (DCM). METHODS: A total of 25 patients with DCM and 15 healthy controls were enrolled. All subjects underwent T1 mapping using modified look-locker inversion recovery, and the patients underwent late gadolinium-enhancement (LGE) imaging. Basal and mid-ventricular levels were divided into eight segments and the T1 value was measured in each segment...
March 7, 2018: Magnetic Resonance in Medical Sciences: MRMS
Shuanglun Xie, Benoit Desjardins, Maciej Kubala, Jackson Liang, Jiandu Yang, Rob J van der Geest, Robert Schaller, Michael Riley, David Callans, Erica Zado Pac, Francis Marchlinski, Saman Nazarian
BACKGROUND: Criteria for identification of anatomic ventricular tachycardia (VT) substrates in arrhythmogenic right ventricular cardiomyopathy (ARVC) on late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) are unclear. OBJECTIVE: We sought to define a) the association of regional RV epicardial voltage amplitude with the distribution of LGE, and b) appropriate image signal intensity (SI) thresholds for VT substrate identification, in ARVC. METHODS: Pre-procedural LGE-CMR and epicardial electrogram mapping were performed in 10 ARVC patients...
March 1, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Sahadev T Reddy, Ngoc L Thai, Jose Oliva, Kusum B Tom, Michael K Dishart, Mark Doyle, June A Yamrozik, Ronald B Williams, Moneal Shah, Adil Wani, Anil Singh, Rishi Maheswary, Robert W W Biederman
BACKGROUND: The preoperative workup of orthotopic liver transplantation (OLT) patents is practically complex given the need for multiple imaging modalities. We recently demonstrated in our Proof-of-Concept study the value of a One-Stop-Shop approach using Cardiovascular MRI (CMR) to address this complex problem. However, this approach requires further validation in a larger cohort, as detection of HCC as well as cardiovascular risk assessment is critically important in these patients...
March 2, 2018: Clinical Transplantation
Nadia A Farrag, Venkat Ramanan, Graham A Wright, Eranga Ukwatta
PURPOSE: Myocardial infarct (MI) may consist of an infarct core (IC) and a heterogeneous, semi-viable border zone (BZ). Patients with chronic MI in the left ventricular (LV) myocardium are at increased risk of developing ventricular arrhythmias, and may therefore qualify for implantable cardioverter defibrillator (ICD) therapy. Indices based on MI mass, as determined by cardiac magnetic resonance (CMR) imaging, are shown to be sensitive in predicting adverse ventricular arrhythmic events...
March 1, 2018: Medical Physics
Guang Yang, Xiahai Zhuang, Habib Khan, Shouvik Haldar, Eva Nyktari, Lei Li, Ricardo Wage, Xujiong Ye, Greg Slabaugh, Raad Mohiaddin, Tom Wong, Jennifer Keegan, David Firmin
PURPOSE: Atrial fibrillation (AF) is the most common heart rhythm disorder and causes considerable morbidity and mortality, resulting in a large public health burden that is increasing as the population ages. It is associated with atrial fibrosis, the amount and distribution of which can be used to stratify patients and to guide subsequent electrophysiology ablation treatment. Atrial fibrosis may be assessed non-invasively using late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) where scar tissue is visualised as a region of signal enhancement...
February 26, 2018: Medical Physics
Hubert Cochet, Rémi Dubois, Seigo Yamashita, Nora Al Jefairi, Benjamin Berte, Jean-Marc Sellal, Darren Hooks, Antonio Frontera, Sana Amraoui, Adlane Zemoura, Arnaud Denis, Nicolas Derval, Frederic Sacher, Olivier Corneloup, Valérie Latrabe, Stéphanie Clément-Guinaudeau, Jatin Relan, Sohail Zahid, Patrick M Boyle, Natalia A Trayanova, Olivier Bernus, Michel Montaudon, François Laurent, Mélèze Hocini, Michel Haïssaguerre, Pierre Jaïs
OBJECTIVES: This study sought to assess the relationship between fibrosis and re-entrant activity in persistent atrial fibrillation (AF). BACKGROUND: The mechanisms involved in sustaining re-entrant activity during AF are poorly understood. METHODS: Forty-one patients with persistent AF (age 56 ± 12 years; 6 women) were evaluated. High-resolution electrocardiographic imaging (ECGI) was performed during AF by using a 252-chest electrode array, and phase mapping was applied to locate re-entrant activity...
January 2018: JACC. Clinical Electrophysiology
Nirav Patel, Pavani Kolakalapudi, Garima Arora
The utility and role of cardiac magnetic resonance (CMR) as a non-invasive diagnostic imaging modality has been well recognized in the field of cardiovascular disease. Use of late gadolinium enhancement (LGE) has further enhanced CMR's ability to determine structural, functional, and prognostic information in various cardiovascular diseases. The delivery and distribution of gadolinium as an extracellular agent allows the detection of edema, fibrosis, and infiltration in the myocardium. The pattern of LGE in cardiomyopathies enables us to distinguish among various disease processes non-invasively...
February 23, 2018: Echocardiography
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