keyword
MENU ▼
Read by QxMD icon Read
search

Osteoporosis perfusion

keyword
https://www.readbyqxmd.com/read/27833010/naringin-promotes-fracture-healing-through-stimulation-of-angiogenesis-by-regulating-the-vegf-vegfr-2-signaling-pathway-in-osteoporotic-rats
#1
Nan Song, Zhihu Zhao, Xinlong Ma, Xiaolei Sun, Jianxiong Ma, Fengbo Li, Lei Sun, Jianwei Lv
Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear...
November 8, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27636578/bisphosphonates-inhibit-pain-bone-loss-and-inflammation-in-a-rat-tibia-fracture-model-of-complex-regional-pain-syndrome
#2
Liping Wang, Tian-Zhi Guo, Tzuping Wei, Wen-Wu Li, Xiaoyou Shi, J David Clark, Wade S Kingery
BACKGROUND: Bisphosphonates are used to prevent the bone loss and fractures associated with osteoporosis, bone metastases, multiple myeloma, and osteogenesis deformans. Distal limb fractures cause regional bone loss with cutaneous inflammation and pain in the injured limb that can develop into complex regional pain syndrome (CRPS). Clinical trials have reported that antiresorptive bisphosphonates can prevent fracture-induced bone loss, inhibit serum inflammatory cytokine levels, and alleviate CRPS pain...
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27541685/reduction-of-longitudinal-vertebral-blood-perfusion-and-its-likely-causes-a-quantitative-dynamic-contrast-enhanced-mr-imaging-study-of-a-rat-osteoporosis-model
#3
Jingqi Zhu, Lin Zhang, Xing Wu, Zuogang Xiong, Yuyou Qiu, Ting Hua, Guangyu Tang
Purpose To determine the longitudinal relationships among lumbar vertebral blood perfusion, bone mass, and marrow adipose tissue in a rat osteoporosis model after ovariectomy by using quantitative dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging, microcomputed tomography (micro-CT), and proton MR spectroscopy. Materials and Methods In this animal review committee-approved study, lumbar vertebrae were evaluated through MR spectroscopy, quantitative DCE MR imaging, micro-CT, and histopathologic analysis, and blood was examined at 0, 2, 6, 10, 14, 18, and 24 weeks after ovariectomy consisting of exposure of the ovaries but no excision (n = 35) or sham operation, defined as exposure of the ovaries but no excision (n = 35)...
August 19, 2016: Radiology
https://www.readbyqxmd.com/read/26636416/immunolocalization-of-mmp-2-9-and-13-in-prednisolone-induced-osteoporosis-in-mice
#4
Bao Sun, Jing Sun, Xiuchun Han, Hongrui Liu, Juan Li, Juan Du, Wei Feng, Bo Liu, Jian Cui, Jie Guo, Norio Amizuka, Minqi Li
Long-term use of glucocorticoids (GC) causes rapid bone loss and increases the risk of osteoporotic fractures. Matrix metalloproteinase (MMPs), the most prominent kind of proteases implicated in the proteolytic degradation of the extracellular matrix (ECM), have been reported to be involved in pathological process of GC induced osteoporosis. However, the underlining mechanisms are still unclear. The aim of this study was to investigate the spatial expression and the potential function of MMP 2, 9 and 13 in osteoporosis induced by prednisolone in the tibiae of mice...
June 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/26135008/intestinal-absorption-and-metabolism-of-epimedium-flavonoids-in-osteoporosis-rats
#5
Jing Zhou, Yi Hua Ma, Zhong Zhou, Yan Chen, Ying Wang, Xia Gao
Herba Epimdii is a traditional Chinese medicine used to treat osteoporosis. Its main pharmacological ingredients are flavonoids. In previous studies conducted in healthy animals, we showed that epimedium flavonoids could be hydrolyzed into secondary glycosides or aglycon by intestinal flora or enzymes, thereby enhancing their absorption and antiosteoporosis activity. To study the medicine in the pathologic state, epimedium flavonoids were incubated with intestinal mucosa and feces in vitro and intestinal perfusion in situ to explore the differences in absorption and metabolism between sham and osteoporosis rats...
October 2015: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/26128834/tu-ab-204-00-advances-in-cone-beam-ct-and-emerging-applications
#6
(no author information available yet)
UNLABELLED: This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques.Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128832/tu-ab-204-01-advances-in-c-arm-cbct-for-brain-perfusion-imaging
#7
G Chen
UNLABELLED: This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques.Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128830/tu-ab-204-03-advances-in-cbct-for-orhtopaedics-and-bone-health-imaging
#8
W Zbijewski
UNLABELLED: This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques.Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128829/tu-ab-204-02-advances-in-c-arm-cbct-for-cardiac-interventions
#9
R Fahrig
UNLABELLED: This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques.Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128828/tu-ab-204-04-advances-in-cbct-for-breast-imaging
#10
J Boone
UNLABELLED: This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques.Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/25848257/mechanism-of-enhanced-antiosteoporosis-effect-of-circinal-icaritin-by-self-assembled-nanomicelles-in-vivo-with-suet-oil-and-sodium-deoxycholate
#11
Jun Jiang, Jie Li, Zhenhai Zhang, E Sun, Liang Feng, Xiaobin Jia
BACKGROUND: Circinal-icaritin (CIT), one new active aglycone of Epimedium, can exert a beneficial effect on osteoporotic bone. However, its low bioavailability limits its clinical efficacy for the treatment of osteoporosis. MATERIALS AND METHODS: In this paper, suet oil (SO) was used to improve the oral bioavailability of CIT and enhance its antiosteoporosis effect and absorption. After oral administration of CIT together with SO, the CIT and SO self-assembled into nanomicelles under the action of sodium deoxycholate (DOC) by bile secretion...
2015: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/25668922/polymethylmethacrylate-pulmonary-embolism-as-a-complication-of-percutaneous-vertebroplasty-in-cancer-patients
#12
Natasa Milojkovic, Samer Homsi
Percutaneous vertebroplasty is frequently used in the treatment of vertebral body fractures due to osteoporosis, vertebral body metastasis, or myeloma. Acrylic cement of polymethylmethacrylate injected into the vertebral body can leak into the paravertebral venous system and reach the pulmonary artery via the azygos vein leading to a cement pulmonary embolism. We are presenting a case of a 78 year old woman who was found to have polymethylmethacrylate pulmonary embolism as a result of vertebroplasty used for vertebral collapse from metastatic breast cancer...
December 2014: Journal of the Arkansas Medical Society
https://www.readbyqxmd.com/read/25410523/characterization-of-bone-perfusion-by-dynamic-contrast-enhanced-magnetic-resonance-imaging-and-positron-emission-tomography-in-the-dunkin-hartley-guinea-pig-model-of-advanced-osteoarthritis
#13
Jonathan P Dyke, Michael Synan, Paula Ezell, Douglas Ballon, Jennifer Racine, Roy K Aaron
This study characterizes changes in subchondral bone circulation in OA and examines relationships to bone structure and cartilage degeneration in Dunkin-Hartley guinea pigs. We have used dynamic contrast-enhanced MRI (DCE-MRI) and PET, with pharmacokinetic modeling, to characterize subchondral bone perfusion. Assessments are made of perfusion kinetics and vascular permeability by MRI, and blood volume and flow, and radionuclide incorporation into bone, by PET. These parameters are compared to cartilage lesion severity and bone histomorphometry...
March 2015: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/25056263/-implantation-of-a-salto-2-total-ankle-prosthesis
#14
S Lieske, K Schenk, H W Neumann, M John
AIM OF SURGERY: Operative treatment of advanced primary and secondary arthritis of the ankle was carried out with the aim of achieving pain-free movement and retention of mobility. INDICATIONS: Surgery is indicated when conservative therapy is no longer sufficient for treatment of arthritis of the ankle with painful limited movement, sufficient bony joint conditions and correctable instability or axis malpositioning. CONTRAINDICATIONS: Surgery is not recommended with general surgical or anesthesiological contraindications, rampant infections, severe disturbances of peripheral perfusion, bony defects in areas relevant for anchoring, unstable soft tissue conditions, talus necrosis >30 %, manifest osteoporosis and severe non-correctable instability or malpositioning...
August 2014: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/25003121/muscle-based-pharmacokinetic-modeling-of-marrow-perfusion-for-osteoporotic-bone-in-females
#15
Heather Ting Ma, James F Griffth, Ping-Chung Leung
The pharmacokinetic model has been widely used in tissue perfusion analysis, such as bone marrow perfusion. In the modeling process, the arterial input function is important to guarantee the reliability of the fitting result. However, the arterial input function is variable and hard to control, which makes it difficult to compare results across different studies. The purpose of this study was to establish a muscle-based pharmacokinetic model for bone marrow perfusion without using arterial input function. Erector spinae muscle around the vertebral body was selected as the reference region...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24242187/prolyl-hydroxylase-inhibitors-protect-from-the-bone-loss-in-ovariectomy-rats-by-increasing-bone-vascularity
#16
Xiaodong Liu, Yihui Tu, Lianfang Zhang, Jin Qi, Tong Ma, Lianfu Deng
The hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) pathway is involved in skeletal development, bone repair, and postmenopausal osteoporosis. Inhibitors of prolyl hydroxylases (PHD) enhance vascularity, increase callus formation in a stabilized fracture model, and activate the HIF-1α/VEGF pathway. This study examined the effects of estrogen on the HIF-1α/VEGF pathway in osteoblasts and whether PHD inhibitors can protect from bone loss in postmenopausal osteoporosis. Osteoblasts were treated with estrogen, and expressions of HIF-1α and VEGF were measured at mRNA (qPCR) and protein (Western blot) levels...
May 2014: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/24217841/marked-elevation-of-transaminases-and-pancreatic-enzymes-in-severe-malnourished-male-with-eating-disorder
#17
C Urso, S Brucculeri, G Caimi
We report a case of a 45 year old Caucasian malnourished male with an history of eating disorder who developed severe liver and pancreatic damage and multiorgan disfunction. At admission to our department, his body mass index (BMI) was 11.1. Biochemical evaluation showed elevated serum levels of transaminases (AST= 2291 U/L, ALT= 1792 U/L), amylase (3620 U/L), lipase (4102 U/L), CPK= 1370 U/L, LDH= 2082 U/L. No other cause of acute liver and pancreatic damage was evidenced. Haematological disorders (anemia, thrombocytopenia, leukopenia) found on admission seem related to bone marrow hypoplasia and to gelatinous marrow transformation described in severe state of malnutrition...
2013: La Clinica Terapeutica
https://www.readbyqxmd.com/read/24101962/intractable-metabolic-acidosis-in-a-child-with-propionic-acidemia-undergoing-liver-transplantation-a-case-report
#18
Jiyoung Ryu, Young Hee Shin, Justin Sangwook Ko, Mi Sook Gwak, Gaab-Soo Kim
Propionic acidemia (PA) is a rare autosomal recessive disorder of metabolism caused by deficient activity of the mitochondrial enzyme propionyl-CoA carboxylase. The clinical manifestations are metabolic acidosis, poor feeding, lethargy, vomiting, osteoporosis, neurological dysfunction, pancytopenia, developmental retardation and cardiomyopathy. Liver transplantation has recently been considered as one of the treatment options for patients with PA. This case report describes several anesthetic considerations for patients with PA undergoing liver transplantation...
September 2013: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/23571049/validated-laser-doppler-protocol-for-measurement-of-mouse-bone-blood-perfusion-response-to-age-or-ovariectomy-differs-with-genetic-background
#19
Bernard Roche, Arnaud Vanden-Bossche, Myriam Normand, Luc Malaval, Laurence Vico, Marie-Hélène Lafage-Proust
The physiological role of bone vascularization in bone metabolism begins to be understood; however, its involvement in pathological situations remains poorly explored. Bone blood supply depends on both vascular density and blood flow. However, in mice, the specific evaluation of perfusion in bone suffers from a lack of easy-handling measurement tools. In the present study, we first developed a Laser Doppler Perfusion Measurement (LDPM) protocol in mouse tibia, which we validated with ex vivo and in vivo experiments...
August 2013: Bone
https://www.readbyqxmd.com/read/23365908/relationship-between-marrow-perfusion-and-bone-mineral-density-a-pharmacokinetic-study-of-dce-mri
#20
Heather T Ma, James F Griffith, Xinxin Zhao, Haiyan Lv, David K W Yeung, Ping-Chung Leung
A reduced bone perfusion has been found for osteoporotic subjects in previous studies. However, the physiological changes underlying the varied perfusion function is not well known yet. Tofts model is one of the most frequently used pharmacokinetic models in analyzing perfusion process. This study modified the Tofts model by replacing the arterial input function (AIF) by a new algorithm. The modified model was then employed to analyze vertebral bone marrow perfusion in subjects with different bone mineral density (BMD)...
2012: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
keyword
keyword
64555
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"