keyword
https://read.qxmd.com/read/38198033/diabetes-and-the-microvasculature-of-the-bone-and-marrow
#1
REVIEW
Teresa Le, Amanda Salas Sanchez, Danyah Nashawi, Sunidhi Kulkarni, Rhonda D Prisby
PURPOSE OF REVIEW: The purpose of this review is to highlight the evidence of microvascular dysfunction in bone and marrow and its relation to poor skeletal outcomes in diabetes mellitus. RECENT FINDINGS: Diabetes mellitus is characterized by chronic hyperglycemia, which may lead to microangiopathy and macroangiopathy. Micro- and macroangiopathy have been diagnosed in Type 1 and Type 2 diabetes, coinciding with osteopenia, osteoporosis, enhanced fracture risk and delayed fracture healing...
January 10, 2024: Current Osteoporosis Reports
https://read.qxmd.com/read/37898921/a-bioartificial-and-vasculomorphic-bone-matrix-based-organoid-mimicking-microanatomy-of-flat-and-short-bones
#2
JOURNAL ARTICLE
Roberto Toni, Fulvio Barbaro, Giusy Di Conza, Nicoletta Zini, Giulia Remaggi, Lisa Elviri, Giulia Spaletta, Enrico Quarantini, Marco Quarantini, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Francesca Ravanetti, Simone Sprio, Anna Tampieri
We engineered an in vitro model of bioartificial 3D bone organoid consistent with an anatomical and vascular microenvironment common to mammalian flat and short bones. To achieve this, we chose the decellularized-decalcified matrix of the adult male rat scapula, implemented with the reconstruction of its intrinsic vessels, obtained through an original intravascular perfusion with polylevolactic (PLLA), followed by coating of the PLLA-fabricated vascularization with rat tail collagen. As a result, the 3D bone and vascular geometry of the native bone cortical and cancellous compartments was reproduced, and the rat tail collagen-PLLA biomaterial could in vitro act as a surrogate of the perivascular extracellular matrix (ECM) around the wall of the biomaterial-reconstituted cancellous vessels...
October 29, 2023: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/37552982/bone-on-a-chip-a-3d-dendritic-network-in-a-screening-platform-for-osteocyte-targeted-drugs
#3
JOURNAL ARTICLE
Maria Veronica Lipreri, Gemma Di Pompo, Elisa Boanini, Gabriela Graziani, Enrico Sassoni, Nicola Baldini, Sofia Avnet
Age-related musculoskeletal disorders, including osteoporosis, are frequent and associated with long lasting morbidity, in turn significantly impacting on healthcare system sustainability. There is therefore a compelling need to develop reliable preclinical models of disease and drug screening to validate novel drugs possibly on a personalized basis, without the need of in vivo assay. In the context of bone tissue, although the osteocyte network is a well-recognized therapeutic target, current in vitro preclinical models are unable to mimic its physiologically relevant and highly complex structure...
August 8, 2023: Biofabrication
https://read.qxmd.com/read/37110373/the-preventive-effects-of-probiotic-prevotella-histicola-on-the-bone-loss-of-mice-with-ovariectomy-mediated-osteoporosis
#4
JOURNAL ARTICLE
Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Ren-Wang Sheng, Ruo-Lan Zhang, Meng-Ting Wu, Jia-Yu Chi, Rui-Xin Zhou, Yun-Feng Rui
It has been demonstrated that the disturbance of gut microbiota (GM) is closely related to the reduction of bone mass and incidence of osteoporosis (OP). The aim of this study is to investigate whether the supplementation of Prevotella histicola (Ph) can prevent the bone loss in mice with ovariectomy (OVX)-mediated OP, and further explore relevant mechanisms. Regular (once a day for 8 consecutive weeks) and quantitative (200 µL/d) perfusion of Ph (the bacteria that orally gavaged) was conducted starting from 1 week after the construction of mice models...
April 6, 2023: Microorganisms
https://read.qxmd.com/read/36609369/alternatives-to-dexa-for-the-assessment-of-bone-density-a-systematic-review-of-the-literature-and-future-recommendations
#5
REVIEW
Nachiket Deshpande, Moustafa S Hadi, Jock C Lillard, Peter G Passias, Joseph R Linzey, Yamaan S Saadeh, Michael LaBagnara, Paul Park
OBJECTIVE: Osteoporosis has significant implications in spine fusion surgery, for which reduced spinal bone mineral density (BMD) can result in complications and poorer outcomes. Currently, dual-energy x-ray absorptiometry (DEXA) is the gold standard for radiographic diagnosis of osteoporosis, although DEXA accuracy may be limited by the presence of degenerative spinal pathology. In recent years, there has been an evolving interest in using alternative imaging, including CT and MRI, to assess BMD...
April 1, 2023: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/36350408/study-on-mass-transfer-in-the-bone-lacunar-canalicular-system-under-different-gravity-fields
#6
JOURNAL ARTICLE
Hao Wang, Lilan Gao, Xuyi Chen, Chunqiu Zhang
INTRODUCTION: The bone lacunar-canalicular system (LCS) is an important microstructural basis for signaling and material transport in bone tissue, guaranteeing normal physiological processes in tissues. Spaceflight astronauts and elderly osteoporosis are related to its function, so it is necessary to reveal the mass transfer laws in bone microstructure under different gravity fields to provide insight for effective clinical treatment. MATERIALS AND METHODS: Using the natural LCS structure of bovine tibial cortical bone as the object, the mass transfer experiments on cortical bone were conducted by using sodium fluorescein tracer through different frequency pulsating pressure provided by dynamic perfusion loading device and different high G environments provided by high-speed centrifuge to analyze the mass transfer laws under different gravity fields and different pulsating pressures...
November 9, 2022: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/35854057/zoledronate-combined-metal-organic-frameworks-for-bone-targeting-and-drugs-deliveries
#7
JOURNAL ARTICLE
Yixiao Pan, Jiahao Wang, Zichao Jiang, Qi Guo, Zhen Zhang, Jingyi Li, Yihe Hu, Long Wang
Medicine treatments for bone-related diseases such as osteoporosis, bone metastasis, osteomyelitis, and osteolysis are often limited by insufficient drug concentration at the lesion sites owing to the low perfusion of bone tissue. A carrier that can deliver multiple bone destruction site-targeting drugs is required to address this limitation. Here, we reported a novel bone-targeting nano-drug delivery platform formed by the integration of zoledronate (ZOL) and zeolitic imidazolate framework-8 (ZIF-8) nanoparticles...
July 19, 2022: Scientific Reports
https://read.qxmd.com/read/35395788/correlation-between-musculoskeletal-mass-and-perfusion-in-patients-with-gastrointestinal-malignancy-a-preliminary-study-based-on-quantitative-ct-and-ct-perfusion
#8
JOURNAL ARTICLE
Rui Ji, Lin Zhang, Yongju Shen, Rui Tang, Yun Tu, Guangyu Tang, Jingqi Zhu
BACKGROUND: To investigate the correlation between musculoskeletal mass and perfusion using quantitative computer tomography (QCT) and CT perfusion (CTP) in patients with gastrointestinal malignancy. METHODS: In this prospective study, 96 patients (mean age 66 years, range 25-90; 63.5% male) with gastrointestinal malignancy underwent QCT and CTP between May 2019 and February 2021. Bone mineral density (BMD) and body composition [perivertebral muscular mass index (PMI), skeletal muscular mass index (SMI) and muscular fat fraction] were evaluated through QCT...
April 8, 2022: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/35141833/the-impact-of-imaging-time-and-contrast-agent-dose-on-screening-for-osteoporosis-with-contrast-enhanced-ct
#9
JOURNAL ARTICLE
Mischa Woisetschläger, Eva Klintström, Anna Spångeus
BACKGROUND: Screening for osteoporosis with contrast-enhanced computed tomography (CT) is promising for identifying high-risk osteoporotic patients. Our aims were (1) to investigate the estimated volume bone mineral density (vBMD) change over time after contrast injection (CT perfusion imaging, CTPI); and (2) to examine the influence of contrast dose on vBMD. METHODS: Fifteen patients, aged 71 ± 9 years (mean ± standard deviation, range 55-86) underwent a CTPI examination (28 scans within 63 s) of the upper body followed (after a waiting time of 10 min) by a full 4-phase CT examination (4 scans within 4 min)...
February 10, 2022: European Radiology Experimental
https://read.qxmd.com/read/35064317/identification-of-abnormal-bmd-and-osteoporosis-in-postmenopausal-women-with-t2-corrected-q-dixon-and-reduced-fov-ivim-correlation-with-qct
#10
JOURNAL ARTICLE
Xiangwen Li, Rong Lu, Yuxue Xie, Qing Li, Hongyue Tao, Shuang Chen
OBJECTIVE: To investigate the predictive value of quantitative Dixon (Q-Dixon) and intravoxel incoherent motion (IVIM) parameters in identifying normal bone mineral density (BMD), osteopenia, and osteoporosis in postmenopausal women. METHODS: We enrolled 105 postmenopausal female subjects who underwent 3 T MRI, including T2*-corrected Q-Dixon and reduced-field-of-view (reduced-FOV) IVIM sequences. The measurement of Q-Dixon and IVIM parameters was performed on the L3 vertebral body...
July 2022: European Radiology
https://read.qxmd.com/read/34968494/role-of-nitric-oxide-in-type-1-diabetes-induced-osteoporosis
#11
REVIEW
Sajad Jeddi, Nasibeh Yousefzadeh, Khosrow Kashfi, Asghar Ghasemi
Type 1 diabetes (T1D)-induced osteoporosis is characterized by decreased bone mineral density, bone quality, rate of bone healing, bone formation, and increased bone resorption. Patients with T1D have a 2-7-fold higher risk of osteoporotic fracture. The mechanisms leading to increased risk of osteoporotic fracture in T1D include insulin deficiency, hyperglycemia, insulin resistance, lower insulin-like growth factor-1, hyperglycemia-induced oxidative stress, and inflammation. In addition, a higher probability of falling, kidney dysfunction, weakened vision, and neuropathy indirectly increase the risk of osteoporotic fracture in T1D patients...
March 2022: Biochemical Pharmacology
https://read.qxmd.com/read/34863272/vibration-therapy-as-an-intervention-for-enhancing-trochanteric-hip-fracture-healing-in-elderly-patients-a-randomized-double-blinded-placebo-controlled-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Ronald Man Yeung Wong, Simon Kwoon Ho Chow, Ning Tang, Yik Lok Chung, James Griffith, Wing Hong Liu, Raymond Wai Kit Ng, Chi Yin Tso, Wing Hoi Cheung
BACKGROUND: There are more than 300,000 hip fractures yearly in the USA with mortality rates of 20% within 1 year. The treatment of osteoporotic fractures is a major challenge as bone quality is poor, and healing is expected to delay due to the impaired healing properties with respect to bone formation, angiogenesis, and mineralization. Enhancement of osteoporotic fracture healing and function is therefore critical as a major goal in modern fracture management. Previous pre-clinical studies have shown that low-magnitude high-frequency vibration (LMHFV) accelerates osteoporotic fracture healing...
December 4, 2021: Trials
https://read.qxmd.com/read/34689107/mesenchymal-stem-cells-prevent-ovariectomy-induced-osteoporosis-formation-in-mice-through-intraosseous-vascular-remodeling
#13
JOURNAL ARTICLE
Weizhou Wang, Yanghao Wang, Zhihong Tang, Yongcheng Chen, Zhui Liu, Hao Duan, Zongyu Zhong, Fei He
Mesenchymal stem cells (MSCs) can promote osteogenesis and are a promising therapy for postmenopausal osteoporosis. However, the relationship between improved intraosseous microcirculation and increased bone mass induced by MSCs in postmenopausal osteoporosis remains unclear. After the primary MSCs were characterized, they were transplanted into ovariectomized mice. MSCs transplantation enhanced the trabecular number, trabecular bone volume/total volume, and trabecular bone mineral density in ovariectomized mice...
December 10, 2021: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/34335280/tanshinol-alleviates-microcirculation-disturbance-and-impaired-bone-formation-by-attenuating-txnip-signaling-in-gio-rats
#14
JOURNAL ARTICLE
Wenxiu Lai, Yulin Mo, Dongtao Wang, Ying Zhong, Lujiao Lu, Jiajia Wang, Liao Cui, Yanzhi Liu, Yajun Yang
Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still not entirely clear. In the present study, we determined the parameters related to microstructure and function of bone tissue, bone microcirculation, and TXNIP signaling to investigate the beneficial effects of tanshinol on skeleton and its molecular mechanism in GIO rats...
2021: Frontiers in Pharmacology
https://read.qxmd.com/read/34326210/counteracting-age-related-vegf-signaling-insufficiency-promotes-healthy-aging-and-extends-life-span
#15
JOURNAL ARTICLE
M Grunewald, S Kumar, H Sharife, E Volinsky, A Gileles-Hillel, T Licht, A Permyakova, L Hinden, S Azar, Y Friedmann, P Kupetz, R Tzuberi, A Anisimov, K Alitalo, M Horwitz, S Leebhoff, O Z Khoma, R Hlushchuk, V Djonov, R Abramovitch, J Tam, E Keshet
Aging is an established risk factor for vascular diseases, but vascular aging itself may contribute to the progressive deterioration of organ function. Here, we show in aged mice that vascular endothelial growth factor (VEGF) signaling insufficiency, which is caused by increased production of decoy receptors, may drive physiological aging across multiple organ systems. Increasing VEGF signaling prevented age-associated capillary loss, improved organ perfusion and function, and extended life span. Healthier aging was evidenced by favorable metabolism and body composition and amelioration of aging-associated pathologies including hepatic steatosis, sarcopenia, osteoporosis, "inflammaging" (age-related multiorgan chronic inflammation), and increased tumor burden...
July 30, 2021: Science
https://read.qxmd.com/read/34204387/-18-f-sodium-fluoride-pet-as-a-diagnostic-modality-for-metabolic-autoimmune-and-osteogenic-bone-disorders-cellular-mechanisms-and-clinical-applications
#16
REVIEW
Peter Sang Uk Park, William Y Raynor, Yusha Sun, Thomas J Werner, Chamith S Rajapakse, Abass Alavi
In a healthy body, homeostatic actions of osteoclasts and osteoblasts maintain the integrity of the skeletal system. When cellular activities of osteoclasts and osteoblasts become abnormal, pathological bone conditions, such as osteoporosis, can occur. Traditional imaging modalities, such as radiographs, are insensitive to the early cellular changes that precede gross pathological findings, often leading to delayed disease diagnoses and suboptimal therapeutic strategies. 18 F-sodium fluoride (18 F-NaF)-positron emission tomography (PET) is an emerging imaging modality with the potential for early diagnosis and monitoring of bone diseases through the detection of subtle metabolic changes...
June 17, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33708496/heart-transplantation-the-berlin-experience-and-perspectives
#17
REVIEW
Mariano Francisco Del Maria Javier, Eva Maria Javier Delmo, Roland Hetzer
In patients with end-stage heart failure, heart transplants are now an ingrained practice, as they provide satisfying long-term results with good predictability and quality of life. The successful outcome has evolved from the development of effective immunosuppression, recognition of allograft rejection through diagnostic modalities and improvement in donor organ perfusion. Unfortunately, transplant availability is constrained by the shortage of donor organs and is therefore considered a casuistic therapy. The outcome is defined by unwanted effects of immunosuppressants, increased tumor occurrence and chronic transplant angiopathies...
February 2021: Cardiovascular Diagnosis and Therapy
https://read.qxmd.com/read/33666016/-three-dimensional-finite-element-analysis-of-optimal-distribution-model-of-fillers-in-vertebroplasty
#18
JOURNAL ARTICLE
De-Guo Wang, Yang Li, Hong-Ling Yin, Jun Li, Jiao Qu, Min-Bo Jiang, Ji-Wei Tian
OBJECTIVE: To establish a three-dimensional finite element model of osteoporosis and to study the stiffness recovery of injured vertebrae and stress analysis of adjacent vertebrae after percutaneous vertebroplasty under different perfusion and distribution conditions by simulating fluid flow into the vertebral body. METHODS: A male healthy volunteer was selected. CT scans were performed from T11 to L2 . Mimics 15.0 and ABAQUS 6.11 software were used to extract CT images...
January 25, 2021: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://read.qxmd.com/read/33541442/stat3-activation-by-catalpol-promotes-osteogenesis-angiogenesis-coupling-thus-accelerating-osteoporotic-bone-repair
#19
JOURNAL ARTICLE
Liang Chen, Ri-Yan Zhang, Jun Xie, Jia-Yi Yang, Kang-Hao Fang, Chen-Xuan Hong, Rong-Bo Yang, Najeeb Bsoul, Lei Yang
BACKGROUND: Bone fracture repair has gained a lot of attention due to the high incidence of delayed union or even nonunion especially in osteoporotic patients, resulting in a dreadful impact on the quality of life. However, current therapies involve the costly expense and hence become unaffordable strategies for fracture recovery. Herein, developing new strategies for better bone repair is essential and urgent. Catalpol treatment has been reported to attenuate bone loss and promote bone formation...
February 4, 2021: Stem Cell Research & Therapy
https://read.qxmd.com/read/32564438/regular-supplementation-with-resveratrol-improves-bone-mineral-density-in-postmenopausal-women-a-randomized-placebo-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Rachel Hx Wong, Jay Jay Thaung Zaw, Cory J Xian, Peter Rc Howe
Resveratrol, a naturally occurring polyphenol in red grapes and berries, can act as a phytoestrogen. It has been shown to improve both systemic and cerebral circulatory functions, possibly through activation of endothelial estrogen receptors. in vitro and in vivo studies in rodent models also indicate a bone-protective role for resveratrol, particularly in ovariectomized rat models that mimic postmenopausal osteoporosis caused by estrogen deficiency. Hypothesizing a circulatory benefit of resveratrol in bone tissue, we investigated whether resveratrol supplementation could improve bone health in postmenopausal women...
November 2020: Journal of Bone and Mineral Research
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