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https://www.readbyqxmd.com/read/27931504/clinical-benefits-of-stem-cells-for-chronic-symptomatic-systolic-heart-failure-a-systematic-review-of-the-existing-data-and-ongoing-trials
#1
Marie-France Poulin, Anjan Deka, Burhan Mohamedali, Gary L Schaer
The benefits of stem cell therapy for patients with chronic symptomatic systolic heart failure due to ischemic and nonischemic cardiomyopathy (ICM and NICM, respectively) are unclear. We performed a systematic review of major published and ongoing trials of stem cell therapy for systolic heart failure and compared measured clinical outcomes for both types of cardiomyopathy. The majority of the 29 published studies demonstrated clinical benefits of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs)...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27930695/coordinated-activation-of-vegf-vegfr-2-and-ppar%C3%AE-pathways-by-a-multi-component-chinese-medicine-dhi-accelerated-recovery-from-peripheral-arterial-disease-in-type-2-diabetic-mice
#2
Shuang He, Tiechan Zhao, Hao Guo, Yanzhi Meng, Gangjian Qin, David A Goukassian, Jihong Han, Xuimei Gao, Yan Zhu
Diabetic mellitus (DM) patients are at an increased risk of developing peripheral arterial disease (PAD). Danhong injection (DHI) is a Chinese patent medicine widely used for several cardiovascular indications but the mechanism of action is not well-understood. We investigated the therapeutic potential of DHI on experimental PAD in mice with chemically induced as well as genetic (KKAy) type 2 DM and the overlapping signaling pathways regulating both therapeutic angiogenesis and glucose homeostasis. Compared with normal genetic background wild type (WT) mice, both DM mice showed impaired perfusion recovery in hind-limb ischemia (HLI) model...
2016: PloS One
https://www.readbyqxmd.com/read/27905865/transient-bone-marrow-edema-syndrome-versus-osteonecrosis-perfusion-patterns-at-dynamic-contrast-enhanced-mr-imaging-with-high-temporal-resolution-can-allow-differentiation
#3
Tobias Geith, Thomas Niethammer, Stefan Milz, Olaf Dietrich, Maximilian Reiser, Andrea Baur-Melnyk
Purpose To prospectively evaluate the perfusion patterns at quantitative dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging of transient bone marrow edema syndrome (TBMES) and avascular osteonecrosis. Materials and Methods Institutional review board approval and written informed consent were obtained. Thirty-two patients (21 men, 11 women; mean age, 48 years; 26 hips, 10 knees) underwent conventional MR imaging and a dynamic contrast-enhanced three-dimensional spoiled gradient-echo sequence at 3 T...
December 1, 2016: Radiology
https://www.readbyqxmd.com/read/27905554/increased-plasma-vegf-levels-following-ischemic-preconditioning-are-associated-with-downregulation-of-mirna-762-and-mir-3072-5p
#4
Koji Ueno, Makoto Samura, Tamami Nakamura, Yuya Tanaka, Yuriko Takeuchi, Daichi Kawamura, Masaya Takahashi, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
Ischemic preconditioning (IPC) has protective effects against ischemia-perfusion injury of organs. In the present study, we investigated the associated mechanisms after performing remote IPC (rIPC) of lower limbs by clamping abdominal aorta in mice. Subsequent experiments showed decreased damage and paralysis of lower limbs following spinal cord injury (SCI). Concomitantly, plasma vascular endothelial growth factor (VEGF) levels were increased 24 h after rIPC compared with those in sham-operated animals. In subsequent microRNA analyses, thirteen microRNAs were downregulated in exosomes 24 h after rIPC...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27903568/effects-of-trans-endocardial-delivery-of-bone-marrow-derived-cd133-cells-on-left-ventricle-perfusion-and-function-in-patients-with-refractory-angina-final-results-of-randomized-double-blinded-placebo-controlled-regent-vsel-trial
#5
Wojciech Wojakowski, Tomasz Jadczyk, Aleksandra Michalewska-Wludarczyk, Zofia Parma, Miroslaw Markiewicz, Wojciech Rychlik, Magdalena Kostkiewicz, Katarzyna Gruszczynska, Anna Blach, Monika Dzierzak-Mietla, Wojciech Wanha, Joanna Ciosek, Beata Ochala, Lukasz Rzeszutko, Wieslaw Cybulski, Lukasz Partyka, Wojciech Zasada, Witold Wludarczyk, Sebastian Dworowy, Waclaw B Kuczmik, Grzegorz Smolka, Tomasz Z Pawlowski, Andrzej Ochala, Michal Tendera
RATIONALE: New therapies for refractory angina are needed. OBJECTIVE: Assessment of trans-endocardial delivery of bone marrow (BM) CD133(+)cells in patients with refractory angina. METHODS AND RESULTS: Randomized, double-blinded, placebo-controlled trial enrolled 31 patients with recurrent CCS II-IV angina despite optimal medical therapy, ≥ one myocardial segment with inducible ischemia in Tc-99m SPECT who underwent BM biopsy and were allocated to cells (n=16) or placebo (n=15)...
November 30, 2016: Circulation Research
https://www.readbyqxmd.com/read/27842674/radiation-dose-in-cardiac-spect-ct-an-estimation-of-ssde-and-effective-dose
#6
Hamid Abdollahi, Isaac Shiri, Yazdan Salimi, Maghsoud Sarebani, Reza Mehdinia, Mohammad Reza Deevband, Seied Rabi Mahdavi, Ahmad Sohrabi, Ahmad Bitarafan-Rajabi
AIMS: The dose levels for Computed Tomography (CT) localization and attenuation correction of Single Photon Emission Computed Tomography (SPECT) are limited and reported as Volume Computed Tomography Dose Index (CTDIvol) and Dose-Length Product (DLP). This work presents CT dose estimation from Cardiac SPECT/CT based on new American Association of Physicists in Medicine (AAPM) Size Specific Dose Estimation (SSDE) parameter, effective dose, organ doses and also emission dose from nuclear issue...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27833010/naringin-promotes-fracture-healing-through-stimulation-of-angiogenesis-by-regulating-the-vegf-vegfr-2-signaling-pathway-in-osteoporotic-rats
#7
Nan Song, Zhihu Zhao, Xinlong Ma, Xiaolei Sun, Jianxiong Ma, Fengbo Li, Lei Sun, Jianwei Lv
Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear...
November 8, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27821724/preserve-ami-a-randomized-double-blind-placebo-controlled-clinical-trial-of-intracoronary-administration-of-autologous-cd34-cells-in-patients-with-left-ventricular-dysfunction-post-stemi
#8
Arshed A Quyyumi, Alejandro Vasquez, Dean Kereiakes, Marc Klapholz, Gary L Schaer, Ahmed Abdel-Latif, Stephen Frohwein, Timothy D Henry, Richard A Schatz, Nabil Dib, Catalin Toma, Charles J Davidson, Gregory W Barsness, David Shavelle, Martin Cohen, Joseph Poole, Thomas J Moss, Pamela Hyde, AnnaMaria Kanakaraj, Vitaly Druker, Amy Chung, Candice Junge, Robert A Preti, Robin L Smith, David J Mazzo, Andrew Pecora, Douglas W Losordo
RATIONALE: Despite direct immediate intervention and therapy, ST segment Elevation Myocardial Infarction (STEMI) victims remain at risk for infarct expansion, heart failure, re-infarction, repeat revascularization and death. OBJECTIVE: To evaluate the safety and bioactivity of autologous CD34+ cell (CLBS10) intracoronary infusion in patients with left ventricular dysfunction (LVD) post-STEMI. METHODS AND RESULTS: Patients who underwent successful stenting for STEMI and had LVD (ejection fraction [EF] ≤48%) ≥4 days post-stent were eligible for enrollment...
November 7, 2016: Circulation Research
https://www.readbyqxmd.com/read/27818910/biologically-inspired-smart-release-system-based-on-3d-bioprinted-perfused-scaffold-for-vascularized-tissue-regeneration
#9
Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Grace Zhang
A critical challenge to the development of large-scale artificial tissue grafts for defect reconstruction is vascularization of the tissue construct. As an emerging tissue/organ manufacturing technique, 3D bioprinting offers great precision in controlling the internal architecture of a scaffold with preferable mechanical strength and printing complicated microstructures comparable to native tissue. However, current bioprinting techniques still exhibit difficulty in achieving biomimetic nano resolution and cooperating with bioactive spatiotemporal signals...
August 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27754785/androgen-receptor-mediated-genomic-androgen-action-augments-ischemia-induced-neovascularization
#10
Yuen Ting Lam, Laura Lecce, Joanne T M Tan, Christina A Bursill, David J Handelsman, Martin K C Ng
Increasing evidence indicates that androgens regulate ischemia-induced neovascularization. However, the role of genomic androgen action mediated by androgen receptor (AR), a ligand-activated nuclear transcription factor, remains poorly understood. Using an AR knockout (KO) mouse strain that contains a transcriptionally inactive AR (AR(Δex3)KO), we examined the role of AR genomic function in modulating androgen-mediated augmentation of ischemia-induced neovascularization. Castrated wild-type (AR(WT)) and AR(Δex3)KO mice were implanted with 5α-dihydrotestosterone (DHT) or placebo pellets after hindlimb ischemia (HLI)...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27729575/neurorestorative-responses-to-delayed-human-mesenchymal-stromal-cells-treatment-of-stroke-in-type-2-diabetic-rats
#11
Tao Yan, Poornima Venkat, Michael Chopp, Alex Zacharek, Ruizhuo Ning, Cynthia Roberts, Yi Zhang, Mei Lu, Jieli Chen
BACKGROUND AND PURPOSE: Comorbidity of diabetes mellitus and stroke results in worse functional outcome, poor long-term recovery, and extensive vascular damage. We investigated the neurorestorative effects and mechanisms of stroke treatment with human bone marrow-derived mesenchymal stromal cells (hMSCs) in type 2 diabetes mellitus (T2DM) rats. METHODS: Adult male Wistar rats were induced with T2DM, subjected to 2 hours of middle cerebral artery occlusion (MCAo) and treated via tail-vein injection with (1) PBS (n=8) and (2) hMSCs (n=10; 5×10(6)) at 3 days after MCAo...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27665225/the-impact-cabg-trial-a-multicenter-randomized-clinical-trial-of-cd133-stem-cell-therapy-during-coronary-artery-bypass-grafting-for-ischemic-cardiomyopathy
#12
Nicolas Noiseux, Samer Mansour, Richard Weisel, Louis-Mathieu Stevens, Shant Der Sarkissian, Katherine Tsang, Andrew M Crean, Eric Larose, Shu-Hong Li, Bernd Wintersperger, Minh Quan Vu, Ignacio Prieto, Ren-Ke Li, Denis Claude Roy, Terrence M Yau
OBJECTIVES: The IMPACT-CABG trial is the first North American multicenter phase II randomized study of intramyocardial delivery of autologous CD133(+) stem cells in patients with chronic ischemic cardiomyopathy undergoing coronary artery bypass grafting. The primary objective was to demonstrate safety, including freedom from major adverse cardiac events. The secondary objective was to evaluate feasibility of same-day autologous cell preparation. Although the trial was not powered to evaluate LV function, exploratory data were collected...
August 13, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27660293/restoration-of-hydrogen-sulfide-production-in-diabetic-mice-improves-reparative-function-of-bone-marrow-cells
#13
Zhongjian Cheng, Venkata Naga Srikanth Garikipati, Emily Nickoloff, Chunlin Wang, David J Polhemus, Jibin Zhou, Cynthia Benedict, Mohsin Khan, Suresh K Verma, Joseph E Rabinowitz, David Lefer, Raj Kishore
BACKGROUND: Bone marrow cell (BMC)-based treatment for critical limb ischemia in diabetic patients yielded a modest therapeutic effect resulting from cell dysfunction. Therefore, approaches that improve diabetic stem/progenitor cell functions may provide therapeutic benefits. Here, we tested the hypothesis that restoration of hydrogen sulfide (H2S) production in diabetic BMCs improves their reparative capacities. METHODS: Mouse BMCs were isolated by density-gradient centrifugation...
November 8, 2016: Circulation
https://www.readbyqxmd.com/read/27565072/harvest-tissue-source-does-not-alter-the-protective-power-of-stromal-cell-therapy-after-intestinal-ischemia-and-reperfusion-injury
#14
Amanda R Jensen, Morenci M Manning, Sina Khaneki, Natalie A Drucker, Troy A Markel
BACKGROUND: Transplantation of mesenchymal stromal cells (MSCs) may be a novel treatment for intestinal ischemia. The optimal stromal cell source that could yield maximal protection after injury, however, has not been identified. We hypothesized that (1) MSCs would increase survival and mesenteric perfusion, preserve intestinal histologic architecture, and limit inflammation after intestinal ischemia and reperfusion (I/R) injury, and (2) MSCs harvested from different sources of tissue would have equivalent protective properties to the intestine after I/R inury...
August 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27541685/reduction-of-longitudinal-vertebral-blood-perfusion-and-its-likely-causes-a-quantitative-dynamic-contrast-enhanced-mr-imaging-study-of-a-rat-osteoporosis-model
#15
Jingqi Zhu, Lin Zhang, Xing Wu, Zuogang Xiong, Yuyou Qiu, Ting Hua, Guangyu Tang
Purpose To determine the longitudinal relationships among lumbar vertebral blood perfusion, bone mass, and marrow adipose tissue in a rat osteoporosis model after ovariectomy by using quantitative dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging, microcomputed tomography (micro-CT), and proton MR spectroscopy. Materials and Methods In this animal review committee-approved study, lumbar vertebrae were evaluated through MR spectroscopy, quantitative DCE MR imaging, micro-CT, and histopathologic analysis, and blood was examined at 0, 2, 6, 10, 14, 18, and 24 weeks after ovariectomy consisting of exposure of the ovaries but no excision (n = 35) or sham operation, defined as exposure of the ovaries but no excision (n = 35)...
August 19, 2016: Radiology
https://www.readbyqxmd.com/read/27514011/mesenchymal-stem-cells-in-corneal-neovascularization-comparison-of-different-application-routes
#16
Emma Ghazaryan, Yan Zhang, Yuxi He, Xin Liu, Ying Li, Jianan Xie, Guanfang Su
The purpose of the present study is to investigate the effect of mesenchymal stem cells in corneal neovascularization and wound healing, and to compare the effectiveness of two possible application routes, subconjunctival injection and amniotic membrane transplantation. Chemical injury was induced by application of sodium hydroxide to the rats' corneas. After 7 days, the animals were divided into three groups. Different treatment methods were used for each group as follows: i) Group 1, injection of bone marrow‑derived mesenchymal stem cells (BMSCs) under the conjunctiva; ii) group 2, transplantation of amniotic membranes, previously seeded with BMSCs; and iii) group 3, the untreated control group...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27507404/resolvin-d2-enhances-postischemic-revascularization-while-resolving-inflammation
#17
Michael J Zhang, Brian E Sansbury, Jason Hellmann, James F Baker, Luping Guo, Caitlin M Parmer, Joshua C Prenner, Daniel J Conklin, Aruni Bhatnagar, Mark A Creager, Matthew Spite
BACKGROUND: Resolvins are lipid mediators generated by leukocytes during the resolution phase of inflammation. They have been shown to regulate the transition from inflammation to tissue repair; however, it is unknown whether resolvins play a role in tissue revascularization following ischemia. METHODS: We used a murine model of hind limb ischemia (HLI), coupled with laser Doppler perfusion imaging, microcomputed tomography, and targeted mass spectrometry, to assess the role of resolvins in revascularization and inflammation resolution...
August 30, 2016: Circulation
https://www.readbyqxmd.com/read/27380735/mesenchymal-stromal-cell-therapy-in-ischemic-heart-disease
#18
Jens Kastrup, Naja Dam Mygind, Abbas Ali Qayyum, Anders Bruun Mathiasen, Mandana Haack-Sørensen, Annette Ekblond
Although, treatment of ischemic heart disease (IHD) has improved considerably within the last decades, it is still the main cause of death worldwide. Despite maximum treatment, many IHD patients suffer from refractory angina and heart failure, which severely limits their daily lives. Moreover, IHD is very costly for the health care system. Therefore, new treatment options and strategies are being researched intensely. Stem cell therapy to improve myocardial perfusion and stimulate growth of new cardiomyocytes could be a new way to go...
September 22, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27380410/cell-size-critically-determines-initial-retention-of-bone-marrow-mononuclear-cells-in-the-heart-after-intracoronary-injection-evidence-from-a-rat-model
#19
Niall G Campbell, Masahiro Kaneko, Yasunori Shintani, Takuya Narita, Vinit Sawhney, Steven R Coppen, Kenta Yashiro, Anthony Mathur, Ken Suzuki
Intracoronary injection of bone marrow mononuclear cells (BMMNC) is an emerging treatment for heart failure. Initial donor cell retention in the heart is the key to the success of this approach, but this process remains insufficiently characterized. Although it is assumed that cell size of injected cells may influence their initial retention, no scientific evidence has been reported. We developed a unique model utilizing an ex-vivo rat heart perfusion system, enabling quantitative assessment of retention of donor cells after intracoronary injection...
2016: PloS One
https://www.readbyqxmd.com/read/27349212/clinical-benefits-of-stem-cells-for-chronic-symptomatic-systolic-heart-failure-a-systematic-review-of-the-existing-data-and-ongoing-trials
#20
Marie-France Poulin, Anjan Deka, Burhan Mohamedali, Gary L Schaer
The benefits of stem cell therapy for patients with chronic symptomatic systolic heart failure due to ischemic (ICM) and non-ischemic cardiomyopathy (NICM) are unclear. We performed a systematic review of major published and ongoing trials of stem cell therapy for systolic heart failure and compared measured clinical outcomes for both types of cardiomyopathy. The majority of the 29 published studies demonstrated clinical benefits of autologous bone marrow derived stem cells. Left ventricular ejection fraction (LVEF) was improved in the majority of trials after therapy...
June 27, 2016: Cell Transplantation
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