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https://www.readbyqxmd.com/read/29668587/impact-of-bone-marrow-mononuclear-cells-therapy-on-left-ventricular-function-in-patients-with-st-elevated-myocardial-infarction-a-meta-analysis
#1
Chao Wang, Xiujiang Han, Yongjian Li, Boya Zhang
BACKGROUND: Bone marrow mononuclear cell (BMMNC) therapy has been used as an adjunctive treatment in patients with ST-elevated myocardial infarction (STEMI). However, the therapeutic efficacy of this approach remains controversial. The present meta-analysis is aimed to evaluate the impact of cell therapy on left ventricular function after STEMI. METHODS: We searched through PubMed and EMBASE databases till 2017 for all relevant publications using certain search terms...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29662787/steroid-associated-osteonecrosis-animal-model-in-rats
#2
Li-Zhen Zheng, Jia-Li Wang, Ling Kong, Le Huang, Li Tian, Qian-Qian Pang, Xin-Luan Wang, Ling Qin
Objective: Established preclinical disease models are essential for not only studying aetiology and/or pathophysiology of the relevant diseases but more importantly also for testing prevention and/or treatment concept(s). The present study proposed and established a detailed induction and assessment protocol for a unique and cost-effective preclinical steroid-associated osteonecrosis (SAON) in rats with pulsed injections of lipopolysaccharide (LPS) and methylprednisolone (MPS). Methods: Sixteen 24-week-old male Sprague-Dawley rats were used to induce SAON by one intravenous injection of LPS (0...
April 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662771/therapeutic-effects-analysis-of-percutaneous-kyphoplasty-for-osteoporotic-vertebral-compression-fractures-a-multicentre-study
#3
Huilin Yang, Liang Chen, Zhaomin Zheng, Guoyong Yin, William W Lu, Genlin Wang, Xuesong Zhu, Dechun Geng, Jun Zhou, Bin Meng, Haiqing Mao, Tao Liu, Junjie Niu, Tiansi Tang, Jun Zou
Background: Percutaneous kyphoplasty (PKP), a minimally invasive treatment, has been widely used for osteoporotic vertebral compression fractures (OVCFs). Objective: To retrospectively analyse the therapeutic effects of PKP using a series of key techniques in a multicentre study. Methods: From May 2000 to December 2016, PKP was performed using a series of key techniques (puncture, reduction, and perfusion techniques) for the treatment of 4532 OVCF patients...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29608865/vascularization-in-craniofacial-bone-tissue-engineering
#4
T Tian, T Zhang, Y Lin, X Cai
Craniofacial bones, separate from the appendicular skeleton, bear a significant amount of strain and stress generated from mastication-related muscles. Current research on the regeneration of craniofacial bone focuses on the reestablishment of an elaborate vascular network. In this review, current challenges and efforts particularly in advances of scaffold properties and techniques for vascularization remodeling in craniofacial bone tissue engineering will be discussed. A microenvironment of ischemia and hypoxia in the biomaterial core drives propagation and reorganization of endothelial progenitor cells (EPCs) to assemble into a primitive microvascular framework...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29607450/multiple-reaction-monitoring-targeted-lc-ms-analysis-of-potential-cell-death-marker-proteins-for-increased-bioprocess-control
#5
Simone Albrecht, Christian Kaisermayer, David Reinhart, Monica Ambrose, Renate Kunert, Anna Lindeberg, Jonathan Bones
The monitoring of protein biomarkers for the early prediction of cell stress and death is a valuable tool for process characterization and efficient biomanufacturing control. A representative set of six proteins, namely GPDH, PRDX1, LGALS1, CFL1, TAGLN2 and MDH, which were identified in a previous CHO-K1 cell death model using discovery LC-MSE was translated into a targeted liquid chromatography multiple reaction monitoring mass spectrometry (LC-MRM-MS) platform and verified. The universality of the markers was confirmed in a cell growth model for which three Chinese hamster ovary host cell lines (CHO-K1, CHO-S, CHO-DG44) were grown in batch culture in two different types of basal media...
April 2, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29603787/intraoperative-use-of-indocyanine-green-angiography-for-selecting-the-more-reliable-perforator-of-the-anterolateral-thigh-flap-a-comparison-study
#6
Simone La Padula, Barbara Hersant, Jean Paul Meningaud
INTRODUCTION: Anatomical variability of anterolateral thigh flap (ALT) perforators has been reported. The aim of this study is to assess if the use of intraoperative indocyanine green angiography (iICGA) can help surgeons to choose the ALT flap best perforator to be preserved. PATIENTS AND METHODS: A retrospective study was conducted in 28 patients with open tibial fracture, following a road traffic crash, who had undergone ALT flap. Patients were classified into two groups: ICGA group (iICGA was used to select the more reliable perforator) and control group...
March 30, 2018: Microsurgery
https://www.readbyqxmd.com/read/29588823/histological-evaluation-of-orthodontic-tooth-movement-following-low-level-laser-irradiation-in-rabbits
#7
Mostafa Abtahi, Nasrollah Saghravanian, Maryam Poosti, Hooman Shafaee
Background: Reduction of orthodontic treatment time is a major concern for orthodontists. Low level laser therapy (LLL) has been widely used in dentistry and it has been claimed that it could stimulate bone formation. Objective: The aim of the present study was to evaluate histological effects of LLL on alveolar bone remodeling during experimental tooth movement in rabbits. Methods: In this experimental study which was performed in the animal lab of Mashhad Dental School in 2016 twenty pre-pubertal female albino rabbits with the mean age of 8±1 weeks were randomly assigned into two groups...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29576595/therapeutic-efficacy-of-autologous-non-mobilized-enriched-circulating-endothelial-progenitors-in-patients-with-critical-limb-ischemia-the-scelta-trial
#8
Francesco Liotta, Francesco Annunziato, Sergio Castellani, Maria Boddi, Brunetto Alterini, Giovanni Castellini, Benedetta Mazzanti, Lorenzo Cosmi, Manlio Acquafresca, Filippo Bartalesi, Beatrice Dilaghi, Walter Dorigo, Gabriele Graziani, Benedetta Bartolozzi, Guido Bellandi, Giulia Carli, Alessandro Bartoloni, Aaron Fargion, Filippo Fassio, Paolo Fontanari, Giancarlo Landini, Eleonora A M Lucente, Stefano Michelagnoli, Carolina Orsi Battaglini, Grazia Panigada, Clara Pigozzi, Valentina Querci, Veronica Santarlasci, Paola Parronchi, Nicola Troisi, Cristiana Baggiore, Paola Romagnani, Edoardo Mannucci, Riccardo Saccardi, Carlo Pratesi, Gianfranco Gensini, Sergio Romagnani, Enrico Maggi
BACKGROUND: The therapeutic efficacy of bone marrow mononuclear cells (BM-MNC) autotransplantation in critical limb ischemia (CLI) has been reported. Variable proportions of circulating monocytes express low levels of CD34 (CD14+ CD34low cells) and behave in vitro as endothelial progenitor cells (EPCs). The aim of the present randomized clinical trial was to compare the safety and therapeutic effects of enriched circulating EPCs (ECEPCs) with BM-MNC administration.Methods and Results:ECEPCs (obtained from non-mobilized peripheral blood by immunomagnetic selection of CD14+ and CD34+ cells) or BM-MNC were injected into the gastrocnemius of the affected limb in 23 and 17 patients, respectively...
March 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29569981/regulatory-t-cells-within-bone-marrow-derived-stem-cells-actively-confer-immunomodulatory-and-neuroprotective-effects-against-stroke
#9
Elliot G Neal, Sandra A Acosta, Yuji Kaneko, Xunming Ji, Cesario V Borlongan
Regulatory T-cells (Tregs ) may exert a neuroprotective effect on ischemic stroke by inhibiting both inflammation and effector T-cell activation. Transplantation of human bone marrow-derived stem cells (BMSCs) in ischemic stroke affords neuroprotection that results in part from the cells' anti-inflammatory property. However, the relationship between Tregs and BMSCs in treatment of ischemic stroke has not been fully elucidated. Here, we tested the hypothesis that Tregs within the BMSCs represent active mediators of immunomodulation and neuroprotection in experimental stroke...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29559604/-angiogenic-ability-of-3-different-tissues-derived-mesenchymal-stem-cells-on-endothelial-progenitor-cells
#10
Siqi Wang, Haiyuan Lu, Lamei Cheng
To compare the ability between bone marrow-derived mesenchymal stem cells (MSCs) (BM-MSCs) and adipose-derived MSCs (AD-MSCs) or umbilical cord-derived MSCs (UC-MSCs) on promotion of vessels formation and vessels stabilization relevant to the functions of EPCs.
 Methods: In vitro, co-culture blood vessel test was performed to compare the angiogenic ability between BM-MSCs, AD-MSCs or UC-MSCs. In vivo, angiogenic assay dependent on basement membrane matrix Matrigel and immunohistochemistry were performed to compare the ability of vessels formation functions between BM-MSCs and AD-MSCs or UC-MSCs...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29553564/posterior-semicircular-canal-approach-for-inner-ear-gene-delivery-in-neonatal-mouse
#11
Kevin Isgrig, Wade W Chien
Inner ear gene therapy offers great promise as a potential treatment for hearing loss and dizziness. One of the critical determinants of the success of inner ear gene therapy is to find a delivery method which results in consistent transduction efficiency of targeted cell types while minimizing hearing loss. In this study, we describe the posterior semicircular canal approach as a viable method for inner ear gene delivery in neonatal mice. We show that gene delivery through the posterior semicircular canal is able to perfuse the entire inner ear...
March 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29545214/hybrid-quantitative-mri-using-chemical-shift-displacement-and-recovery-based-simultaneous-water-and-lipid-imaging-a-preliminary-study
#12
Naoki Ohno, Tosiaki Miyati, Shuto Suzuki, Hirohito Kan, Toshitaka Aoki, Yoshitaka Nakamura, Yuki Hiramatsu, Satoshi Kobayashi, Toshifumi Gabata
PURPOSE: To suppress olefinic signals and enable simultaneous and quantitative estimation of multiple functional parameters associated with water and lipid, we investigated a modified method using chemical shift displacement and recovery-based separation of lipid tissue (SPLIT) involving acquisitions with different inversion times (TIs), echo times (TEs), and b-values. MATERIALS AND METHODS: Single-shot diffusion echo-planar imaging (SSD-EPI) with multiple b-values (0-3000 s/mm2 ) was performed without fat suppression to separate water and lipid images using the chemical shift displacement of lipid signals in the phase-encoding direction...
March 12, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29536291/feasibility-study-of-a-novel-general-purpose-czt-based-digital-spect-camera-initial-clinical-results
#13
Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn, Simona Ben-Haim
BACKGROUND: The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 prototype, Molecular Dynamics) was evaluated in various clinical settings. Images obtained in the prototype system were compared to images from an analog camera fitted with high-resolution collimators. Clinical feasibility, image quality, and diagnostic performance of the prototype were evaluated in 36 SPECT studies in 35 patients including bone (n = 21), brain (n = 5), lung perfusion (n = 3), and parathyroid (n = 3) and one study each of sentinel node and labeled white blood cells...
March 14, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29532760/efficacy-and-safety-of-autologous-cell-based-therapy-in-patients-with-no-option-critical-limb-ischaemia-a-meta-analysis
#14
Fadilah S Abdul Wahid, Nor Azimah Ismail, Wan Fariza Wan Jamaluddin, Nor Asiah Muhamad, Mohamad Mohamad Azim Mohamad Idris, Nai Ming Lai
BACKGROUND: Revascularisation therapy is the curent gold standard of care for critical limb ischaemia (CLI), although a significant proportion of patients with CLI either are not fit for or do not respond well to this procedure. Recently, novel angiogeneic therapies such as the use of autologous cell-based therapy (CBT) have been examined, but the results of individual trials were inconsistent. OBJECTIVE: To pool all published studies that compared the safety and efficacy of autologous CBT derived from different sources and phenotypes with non cell-based therapy (NCT) in CLI patients...
March 13, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29529399/angiogenesis-in-peripheral-arterial-disease
#15
REVIEW
Chakradhari Inampudi, Emmanuel Akintoye, Tomo Ando, Alexandros Briasoulis
Peripheral arterial disease (PAD) refers to narrowing of the peripheral arteries and atherosclerosis is the most important cause. In patients with PAD, revascularization is the preferred therapeutic strategy; nonetheless several patients are not deemed candidates for it due to advanced disease or several comorbidities. The main target of therapeutic angiogenesis is to promote development of new arterial vessels and improve perfusion of ischemic tissue. Angiogenic growth factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), administered intramuscularly or intra-arterially, have been shown to promote angiogenesis and development of collateral vasculature in preclinical studies...
March 9, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29509489/correlations-between-intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-parameters-and-18-f-fdg-pet-ct-metabolic-parameters-in-patients-with-vertebral-bone-metastases-initial-experience
#16
Sunghoon Park, Joon-Kee Yoon, Nam-Su Chung, Sang Hyun Kim, Jinwoo Hwang, Hyun Young Lee, Kyu-Sung Kwack
OBJECTIVE: To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging (DWI) parameters and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters in patients with vertebral bone metastases. METHODS: Nineteen patients with vertebral bone metastases were retrospectively included in this institutional review board-approved study. All patients underwent IVIM DWI and 18F-FDG PET/CT before treatment...
March 6, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29504151/bone-vascularized-composite-allotransplantation-model-in-swine-tibial-defect-evaluation-of-surgical-angiogenesis-and-transplant-viability
#17
Dimitra Kotsougiani, Caroline A Hundepool, Liselotte F Bulstra, Patricia F Friedrich, Alexander Y Shin, Allen T Bishop
INTRODUCTION: In prior small animal studies, we maintained vascularized bone allotransplant viability without long-term immunotherapy. Instead, an autogenous neoangiogenic circulation is created from implanted vessels, sufficient to maintain bone viability with only 2 weeks immunosupression. Blood flow is maintained despite rejection of the allogeneic vascular pedicle thereafter. We have previously described a large animal (swine) pre-clinical model, reconstructing tibial defects with vascularized tibial allotransplants...
March 5, 2018: Microsurgery
https://www.readbyqxmd.com/read/29503808/microstructure-characterization-of-bone-metastases-from-prostate-cancer-with-diffusion-mri-preliminary-findings
#18
Colleen Bailey, David J Collins, Nina Tunariu, Matthew R Orton, Veronica A Morgan, Thorsten Feiweier, David J Hawkes, Martin O Leach, Daniel C Alexander, Eleftheria Panagiotaki
Purpose: To examine the usefulness of rich diffusion protocols with high b -values and varying diffusion time for probing microstructure in bone metastases. Analysis techniques including biophysical and mathematical models were compared with the clinical apparent diffusion coefficient (ADC). Methods: Four patients were scanned using 13 b -values up to 3,000 s/mm2 and diffusion times ranging 18-52 ms. Data were fitted to mono-exponential ADC, intravoxel incoherent motion (IVIM), Kurtosis and Vascular, extracellular, and restricted diffusion for cytometry in tumors (VERDICT) models...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29474746/a-systematic-review-of-the-evidence-and-analysis-of-the-consequences
#19
REVIEW
J-Matthias Löhr, Nikola Panic, Miroslav Vujasinovic, Caroline S Verbeke
Senior people constitute the fastest growing segment of the population. The elderly are at risk for malnutrition, thought to be caused by reduced food intake or involution of the physiological capacity of the GI tract. Age-related changes are well known in other secretory organs such as liver, kidney, and intestine. The pancreas, representing a metabolically active organ with uptake and breakdown of essential nutritional components, changes its morphology and function with age. During childhood, the volume of the pancreas increases, reaching a plateau between 20-60 years, and declines thereafter...
February 23, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29466037/time-required-to-achieve-maximum-concentration-of-amikacin-in-synovial-fluid-of-the-distal-interphalangeal-joint-after-intravenous-regional-limb-perfusion-in-horses
#20
Isabelle Kilcoyne, Jorge E Nieto, Heather K Knych, Julie E Dechant
OBJECTIVE To determine the maximum concentration (Cmax) of amikacin and time to Cmax (Tmax) in the distal interphalangeal (DIP) joint in horses after IV regional limb perfusion (IVRLP) by use of the cephalic vein. ANIMALS 9 adult horses. PROCEDURES Horses were sedated and restrained in a standing position and then subjected to IVRLP (2 g of amikacin sulfate diluted to 60 mL with saline [0.9% NaCl] solution) by use of the cephalic vein. A pneumatic tourniquet was placed 10 cm proximal to the accessory carpal bone...
March 2018: American Journal of Veterinary Research
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