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https://www.readbyqxmd.com/read/28415416/in-vitro-and-in-vivo-corrosion-mechanical-properties-and-biocompatibility-evaluation-of-mgf2-coated-mg-zn-zr-alloy-as-cancellous-screws
#1
Zhen Li, Sun Shizhao, Minfang Chen, Bradley Dean Fahlman, Debao Liu, Hongwei Bi
Magnesium (Mg) and its alloys as biodegradable materials have received much attention in the orthopedics applications; however, the corrosion behavior of these metals in vivo remains challenging. In this work, a dense and nanoscale magnesium fluoride (MgF2) coating was deposited on the surface of Mg-Zn-Zr (MZZ) alloy cancellous screw. The MZZ cancellous screw with MgF2 coating maintained an integrated shape and high yield tensile stress after 30days immersion in SBF, comparing with the bare screw. Hydrogen releasing rate of the MZZ samples was suppressed at a lower level at the initial stage, which is in favour of the adhesion of the cells...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28408376/a-comparative-study-of-tissue-engineered-constructs-from-acropora-and-porites-coral-in-a-large-animal-bone-defect-model
#2
A Decambron, M Manassero, M Bensidhoum, B Lecuelle, D Logeart-Avramoglou, H Petite, V Viateau
OBJECTIVES: To compare the therapeutic potential of tissue-engineered constructs (TECs) combining mesenchymal stem cells (MSCs) and coral granules from either Acropora or Porites to repair large bone defects. MATERIALS AND METHODS: Bone marrow-derived, autologous MSCs were seeded on Acropora or Porites coral granules in a perfusion bioreactor. Acropora-TECs (n = 7), Porites-TECs (n = 6) and bone autografts (n = 2) were then implanted into 25 mm long metatarsal diaphyseal defects in sheep...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28401793/developing-a-customized-perfusion-bioreactor-prototype-with-controlled-positional-variability-in-oxygen-partial-pressure-for-bone-and-cartilage-tissue-engineering
#3
Poh Soo Lee, Hagen Eckert, Ricarda Hess, Michael Gelinsky, Derrick Rancourt, Roman Krawetz, Gianaurelio Cuniberti, Dieter Scharnweber
Skeletal development is a multi-step process that involves the complex interplay of multiple cell types at different stages of development. Besides biochemical and physical cues, oxygen tension also plays a pivotal role in influencing cell fate during skeletal development. At physiological conditions, bone cells generally reside in relatively oxygenated environment whereas the chondrocytes reside in hypoxic environment. However, it is technically challenging to achieve such defined, yet diverse oxygen distribution on traditional in vitro cultivation platforms...
April 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28374977/hypoxic-preconditioning-induced-autophagy-enhances-survival-of-engrafted-endothelial-progenitor-cells-in-ischaemic-limb
#4
Pei Zhou, Yu-Zhen Tan, Hai-Jie Wang, Guo-Dong Wang
Recent clinical studies have suggested that endothelial progenitor cells (EPCs) transplantation provides a modest benefit for treatment of the ischaemic diseases such as limb ischaemia. However, cell-based therapies have been limited by poor survival of the engrafted cells. This investigation was designed to establish optimal hypoxia preconditioning and evaluate effects of hypoxic preconditioning-induced autophagy on survival of the engrafted EPCs. Autophagy of CD34(+) VEGFR-2(+) EPCs isolated from rat bone marrow increased after treatment with 1% O2 ...
April 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28374486/a-novel-cxcr4-antagonist-enhances-angiogenesis-via-modifying-the-ischaemic-tissue-environment
#5
Xiaoqing Yan, Xiaozhen Dai, Luqing He, Xiao Ling, Minglong Shao, Chi Zhang, Yuehui Wang, Jian Xiao, Lu Cai, Xiaokun Li, Yi Tan
Endothelial progenitor cells (EPCs) play a capital role in angiogenesis via directly participating in neo-vessel formation and secreting pro-angiogenic factors. Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 play a critical role in the retention and quiescence of EPCs within its niche in the bone marrow. Disturbing the interaction between SDF-1 and CXCR4 is an effective strategy for EPC mobilization. We developed a novel CXCR4 antagonist P2G, a mutant protein of SDF-1β with high antagonistic activity against CXCR4 and high potency in enhancing ischaemic angiogenesis and blood perfusion...
April 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28358605/therapeutic-use-of-regional-limb-perfusion-in-a-chicken
#6
Cameron M Ratliff, Bianca A Zaffarano
A 2-year-old, 3.8-kg male Rhode Island red rooster was examined for lameness and progressive swelling of the right foot of several month's duration. Radiographs of the right foot demonstrated soft tissue swelling and a smoothly marginated periosteal reaction evident of inflammation affecting the bones. Results of a complete blood count showed a moderate leukocytosis and an elevated total protein concentration. Systemic antibiotic and anti-inflammatory therapy was started, but the bird had not improved at recheck examination...
March 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28357093/triple-phase-99m-tc-3p-rgd2-imaging-of-peripheral-primitive-neuroectodermal-tumor-in-the-hip-muscle-group-with-bone-metastasis
#7
Jingjing Fu, Jinhua Song, Youcai Zhao, Feng Wang, Guoqiang Shao
Peripheral primitive neuroectodermal tumors (pPNETs) are a group of aggressive neoplasms that are most commonly encountered in pediatric patients and may be located in the abdomen, pelvis, thoracopulmonary region and, rarely, in the head and neck region. pPNETs in adults are extremely rare. The present study reports a case of pPNET located in the hip muscles with bone metastasis. The patient was a 44-year-old woman who complained of progressive pain and swelling with a mass near the left hip. Computed tomography (CT) and enhanced CT revealed a soft tissue mass lesion in the hip muscle group measuring 4...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28356443/a-microrna93-irf9-irg1-itaconic-acid-pathway-modulates-m2-like-macrophage-polarization-to-revascularize-ischemic-muscle
#8
Vijay Chaitanya Ganta, Min Hyub Choi, Anna Kutateladze, Todd E Fox, Charles R Farber, Brian H Annex
Background -Currently no therapies exist for treating, and improving outcomes in patients with severe peripheral arterial disease (PAD). MicroRNA93 (miR93) has been shown to favorably modulate angiogenesis and reduce tissue loss in genetic PAD models. However, the cell specific function, downstream mechanisms or signaling involved in miR93 mediated ischemic muscle neovascularization is not clear. Macrophages were best known to modulate arteriogenic response in PAD and the extent of arteriogenic response induced by macrophages is dependent on greater M2 to M1-activation/polarization state...
March 29, 2017: Circulation
https://www.readbyqxmd.com/read/28351209/effects-of-multiple-injection-of-bone-marrow-mononuclear-cells-on-spinal-cord-injury-of-rats
#9
Kenji Kanekiyo, Norihiko Nakano, Tamami Homma, Yoshihiro Yamada, Masahiro Tamachi, Yoshihisa Suzuki, Masanori Fukushima, Fukuki Saito, Chizuka Ide
The effects of multiple-injection of bone marrow mononuclear cells (BMNCs) on spinal cord injury (SCI) were compared with those of single-injection in rats. BMNCs separated by density-gradient centrifugation from a bone marrow perfusate were injected 3 times (once weekly) through the cerebrospinal fluid (CSF) via the 4th ventricle, and the locomotor improvement and tissue recovery, including axonal regeneration, were compared with those of single-injection. While the single-injection group showed a steep elevation of the BBB (Basso-Beattie-Bresnahan) score 1 week after transplantation, the multiple-injection group maintained a similar steep elevation for 2 weeks after transplantation, and the BBB scores of the multiple-injection group remained thereafter at a level around 2-3 points higher than those of the single-injection group until the end of the experiment...
March 28, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28350682/vasculature-of-a-medial-femoral-condyle-free-flap-in-intact-and-osteotomized-flaps
#10
Maciej Rysz, Wojciech Grabczan, Maciej Jan Mazurek, Romuald Krajewski, Dariusz Grzelecki, Bogdan Ciszek
BACKGROUND: A small size and difficulties with shaping a medial femoral condyle corticocancellous bone flap are factors limiting its use. The goal of this study was to evaluate range of vascular supply to a medial femoral condyle corticocancellous bone flap to determine whether harvesting of larger flaps and performing a flap osteotomy would compromise the vasculature of a flap's bone. METHODS: Twenty-four limbs were dissected and medial femoral condyle corticocancellous bone flaps were harvested with skin paddles...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28347909/bone-marrow-perfusion-measured-with-dynamic-contrast-enhanced-magnetic-resonance-imaging-is-correlated-to-body-mass-index-in-adults
#11
Jean-François Budzik, Guillaume Lefebvre, Hélène Behal, Sébastien Verclytte, Pierre Hardouin, Pedro Teixeira, Anne Cotten
Bone marrow metabolism is complex and far from being fully understood. Novel aspects, such as the roles of bone marrow adiposity and vascularisation in bone metabolism currently attract attention. There is also a growing interest in the influence obesity might have on bone metabolism. Our objective was to determine the effect of BMI on bone marrow perfusion parameters using dynamic contrast-enhanced magnetic resonance imaging. This prospective monocentric study was approved by our local Ethics committee. Written consent was obtained...
March 24, 2017: Bone
https://www.readbyqxmd.com/read/28338421/harnessing-the-osteogenicity-of-in-vitro-stem-cell-derived-mineralized-extracellular-matrix-as-3d-biotemplate-to-guide-bone-regeneration
#12
Yoke Chin Chai, Johanna Bolander, Ioannis Papantoniou, Jennifer Patterson, Jef Vleugels, Jan Schrooten, Frank P Luyten
Advanced biomaterials that are capable of guiding robust bone regeneration are highly demanded for translational therapy of bone defects or bone augmentation in clinics. One of the strategic approaches is to produce tissue engineering (TE) constructs that mediate bone regeneration by recapitulating the natural bone formation or healing process. In this study, we aimed at producing devitalized mineralized carriers with augmented bone forming capacity via a modified culture protocol (i.e., culture conditions with high calcium and/or phosphate concentrations) that first promotes cell growth and, subsequently, mineralized extracellular matrix (ECM) deposition by human periosteum-derived osteoprogenitor cells (hPDCs) on additive manufactured three-dimensional (3D) porous titanium (Ti)-based scaffolds...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28299027/the-effect-of-locally-administered-pamidronate-on-autogenous-bone-graft-in-maxillofacial-reconstruction-a-randomized-clinical-trial
#13
M Bayat, A Garajei, E Afshari Pour, M Hasheminasab, Y Ghorbani, M H Kalantar Motamedi, N Bahrami
BACKGROUND: Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption. OBJECTIVE: To assess the effect of administration of biphosphonates on bone resorption. METHODS: 20 patients with bony defects who were candidates for free autogenous grafts were randomized into "pamidronate" and "control" groups...
2017: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/28295901/high-aldehyde-dehydrogenase-activity-identifies-a-subset-of-human-mesenchymal-stromal-cells-with-vascular-regenerative-potential
#14
Stephen E Sherman, Miljan Kuljanin, Tyler T Cooper, David M Putman, Gilles A Lajoie, David A Hess
During culture expansion, multipotent mesenchymal stromal cells (MSCs) differentially express aldehyde dehydrogenase (ALDH), an intracellular detoxification enzyme that protects long-lived cells against oxidative stress. Thus, MSC selection based on ALDH-activity may be used to reduce heterogeneity and distinguish MSC subsets with improved regenerative potency. After expansion of human bone marrow-derived MSCs, cell progeny was purified based on low versus high ALDH-activity (ALDH(hi) ) by fluorescence-activated cell sorting, and each subset was compared for multipotent stromal and provascular regenerative functions...
March 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/28294194/phosphodiesterase-5-inhibition-preserves-renal-hemodynamics-and-function-in-mice-with-diabetic-kidney-disease-by-modulating-mir-22-and-bmp7
#15
Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M Isidori, Mary Anna Venneri
Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P < 0.001), the increase of urine albumin creatinine ratio (P < 0...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28291964/application-of-a-parallelizable-perfusion-bioreactor-for-physiologic-3d-cell-culture
#16
Dominik Egger, Sarah Spitz, Monica Fischer, Stephan Handschuh, Martin Glösmann, Benedikt Friemert, Monika Egerbacher, Cornelia Kasper
It is crucial but challenging to keep physiologic conditions during the cultivation of 3D cell scaffold constructs for the optimization of 3D cell culture processes. Therefore, we demonstrate the benefits of a recently developed miniaturized perfusion bioreactor together with a specialized incubator system that allows for the cultivation of multiple samples while screening different conditions. Hence, a decellularized bone matrix was tested towards its suitability for 3D osteogenic differentiation under flow perfusion conditions...
March 15, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28281283/artificial-organs-2016-a-year-in-review
#17
REVIEW
Angela T Hadsell, Paul S Malchesky
In this Editor's Review, articles published in 2016 are organized by category and briefly summarized. We aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ Replacement, Recovery, and Regeneration. As the official journal of The International Federation for Artificial Organs, The International Faculty for Artificial Organs, the International Society for Mechanical Circulatory Support, the International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level...
March 2017: Artificial Organs
https://www.readbyqxmd.com/read/28265697/intravoxel-incoherent-motion-diffusion-weighted-magnetic-resonance-imaging-of-focal-vertebral-bone-marrow-lesions-initial-experience-of-the-differentiation-of-nodular-hyperplastic-hematopoietic-bone-marrow-from-malignant-lesions
#18
Sunghoon Park, Kyu-Sung Kwack, Nam-Su Chung, Jinwoo Hwang, Hyun Young Lee, Jae Ho Kim
OBJECTIVE: To evaluate the ability of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) parameters to differentiate nodular hyperplastic hematopoietic bone marrow (HHBM) from malignant vertebral bone marrow lesions (VBMLs). MATERIALS AND METHODS: A total of 33 patients with 58 VBMLs, including 9 nodular HHBM lesions, 39 bone metastases, and 10 myelomas, were retrospectively assessed. All diagnoses were confirmed either pathologically or via image assessment...
March 6, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28230059/synergistic-effects-of-dimethyloxallyl-glycine-and-recombinant-human-bone-morphogenetic-protein-2-on-repair-of-critical-sized-bone-defects-in-rats
#19
Xin Qi, Yang Liu, Zhen-Yu Ding, Jia-Qing Cao, Jing-Huan Huang, Jie-Yuan Zhang, Wei-Tao Jia, Jing Wang, Chang-Sheng Liu, Xiao-Lin Li
In bone remodeling, osteogenesis is closely coupled to angiogenesis. Bone tissue engineering using multifunctional bioactive materials is a promising technique which has the ability to simultaneously stimulate osteogenesis and angiogenesis for repair of bone defects. We developed mesoporous bioactive glass (MBG)-doped poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) composite scaffolds as delivery vehicle. Two bioactive molecules, dimethyloxalylglycine (DMOG), a small-molecule angiogenic drug, and recombinant human bone morphogenetic protein-2 (rhBMP-2), an osteoinductive growth factor, were co-incorporated into the scaffold...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28225579/intravoxel-incoherent-motion-mri-assessment-of-chemoradiation-induced-pelvic-bone-marrow-changes-in-cervical-cancer-and-correlation-with-hematological-toxicity
#20
Elaine Yuen Phin Lee, Jose Angelo Udal Perucho, Vince Vardhanabhuti, Jian He, Steven Wai Kwan Siu, Siew Fei Ngu, Nina A Mayr, William T C Yuh, Queenie Chan, Pek-Lan Khong
PURPOSE: To investigate bone marrow changes after chemoradiation (CRT) using intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) and correlate imaging changes with hematological toxicity (HT) in patients with locally advanced cervical cancer. MATERIALS AND METHODS: Thirty-nine patients with newly diagnosed cervical cancer were prospectively recruited for two sequential 3.0T IVIM-MRI studies: before treatment (MRI-1) and 3-4 weeks after standardized CRT (MRI-2)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
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