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https://www.readbyqxmd.com/read/28088373/dynamic-contrast-enhanced-magnetic-resonance-imaging-dce-mri-for-the-prediction-of-non-union-consolidation
#1
Christian Fischer, Mareike Nissen, Gerhard Schmidmaier, Thomas Bruckner, Hans-Ulrich Kauczor, Marc-André Weber
INTRODUCTION: Non-union perfusion can be visualized with dynamic contrast-enhanced (DCE) MRI. This study evaluated DCE-MRI to predict non-union consolidation after surgery and detect factors that affect bone healing. MATERIALS AND METHODS: Between 2010 and 2015 non-union perfusion was prospectively quantified in 205 patients (mean age, 51.5 years, 129 men, 76 women) before intervention and at 6, 12, 26, 52 and more weeks follow-up. DCE-MRI results were related to the osseous consolidation, the ability to predict successful outcome was estimated by ROC analysis...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28059803/whole-body-vibration-wbv-following-spinal-cord-injury-sci-in-rats-timing-of-intervention
#2
Marilena Manthou, Diana Saad Yousif Abdulla, Stoyan Pavlov Pavlov, Ramona Jansen, Habib Bendella, Klaus Nohroudi, Gregor Stein, Carolin Mmeyer, Ozlem Ozsoy, Umut Ozsoy, Yasemin Behram Kandemir, Levent Sarikcioglu, Oliver Semler, Eckhard Schoenau, Sarah Dunlop, Doychin Nikolov Angelov
BACKGROUND: Following spinal cord injury (SCI), exercise training provides a wide range of benefits and promotes activity-dependent synaptic plasticity. Whole body vibration (WBV) in SCI patients improves walking and spasticity as well as bone and muscle mass. However, little is known about the effects of timing or frequency of intervention. OBJECTIVE: To determine which WBV-onset improves locomotor and bladder functions and influences synaptic plasticity beneficially...
January 4, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28040755/short-and-long-term-outcomes-of-intramyocardial-implantation-of-autologous-bone-marrow-derived-cells-for-the-treatment-of-ischaemic-heart-disease
#3
Hiroshi Kurazumi, Akira Fujita, Tamami Nakamura, Ryo Suzuki, Masaya Takahashi, Bungo Shirasawa, Akihito Mikamo, Kimikazu Hamano
OBJECTIVES: Ischaemic heart disease remains a major cause of death in Japan. We have implanted autologous bone marrow-derived cells locally into the ischaemic region as a therapy in addition to coronary artery bypass grafting since 1999. We describe the outcomes of our cell therapy for ischaemic heart disease. METHODS: Eleven patients underwent local implantation of bone marrow-derived cells into the ischaemic region during coronary artery bypass grafting. Clinical outcomes during the acute and chronic phases were recorded...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28011101/cartilage-mri-t2-%C3%A2-relaxation-time-and-perfusion-changes-of-the-knee-in-a-5-6-nephrectomy-rat-model-of-chronic-kidney-disease
#4
C-Y Wang, Y-J Peng, Y-J Hsu, H-S Lee, Y-C Chang, C-S Chang, S-W Chiang, Y-C Hsu, M-H Lin, G-S Huang
OBJECTIVE: Chronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2(∗) relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2(∗) as imaging biomarkers to monitor disease progression...
December 21, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28007011/mimicking-the-acute-myeloid-leukemia-niche-for-molecular-study-and-drug-screening
#5
Mohammad Houshmand, Masoud Soleimani, Amir Atashi, Giuseppe Saglio, Mohammad Abdollahi, Mahin Nikougoftar Zarif
Bone marrow niche is a major contributing factor in leukemia development and drug resistance in acute myeloid leukemia (AML) patients. Although mimicking leukemic bone marrow niche relies on two-dimensional (2D) culture conditions, it cannot recapitulate complex bone marrow structure that causes introduction of different three-dimensional (3D) scaffolds. Simultaneously, microfluidic platform by perfusing medium culture mimic interstitial fluid flow, along with 3D scaffold would help for mimicking bone marrow microenvironment...
January 13, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28006094/responses-of-mscs-to-3d-scaffold-matrix-mechanical-properties-under-oscillatory-perfusion-culture
#6
Guobao Chen, Rui Xu, Chang Zhang, Yonggang Lv
Both fluid shear stress and matrix stiffness are implicated in bone metabolism and functional adaptation, but the synergistic action of these mechanical cues on the biological behaviors of mesenchymal stem cells (MSCs) is still not well-known. In the present work, a homemade oscillatory flow device was applied to investigate the effects of matrix stiffness on MSCs survival, distribution, and osteogenic differentiation in three-dimensional (3D) conditions. Furthermore, the flow field and cell growth in this bioreactor were theoretically simulated...
January 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27997565/in-vivo-non-invasive-characterization-of-human-bone-by-hybrid-broadband-600-1200-nm-diffuse-optical-and-correlation-spectroscopies
#7
Sanathana Konugolu Venkata Sekar, Marco Pagliazzi, Eugènia Negredo, Fabrizio Martelli, Andrea Farina, Alberto Dalla Mora, Claus Lindner, Parisa Farzam, Núria Pérez-Álvarez, Jordi Puig, Paola Taroni, Antonio Pifferi, Turgut Durduran
Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue...
2016: PloS One
https://www.readbyqxmd.com/read/27979038/baseline-assessment-and-comparison-of-arterial-anatomy-hyperemic-flow-and-skeletal-muscle-perfusion-in-peripheral-artery-disease-the-cardiovascular-cell-therapy-research-network-patients-with-intermittent-claudication-injected-with-aldh-bright-cells-cctrn-pace
#8
Bharath Ambale Venkatesh, Victor Nauffal, Chikara Noda, Tomoki Fujii, Phillip C Yang, Judy Bettencourt, Erin P Ricketts, Michael Murphy, Nicholas J Leeper, Lem Moyé, Ray F Ebert, Raja Muthupillai, David A Bluemke, Emerson C Perin, Alan T Hirsch, João A C Lima
BACKGROUND: Peripheral artery disease (PAD) is important to public health as a major contributor to cardiovascular morbidity and mortality. Recent developments in magnetic resonance imaging (MRI) techniques permit improved assessment of PAD anatomy and physiology, and may serve as surrogate end points after proangiogenic therapies. METHODS: The PACE study is a randomized, double-blind, placebo-controlled clinical trial designed to assess the physiologic impact and potential clinical efficacy of autologous bone marrow-derived ALDH(br) stem cells...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27973959/three-dimensional-digitalized-virtual-planning-for-saphenous-artery-flap-a-pilot-study
#9
Yuan Z Zhang, Shu Z Wen, Hui Q Zhang, Ya G Li, Jian M Zhao, Yong Yang
OBJECTIVE: Since the 1970s, research and applications on flap and muscle flap had solved many problems in microsurgical reconstruction. However, the traditional flap design is completely dependent on two-dimensional (2D) images. The purpose of this study was to discuss the methods in the visualization of saphenous artery flap by digitalized technique and its applications by digitalized technique. METHODS: Two adult fresh cadaver specimens, one male and one female, were subject to radiographic computerized tomography (CT) scanning before and after perfused with lead oxide-gelatine mixture, whose collimation are 0...
December 2016: Comput Assist Surg (Abingdon)
https://www.readbyqxmd.com/read/27931504/clinical-benefits-of-stem-cells-for-chronic-symptomatic-systolic-heart-failure-a-systematic-review-of-the-existing-data-and-ongoing-trials
#10
Marie-France Poulin, Anjan Deka, Burhan Mohamedali, Gary L Schaer
The benefits of stem cell therapy for patients with chronic symptomatic systolic heart failure due to ischemic and nonischemic cardiomyopathy (ICM and NICM, respectively) are unclear. We performed a systematic review of major published and ongoing trials of stem cell therapy for systolic heart failure and compared measured clinical outcomes for both types of cardiomyopathy. The majority of the 29 published studies demonstrated clinical benefits of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs)...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27930695/coordinated-activation-of-vegf-vegfr-2-and-ppar%C3%AE-pathways-by-a-multi-component-chinese-medicine-dhi-accelerated-recovery-from-peripheral-arterial-disease-in-type-2-diabetic-mice
#11
Shuang He, Tiechan Zhao, Hao Guo, Yanzhi Meng, Gangjian Qin, David A Goukassian, Jihong Han, Xuimei Gao, Yan Zhu
Diabetic mellitus (DM) patients are at an increased risk of developing peripheral arterial disease (PAD). Danhong injection (DHI) is a Chinese patent medicine widely used for several cardiovascular indications but the mechanism of action is not well-understood. We investigated the therapeutic potential of DHI on experimental PAD in mice with chemically induced as well as genetic (KKAy) type 2 DM and the overlapping signaling pathways regulating both therapeutic angiogenesis and glucose homeostasis. Compared with normal genetic background wild type (WT) mice, both DM mice showed impaired perfusion recovery in hind-limb ischemia (HLI) model...
2016: PloS One
https://www.readbyqxmd.com/read/27912680/biomimetic-approaches-for-bone-tissue-engineering
#12
Johnathan Ng, Kara Spiller, Jonathan Bernhard, Gordana Vunjak-Novakovic
Although autologous bone grafts are considered a gold standard for the treatment of bone defects, they are limited by donor site morbidities and geometric requirements. Tissue engineering can overcome such limitations by creating fully viable biological bone grafts. We review here the use of native bone matrix, autologous mesenchymal cells and perfusion bioreactor systems as a tissue-engineering paradigm to grow bone in vitro. We also discuss emergent vascularization strategies to promote graft survival in vivo, and the role of inflammation in bone repair...
December 2, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27905865/transient-bone-marrow-edema-syndrome-versus-osteonecrosis-perfusion-patterns-at-dynamic-contrast-enhanced-mr-imaging-with-high-temporal-resolution-can-allow-differentiation
#13
Tobias Geith, Thomas Niethammer, Stefan Milz, Olaf Dietrich, Maximilian Reiser, Andrea Baur-Melnyk
Purpose To prospectively evaluate the perfusion patterns at quantitative dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging of transient bone marrow edema syndrome (TBMES) and avascular osteonecrosis. Materials and Methods Institutional review board approval and written informed consent were obtained. Thirty-two patients (21 men, 11 women; mean age, 48 years; 26 hips, 10 knees) underwent conventional MR imaging and a dynamic contrast-enhanced three-dimensional spoiled gradient-echo sequence at 3 T...
December 1, 2016: Radiology
https://www.readbyqxmd.com/read/27905554/increased-plasma-vegf-levels-following-ischemic-preconditioning-are-associated-with-downregulation-of-mirna-762-and-mir-3072-5p
#14
Koji Ueno, Makoto Samura, Tamami Nakamura, Yuya Tanaka, Yuriko Takeuchi, Daichi Kawamura, Masaya Takahashi, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
Ischemic preconditioning (IPC) has protective effects against ischemia-perfusion injury of organs. In the present study, we investigated the associated mechanisms after performing remote IPC (rIPC) of lower limbs by clamping abdominal aorta in mice. Subsequent experiments showed decreased damage and paralysis of lower limbs following spinal cord injury (SCI). Concomitantly, plasma vascular endothelial growth factor (VEGF) levels were increased 24 h after rIPC compared with those in sham-operated animals. In subsequent microRNA analyses, thirteen microRNAs were downregulated in exosomes 24 h after rIPC...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904225/the-inferior-medial-genicular-artery-and-its-vascularization-of-the-pes-anserinus-superficialis-a-cadaveric-study
#15
Lena Hirtler, Manuel Ederer, Mike Faber, Patrick Weninger
BACKGROUND: A common method for reconstruction of the anterior cruciate ligament (ACL) is it's replacement by a free avascular graft, using the gracilis and/or semitendinosus tendons. These grafts pass a vulnerable phase in the ligamentization-process during the 1(st) year after reconstruction. The aims of this study were first to evaluate the vascularization of the pes anserinus superficialis (PAS) by the inferior medial genicular artery (IMGA) and second to develop a pedunculated surgical technique for ACL reconstruction, to preserve a maximal amount of natural vascularization of the tendons inserting at the PAS...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27903568/effects-of-trans-endocardial-delivery-of-bone-marrow-derived-cd133-cells-on-left-ventricle-perfusion-and-function-in-patients-with-refractory-angina-final-results-of-randomized-double-blinded-placebo-controlled-regent-vsel-trial
#16
Wojciech Wojakowski, Tomasz Jadczyk, Aleksandra Michalewska-Wludarczyk, Zofia Parma, Miroslaw Markiewicz, Wojciech Rychlik, Magdalena Kostkiewicz, Katarzyna Gruszczynska, Anna Blach, Monika Dzierzak-Mietla, Wojciech Wanha, Joanna Ciosek, Beata Ochala, Lukasz Rzeszutko, Wieslaw Cybulski, Lukasz Partyka, Wojciech Zasada, Witold Wludarczyk, Sebastian Dworowy, Waclaw B Kuczmik, Grzegorz Smolka, Tomasz Z Pawlowski, Andrzej Ochala, Michal Tendera
RATIONALE: New therapies for refractory angina are needed. OBJECTIVE: Assessment of trans-endocardial delivery of bone marrow (BM) CD133(+)cells in patients with refractory angina. METHODS AND RESULTS: Randomized, double-blinded, placebo-controlled trial enrolled 31 patients with recurrent CCS II-IV angina despite optimal medical therapy, ≥ one myocardial segment with inducible ischemia in Tc-99m SPECT who underwent BM biopsy and were allocated to cells (n=16) or placebo (n=15)...
November 30, 2016: Circulation Research
https://www.readbyqxmd.com/read/27901210/effects-of-alveolar-bone-displacement-with-segmental-osteotomy-micro-ct-and-histomorphometric-analysis-in-rats
#17
Taegun Kim, Won Lee, Sang-Ho Baek, Sungwoon Pyo, Yoon-Ah Kook, Mohamed Bayome, Insoo Kim
The purpose of this study was to evaluate the effects of segmental osteotomy on the blood vessels and osteoclasts in rats using micro-computed tomography (micro-CT) and histomorphometric analysis. After segmental osteotomy was performed around the maxillary first molars of 36 male Sprague-Dawley rats (n = 72), the samples were divided into a control group (no displacement), 0.5 D group (0.5 mm buccal displacement) and 1.0 D group (1.0 mm buccal displacement) (n = 24/group). At 1, 2, 4 and 8 weeks after surgery, changes in the blood vessel volume were investigated using micro-CT with perfusion of radiopaque silicone rubber...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27870350/the-periosteum-of-the-zygomatic-arch-vascularization-and-growth
#18
Susan W Herring, Pannee Ochareon
In addition to conveying the forces of attaching muscles and ligaments to the zygomatic and temporal bones, the arch periosteum is responsible for lateral apposition and medial resorption during the growth period. In this contribution, we describe the vasculature of the zygomatic arch in young pigs (Sus scrofa dom.) in order to understand the relationship of osseous and periosteal vessels to each other, to surrounding tissues, and to patterns of modeling. Subjects 2-6 weeks of age were perfused with vascular fill; some also received the vital bone label calcein...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27842674/radiation-dose-in-cardiac-spect-ct-an-estimation-of-ssde-and-effective-dose
#19
Hamid Abdollahi, Isaac Shiri, Yazdan Salimi, Maghsoud Sarebani, Reza Mehdinia, Mohammad Reza Deevband, Seied Rabi Mahdavi, Ahmad Sohrabi, Ahmad Bitarafan-Rajabi
AIMS: The dose levels for Computed Tomography (CT) localization and attenuation correction of Single Photon Emission Computed Tomography (SPECT) are limited and reported as Volume Computed Tomography Dose Index (CTDIvol) and Dose-Length Product (DLP). This work presents CT dose estimation from Cardiac SPECT/CT based on new American Association of Physicists in Medicine (AAPM) Size Specific Dose Estimation (SSDE) parameter, effective dose, organ doses and also emission dose from nuclear issue...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27833010/naringin-promotes-fracture-healing-through-stimulation-of-angiogenesis-by-regulating-the-vegf-vegfr-2-signaling-pathway-in-osteoporotic-rats
#20
Nan Song, Zhihu Zhao, Xinlong Ma, Xiaolei Sun, Jianxiong Ma, Fengbo Li, Lei Sun, Jianwei Lv
Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear...
January 5, 2017: Chemico-biological Interactions
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