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https://www.readbyqxmd.com/read/29760944/characteristics-of-insulin-na%C3%A3-ve-people-with-type-2-diabetes-who-successfully-respond-to-insulin-glargine-u100-after-24-weeks-of-treatment-a-meta-analysis-of-individual-participant-data-from-3-randomized-clinical-trials
#1
M H Cummings, D Cao, I Hadjiyianni, L L Ilag, M H Tan
Background: To identify baseline/clinical characteristics associated with clinically meaningful responses to insulin glargine 100 U/mL (IGlar) in insulin-naive people with type 2 diabetes mellitus (T2DM). Methods: Individual participant data were pooled from 3 randomized trials to compare baseline characteristics and clinical outcomes associated with 24-week response to IGlar in combination with non-insulin antihyperglycemic agents in participants with T2DM. Responders were defined as achieving endpoint HbA1c target < 53 mmol/mol (< 7%) and/or ≥ 11 mmol/mol (≥ 1%) HbA1c reduction from baseline...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29728302/clinically-significant-cognitive-impairment-in-older-adults-with-type-1-diabetes
#2
Naomi S Chaytor, Celestina Barbosa-Leiker, Christopher M Ryan, Laura T Germine, Irl B Hirsch, Ruth S Weinstock
AIMS: Little is known about cognition in older adults with type 1 diabetes. The aim of this study was to identify correlates of clinically significant cognitive impairment. METHODS: Neuropsychological, diabetes-related and glycemic (HbA1c, Continuous Glucose Monitoring; CGM) data were collected from 201 older adults (≥60 years) with longstanding type 1 diabetes. RESULTS: Clinically significant cognitive impairment (≥2 cognitive tests ≥1...
April 14, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29721018/efficacy-and-safety-of-insulin-degludec-versus-insulin-glargine-a-systematic-review-and-meta-analysis-of-fifteen-clinical-trials
#3
REVIEW
Wei Liu, Xiaojie Yang, Jing Huang
Aims: Insulin degludec (IDeg) and insulin glargine (IGlar) are both proved to be effective in diabetes. This study aimed to assess the effects and safety of IDeg versus IGlar. Methods: A systematic literature search was conducted using the PubMed, EMBASE, and Cochrane Library electronic databases to identify all randomized controlled trials (RCTs). Results: Fifteen RCTs were identified. The combined data showed that the decrease in the glycosylated hemoglobin (HbA1c) level was slightly different, and the proportion of patients who achieved HbA1c < 7% was similar between the IDeg and IGlar groups...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29718785/finally-after-56-years-of-type-1-diabetes-a-regimen-that-works
#4
David S H Bell
Prior to the availability of degludec and regular human insulin inhalation powder in the type 1 diabetic patient glycemic control with subcutaneous insulin injections was difficult to obtain due to nocturnal, pre-prandial and often severe hypoglycemia as well as post-prandial hyperglycemia and hypoglycemia due to "stacking" of insulin. A 62-year-old female with type 1 diabetes for 56 years who could not be controlled with continuous subcutaneous insulin aspart infusion obtained glycemic control without significant hypoglycemia or increased post-prandial glycemic excursions utilizing degludec insulin for basal needs and technosphere before meals and between meals if needed...
May 2, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29713480/real-world-crude-incidence-of-hypoglycemia-in-adults-with-diabetes-results-of-the-inhypo-dm-study-canada
#5
Alexandria Ratzki-Leewing, Stewart B Harris, Selam Mequanint, Sonja M Reichert, Judith Belle Brown, Jason Edward Black, Bridget L Ryan
Objective: Very few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29701487/patient-preferences-for-diabetes-related-complications-in-taiwan
#6
Yi-Ju Lin, Chin-Yuan Wang, Ssu-Wei Cheng, Yu Ko
BACKGROUND: As the prevalence of diabetes mellitus (DM) continues to increase rapidly, there has been a rising need not only to assess the clinical outcomes but also the impact of DM on the health-related quality of life (HRQoL) of affected individuals. Most previous studies have found that having complications is strongly associated with decreased HRQoL in DM patients. As such, it is crucial to measure individuals' preferences for DM-related complications in order to assess the magnitude of complications' effect on overall HRQoL...
April 27, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29656504/efficacy-and-safety-of-myl-1501d-vs-insulin-glargine-in-patients-with-type-1-diabetes-after-52-weeks-results-of-the-instride-1-phase-iii-study
#7
Thomas C Blevins, Abhijit Barve, Bin Sun, Michael Ankersen
AIM: To test the safety and efficacy of MYL-1501D, a proposed insulin glargine biosimilar, in patients with type 1 diabetes mellitus (T1DM). METHODS: The safety and efficacy of MYL-1501D and reference insulin glargine were evaluated in INSTRIDE 1, a 52-week, open-label, randomized, phase III study in patients with T1DM. The primary objective was to determine whether once-daily MYL-1501D was non-inferior to once-daily insulin glargine when administered in combination with mealtime insulin lispro based on change in glycated haemoglobin (HbA1c) from baseline to week 24...
April 15, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29649221/long-acting-insulin-analogues-for-type-1-diabetes-an-overview-of-systematic-reviews-and-meta-analysis-of-randomized-controlled-trials
#8
Fernanda O Laranjeira, Keitty R C de Andrade, Ana C M G Figueiredo, Everton N Silva, Mauricio G Pereira
BACKGROUND: The comparison between long acting insulin analogues (LAIA) and human insulin (NPH) has been investigated for decades, with many randomized controlled trials (RCTs) and systematic reviews giving mixed results. This overlapping and contradictory evidence has increased uncertainty on coverage decisions at health systems level. AIM: To conduct an overview of systematic reviews and update existing reviews, preparing new meta-analysis to determine whether LAIA are effective for T1D patients compared to NPH...
2018: PloS One
https://www.readbyqxmd.com/read/29619751/basal-bolus-insulin-therapy-with-gla-300-during-hospitalization-reduces-nocturnal-hypoglycemia-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-study
#9
Fumitaka Okajima, Yuko Nakamura, Yuji Yamaguchi, Yuki Shuto, Katsuhito Kato, Hitoshi Sugihara, Naoya Emoto
INTRODUCTION: Although reduction in the incidence of nocturnal hypoglycemia, as estimated by symptom or self-monitored plasma glucose, was shown to be more pronounced with 300 units/mL insulin glargine (Gla-300) than with 100 units/mL insulin glargine (Gla-100) in type 2 diabetes patients, the exact frequency of nocturnal hypoglycemia estimated with continuous glucose monitoring (CGM) has not been reported. METHODS: Forty patients with type 2 diabetes who were admitted for glycemic control with basal-bolus insulin therapy (BBT) were randomized into the Gla-100 and Gla-300 groups...
April 4, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29618670/usage-of-continuous-glucose-monitoring-cgm-for-detecting-an-unrecognized-hypoglycemia-and-management-of-glucocorticoid-replacement-therapy-in-adult-patients-with-central-hypoadrenalism
#10
Takuya Watanabe, Atsushi Ozawa, Sumiyasu Ishii, Takuya Tomaru, Nobuyuki Shibusawa, Tsugumichi Saito, Eijiro Yamada, Kazuhiko Horiguchi, Yasuyo Nakajima, Shunichi Matsumoto, Satoshi Yoshino, Akiko Katano-Toki, Koshi Hashimoto, Masatomo Mori, Shuichi Okada, Tetsurou Satoh, Masanobu Yamada
Patients with adrenal insufficiency require appropriate glucocorticoid replacement therapy; however, reliable biological parameters for optimizing glucocorticoid supplementation are limited. The physician has to rely primarily on clinical judgment, carefully taking into account signs and symptoms potentially suggestive of over- or under-replacement. We have found that some patients who are viewed as receiving sufficient doses of glucocorticoids occasionally exhibit morning headache or morning discomfort, which may be caused by unrecognized nocturnal hypoglycemia...
April 4, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29614124/evaluation-of-glycemic-variability-in-chronic-liver-disease-patients-with-type-2-diabetes-mellitus-using-continuous-glucose-monitoring
#11
Fumi Honda, Akira Hiramatsu, Hideyuki Hyogo, Hiroshi Aikata, Kana Daijo, Yuji Teraoka, Yuki Inagaki, Kei Morio, Tomoki Kobayashi, Takashi Nakahara, Yuko Nagaoki, Tomokazu Kawaoka, Masayasu Yoneda, Masataka Tsuge, Michio Imamura, Yoshiiku Kawakami, Hidenori Ochi, Kazuaki Chayama
BACKGROUND AND AIMS: The feature of blood glucose dynamics in patients with chronic liver disease (CLD) is marked blood glucose fluctuations. However, the detail of blood glucose dynamics is not well known. The aim of the present study was to evaluate glycemic fluctuations by continuous glucose monitoring (CGM). MATERIALS AND METHODS: A total of 105 CLD patients with type 2 diabetes mellitus (T2DM) were enrolled in this study. Various parameters of glycemic variability were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29613998/continuous-glucose-monitoring-at-high-altitude-effects-on-glucose-homeostasis
#12
Neil E Hill, Kevin Deighton, Jamie Matu, Shivani Misra, Nick S Oliver, Carrie Newman, Adrian Mellor, John O'Hara, David Woods
PURPOSE: Exposure to high altitude has been shown to enhance both glucose and lipid utilization depending on experimental protocol. In addition, high and low blood glucose levels have been reported at high altitude. We hypothesized that gradual ascent to high altitude results in changes in glucose levels in healthy young adults. METHODS: 25 adult volunteers, split into two teams, took part in the British Services Dhaulagiri Medical Research Expedition completing 14 days of trekking around the Dhaulagiri circuit in Nepal reaching a peak altitude of 5300m on Day 11 of the trek...
April 27, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29608107/a-randomized-clinical-trial-of-the-effect-of-continuous-glucose-monitoring-on-nocturnal-hypoglycemia-daytime-hypoglycemia-glycemic-variability-and-hypoglycemia-confidence-in-persons-with-type-1-diabetes-treated-with-multiple-daily-insulin-injections-gold-3
#13
Arndís F Ólafsdóttir, William Polonsky, Jan Bolinder, Irl B Hirsch, Sofia Dahlqvist, Hans Wedel, Thomas Nyström, Magnus Wijkman, Erik Schwarcz, Jarl Hellman, Tim Heise, Marcus Lind
BACKGROUND: To evaluate the effects of continuous glucose monitoring (CGM) on nocturnal and daytime hypoglycemia in persons with type 1 diabetes treated with multiple daily insulin injections (MDI); we also evaluated factors related to differences in hypoglycemia confidence in this population. METHODS: Evaluations were performed from the GOLD randomized trial, an open-label multicenter crossover randomized clinical trial (n = 161) over 69 weeks comparing CGM to self-measurement of blood glucose (SMBG) in persons with type 1 diabetes treated with MDI...
April 2, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29574635/relative-contribution-of-fasting-and-postprandial-blood-glucose-in-overall-glycemic-control-post-hoc-analysis-of-a-phase-iv-randomized-trial
#14
Qing Su, Jun Liu, Pengfei Li, Lei Qian, Wenying Yang
INTRODUCTION: Few prospective clinical trials have investigated the role of fasting blood glucose (FBG) and/or postprandial glucose (PPG) in assessing overall glycemic control by using different insulin regimens. In the present post hoc analysis, we assessed the contribution of FBG and/or PPG in overall glycemic control in Chinese patients under insulin treatment. METHODS: CLASSIFY is a phase IV, randomized, open-label, 26-week, parallel-arm, treat-to-target, multinational, controlled study in patients with type 2 diabetes mellitus to compare the efficacy and safety of insulin lispro mix 25 (LM25) and insulin lispro mix 50 (LM50) as starter insulins...
March 24, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29565719/effect-of-insulin-analogs-on-frequency-of-non-severe-hypoglycemia-in-patients-with-type-1-diabetes-prone-to-severe-hypoglycemia-much-higher-rates-detected-by-continuous-glucose-monitoring-than-by-self-monitoring-of-blood-glucose-the-hypoana-trial
#15
Rikke Mette Agesen, Peter Lommer Kristensen, Henning Beck-Nielsen, Kirsten Nørgaard, Hans Perrild, Tonny Jensen, Hans-Henrik Parving, Birger Thorsteinsson, Lise Tarnow, Ulrik Pedersen-Bjergaard
BACKGROUND: Hypoglycemia is an increasingly important endpoint in clinical diabetes trials. The assessment of hypoglycemia should therefore be as complete as possible. Blinded continuous glucose monitoring (CGM) provides an improved opportunity to capture asymptomatic and nocturnal events. Here we report results from the HypoAna trial comparing all-analog-insulin therapy (aspart/detemir) with all-human-insulin therapy (neutral protamine Hagedorn/regular) on non-severe hypoglycemia (symptomatic and asymptomatic hypoglycemia) as assessed by blinded CGM and compared with data obtained by self-monitoring of blood glucose (SMBG) in patients with type 1 diabetes and recurrent severe hypoglycemia...
March 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29535135/day-and-night-closed-loop-insulin-delivery-in-a-broad-population-of-pregnant-women-with-type-1-diabetes-a-randomized-controlled-crossover-trial
#16
Zoe A Stewart, Malgorzata E Wilinska, Sara Hartnell, Leanne K O'Neil, Gerry Rayman, Eleanor M Scott, Katharine Barnard, Conor Farrington, Roman Hovorka, Helen R Murphy
OBJECTIVE: Despite advances in technology, optimal glucose control remains elusive and neonatal complications ubiquitous in type 1 diabetes (T1D) pregnancy. Our aim was to examine the safety, efficacy, and longer-term feasibility of day-and-night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We recruited 16 pregnant women (mean [SD]: age 32.8 [5.0] years, T1D duration 19.4 [10.2] years, HbA1c 8.0% [1.1%], BMI 26.6 [4.4] kg/m2 ) to an open-label, randomized, crossover trial...
March 13, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29525908/treating-type-1-diabetes-mellitus-with-a-rapid-acting-analog-insulin-regimen-vs-regular-human-insulin-in-germany-a-long-term-cost-effectiveness-evaluation
#17
William J Valentine, Kate Van Brunt, Kristina S Boye, Richard F Pollock
OBJECTIVE: The aim of the present study was to evaluate the cost effectiveness of rapid-acting analog insulin relative to regular human insulin in adults with type 1 diabetes mellitus in Germany. METHODS: The PRIME Diabetes Model, a patient-level, discrete event simulation model, was used to project long-term clinical and cost outcomes for patients with type 1 diabetes from the perspective of a German healthcare payer. Simulated patients had a mean age of 21.5 years, duration of diabetes of 8...
June 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29496503/new-injectable-agents-for-the-treatment-of-type-2-diabetes-part-1-injectable-insulins
#18
REVIEW
Christa M George, AhYoung Byun, Amanda Howard-Thompson
The United States Food and Drug Administration has recently approved several new insulin products and new formulations of existing insulin products. These new products may provide advantages over older products, such as a lower risk of nocturnal hypoglycemia and ease of dosing; however, they are costly. The first of 2 articles in a series, this review will describe the potential advantages and disadvantages of these new insulin products.
February 26, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29423761/comparative-safety-and-efficacy-of-insulin-degludec-with-insulin-glargine-in-type-2-and-type-1-diabetes-a-meta-analysis-of-randomized-controlled-trials
#19
Xiao-Wen Zhang, Xin-Lin Zhang, Biao Xu, Li-Na Kang
AIMS: To determine the safety and efficacy of insulin degludec versus glargine in patients with type 1 (T1D) and type 2 (T2D) diabetes mellitus. METHODS: Databases were searched until July 5, 2017. We included randomized controlled trials comparing degludec with glargine in diabetic patients, each with a minimum of 16 weeks of follow-up. RESULTS: Eighteen trials with 16,791 patients were included. Degludec was associated with a statistically significant reduction in risk for all confirmed hypoglycemia at the maintenance treatment period [estimated rate ratio (ERR) 0...
May 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29402981/clinical-features-and-therapeutic-perspectives-on-hypertension-in-diabetics
#20
REVIEW
Shigehiro Katayama, Masako Hatano, Masashi Issiki
Over 50% of patients with diabetes mellitus, either type 1 or 2, ultimately develop hypertension as a complication. In diabetics, this further increases the incidence of cardiovascular disease (CVD) by 2- to 3-fold and accelerates the progression of diabetic nephropathy. Arteriosclerosis, a clinical feature of hypertension in diabetics, develops and advances from a young age. Therefore, in providing treatment, it is necessary to evaluate the degree of arteriosclerosis. Diabetic patients are encouraged to strictly control their blood glucose levels...
April 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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