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Systemic hypertension treatment review

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https://www.readbyqxmd.com/read/29931399/tyrosine-kinase-inhibitor-induced-hypertension
#1
REVIEW
Megha Agarwal, Nidhi Thareja, Melody Benjamin, Andre Akhondi, George D Mitchell
PURPOSE OF REVIEW: The purpose of this paper is to identify commonly used tyrosine kinase inhibitors (TKIs) that are associated with hypertension, primarily, vascular endothelial growth factor (VEGF) signaling pathway (VSP) inhibitors. We review the incidence, mechanism, and strategies for management of TKI-induced HTN. We hope to provide clinicians with guidance on how to manage similar clinical scenarios. RECENT FINDINGS: Many of the newer VSP inhibitors are reviewed here, including cediranib, axitinib, pazopanib, and ponatinib...
June 21, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29928151/a-rare-case-of-rem-sleep-related-bradyarrhythmia-syndrome-with-concomitant-severe-hypertension-a-case-report-and-a-review-of-literature
#2
Gabrielius Jakutis, Vytautas Juknevičius, Juratė Barysienė, Dalia Matačiūnienė, Birutė Petrauskienė, Žaneta Petrulionienė, Aleksandras Laucevičius
Introduction: Rapid eye movement (REM) sleep-related bradyarrhythmia syndrome is characterized by pathological asystoles during the REM sleep phase. It is a rare rhythm disorder, being reported only few times in the literature. Due to non-specific symptoms, REM sleep-related bradyarrhythmia might be often underdiagnosed. Other cardiac diseases associated with pathological sinus arrests must be excluded to establish the correct diagnosis of and appropriate therapy for REM sleep-related bradyarrhythmia...
2018: Acta Medica Lituanica
https://www.readbyqxmd.com/read/29925174/-management-of-blood-pressure-in-acute-ischemic-stroke-a-meta-analysis
#3
Q Huang, J Z Zhang, J Wu
Objective: We are aiming at conducting a meta-analysis of the literature to elucidate the efficacy and safety of anti-hypertension therapy in acute stage of ischemic stroke (AIS). Methods: Researches on the efficacy and safety of anti-hypertension therapy published on PubMed before 1st September 2017 were independently retrieved by two authors.Clinical benign prognosis and death measured as modified Rankin Scale (mRS) ≤2 and mRS=6 were taken as primary indicators of efficacy and safety, respectively.A meta-analysis of included randomized controlled trials (RCTs) was performed by RevMan 5...
June 19, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29916858/nonalcoholic-fatty-liver-disease-and-hypertension-coprevalent-or-corelated
#4
Dimitrios Oikonomou, Georgios Georgiopoulos, Vassiliki Katsi, Chris Kourek, Constantinos Tsioufis, Alexendra Alexopoulou, Evaggelia Koutli, Dimitrios Tousoulis
OBJECTIVE: To provide a comprehensive review summarizing the existing evidence on the association between nonalcoholic fatty liver disease (NAFLD) and hypertension (HT) independent of other components of metabolic syndrome. METHODS: We searched the literature through Medline and the Cochrane Library for studies evaluating the relationship between hypertension and fatty liver disease. RESULTS: Studies testing this association are limited, but agree that HT and fatty liver disease are inter-related independent of other components of the metabolic syndrome such as obesity and diabetes mellitus...
June 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29907885/recognition-and-control-of-hypertension-diabetes-and-dyslipidemia-in-patients-with-rheumatoid-arthritis
#5
Luísa Lima Castro, Cristina Costa Duarte Lanna, Mariana Pimenta Rocha, Antônio Luiz Pinho Ribeiro, Rosa Weiss Telles
Absolute cardiovascular risk of an individual with rheumatoid arthritis (RA) is greater when compared to the general population, and several factors have proven to be important for the development of coronary artery disease (CAD) in these patients, including factors related to the underlying disease, such as the systemic inflammatory response, drugs used in its treatment, and a higher prevalence of traditional risk factors for CAD. Our aim is to describe the recognition and control frequencies of systemic arterial hypertension (SAH), dyslipidemia, and diabetes mellitus (DM) in RA patients...
June 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29879076/primary-central-nervous-system-lymphoma-in-a-patient-with-systemic-lupus-erythematosus-mimicking-high-grade-glioma-a-case-report-and-review-of-literature
#6
Lei Su, Meilin Ding, Lili Chen, Chen Li, Minxi Lao
RATIONALE: Primary central nervous system lymphoma (PCNSL) is a rare disease. Studies of PCNSL in patients with rheumatic diseases are lacking. Neither clinical symptoms nor radiographic manifestation is specific to PCNSL. Therefore, it could be misdiagnosed with other diseases such as brain tumors. Chemotherapy is the primary treatment for PCNSL, while the role of surgery remains controversial. PATIENT CONCERNS: We reported a 39-year-old woman with systemic lupus erythematosus (SLE) developed PCNSL after 15-year treatment with multiple immunosuppressants...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29874475/the-contemporary-management-of-systemic-sclerosis
#7
Maysoon Eldoma, Janet Pope
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease (CTD) characterized by vascular dysfunction, fibrosis, inflammation and autoantibodies. The pathophysiology of SSc is not completely understood, and many patients acquire organ or tissue damage despite advances in treatment. Current treatments target affected organs with modest improvements. Areas covered: This review evaluates several treatment strategies for SSc based on involved organs including skin, pulmonary, cardiac, renal, musculoskeletal and gastrointestinal...
June 6, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29869147/microscopic-polyangiitis-necrotizing-glomerulonephritis-associated-with-pregnancy-case-with-a-20-year-clinical-course-and-review-of-the-literature
#8
Yoichi Oshima, Tatsuya Suwabe, Yuji Marui, Noriko Hayami, Eiko Hasegawa, Masayuki Yamanouchi, Rikako Hiramatsu, Keiichi Sumida, Masahiro Kawada, Akinari Sekine, Hiroki Mizuno, Masahiko Oguro, Junichi Hoshino, Naoki Sawa, Yasuo Ishii, Takeshi Fujii, Kenichi Ohashi, Kenmei Takaichi, Yoshifumi Ubara
A 29-year-old woman with past medical history of hypertension was referred to our hospital for the evaluation of kidney dysfunction (serum creatinine 1.0 mg/dL), proteinuria (0.54 g/gCre), and microscopic hematuria. Renal biopsy before the first pregnancy was supportive for benign nephrosclerosis with no evidence of vasculitis. After her second pregnancy and delivery when she was 32 years old, she developed proteinuria of 3.2 g/gCre, hematuria, and elevated serum creatinine level of 2.6 mg/dL. Second renal biopsy revealed necrotizing glomerulonephritis and her serum MPO-ANCA was positive, leading to the diagnosis of MPA/renal-limited vasculitis (RLV)...
June 5, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29866720/risk-factors-and-determinants-of-carotid-intima-media-thickness-in-children-protocol-for-a-systematic-review-and-meta-analysis
#9
Adina Mihaela Epure, Magali Leyvraz, Yvan Mivelaz, Stefano Di Bernardo, Bruno R da Costa, Arnaud Chiolero, Nicole Sekarski
INTRODUCTION: Carotid intima-media thickness (CIMT) is a surrogate marker of atherosclerosis that is measured in adults and children to better understand the natural history of cardiovascular disease (CVD). In adults, CIMT is predictive of myocardial infarction and stroke. In children and adolescents, CIMT is used to assess vascular changes in the presence of CVD risk factors (obesity, hypertension, smoking, etc) or clinical conditions associated with a high risk for premature CVD. However, there is no comprehensive overview, in a life-course epidemiology perspective, of the risk factors and determinants of CIMT in children...
June 4, 2018: BMJ Open
https://www.readbyqxmd.com/read/29850452/thromboembolic-events-secondary-to-endoscopic-cyanoacrylate-injection-can-we-foresee-any-red-flags
#10
Yujen Tseng, Lili Ma, Tiancheng Luo, Xiaoqing Zeng, Yichao Wei, Ling Li, Pengju Xu, Shiyao Chen
Background: Gastric varices (GV) are associated with high morbidity and mortality in patients with portal hypertension. Endoscopic cyanoacrylate injection is the first-line recommended therapy for GV obliteration. This study aims to explore the reason behind related adverse events and better prevent its occurrence. Methods: A retrospective case series study was conducted from January 1, 2013, to December 31, 2016, to identify patients who experienced severe adverse events secondary to endoscopic cyanoacrylate injection...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29844939/clinical-applications-of-spleen-ultrasound-elastography-a-review
#11
REVIEW
Rafał Mazur, Milena Celmer, Jurand Silicki, Daniel Hołownia, Patryk Pozowski, Krzysztof Międzybrodzki
In the last few years, notable technical progress has taken place in ultrasound elastography. Qualitative methods have been replaced by quantitative ones, such as: transient elastography, acoustic radiation force impulse and shear wave elastography. Owing to the fact that the spleen is superficially located, it is possible to obtain reliable measuring accuracy of its hardness using sonoelastography. Lately, many researchers have been investigating how spleen elasticity changes in patients infected with hepatitis B virus or hepatitis C virus and in patients suffering from liver fibrosis, portal hypertension, esophageal varices or myelofibrosis...
March 2018: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29808707/a-review-of-ace-inhibitors-and-arbs-in-black-patients-with-hypertension
#12
Allison Helmer, Nicole Slater, Sean Smithgall
OBJECTIVE: To review current guidelines and recent data evaluating the efficacy and safety of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in black hypertensive patients. DATA SOURCES: Articles evaluating race-specific outcomes in hypertension were gathered using a MEDLINE search with keywords black, African American, ACE inhibitor, angiotensin receptor blocker, angiotensin system, and hypertension. Studies published from 2000 through April 2018 were reviewed...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29796754/clinical-characteristics-and-ocular-complications-of-patients-with-scleritis-in-japanese
#13
Rie Tanaka, Toshikatsu Kaburaki, Kazuyoshi Ohtomo, Mitsuko Takamoto, Keiko Komae, Jiro Numaga, Yujiro Fujino, Makoto Aihara
PURPOSE: To investigate the clinical characteristics of Japanese patients with scleritis STUDY DESIGN: Retrospective study METHODS: The clinical records of 123 patients with scleritis, who presented to the University of Tokyo Hospital between January, 2004 and December, 2015, were retrospectively reviewed. RESULTS: The cohort comprised 55 men and 68 women (mean age, 57.8±16.4 years), of which 76 showed anterior diffuse scleritis, 17 showed anterior nodular scleritis, 10 showed anterior necrotizing scleritis, and 20 showed posterior scleritis...
May 23, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29793213/end-stage-renal-disease-models-in-the-americas-optimizing-resources-to-achieve-better-health-outcomes
#14
Ramiro E Gilardino, Eduardo González-Pier, Claudia Brabata
End-stage renal disease, the last and most severe stage of chronic kidney disease, represents a major and rising concern for countries in Latin America, driven in large part by aging populations and the near-epidemic rises in diabetes, obesity, and hypertension. This places a great clinical, economic, and social burden on the region's health systems. During the ISPOR 6th Latin America Conference held in Sao Paulo, Brazil, in September 2017, an educational forum debated on value-based decision making in the treatment of end-stage renal disease in Latin America...
May 21, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29785115/management-and-outcomes-of-pregnancy-with-or-without-lupus-nephritis-a-systematic-review-and-meta-analysis
#15
REVIEW
Jiayue Wu, Jinghang Ma, Wei-Hong Zhang, Wen Di
Background: Although it is well established that systemic lupus erythematosus (SLE) negatively affects pregnancy outcomes, there is insufficient evidence on the effect of lupus nephritis (LN) on antenatal management and pregnancy outcomes. We performed a systematic review and meta-analysis to determine the association of LN with management and pregnancy outcomes in SLE patients. Methods: Embase, Medline, Cochrane, and ClinicalTrials.gov were carefully searched for relevant English and Chinese language studies...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29784764/links-between-immunologic-memory-and-metabolic-cycling
#16
REVIEW
Matthew A Cottam, Hana A Itani, Arch A Beasley, Alyssa H Hasty
Treatments for metabolic diseases, such as diet and therapeutics, often provide short-term therapy for metabolic stressors, but relapse is common. Repeated bouts of exposure to, and relief from, metabolic stimuli results in a phenomenon we call "metabolic cycling." Recent human and rodent data suggest metabolic cycling promotes an exaggerated response and ultimately worsened metabolic health. This is particularly evident with cycling of body weight and hypertension. The innate and adaptive immune systems have a profound impact on development of metabolic disease, and current data suggest that immunologic memory may partially explain this association, especially in the context of metabolic cycling...
June 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29784594/the-effect-of-increasing-catheter-distance-from-the-deep-junction-on-the-outcomes-of-radiofrequency-vein-ablation
#17
Afsha Aurshina, Yawei Zhang, Fang Wang, Jonathan Cardella, Kristine Orion, Bauer Sumpio, Timur Sarac, Cassius Iyad Ochoa Chaar
OBJECTIVE: Thermal vein ablation (VA) is the recommended treatment modality for superficial venous reflux, with a recommended positioning of the catheter at 2 to 3 cm from the junction of the deep venous system. In contrast, novel sealing technology for saphenous VA involves treatment starting at 3 to 5 cm distal to the deep junction. This study examines the effect of increasing catheter distance from the junction on the outcomes of VA using radiofrequency. METHODS: A retrospective single-center review of patients treated with VA was performed...
May 18, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29779164/update-on-endothelin-receptor-antagonists-in-hypertension
#18
REVIEW
Michel Burnier
To review the most recent data on the development of endothelin receptor antagonists (ERAs) for the treatment of hypertension and the management of diabetic nephropathy RECENT FINDINGS: Recent reviews and meta-analyses of experimental and clinical data obtained with ERAs confirmed that endothelin receptor blockade is associated with significant decreases in blood pressure in essential hypertension but also in resistant hypertension. In addition, in patients with diabetic nephropathy, ERAs induce significant 30-40% decreases in albuminuria when administered on top of blockers of the renin-angiotensin system...
May 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29773070/humoral-immunity-in-heart-failure
#19
Khadija Rafiq
Cardiovascular disease (CVD) is a class of diseases that involve disorders of heart and blood vessels, including: hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, which finally lead to heart failure (HF). There are several treatments available all over the world, but still CVD and heart failure became the number one problem causing death every year worldwide. Both experimental and clinical studies have shown a role for inflammation in the pathogenesis of heart failure...
May 17, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29773069/high-altitude-pulmonary-hypertension
#20
Maurizio Bussotti, Giovanni Marchese
The effects of hypoxia on the human organism has been considered doubly fascinating by the scientific community: the knowledge of the discrete mechanisms allowing the acclimatization both at the genetic level or through the cell mediators production in addition to the macroscopic responses of the cardio-circulatory and ventilatory systems to a hypoxic environment has been progressively developed since the last century; moreover granting a safer stay in hypoxic conditions not only for the residents but also for the different cathegories of workers, sportsmen and tourists has been considered a worthy aim of the medical activity...
May 17, 2018: Cardiovascular & Hematological Disorders Drug Targets
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