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Systemic hypertension treatment review

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https://www.readbyqxmd.com/read/29454466/-dermoid-cysts-of-the-posterior-cerebral-fossa-in-children-revealed-by-recurrent-aseptic-meningitis-report-of-two-cases-and-a-review-of-the-literature
#1
R Kouadria, M Derkaoui
INTRODUCTION: Dermoid cysts of central nervous system are very rare. The usual clinical presentation is dominated by intracranial hypertension, epilepsy and cranial palsy. The revelation mode could be recurrent aseptic meningitis. AIM: The aim of this case report is to consider the dermoid cyst as regards the differential diagnosis in children treated for recurrent aseptic meningitis to avoid misdiagnosis and ice qui a orienté le diagnostic à une méningitnadequate treatment...
February 14, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29449364/diabetic-cardiomyopathy-an-update-of-mechanisms-contributing-to-this-clinical-entity
#2
REVIEW
Guanghong Jia, Michael A Hill, James R Sowers
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes associated with heart failure are considerably worse for patients with diabetes mellitus than for those without diabetes mellitus. In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia, has led to the descriptive terminology, diabetic cardiomyopathy...
February 16, 2018: Circulation Research
https://www.readbyqxmd.com/read/29446067/headache-linked-to-intracranial-hypertension-and-hypertrophic-pachymeningitis-as-the-initial-and-dominant-presentation-of-granulomatosis-with-polyangiitis-case-report-and-review-of-the-recent-literature
#3
Marianthi A Arnaoutoglou, Chrysostomos G Xerras, Ioannis K Kalevrosoglou, Vasileios D Rafailidis, Konstantinos P Notas, Thomas I Tegos
OBJECTIVE: The objective of this article is to report a rare case of headache as the initial symptom of granulomatosis with polyangiitis (GPA) and to review the recent literature. BACKGROUND: Granulomatosis with polyangiitis is a rare, systemic, autoimmune disease of unknown etiology. GPA has a wide spectrum of clinical symptomatology, including involvement of the nervous system, even as the initial manifestation. Symptoms of the peripheral nervous system used to dominate the clinical symptomatology...
February 15, 2018: Headache
https://www.readbyqxmd.com/read/29445908/gender-differences-in-epidemiology-pathophysiology-and-treatment-of-hypertension
#4
REVIEW
Paolo Di Giosia, Paolo Giorgini, Cosimo Andrea Stamerra, Marco Petrarca, Claudio Ferri, Amirhossein Sahebkar
PURPOSE OF REVIEW: This review aims to examine gender differences in both the epidemiology and pathophysiology of hypertension and to explore gender peculiarities on the effects of antihypertensive agents in decreasing BP and CV events. RECENT FINDINGS: Men and women differ in prevalence, awareness, and control rate of hypertension in an age-dependent manner. Studies suggest that sex hormones changes play a pivotal role in the pathophysiology of hypertension in postmenopausal women...
February 14, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29438494/artificial-intelligence-in-drug-combination-therapy
#5
Igor F Tsigelny
Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a physician often meets a patient having a genomic profile including more than five molecular aberrations. Drug combination therapy has been an area of interest for a while, for example the classical work of Loewe devoted to the synergism of drugs was published in 1928-and it is still used in calculations for optimal drug combinations...
February 9, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29417823/drug-induced-pulmonary-arterial-hypertension-a-primer-for-clinicians-and-scientists
#6
Mark E Orcholski, Ke Yuan, Charlotte Rajasingh, Halley Tsai, Elya A Shamskhou, Navneet Kaur Dhillon, Norbert F Voelkel, Roham T Zamanian, Vinicio A de Jesus Perez
Drug-induced pulmonary arterial hypertension (D-PAH) is a form of World Health Organization (WHO) Group 1 pulmonary hypertension (PH) defined by severe small vessel loss and obstructive vasculopathy, which leads to progressive right heart failure and death. To date, 16 different compounds have been associated with D-PAH, including anorexigens, recreational stimulants, and more recently, several Food and Drug Administration (FDA)-approved medications. While the clinical manifestation, pathology, and hemodynamic profile of D-PAH are indistinguishable from other forms of PAH, its clinical course can be unpredictable and to some degree dependent on removal of the offending agent...
February 8, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29413506/pulmonary-arterial-hypertension-in-the-setting-of-scleroderma-is-different-than-in-the-setting-of-lupus-a-review
#7
REVIEW
Isabel S Bazan, Kofi A Mensah, Anastasiia A Rudkovskaia, Percy K Adonteng-Boateng, Erica L Herzog, Lenore Buckley, Wassim H Fares
Pulmonary hypertension (PH) is a clinical syndrome that is subdivided into five groups per the World Health Organization (WHO) classification, based largely on hemodynamic and pathophysiologic criteria. WHO Group 1 PH, termed pulmonary arterial hypertension (PAH), is a clinically progressive disease that can eventually lead to right heart failure and death, and it is hemodynamically characterized by pre-capillary PH and increased pulmonary vascular resistance in the absence of elevated left ventricular filling pressures...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29410175/everolimus-as-cancer-therapy-cardiotoxic-or-an-unexpected-antiatherogenic-agent-a-narrative-review
#8
REVIEW
Georgios Karvelas, Aikaterini Roumpi, Christoforos Komporozos, Konstantinos Syrigos
Everolimus (EVE) is now approved by many agencies for the treatment of variable neoplasms. The risk of adverse events with these agent is not adequately defined. The purpose of this review was to summarize the everolimus - induced cardiotoxic effects to patients that received the specific drug as an antineoplastic factor and evaluate any possible anti-atherogenic effects due to systemic use of the drug. PubMed was searched for articles until August 2017. Articles included an expanded-access clinical trial, as well as phase 2 or 3 clinical trials (most of them were randomized)...
February 2, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29406364/gender-differences-in-hypertension
#9
Jane F Reckelhoff
PURPOSE OF REVIEW: The review is a short discussion of sex/gender differences in blood pressure control with a focus on gender differences in hypertension awareness, prevalence, and treatment, the new American College of Cardiology/American Heart Association Guidelines, and recent discoveries in animal models and humans on mechanisms responsible for sex/gender differences in hypertension. RECENT FINDINGS: Hypertension awareness is greater in women than men, the prevalence of hypertension is higher in men than women until after menopause, and although the American College of Cardiology/American Heart Association Guidelines recommend similar treatment for men and women, this is not currently the case in practice...
February 5, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29401665/the-impact-of-vitamin-d-in-the-treatment-of-essential-hypertension
#10
REVIEW
Christian Legarth, Daniela Grimm, Markus Wehland, Johann Bauer, Marcus Krüger
The aim of this review is to investigate, whether there is a possible link between vitamin D supplementation and the reduction of blood pressure in hypertensive patients. The renin-angiotensin-aldosterone system is known for being deeply involved in cardiovascular tonus and blood pressure regulation. Hence, many of the pharmaceutical antihypertensive drugs inhibit this system. Interestingly, experimental studies in mice have indicated that vitamin D supplementation significantly lowers renin synthesis and blood pressure...
February 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29400991/lifestyle-genomics-and-the-metabolic-syndrome-a-review-of-genetic-variants-that-influence-response-to-diet-and-exercise-interventions
#11
Peri H Fenwick, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Dawna Royall, Paula Brauer, Angelo Tremblay, Doug Klein, David M Mutch
Metabolic syndrome (MetS) comprises a cluster of risk factors that includes central obesity, dyslipidemia, impaired glucose homeostasis and hypertension. Individuals with MetS have elevated risk of type 2 diabetes and cardiovascular disease; thus placing significant burdens on social and healthcare systems. Lifestyle interventions (comprised of diet, exercise or a combination of both) are routinely recommended as the first line of treatment for MetS. Only a proportion of people respond, and it has been assumed that psychological and social aspects primarily account for these differences...
February 5, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29393580/bosentan-therapy-for-pulmonary-arterial-hypertension-and-chronic-thromboembolic-pulmonary-hypertension-a-systemic-review-and-meta-analysis
#12
Xinwang Chen, Zhenguo Zhai, Ke Huang, Wanmu Xie, Jun Wan, Chen Wang
BACKGROUND: Bosentan therapy has been recommended for pulmonary arterial hypertension (PAH) and might be beneficial for chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to evaluate the specific effects of bosentan for PAH and CTEPH. METHODS: We performed a systemic review and meta-analysis of randomized controlled trials (RCTs) comparing efficacy and safety of bosentan treatment for PAH and CTEPH through major biomedical database. RESULTS: A total of 10 RCTs including 1185 patients were enrolled...
February 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29384050/polyphenols-potential-use-in-the-prevention-and-treatment-of-cardiovascular-diseases
#13
Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo Fg Cicero, Giuseppe Lippi, Manfredi Rizzo, Peter P Toth, Maciej Banach
BACKGROUND: Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses. Their effects on human health depend on the amount consumed and on their bioavailability. Many studies have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure, improving endothelial function, increasing antioxidant defences, inhibiting platelet aggregation and low-density lipoprotein oxidation, and reducing inflammatory responses...
January 29, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29382608/metabolic-syndrome-autoimmunity-and-rheumatic-diseases
#14
REVIEW
Gabriela Medina, Olga Vera-Lastra, Ana Lilia Peralta-Amaro, María Pilar Jiménez-Arellano, Miguel Angel Saavedra, María Pilar Cruz-Domínguez, Luis J Jara
Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular (CV) risk factors including obesity and visceral adiposity, insulin resistance, dyslipidemia and hypertension contributing to CV mortality. The interface between the metabolic and immune systems has been of great interest recently. These interactions are regulated through genetics, nutritional status, and the intestinal microbiome. Alterations in the immune-metabolic cross-talk contribute to the development of autoimmune diseases. Adipokines exert a variety of metabolic activities contributing to the ethiopathogenesis of MetS and are involved in the regulation of both inflammatory processes and autoimmunity occurring in rheumatic diseases...
January 27, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29378252/gut-microbiota-hypertension-and-chronic-kidney-disease-recent-advances
#15
REVIEW
Antonio Sircana, Franco De Michieli, Renato Parente, Luciana Framarin, Nicola Leone, Mara Berrutti, Elena Paschetta, Daria Bongiovanni, Giovanni Musso
A large number of different microbial species populates intestine. Extensive research has studied the entire microbial population and their genes (microbiome) by using metagenomics, metatranscriptomics and metabolomic analysis. Studies suggest that the imbalances of the microbial community causes alterations in the intestinal homeostasis, leading to repercussions on other systems: metabolic, nervous, cardiovascular, immune. These studies have also shown that alterations in the structure and function of the gut microbiota play a key role in the pathogenesis and complications of Hypertension (HTN) and Chronic Kidney Disease (CKD)...
January 26, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29361405/neuroinflammation-and-sympathetic-overactivity-mechanisms-and-implications-in-hypertension
#16
REVIEW
Dhanush Haspula, Michelle A Clark
Essential hypertension is a multifactorial disorder with a strong genetic predisposition. Although anti-hypertensive medications have drastically reduced cardiovascular diseases mortality and morbidity rates, a significant percentage of hypertensive individuals currently on anti-hypertensive therapy, remain hypertensive. In spite of the emergence of transgenic animals and sophisticated tools to study the pathophysiology of hypertension, unraveling the causal mechanisms remains a challenge. Research on borderline hypertensive humans and/or prehypertensive rat models revealed an elevation in centrally-mediated sympathetic activity and a heightened neuroinflammatory state...
January 12, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29360462/association-between-portosystemic-shunts-and-increased-complications-and-mortality-in-patients-with-cirrhosis
#17
Macarena Simón-Talero, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Michael Praktiknjo, Martin H Maurer, Alexander Zipprich, Michela Triolo, Guillaume Vangrinsven, Rita Garcia-Martinez, Annette Dam, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G Abraldes, Marta Lopez, Guido Kukuk, Aleksander Krag, Rafael Bañares, Wim Laleman, Vincenzo La Mura, Cristina Ripoll, Annalisa Berzigotti, Jonel Trebicka, Jose Luis Calleja, Puneeta Tandon, Virginia Hernandez-Gea, Thomas Reiberger, Agustín Albillos, Emmanuel A Tsochatzis, Salvador Augustin, Joan Genescà, Sergi Quiroga, Dominic Yu, Mattias Mandorfer, Juan Carlos Garcia-Pagan, Claudia Berbel, Jose Ferrusquia, Michel Ble, Mari Angeles Garcia-Criado, Ernest Belmonte, Michael Ney, Cristina Margini, Stefania Casu, Giuseppe Murgia, Christiane Ludwig, Martin Rönsch, Dietrich Stoevesandt, Laura Carrion, Enrique Ramón Botella
BACKGROUND & AIMS: Spontaneous portosystemic shunts (SPSSs) have been associated with hepatic encephalopathy (HE). Little is known about their prevalence among patients with cirrhosis or clinical effects. We investigated the prevalence and characteristics of SPSSs in patients with cirrhosis and their outcomes. METHODS: We performed a retrospective study of 1729 patients with cirrhosis who underwent abdominal computed tomography or magnetic resonance imaging analysis from 2010 through 2015 at 14 centers in Canada and Europe...
January 20, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29353099/cardiovascular-involvement-in-systemic-rheumatic-diseases-an-integrated-view-for-the-treating-physicians
#18
REVIEW
Kwang Seob Lee, Andreas Kronbichler, Michael Eisenhut, Keum Hwa Lee, Jae Il Shin
Systemic autoimmune diseases can affect various kinds of organs including the kidney, the skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic diseases has been shown to affect myocardium, pericardium, cardiac vessels, conduction system and valves, eventually leading to mortality. In general, underlying chronic inflammation lead to premature atherosclerosis, but also other manifestations such as arrhythmia and heart failure may have a 'silent' progress. Traditional cardiovascular risk factors play a secondary role, while disease-specific factors (i...
January 15, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29350384/the-importance-of-psychosocial-factors-in-management-of-pulmonary-arterial-hypertension-patients
#19
Maria A Sobczak-Kaleta, Adam Torbicki, Jarosław D Kasprzak
Pulmonary arterial hypertension (PAH) is significantly reshaping personal and professional lives of patients due to its chronic nature, varying clinical profile and uncertain perspectives of treatment. PAH is at this time an incurable disease, which requires to consider not only strictly medical dimension, but also the psychosocial aspects of care. This paper discusses therefore the psychological problems most commonly reported by PAH patients. It reviews the instruments used to assess them. We describe the relationships between the quality of life and depressive symptoms and the physical activity of the PAH patients, which have deep treatment-related consequences...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350061/the-adverse-effects-of-environmental-noise-exposure-on-oxidative-stress-and-cardiovascular-risk
#20
Thomas Münzel, Mette Sørensen, Frank P Schmidt, Erwin Schmidt, Sebastian Steven, Swenja Kröller-Schön, Andreas Daiber
Epidemiological studies have provided evidence that traffic noise exposure is linked to cardiovascular diseases such as arterial hypertension, myocardial infarction and stroke. Noise is a non-specific stressor that activates the autonomous nervous system and endocrine signaling. According to the noise reaction model introduced by Babisch and colleagues, chronic low levels of noise can cause so called non-auditory effects, such as disturbances of activity, sleep and communication, which can trigger a number of emotional responses, including annoyance and subsequent stress...
January 19, 2018: Antioxidants & Redox Signaling
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