Jan Scott, Frank Iorfino, William Capon, Jacob Crouse, Barnaby Nelson, Andrew M Chanen, Dominic Dwyer, Philippe Conus, Andreas Bechdolf, Aswin Ratheesh, Andrea Raballo, Alison Yung, Michael Berk, Sarah McKenna, Samuel Hockey, Alexis Hutcheon, Elizabeth Scott, Pat McGorry, Jai Shah, Ian B Hickie
Globally, 75% of depressive, bipolar, and psychotic disorders emerge by age 25 years. However, these disorders are often preceded by non-specific symptoms or attenuated clinical syndromes. Difficulties in determining optimal treatment interventions for these emerging mental disorders, and uncertainties about accounting for co-occurring psychopathology and illness trajectories, have led many youth mental health services to adopt transdiagnostic clinical staging frameworks. In this Health Policy paper, an international working group highlights ongoing challenges in applying transdiagnostic staging frameworks in clinical research and practice, and proposes refinements to the transdiagnostic model to enhance its reliability, consistent recording, and clinical utility...
April 18, 2024: Lancet Psychiatry