keyword
https://read.qxmd.com/read/38537223/a-systems-framework-for-investigating-the-roles-of-multiple-transporters-and-their-impact-on-drug-resistance
#1
JOURNAL ARTICLE
Manfredi di San Germano, J Krishnan
Efflux transporters are a fundamental component of both prokaryotic and eukaryotic cells, play a crucial role in maintaining cellular homeostasis, and represent a key bridge between single cell and population levels. From a biomedical perspective, they play a crucial role in drug resistance (and especially multi-drug resistance, MDR) in a range of systems spanning bacteria and human cancer cells. Typically, multiple efflux transporters are present in these cells, and the efflux transporters transport a range of substrates (with partially overlapping substrates between transporters)...
January 23, 2024: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://read.qxmd.com/read/38537214/inflammatory-and-malignant-uptake-along-crohn-perianal-fistula-on-18f-fdg
#2
JOURNAL ARTICLE
Spencer McKinley, Favour Garuba, Malak Itani, Parakkal Deepak, David H Ballard
Inflammatory increased metabolic activity was discovered in the left anal canal on an 18F-FDG PET/CT scan performed for initial staging of anal squamous cell carcinoma in a patient with history of perianal Crohn disease. This increased uptake was due to a complex intersphincteric perianal fistula with supralevator extension, with a secondary, contiguous, superficial focus of squamous cell carcinoma at the anal verge that was identified on an MRI performed on the same day.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537207/unusual-metastasis-of-signet-ring-cell-gastric-cancer-that-could-not-be-detected-with-18f-fdg-pet-but-with-68ga-fapi-pet-ct
#3
JOURNAL ARTICLE
Murat Yilmaz Kiran, Leman Damla Ercan, Ecem Karatay, Duygu Has Simsek, Yasemin Sanli
A 70-year-old man who was scheduled for surgery because of the recurrence of gastric cancer was referred to our clinic preoperatively. The patient underwent a comprehensive evaluation through 18F-FDG and 68Ga-FAPI (68Ga-labeled FAP inhibitors) PET/CT scans. The 68Ga-FAPI PET/CT scan was particularly valuable in this case because of its ability to detect recurrent mass lesions and identify unusual metastatic sites compared with the 18F-FDG PET/CT scan.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537198/biokc-a-collaborative-platform-for-curation-and-annotation-of-molecular-interactions
#4
JOURNAL ARTICLE
Carlos Vega, Marek Ostaszewski, Valentin Grouès, Reinhard Schneider, Venkata Satagopam
Curation of biomedical knowledge into systems biology diagrammatic or computational models is essential for studying complex biological processes. However, systems-level curation is a laborious manual process, especially when facing ever-increasing growth of domain literature. New findings demonstrating elaborate relationships between multiple molecules, pathways and cells have to be represented in a format suitable for systems biology applications. Importantly, curation should capture the complexity of molecular interactions in such a format together with annotations of the involved elements and support stable identifiers and versioning...
March 27, 2024: Database: the Journal of Biological Databases and Curation
https://read.qxmd.com/read/38537163/iso-bai-guided-surface-recrystallization-for-over-14-tin-halide-perovskite-solar-cells
#5
JOURNAL ARTICLE
Pok Fung Chan, Minchao Qin, Chun-Jen Su, Liping Ye, Xuezhou Wang, Yunfan Wang, Xin Guan, Zhen Lu, Gang Li, To Ngai, Sai Wing Tsang, Ni Zhao, Xinhui Lu
Tin-based perovskite solar cells (PSCs) are promising environmentally friendly alternatives to their lead-based counterparts, yet they currently suffer from much lower device performance. Due to variations in the chemical properties of lead (II) and tin (II) ions, similar treatments may yield distinct effects resulting from differences in underlying mechanisms. In this work, a surface treatment on tin-based perovskite is conducted with a commonly employed ligand, iso-butylammonium iodide (iso-BAI). Unlike the passivation effects previously observed in lead-based perovskites, such treatment leads to the recrystallization of the surface, driven by the higher solubility of tin-based perovskite in common solvents...
March 27, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38537144/first-report-of-powdery-mildew-on-berchemia-floribunda-caused-by-erysiphe-berchemiae-in-china
#6
JOURNAL ARTICLE
Leitao Tan, Yiming Shi, Yun He, Chengui Zhao, Wei Ding, Qiuping Liu
The genus Berchemia (family Rhamnaceae), a group of climbing plants, is mainly distributed in Asia, Africa, and South America. Berchemia plants are widely used in traditional medicine in some Asian countries (Inoshiri et al. 1987). For example, in Japan, B. racemosa (synonym B. floribunda ) is used for the treatment of gallstones, liver diseases, neuralgia, and stomach cramps, and in China, B. floribunda is used for the treatment of rheumatism and lumbago. In August 2022, typical powdery mildew symptoms were observed on wild B...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537142/first-report-of-fusarium-falciforme-causing-root-and-rhizome-rot-of-epimedium-sagittatum-in-china
#7
JOURNAL ARTICLE
Leixia Chu, Diandian Li, Wenchuan Hou, Zhiwei Dan, Xiaojie Wang, Chengming Dong
Epimedium sagittatum (Sieb.et Zucc.) Maxim., a perennial herb, is an important medicinal plant, rich in flavonoids, and widely used in the treatment of sexual dysfunction, rheumatic disease, and cancers (Tan et al. 2016). In July 2022, a disease of root and rhizome was found on E. sagittatum aged 1-8 years in a planting area (266 ha) of Zhumadian City (32°58'12" N, 114°37'48" E), Henan Province, China. The disease incidence per field (660 m2 ) was around 10-15% in six randomly surveyed fields planted with about 10,000 E...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537140/first-report-of-soybean-root-rot-caused-by-fusarium-proliferatum-in-the-republic-of-korea
#8
JOURNAL ARTICLE
In-Jeong Kang, Mirang Lee, Sang Yun Han, Yul-Ho Kim, Sungwoo Lee
Fusarium species are widespread soilborne pathogens that can cause damping-off, root rot, and wilting in soybean [ Glycine max (L.) Merrill], subsequently leading to significant yield suppression. Several Fusarium spp. have already been documented for their pathogenicity on soybean plants in the Republic of Korea. The nationwide monitoring of soybean diseases continues to identify new pathogenic Fusarium spp. In 2016, five plant samples at R3-R4 growth stages, showing symptoms of wilting in the upper parts and root rot, were collected in Suwon, Gyeonggi, Republic of Korea...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537137/development-of-a-long-amplicon-pma-qpcr-assay-for-detection-of-viable-xanthomonas-arboricola-pv-pruni-cells-in-peach-trees
#9
JOURNAL ARTICLE
Milan Panth, Enoch Noh, Guido Schnabel, Hehe Wang
Bacterial spot is one of the most serious diseases of peach caused by the pathogen Xanthomonas arboricola pv. pruni (XAP), leading to early defoliation and unmarketable fruit. The pathogen can overwinter in peach twigs and form spring cankers, which are considered the primary inoculum source for early season leaf and fruitlet infection. The amount of overwintering bacterial inoculum plays a critical role for the bacterial spot development, but no reliable quantification method is available. Thus, we developed a long-amplicon propidium monoazide (PMA)-qPCR assay for specific detection of viable XAP cells...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#10
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537130/comprehensive-molecular-classification-predicted-microenvironment-profiles-and-therapy-response-for-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Yihong Chen, Xiangying Deng, Yin Li, Ying Han, Yinghui Peng, Wantao Wu, Xinwen Wang, Jiayao Ma, Erya Hu, Xin Zhou, Edward Shen, Shan Zeng, Changjing Cai, Yiming Qin, Hong Shen
BACKGROUND AND AIMS: Tumor microenvironment (TME) heterogeneity leads to a discrepancy in survival prognosis and clinical treatment response for hepatocellular carcinoma (HCC) patients. The clinical applications of documented molecular subtypes are constrained by several issues. APPROACH AND RESULTS: We integrated three single-cell datasets to describe the TME landscape and identified six prognosis-related cell subclusters. Unsupervised clustering of subcluster-specific markers was performed to generate transcriptomic subtypes...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537119/constructing-linear-oriented-pre-vascularized-human-spinal-cord-tissues-for-spinal-cord-injury-repair
#12
JOURNAL ARTICLE
Caixia Fan, Hui Cai, Lulu Zhang, Xianming Wu, Junyan Yan, Lifang Jin, Baowei Hu, Jiaxiong He, Yanyan Chen, Yannan Zhao, Jianwu Dai
Repairing spinal cord injury (SCI) is a global medical challenge lacking effective clinical treatment. Developing human-engineered spinal cord tissues that can replenish lost cells and restore a regenerative microenvironment offers promising potential for SCI therapy. However, creating vascularized human spinal cord-like tissues that mimic the diverse cell types and longitudinal parallel structural features of spinal cord tissues remains a significant hurdle. In present study, vascularized spinal cord tissues (VSCT) were engineered using embryonic human spinal cord-derived neural cells and endothelial cells on linear ordered collagen scaffolds (LOCS)...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38537114/should-research-administrators-be-regulated-as-carefully-as-researchers
#13
JOURNAL ARTICLE
Jason Scott Robert
This essay assesses the rationale for regulating research administrators as carefully as they regulate researchers. The reasons for such regulation are identical: protecting scientific integrity, ensuring responsible use of public funds, addressing the lack of effective recourse for victims, creating negative consequences for misbehaving actors, and addressing high incentives for misconduct. Whereas the reasons compelling us to regulate research administrators are obvious, counterarguments to administrative oversight are based on suggestions that the incidence and prevalence of cases of administrative misconduct are too low to warrant formal regulation...
March 27, 2024: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://read.qxmd.com/read/38537113/chewing-through-challenges-exploring-the-evolutionary-pathways-to-wood-feeding-in-insects
#14
JOURNAL ARTICLE
Cristian F Beza-Beza, Brian M Wiegmann, Jessica A Ware, Matt Petersen, Nicole Gunter, Marissa E Cole, Melbert Schwarz, Matthew A Bertone, Daniel Young, Aram Mikaelyan
Decaying wood, while an abundant and stable resource, presents considerable nutritional challenges due to its structural rigidity, chemical recalcitrance, and low nitrogen content. Despite these challenges, certain insect lineages have successfully evolved saproxylophagy (consuming and deriving sustenance from decaying wood), impacting nutrient recycling in ecosystems and carbon sequestration dynamics. This study explores the uneven phylogenetic distribution of saproxylophagy across insects and delves into the evolutionary origins of this trait in disparate insect orders...
March 27, 2024: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://read.qxmd.com/read/38537110/deletion-of-dictyostelium-tpc2-gene-forms-multi-tipped-structures-regulates-autophagy-and-cell-type-patterning
#15
JOURNAL ARTICLE
Madhubala Rathore, Ashima Thakur, Shweta Saran
BACKGROUND INFORMATION: Two pore channels (TPCs) are voltage-gated ion channel superfamily members that release Ca2+ from acidic intracellular stores and are ubiquitously present in both animals and plants. Starvation initiates multicellular development in Dictyostelium discoideum. Increased intracellular calcium levels bias Dictyostelium cells towards the stalk pathway and thus we decided to analyze the role of TPC2 in development, differentiation, and autophagy. RESULTS: We showed TPC2 protein localizes in lysosome-like acidic vesicles and the in situ data showed stalk cell biasness...
March 27, 2024: Biology of the Cell
https://read.qxmd.com/read/38537079/amino-acid-supplementation-confers-protection-to-red-blood-cells-prior-to-plasmodium-falciparum-bystander-stress
#16
JOURNAL ARTICLE
Heather Colvin Binns, Elmira Alipour, Cameron E Sherlock, Dinah S Nahid, John F Whitesides, Anderson O'Brien Cox, Cristina M Furdui, Glen S Marrs, Daniel B Kim-Shapiro, Regina Joice Cordy
Malaria is a highly oxidative parasitic disease in which anemia is the most common clinical symptom. A major contributor to malarial anemia pathogenesis is the destruction of bystander, uninfected red blood cells (RBCs). Metabolic fluctuations are known to occur in the plasma of individuals with acute malaria, emphasizing the role of metabolic changes in disease progression and severity. Here, we report that conditioned media from Plasmodium falciparum culture induces oxidative stress in uninfected, catalase-depleted RBCs...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537065/a-multicenter-study-of-venetoclax-based-treatment-for-patients-with-richter-transformation-of-chronic-lymphocytic-leukemia
#17
JOURNAL ARTICLE
Paul Joseph Hampel, Mahesh Swaminathan, Kerry A Rogers, Erin M Parry, Jan A Burger, Matthew S Davids, Wei Ding, Alessandra Ferrajoli, Jonathan Mitry Hyak, Nitin Jain, Saad S Kenderian, Yucai Wang, William G Wierda, Jennifer A Woyach, Sameer A Parikh, Philip A Thompson
Patients with chronic lymphocytic leukemia (CLL) who develop Richter transformation (RT) have a poor prognosis when treated with chemoimmunotherapy regimens used for de novo diffuse large B-cell lymphoma. Venetoclax, a BCL2 inhibitor, has single agent efficacy in patients with RT and is potentially synergistic with chemoimmunotherapy. In this multicenter, retrospective study, we evaluated 62 patients with RT who received venetoclax-based treatment outside of a clinical trial, in combination with a Bruton tyrosine kinase inhibitor (BTKi; n=28), R-CHOP (n=13), or intensive chemoimmunotherapy other than R-CHOP (n=21)...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537062/late-cytomegalovirus-disease-after-hematopoietic-cell-transplantation-significance-of-novel-transplantation-techniques
#18
JOURNAL ARTICLE
Alicja Sadowska-Klasa, Sezen Özkök, Hu Xie, Wendy M Leisenring, Danniel Zamora, Sachiko Seo, Jordan Sheldon, Stephanie J Lee, Keith R Jerome, Margaret L Green, Michael J Boeckh
Pre-emptive therapy (PET) and letermovir prophylaxis are effective in preventing CMV disease within the first 100 days after allogeneic hematopoietic cell transplantation (HCT) but are associated with late-onset CMV disease. We retrospectively examined the clinical manifestations, risk factors, prevention algorithm, and outcome of late CMV disease in CMV seropositive day 100 survivors transplanted between 2001-2017 (PET cohort) and 2018-2021 (letermovir cohort). There were 187 episodes of late CMV disease among 2469 day 100 survivors and the estimated cumulative incidence of first late CMV disease was 6...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537061/cost-effectiveness-of-bevacizumab-therapy-in-the-care-of-patients-with-hereditary-hemorrhagic-telangiectasia
#19
JOURNAL ARTICLE
Daniel Wang, Satoko Ito, Christina Waldron, Ayesha Butt, Ellen Zhang, Harlan Krumholz, Hanny Al-Samkari, George Goshua
No FDA or EMA approved therapies exist for bleeding due to hereditary hemorrhagic telangiectasia (HHT), the second-most-common inherited bleeding disorder worldwide. The current standard-of-care (SOC) includes iron and red cell supplementation, alongside the necessary hemostatic procedures, none of which target underlying disease pathogenesis. Recent evidence has demonstrated that bleeding pathophysiology is amenable to systemic antiangiogenic therapy with the anti-VEGF bevacizumab. Despite its high cost, the addition of longitudinal bevacizumab to the current SOC may reduce overall healthcare resource utilization and improve patient quality-of-life...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537041/primary-basal-cell-carcinoma-of-the-caruncle-case-report-and-review-of-the-literature
#20
Elizabeth Cecilia Roque-Choque, Jorge Ramiro Villalobos-Espinoza, Isabel Silva-Ocas, Rosa Alvarado-Villacorta, Pedro Muro-Mansilla
We present a rare case of primary caruncle basal cell carcinoma (BCC), a condition with limited occurrences. Our patient, an 80-year-old woman without prior ocular pathological history, presented a 2x2mm pedunculated blackish nodular lesion on the caruncle of her left eye, without local conjunctival or cutaneous involvement. Histological analysis following complete excision confirmed the presence of basal cell carcinoma within the caruncle. Over a span of 30 months, no recurrence has been observed. While scant cases are documented in the literature, we conducted a review of these instances...
2024: Arquivos Brasileiros de Oftalmologia
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