keyword
https://read.qxmd.com/read/38272177/silencing-angptl8-reduces-mouse-preadipocyte-differentiation-and-insulin-signaling
#21
JOURNAL ARTICLE
Anindya Ghosh, Yat Hei Leung, Jeffrey Yu, Robert Sladek, Isabelle Chénier, Abel K Oppong, Marie-Line Peyot, S R Murthy Madiraju, Irina Al-Khairi, Thangavel Alphonse Thanaraj, Jehad Abubaker, Fahd Al-Mulla, Marc Prentki, Mohamed Abu-Farha
ANGPTL8, expressed mainly in the liver and adipose tissue, regulates the activity of lipoprotein lipase (LPL) present in the extracellular space and triglyceride (TG) metabolism through its interaction with ANGPTL3 and ANGPTL4. Whether intracellular ANGPTL8 can also exerts roles in tissues where it is expressed is uncertain. ANGPTL8 expression was low in preadipocytes and much increased during differentiation. To better understand the role of intracellular ANGPTL8 in adipocytes and assess whether it may play a role in adipocyte differentiation, we knocked down its expression in normal mouse subcutaneous preadipocytes...
January 23, 2024: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
https://read.qxmd.com/read/38255766/cinnamyl-alcohol-attenuates-adipogenesis-in-3t3-l1-cells-by-arresting-the-cell-cycle
#22
JOURNAL ARTICLE
Yae Rim Choi, Young-Suk Kim, Min Jung Kim
Cinnamyl alcohol (CA) is an aromatic compound found in several plant-based resources and has been shown to exert anti-inflammatory and anti-microbial activities. However, the anti-adipogenic mechanism of CA has not been sufficiently studied. The present study aimed to investigate the effect and mechanism of CA on the regulation of adipogenesis. As evidenced by Oil Red O staining, Western blotting, and real-time PCR (RT-PCR) analyses, CA treatment (6.25-25 μM) for 8 d significantly inhibited lipid accumulation in a concentration-dependent manner and downregulated adipogenesis-related markers (peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), fatty acid binding protein 4 (FABP4), adiponectin, fatty acid synthase (FAS)) in 3-isobutyl-1-methylxanthine, dexamethasone, and insulin(MDI)-treated 3T3-L1 adipocytes...
January 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38254947/goat-mir-92a-3p-targets-apol-6-gene-to-regulate-the-differentiation-of-intramuscular-precursor-adipocytes
#23
JOURNAL ARTICLE
Wuqie Qubi, Jianying Zheng, Youli Wang, Guishan Xu, Yanyan Li, Yan Xiong, Yong Wang, Wei Liu, Yaqiu Lin
The quality of lamb meat is positively correlated with intramuscular fat content. In recent years, a large number of studies have shown that miRNAs play an important role in the proliferation and differentiation of adipocytes. In this study, we aimed to explore the effect of miR-92a-3p on the differentiation of goat intramuscular preadipocytes. The results showed that the expression level of miR-92a-3p was low in the early stage of differentiation, reached the highest level on the third day of differentiation, and then decreased...
December 30, 2023: Genes
https://read.qxmd.com/read/38253356/the-optimized-priming-effect-of-fgf-1-and-fgf-2-enhances-preadipocyte-lineage-commitment-in-human-adipose-derived-mesenchymal-stem-cells
#24
JOURNAL ARTICLE
Tanakorn Tarapongpun, Nattawat Onlamoon, Kouichi Tabu, Suebwong Chuthapisith, Tetsuya Taga
The cell-assisted lipotransfer technique, integrating adipose-derived mesenchymal stem cells (ADMSCs), has transformed lipofilling, enhancing fat graft viability. However, the multipotent nature of ADMSCs poses challenges. To improve safety and graft vitality and to reduce unwanted lineage differentiation, this study refines the methodology by priming ADMSCs into preadipocytes-unipotent, self-renewing cells. We explored the impact of fibroblast growth factor-1 (FGF-1), fibroblast growth factor-2 (FGF-2), and epidermal growth factor (EGF), either alone or in combination, on primary human ADMSCs during the proliferative phase...
January 22, 2024: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/38238641/autophagic-regulation-of-adipogenesis-through-tp53inp2-insights-from-in-silico-and-in-vitro-analysis
#25
JOURNAL ARTICLE
Mouliganesh Sekar, Kavitha Thirumurugan
Obesity is an epidemic disease associated with multimorbidity resulting in higher mortality risk. The imbalance between energy storage and expenditure is the prime factor in the prognosis of the disease. Specifically, excessive lipid storage through adipogenesis leads to obesity. Adipogenesis is the process that converts preadipocytes into mature adipocytes by regulating major transcription factors like PPARγ and C/EBPα, contributes to lipid storage in adipose tissue. On the contrary, autophagy is a self-degradative process that maintains homeostasis in adipose tissue by regulating adipogenesis and lipolysis...
January 18, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38224425/conjugated-linoleic-acid-reduces-lipid-accumulation-via-down-regulation-expression-of-lipogenic-genes-and-up-regulation-of-apoptotic-genes-in-grass-carp-ctenopharyngodon-idella-adipocyte-in-vitro
#26
JOURNAL ARTICLE
Hua Yu, Zhao-Xia Zou, Wei Wei, Ying Li
The relationship between conjugated linoleic acid (CLA) and lipogenesis has been extensively studied in mammals and some cell lines, but it is relatively rare in fish, and the potential mechanism of action of CLA reducing fat mass remains unclear. The established primary culture model for studying lipogenesis in grass carp (Ctenopharyngodon idella) preadipocytes was used in the present study, and the objective was to explore the effects of CLA on intracellular lipid and TG content, fatty acid composition, and mRNA levels of adipogenesis transcription factors, lipase, and apoptosis genes in grass carp adipocytes in vitro...
January 15, 2024: Marine Biotechnology
https://read.qxmd.com/read/38203803/mir-129-regulates-yak-intramuscular-preadipocyte-proliferation-and-differentiation-through-the-pi3k-akt-pathway
#27
JOURNAL ARTICLE
Chunyu Qin, Hui Wang, Jincheng Zhong, Hongbiao Ran, Wei Peng
miR-129 plays a crucial role in regulating various cellular processes, including adipogenesis; however, its downstream molecular mechanisms remain unclear. In this study, we demonstrated that miR-129 promotes yak adipogenesis in vitro via the PI3K/AKT pathway. Overexpression and interference of miR-129 in yak intramuscular preadipocytes (YIMAs) enhanced and inhibited cell differentiation, respectively, with corresponding changes in cell proliferation. Further investigation revealed that miR-129 enhances AKT and p-AKT activity in the AKT pathway without affecting cell apoptosis, and a specific inhibitor (LY294002) was used to confirm that miR-129 regulates YIMAs proliferation and differentiation through the PI3K/AKT pathway...
January 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38203371/inhibitory-effects-of-sesquiterpenoids-isolated-from-artemisia-scoparia-on-adipogenic-differentiation-of-3t3-l1-preadipocytes
#28
JOURNAL ARTICLE
Jung Im Lee, Jung Hwan Oh, Fatih Karadeniz, Chang-Suk Kong, Youngwan Seo
Obesity and related complications are significant health issues in modern society, largely attributed to a sedentary lifestyle and a carbohydrate-rich diet. Since anti-obesity drugs often come with severe side effects, preventative measures are being sought globally, including dietary changes and functional foods that can counteract weight gain. In this context, plant-based metabolites are extensively studied for their advantageous biological effects against obesity. Several plants within the Artemisia genus have been reported to possess anti-adipogenic properties, preventing adipocytes from maturing and accumulating lipids...
December 22, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38201894/bmp8b-activates-both-smad2-3-and-nf-%C3%AE%C2%BAb-signals-to-inhibit-the-differentiation-of-3t3-l1-preadipocytes-into-mature-adipocytes
#29
JOURNAL ARTICLE
Shenjie Zhong, Xueqing Du, Jing Gao, Guangdong Ji, Zhenhui Liu
Bone morphogenetic protein 8B (BMP8B) has been found to regulate the thermogenesis of brown adipose tissue (BAT) and the browning process of white adipose tissue (WAT). However, there is no available information regarding the role of BMP8B in the process of adipocyte differentiation. Here, we showed that BMP8B down-regulates transcriptional regulators PPARγ and C/EBPα, thereby impeding the differentiation of 3T3-L1 preadipocytes into fully mature adipocytes. BMP8B increased the phosphorylation levels of SMAD2/3, and TP0427736 HCl (SMAD2/3 inhibitor) significantly reduced the ability of BMP8B to inhibit adipocyte differentiation, suggesting that BMP8B repressed adipocyte differentiation through the SMAD2/3 pathway...
December 25, 2023: Nutrients
https://read.qxmd.com/read/38195707/epac1-enhances-brown-fat-growth-and-beige-adipogenesis
#30
JOURNAL ARTICLE
Laia Reverte-Salisa, Sana Siddig, Staffan Hildebrand, Xi Yao, Jelena Zurkovic, Michelle Y Jaeckstein, Joerg Heeren, Frank Lezoualc'h, Natalie Krahmer, Alexander Pfeifer
Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure and cardiometabolic health. However, regulators that specifically increase the number of thermogenic adipocytes are still an unmet need. Here, we show that the cAMP-binding protein EPAC1 is a central regulator of adaptive BAT growth. In vivo, selective pharmacological activation of EPAC1 increases BAT mass and browning of white fat, leading to higher energy expenditure and reduced diet-induced obesity. Mechanistically, EPAC1 coordinates a network of regulators for proliferation specifically in thermogenic adipocytes, but not in white adipocytes...
January 9, 2024: Nature Cell Biology
https://read.qxmd.com/read/38178019/integrated-analysis-strategy-of-genome-wide-functional-gene-mining-reveals-dkk2-gene-underlying-meat-quality-in-shaziling-synthesized-pigs
#31
JOURNAL ARTICLE
Shuaihan He, Yubei Wang, Yabiao Luo, Mingming Xue, Maisheng Wu, Hong Tan, Yinglin Peng, Kejun Wang, Meiying Fang
BACKGROUND: Shaziling pig is a well-known indigenous breed in China who has superior meat quality traits. However, the genetic mechanism and genomic evidence underlying meat quality characteristics of Shaziling pigs are still unclear. To explore and investigate the germplasm characteristics of Shaziling pigs, we totally analyzed 67 individual's whole genome sequencing data for the first time (20 Shaziling pigs [S], 20 Dabasha pigs [DBS], 11 Yorkshire pigs [Y], 10 Berkshire pigs [BKX], 5 Basha pigs [BS] and 1 Warthog)...
January 4, 2024: BMC Genomics
https://read.qxmd.com/read/38172976/current-views-on-selenoprotein-s-in-the-pathophysiological-processes-of-diabetes-induced-atherosclerosis-potential-therapeutics-and-underlying-biomarkers
#32
REVIEW
Shan-Shan Yu, Jian-Ling Du
Atherosclerotic cardiovascular disease (ASCVD) consistently ranks as the primary mortality factor among diabetic people. A thorough comprehension of the pathophysiological routes and processes activated by atherosclerosis (AS) caused by diabetes mellitus (DM), together with the recognition of new contributing factors, could lead to the discovery of crucial biomarkers and the development of innovative drugs against atherosclerosis. Selenoprotein S (SELENOS) has been implicated in the pathology and progression of numerous conditions, including diabetes, dyslipidemia, obesity, and insulin resistance (IR)-all recognized contributors to endothelial dysfunction (ED), a precursor event to diabetes-induced AS...
January 3, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38171546/lncrna-u90926-is-dispensable-for-the-development-of-obesity-associated-phenotypes-in%C3%A2-vivo
#33
JOURNAL ARTICLE
Bristy Sabikunnahar, Sydney Caldwell, Stella Varnum, Tyler Hogan, Karolyn G Lahue, Birgit Rathkolb, Raffaele Gerlini, Nathalia R V Dragano, Antonio Aguilar-Pimentel, Martin Irmler, Adrián Sanz-Moreno, Patricia da Silva-Buttkus, Johannes Beckers, Eckhard Wolf, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Jennifer L Ather, Matthew E Poynter, Dimitry N Krementsov
Obesity is a global health problem characterized by excessive fat accumulation, driven by adipogenesis and lipid accumulation. Long non-coding RNAs (lncRNAs) have recently been implicated in regulating adipogenesis and adipose tissue function. Mouse lncRNA U90926 was previously identified as a repressor of in vitro adipogenesis in 3T3-L1 preadipocytes. Consequently, we hypothesized that, in vivo, U90926 may repress adipogenesis, and hence its deletion would increase weight gain and adiposity. We tested the hypothesis by applying U90926-deficient (U9-KO) mice to a high-throughput phenotyping pipeline...
January 2024: Physiological Reports
https://read.qxmd.com/read/38158141/multiple-omics-analysis-reveals-the-regulation-of-sirt5-on-mitochondrial-function-and-lipid-metabolism-during-the-differentiation-of-bovine-preadipocytes
#34
JOURNAL ARTICLE
Jieyun Hong, Sayed Haidar Abbas Raza, Hongming Ma, Weina Cao, Yuqing Chong, Jiao Wu, Dongmei Xi, Weidong Deng
Preadipocyte differentiation represents a critical stage in adipogenesis, with mitochondria playing an undeniable pivotal role. Given the intricate interplay between transcription and metabolic signaling during adipogenesis, the regulation of sirtuin 5 (SIRT5) on mitochondrial function and lipid metabolism was revealed via multiple omics analysis. The findings suggest that SIRT5 plays a crucial role in promoting mitochondrial biosynthesis and maintaining mitochondrial function during preadipocyte differentiation...
December 27, 2023: Genomics
https://read.qxmd.com/read/38157229/effect-of-dhcr7-on-adipocyte-differentiation-in-goats
#35
JOURNAL ARTICLE
Zhibin Li, Tingting Hu, Ruiwen Li, Jinlan Li, Youli Wang, Yanyan Li, Yaqiu Lin, Yong Wang, Xing Jiani
Cholesterol is regarded as a signaling molecule in regulating the metabolism and function of fat cells, in which 7-Dehydrocholesterol reductase (DHCR7) is a key enzyme that catalyzes the conversion of 7-dehydrocholesterol to cholesterol, however, the exact function of DHCR7 in goat adipocytes remains unknown. Here, the effect of DHCR7 on the formation of subcutaneous and intramuscular fat in goats was investigated in vitro , and the result indicated that the mRNA level of DHCR7 showed a gradual downward trend in subcutaneous adipogenesis, but an opposite trend in intramuscular adipogenesis...
December 29, 2023: Animal Biotechnology
https://read.qxmd.com/read/38151567/obesity-induced-paris-znf746-accumulation-in-adipose-progenitor-cells-leads-to-attenuated-mitochondrial-biogenesis-and-impaired-adipogenesis
#36
JOURNAL ARTICLE
Kazuki Hachiya, Yusuke Deguchi, Takuro Hirata, Tomoya Arikawa, Hiroto Fukai, Tatsuhiro Esashi, Kota Nagasawa, Yuhei Mizunoe, Yuka Nozaki, Masaki Kobayashi, Yoshikazu Higami
White adipose tissue (WAT) is critical for whole-body energy metabolism, and its dysfunction leads to various metabolic disorders. In recent years, many studies have suggested that impaired mitochondria may contribute to obesity-related decline in adipose tissue function, but the detailed mechanisms remain unclear. To investigate these mechanisms, we carried out a comprehensive analysis of WAT from mice with diet-induced obesity. We discovered the transcription factor Parkin interactive substrate (PARIS or ZNF746), which suppresses the expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a key regulator of mitochondrial biogenesis, to be accumulated in adipose progenitor cells from obese mice...
December 27, 2023: Scientific Reports
https://read.qxmd.com/read/38141758/the-p2y2-receptor-mediates-terminal-adipocyte-differentiation-and-insulin-resistance-evidence-for-a-dual-g-protein-coupling-mode
#37
JOURNAL ARTICLE
Shenqi Qian, Yi Shi, Jared Senfeld, Qianman Peng, Jianzhong Shen
Several P2Y nucleotide receptors have been shown to be involved in the early stage of adipocyte differentiation in vitro and insulin resistance in obese mice; however, the exact receptor subtype(s) and its underlying molecular mechanism in relevant human cells are unclear. Here, using human primary visceral preadipocytes as a model, we found that during preadipocyte-to-mature adipocyte differentiation, the P2Y2 nucleotide receptor (P2Y2R) was the most upregulated subtype among the eight known P2Y receptors and the only one further dramatically upregulated after inflammatory TNFα treatment...
December 21, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/38128789/transcriptional-regulatory-mechanism-of-nr2f2-and-znf423-in-avian-preadipocyte-differentiation
#38
JOURNAL ARTICLE
Xiaoqin Li, Dandan Sun, Zheng Wang, Qiangsen Zhao, Yongtong Liu, Zhuocheng Hou
In the poultry industry, excessive abdominal fat deposition is not conducive to meat quality. Therefore, selection for optimal fat content levels in poultry has become a major breeding goal. We previously constructed NR2F2 overexpression (NR2F2OE ) and knockout (NR2F2Δ/Δ/83-125aa ) cell lines using Piggybac and CRISPR/Cas9 techniques, and confirmed that the transcription factor NR2F2 can significantly inhibit the differentiation of avian preadipocytes. In this study, we identified a downstream gene ZNF423 regulated by NR2F2, which is also involved in regulating avian fat deposition...
December 20, 2023: Gene
https://read.qxmd.com/read/38124767/anti%C3%A2-adipogenic-effect-and-underlying-mechanism-of-lignan%C3%A2-enriched-nutmeg-extract-on-3t3%C3%A2-l1-preadipocytes
#39
JOURNAL ARTICLE
Nivethasri Lakshmana Perumal, Sung Kuk Do, Jong-Soon Choi, Je-Ho Lee, Gyung-Tae Ban, Gyuri Kim, Amila Mufida, Hwa Seung Yoo, Byeong-Churl Jang
Nutmeg is the seed derived from Myristica fragrans . Nutmeg seeds contain alkylbenzene derivatives such as myristicin, which are toxic to the human organism, and lignan compounds such as nectandrin B, which possess anti-aging and anti-diabetic properties. However, the anti-adipogenic, prolipolytic and anti-inflammatory effects of lignan-enriched nutmeg extract (LNX) on preadipocytes remain unclear. In the present study, the effects of LNX on lipid accumulation, glycerol release and inflammatory cyclooxygenase-2 (COX-2) expression in differentiated 3T3-L1 preadipocytes were investigated...
January 2024: Biomedical Reports
https://read.qxmd.com/read/38111581/creeping-fat-exhibits-distinct-inflammation-specific-adipogenic-preadipocytes-in-crohn-s-disease
#40
JOURNAL ARTICLE
Nahee Hwang, Dongwoo Kang, Su-Jin Shin, Bo Kyung Yoon, Jaeyoung Chun, Jae-Woo Kim, Sungsoon Fang
Creeping fat (CrF) is an extraintestinal manifestation observed in patients with Crohn's disease (CD). It is characterized by the accumulation of mesenteric adipose tissue (MAT) that wraps around the intestinal wall. Although the role of CrF in CD is still debated, multiple studies have highlighted a correlation between CrF and inflammation, as well as fibrostenosais of the intestine, which contributes to the worsening of CD symptoms. However, the mechanism underlying the potential role of CrF in the development of Crohn's fibrosis remains an enigma...
2023: Frontiers in Immunology
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