Bristy Sabikunnahar, Sydney Caldwell, Stella Varnum, Tyler Hogan, Karolyn G Lahue, Birgit Rathkolb, Raffaele Gerlini, Nathalia R V Dragano, Antonio Aguilar-Pimentel, Martin Irmler, Adrián Sanz-Moreno, Patricia da Silva-Buttkus, Johannes Beckers, Eckhard Wolf, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Jennifer L Ather, Matthew E Poynter, Dimitry N Krementsov
Obesity is a global health problem characterized by excessive fat accumulation, driven by adipogenesis and lipid accumulation. Long non-coding RNAs (lncRNAs) have recently been implicated in regulating adipogenesis and adipose tissue function. Mouse lncRNA U90926 was previously identified as a repressor of in vitro adipogenesis in 3T3-L1 preadipocytes. Consequently, we hypothesized that, in vivo, U90926 may repress adipogenesis, and hence its deletion would increase weight gain and adiposity. We tested the hypothesis by applying U90926-deficient (U9-KO) mice to a high-throughput phenotyping pipeline...
January 2024: Physiological Reports