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preadipocyte AND adipogenesis

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https://www.readbyqxmd.com/read/28102348/ho-1-inhibits-preadipocyte-proliferation-and-differentiation-at-the-onset-of-obesity-via-ros-dependent-activation-of-akt2
#1
Gabriel Wagner, Josefine Lindroos-Christensen, Elisa Einwallner, Julia Husa, Thea-Christin Zapf, Katharina Lipp, Sabine Rauscher, Marion Gröger, Andreas Spittler, Robert Loewe, Florian Gruber, J Catharina Duvigneau, Thomas Mohr, Hedwig Sutterlüty-Fall, Florian Klinglmüller, Gerhard Prager, Berthold Huppertz, Jeanho Yun, Oswald Wagner, Harald Esterbauer, Martin Bilban
Excessive accumulation of white adipose tissue (WAT) is a hallmark of obesity. The expansion of WAT in obesity involves proliferation and differentiation of adipose precursors, however, the underlying molecular mechanisms remain unclear. Here, we used an unbiased transcriptomics approach to identify the earliest molecular underpinnings occuring in adipose precursors following a brief HFD in mice. Our analysis identifies Heme Oxygenase-1 (HO-1) as strongly and selectively being upregulated in the adipose precursor fraction of WAT, upon high-fat diet (HFD) feeding...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28100914/tet-mediated-hydroxymethylcytosine-at-the-ppar%C3%AE-locus-is-required-for-initiation-of-adipogenic-differentiation
#2
Y Yoo, J H Park, C Weigel, D B Liesenfeld, D Weichenhan, C Plass, D-G Seo, A M Lindroth, Y J Park
BACKGROUND/OBJECTIVES: Adipose tissue is one of the main organs regulating energy homeostasis, via energy storage as well as endocrine function. The adipocyte cell number is largely determined by adipogenesis. While the molecular mechanism of adipogenesis has been extensively studied, its role in dynamic DNA methylation plasticity remains unclear. Recently, it has been shown that Tet methylcytosine dioxygenase (TET) are catalytically capable of oxidizing DNA 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) towards a complete removal of the methylated cytosine...
January 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28088621/4-hydroxynonenal-causes-impairment-of-human-subcutaneous-adipogenesis-and-induction-of-adipocyte-insulin-resistance
#3
Mohamed A Elrayess, Shamma Almuraikhy, Wael Kafienah, Afnan Al-Menhali, Fatima Al-Khelaifi, Moataz Bashah, Kamelija Zarkovic, Neven Zarkovic, Georg Waeg, Mohammed Alsayrafi, Morana Jaganjac
OBJECTIVE: Increased adipose production of 4-hydroxynonenal (4-HNE), a bioreactive aldehyde, directly correlates with obesity and insulin resistance. The aim of this study was to elucidate the impact of 4-HNE in mediating adipocyte differentiation and function in two metabolically distinct obese groups; the insulin sensitive (IS) and the insulin resistant (IR). METHODS: Subcutaneous (SC) adipose tissues were obtained from eighteen clinically well characterized obese premenopausal women undergoing weight reduction surgery...
January 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28067305/gomisin-n-inhibits-adipogenesis-and-prevents-high-fat-diet-induced-obesity
#4
Min-Kyung Jang, Ye-Rang Yun, Ji-Hyun Kim, Mi-Hee Park, Myeong Ho Jung
Gomisin N (GN) is a physiological lignan derived from Schisandra chinensis. In the present study, we investigated the inhibitory effects of GN on differentiation of 3T3-L1 preadipocytes and the anti-obesity effects of GN in high-fat diet (HFD)-induced obese mice. Incubation with GN significantly inhibited the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. This inhibitory effect primarily occurred at an early adipogenic stage through impairment of mitotic clonal expansion (MCE) caused by cell cycle arrest at the G1/S phase transition...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060835/histone-h3k9-demethylase-jmjd2b-activates-adipogenesis-by-regulating-h3k9-methylation-on-ppar%C3%AE-and-c-ebp%C3%AE-during-adipogenesis
#5
Min-Kyung Jang, Ji-Hyun Kim, Myeong Ho Jung
Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) contribute to the repression of PPARγ and C/EBPα and inhibition of adipogenesis in 3T3-L1 preadipocytes. The balance of histone methylation is regulated by histone methyltransferases and demethylases. However, it is poorly understood which demethylases are responsible for removing H3K9me3/me2 on the promoter of PPARγ and C/EBPα...
2017: PloS One
https://www.readbyqxmd.com/read/28052263/amplification-of-adipogenic-commitment-by-vstm2a
#6
Blandine Secco, Étienne Camiré, Marc-Antoine Brière, Alexandre Caron, Armande Billong, Yves Gélinas, Anne-Marie Lemay, Kevin M Tharp, Peter L Lee, Stéphane Gobeil, Jean V Guimond, Natacha Patey, David A Guertin, Andreas Stahl, Élie Haddad, David Marsolais, Yohan Bossé, Kivanc Birsoy, Mathieu Laplante
Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28049100/dietary-overload-lithium-decreases-the-adipogenesis-in-abdominal-adipose-tissue-of-broiler-chickens
#7
Shiping Bai, Shuqin Pan, Keying Zhang, Xuemei Ding, Jianping Wang, Qiufeng Zeng, Yue Xuan, Zuowei Su
To investigate the toxic effects of dietary overload lithium on the adipogenesis in adipose tissue of chicken and the role of hypothalamic neuropeptide Y (NPY) in this process, one-day-old male chicks were fed with the basal diet added with 0 (control) or 100mg lithium/kg diet from lithium chloride (overload lithium) for 35days. Abdominal adipose tissue and hypothalamus were collected at day 6, 14, and 35. As a percentage of body weight, abdominal fat decreased (p<0.001) at day 6, 14, and 35, and feed intake and body weight gain decreased during day 7-14, and day 15-35 in overload lithium treated broilers as compared to control...
December 26, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28042862/hydrogen-sulfide-in-the-adipose-tissue-physiology-pathology-and-a-target-for-pharmacotherapy
#8
REVIEW
Jerzy Bełtowski, Anna Jamroz-Wiśniewska
Hydrogen sulfide (H₂S) is synthesized in the adipose tissue mainly by cystathionine γ-lyase (CSE). Several studies have demonstrated that H₂S is involved in adipogenesis, that is the differentiation of preadipocytes to adipocytes, most likely by inhibiting phosphodiesterases and increasing cyclic AMP concentration. The effect of H₂S on adipose tissue insulin sensitivity and glucose uptake is controversial. Some studies suggest that H₂S inhibits insulin-induced glucose uptake and that excess of H₂S contributes to adipose tissue insulin resistance in metabolic syndrome...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28011376/grape-seed-procyanidin-b2-inhibits-adipogenesis-of-3t3-l1-cells-by-targeting-peroxisome-proliferator-activated-receptor-%C3%AE-with-mir-483-5p-involved-mechanism
#9
Jun Zhang, Yazeng Huang, Haiyu Shao, Qing Bi, Jinping Chen, Zhaoming Ye
Procyanidins have lipolysis effect on adipose metabolism, but the underlying mechanism is not fully understood. The aim of present study was to examine the effect of grape seed procyanidin B2 (GSP) on the adipogenic differentiation of 3T3-L1 preadipocyte cell line and investigate the underlying mechanism. The results showed that GSP treatment significantly reduced the intracellular lipid accumulation in induced 3T3-L1 cells by targeting miR-483-5p as well as peroxisome proliferator-activated receptor γ (PPARγ)...
December 20, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27997051/association-of-adipocyte-enhancer-binding-protein-1-with-alzheimer-s-disease-pathology-in-human-hippocampi
#10
Masahiro Shijo, Hiroyuki Honda, Satoshi O Suzuki, Hideomi Hamasaki, Masaaki Hokama, Nona Abolhassani, Yusaku Nakabeppu, Toshiharu Ninomiya, Takanari Kitazono, Toru Iwaki
Adipocyte enhancer binding protein 1 (AEBP1) activates inflammatory responses via the NF-κB pathway in macrophages and regulates adipogenesis in preadipocytes. Up-regulation of AEBP1 in the hippocampi of patients with Alzheimer's disease (AD) has been revealed by microarray analyses of autopsied brains from the Japanese general population (the Hisayama study). In this study, we compared the expression patterns of AEBP1 in normal and AD brains, including in the hippocampus, using immunohistochemistry. The subjects were 24 AD cases and 52 non-AD cases...
December 20, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27982098/arn-analysis-and-visualization-system-for-adipogenic-regulation-network-information
#11
Yan Huang, Li Wang, Lin-Sen Zan
Adipogenesis is the process of cell differentiation through which preadipocytes become adipocytes. Lots of research is currently ongoing to identify genes, including their gene products and microRNAs, that correlate with fat cell development. However, information fragmentation hampers the identification of key regulatory genes and pathways. Here, we present a database of literature-curated adipogenesis-related regulatory interactions, designated the Adipogenesis Regulation Network (ARN, http://210.27.80.93/arn/), which currently contains 3101 nodes (genes and microRNAs), 1863 regulatory interactions, and 33,969 expression records associated with adipogenesis, based on 1619 papers...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27959437/traditional-medicine-sobokchukeo%C3%A2-tang-modulates-the-inflammatory-response-in-adipocytes-and-macrophages
#12
Hoyoung Lee, Eun Hyoung Shim, Myeong Soo Lee, Chang-Seon Myung
Sobokchukeo-Tang (ST) is a well-known formula that is used for treating primary dysmenorrhea caused by blood stasis syndrome (BSS) in Korea and China. The current study investigated the anti‑inflammatory and anti‑adipogenesis effects of ST on adipocytes and macrophages. The anti‑inflammatory efficacy of ST was evaluated in RAW 264.7 cells and differentiated THP‑1 cells. To induce inflammation, the cells were treated with lipopolysaccharide (LPS; 1 µg/ml). Following the induction of inflammation, the levels of proinflammatory cytokines, interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α) in the cell supernatant were detected using enzyme‑linked immunosorbent assay...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27941616/mir-429-inhibits-differentiation-and-promotes-proliferation-in-porcine-preadipocytes
#13
Ying Peng, Fen-Fen Chen, Jing Ge, Jia-Yu Zhu, Xin-E Shi, Xiao Li, Tai-Yong Yu, Gui-Yan Chu, Gong-She Yang
MicroRNAs (miRNAs) are crucial regulatory molecules for adipogenesis. They contribute to the controlling of proliferation and differentiation of preadipocytes. Previous studies revealed an important role of miR-429 in cell invasion, migration, and apoptosis. Our previous work has shown that the expression of miR-429 in subcutaneous fat can be observed in newly born (3-day-old) Rongchang piglets rather than their adult counterparts (180-day-old). This expression pattern suggests that miR-429 might be functionally related to postnatal adipogenesis...
December 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27940362/stat3-stimulates-adipogenic-stem-cell-proliferation-and-cooperates-with-hmga2-during-the-early-stage-of-differentiation-to-promote-adipogenesis
#14
Yanyan Yuan, Yang Xi, Jiayi Chen, Pan Zhu, Jinyu Kang, Zuquan Zou, Fuyan Wang, Shizhong Bu
Signal transducer and activator of transcription 3 (STAT3) is abundantly expressed in the adipose tissue of obese mice and humans, but the role of STAT3 in adipogenesis is still not fully understood. In the present study, we discovered an activation of STAT3 during the early differentiation stage of mouse 3T3-L1 preadipocytes. Stat3 knockdown using siRNA blocked cell cycle progression of both preadipoctes and early differentiating cells. Moreover, accumulation of lipid droplets was inhibited by Stat3 knockdown...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27940057/epigallocatechin-3-gallate-inhibits-adipogenesis-through-down-regulation-of-ppar%C3%AE-and-fas-expression-mediated-by-pi3k-akt-signaling-in-3t3-l1-cells
#15
Mengqing Wu, Dan Liu, Rong Zeng, Tao Xian, Yi Lu, Guohua Zeng, Zhangzetian Sun, Bowei Huang, Qiren Huang
Epigallocatechin-3-gallate (EGCG), a major component in green tea, functions as extensive bioactivities including anti-inflammation, anti-oxidation, and anti-cancer. However, little is known about its anti-adipogenesis and underlying mechanisms. The purport of this study sought to investigate effects of EGCG on 3T3-L1 preadipocyte differentiation and to explore its possible mechanisms. The 3T3-L1 cells were induced to differentiate under the condition of pro-adipogenic cocktail with or without indicated EGCG concentrations (10, 50, 100, 200µM) for 2, 4, 6 and 8 days, respectively...
December 7, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27935133/modulation-of-brown-adipocyte-activity-by-milk-by-products-stimulation-of-brown-adipogenesis-by-buttermilk
#16
Hiroki Asano, Ryosuke Kida, Kengo Muto, Takayuki Y Nara, Ken Kato, Osamu Hashimoto, Teruo Kawada, Tohru Matsui, Masayuki Funaba
Brown adipocytes dissipate chemical energy in the form of heat through the expression of mitochondrial uncoupling protein 1 (Ucp1); Ucp1 expression is further upregulated by the stimulation of β-adrenergic receptors in brown adipocytes. An increase in energy expenditure by activated brown adipocytes potentially contributes to the prevention of or therapeutics for obesity. The present study examined the effects of milk by-products, buttermilk and butter oil, on brown adipogenesis and the function of brown adipocytes...
December 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27928650/cytoglobin-a-potential-marker-for-adipogenic-differentiation-in-preadipocytes-in-vitro
#17
Ayşegül Doğan, Selami Demirci, Binnur Kıratlı, Fikrettin Şahin
Obesity, mainly characterized by the excess fat storage, is a global health problem resulting in serious morbidity and mortality. Identification of molecular mechanisms in adipogenic differentiation pathway might lead to development of new strategies for diagnosis, prevention and therapy of obesity and associated diseases. Discovery of new genes and proteins in the differentiation pathway could help to understand the key specific regulators of the adipogenesis. Cytoglobin (Cygb), identified as a new globin family member protein, is expressed in various tissues...
December 7, 2016: Cytotechnology
https://www.readbyqxmd.com/read/27917474/germacrone-inhibits-adipogenesis-and-stimulates-lipolysis-via-the-amp-activated-protein-kinase-signalling-pathway-in-3t3-l1-preadipocytes
#18
Yuan-Ri Guo, Se-Young Choung
OBJECTIVES: In a previous study, we reported that Aster spathulifolius Maxim extract (ASE) inhibited lipid accumulation and adipocyte differentiation in 3T3-L1 cells. Of the components in ASE, germacrone (GM) was identified as a potent bioactive constituent. GM is known for its anticancer and antiviral activity. However, the effects of GM and the molecular mechanism by which GM regulates adipogenesis and lipolysis were not reported. Therefore, we investigated the effect of GM on adipogenesis and lipolysis and to elucidate its underlying molecular mechanism...
February 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27906176/epigenetic-programming-of-dnmt3a-mediated-by-ap2%C3%AE-is-required-for-granting-preadipocyte-the-ability-to-differentiate
#19
Wei Guo, Jiangnan Chen, Ying Yang, Jianbei Zhu, Jiarui Wu
Adipogenesis has an important role in regulating energy homeostasis in mammals. 3T3-L1 preadipocytes have been widely used as an in vitro model for analyzing the molecular mechanism of adipogenesis. Previous reports indicated that the stage of contact inhibition (CI), through which the proliferating cells exit from the cell cycle, was required for granting preadipocyte the ability to differentiate. While this kind of the granting mechanism remains elusive. In the present study, we showed that DNA (cytosine-5) methyltransferase 3a (Dnmt3a) was upregulated at both the mRNA and protein level during the CI stage, and resulted in increasing promoter methylation of adipogenic genes...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27888346/methionine-and-cysteine-deficiencies-altered-proliferation-rate-and-time-course-differentiation-of-porcine-preadipose-cells
#20
Rosa Castellano, Marie-Hélène Perruchot, Sophie Tesseraud, Sonia Métayer-Coustard, Elizabeth Baeza, Yves Mercier, Florence Gondret
Methionine (Met) is an essential sulfur amino acid (AA) limiting growth and is the precursor of cysteine (Cys), the rate-limiting factor in the synthesis of glutathione, and the main intracellular non-enzymatic antioxidant. This study aimed at determining the effects of limited supplies in Met and(or) Cys in early aspects of adipose tissue development and oxidative stress in differentiated adipocytes. Incremental reductions in Met (70, 40, and 0 µM) were compared with Met 100 µM (control dose) in porcine preadipocytes cultured in media without or with Cys (250 µM)...
November 25, 2016: Amino Acids
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