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preadipocyte AND adipogenesis

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https://www.readbyqxmd.com/read/29140299/pdgfr%C3%AE-regulated-by-mir-34a-and-foxo1-promotes-adipogenesis-in-porcine-intramuscular-preadipocytes-through-erk-signaling-pathway
#1
Yun-Mei Sun, Jin Qin, Shu-Ge Liu, Rui Cai, Xiao-Chang Chen, Xiang-Ming Wang, Wei-Jun Pang
Suitable intramuscular fat (IMF) content improves porcine meat quality. The vital genes regulating IMF deposition are necessary for the selection and breeding of an IMF trait. However, the effect and mechanism of PDGFRα on IMF deposition are still unclear. Here, PDGFRα is moderately expressed in porcine longissimus dorsi muscle (LD), whereas it highly expressed in white adipose tissue (WAT). Moreover, PDGFRα-positive cells were located in the gaps of LD fibers which there were IMF adipocytes. Compared with 180-day-old and lean-type pigs, the levels of PDGFRα were much higher in one-day-old and fat-type pigs...
November 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29138673/the-beneficial-effects-of-quercetin-curcumin-and-resveratrol-in-obesity
#2
REVIEW
Yueshui Zhao, Bo Chen, Jing Shen, Lin Wan, Yinxin Zhu, Tao Yi, Zhangang Xiao
Over the past two decades, obesity has been one of the major public health concerns in most countries. In the search for new molecules that could be used for the treatment of obesity, good perspectives have been opened up for polyphenols, a class of natural bioactive phytochemicals. Experimental and limited clinical trial evidence supports that some polyphenols such as quercetin, curcumin, and resveratrol have potential benefit functions on obesity treatment. This brief review focuses on the main functions of the above-named polyphenols on adipose tissue...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29138456/prep1-prevents-premature-adipogenesis-of-mesenchymal-progenitors
#3
Giorgia Maroni, Vsevolod A Tkachuk, Alexander Egorov, Marco J Morelli, Raffaele Luongo, Elena Levantini, Francesco Blasi, Maria Cristina Magli, Dmitry Penkov
Transcriptional regulators are crucial in adipocyte differentiation. We now show that the homeodomain-containing transcription factor Prep1 is a repressor of adipogenic differentiation since its down-regulation (DR) in both ex vivo bone marrow-derived mesenchymal stromal cells (MSC) and in vitro 3T3-L1 preadipocytes significantly increases their adipogenic differentiation ability. Prep1 acts at a stage preceding the activation of the differentiation machinery because its DR makes cells more prone to adipogenic differentiation even in the absence of the adipogenic inducers...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138005/distinct-hypoxic-regulation-of-preadipocyte-factor-1-pref-1-in-preadipocytes-and-mature-adipocytes
#4
Yunwon Moon, Seongyeol Lee, Bongju Park, Hyunsung Park
Preadipocyte factor-1 (Pref-1) is a secretory soluble protein, which exerts pleiotropic effects on maintenance of cancer stem cell characteristics and commitment of mesenchymal stem cell lineages by inhibiting adipogenesis. Observations that obesity renders the microenvironment of adipose tissues hypoxic and that hypoxia inhibits adipogenesis lead us to investigate whether hypoxia increases the expression of anti-adipogenic Pref-1 in preadipocytes, mature adipocytes, and adipose tissues from obese mouse. In 3T3-L1 preadipocytes, hypoxia induces Pref-1 by a hypoxia-inducible factor 1 (HIF-1)-dependent mechanism accompanied by increase in the levels of the active histone mark, acetylated H3K9/14 (H3K9/14Ac)...
November 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29137239/transcriptome-profiling-in-preadipocytes-identifies-long-noncoding-rnas-as-sam68-targets
#5
Naomi Li, Steven Hébert, Jingwen Song, Claudia L Kleinman, Stéphane Richard
The KH-type RNA binding protein Sam68 is required for adipogenesis. We have previously shown that Sam68-deficient mice have a lean phenotype and are protected against dietary-induced obesity due to defects in mTOR and S6K1 alternative splicing. Herein we profiled the transcriptome of Sam68 wild type and deficient 3T3-L1 mouse preadipocytes. We identified 652 protein-coding genes and 9 ncRNAs that were significantly altered with the loss of Sam68. As expected, downregulated genes were significantly associated with GO terms linked to cell migration, motility, and fat cell differentiation, while upregulated genes were mostly associated with GO terms linked to neurogenesis...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133280/mat2a-promotes-porcine-adipogenesis-by-mediating-h3k27me3-at-wnt10b-locus-and-repressing-wnt-%C3%AE-catenin-signaling
#6
Cunzhen Zhao, Haigang Wu, Naren Qimuge, Weijun Pang, Xiao Li, Guiyan Chu, Gongshe Yang
Methionine adenosyltransferase (MAT) is a critical biological enzyme and that can catalyze L-met and ATP to form S-adenosylmethionine (SAM), which is acted as a biological methyl donor in transmethylation reactions involving histone methylation. However, the regulatory effect of methionine adenosyltransferase2A (MAT2A) and its associated methyltransferase activity on adipogenesis is still unclear. In this study, we investigate the effect of MAT2A on adipogenesis and its potential mechanism on histone methylation during porcine preadipocyte differentiation...
November 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29118419/melatonin-promotes-triacylglycerol-accumulation-via-mt2-receptor-during-differentiation-in-bovine-intramuscular-preadipocytes
#7
Wucai Yang, Keqiong Tang, Yaning Wang, Yingying Zhang, Linsen Zan
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of bovine intramuscular preadipocytes (BIPs), BIPs were incubated with different concentrations of melatonin. Melatonin supplementation at 1 mM significantly increased peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein (C/EBP) β, and C/EBPα expression and promoted the differentiation of BIPs into adipocytes with large lipid droplets and high cellular triacylglycerol (TAG) levels...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095919/raldh1-promotes-adiposity-during-adolescence-independently-of-retinal-signaling
#8
Di Yang, Charles R Krois, Priscilla Huang, Jinshan Wang, Jin Min, Hong Sik Yoo, Yinghua Deng, Joseph L Napoli
All-trans-retinoic acid (RA) inhibits adipogenesis in established preadipocyte cell lines. Dosing pharmacological amounts of RA reduces weight gain in mice fed a high-fat diet, i.e. counteracts diet-induced obesity (DIO). The aldehyde dehydrogenase Raldh1 (Aldh1a1) functions as one of three enzymes that converts the retinol metabolite retinal into RA, and one of many proteins that contribute to RA homeostasis. Female Raldh1-ablated mice resist DIO. This phenotype contrasts with ablations of other enzymes and binding-proteins that maintain RA homeostasis, which gain adiposity...
2017: PloS One
https://www.readbyqxmd.com/read/29094436/low-level-perfluorooctanoic-acid-enhances-3%C3%A2-t3-l1-preadipocyte-differentiation-via-altering-peroxisome-proliferator-activated-receptor-gamma-expression-and-its-promoter-dna-methylation
#9
Yue Ma, Jie Yang, Yanjian Wan, Yang Peng, Shuai Ding, Yuanyuan Li, Bing Xu, Xi Chen, Wei Xia, Yuebin Ke, Shunqing Xu
Recent studies suggest that perfluorooctanoic acid (PFOA) can play a role in the development of obesity; however, the associated mechanisms are poorly understood. We investigated how PFOA exposure affected the differentiation of 3 T3-L1 preadipocytes and the associated transcriptional and epigenetic mechanisms. Cells treated with different doses of PFOA (ranging from 0.01 to 100 μg ml(-1) ) were assessed for proliferation, differentiation and triglyceride accumulation. The gene expression levels of peroxisome proliferator activated receptor gamma (PPARγ) and its target genes were measured...
November 2, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29093466/scara5-plays-a-critical-role-in-the-commitment-of-mesenchymal-stem-cells-to-adipogenesis
#10
Hyemin Lee, Yoo Jeong Lee, Hyeonjin Choi, Jo Woon Seok, Bo Kyung Yoon, Daeun Kim, Ji Yoon Han, Yoseob Lee, Hyo Jung Kim, Jae-Woo Kim
Mesenchymal stem cells have the capacity to give rise to multiple cell types, such as adipocytes, osteoblasts, chondrocytes, and myocytes. However, the molecular events responsible for the lineage specification and differentiation of mesenchymal stem cells remain unclear. Using gene expression profile studies, we determined that Scavenger receptor class A, member 5 (SCARA5) is a novel mediator of adipocyte commitment. SCARA5 was expressed at a higher level in committed A33 preadipocyte cells compared to C3H10T1/2 pluripotent stem cells...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29084388/anti-obesity-effect-of-exopolysaccharides-isolated-from-kefir-grains
#11
Juha Lim, Madhuvanti Kale, Dong-Hyeon Kim, Hong Seok Kim, Jung-Whan Chon, Kun-Ho Seo, Hyeon Gyu Lee, Wallace Yokoyama, Hyunsook Kim
Physiological properties of water-soluble exopolysaccharides (EPS) and residues after EPS removal (Res) from the probiotic kefir were determined in high-fat (HF) diet-fed C57BL/6J mice. EPS solutions showed rheological properties and lower viscosity compared to Β-glucan (BG). EPS significantly suppressed the adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. Mice were fed HF diets containing 5% EPS, 5% BG, 8% Res, or 5% microcrystalline cellulose (control) for 4 weeks. Compared with the control, EPS supplementation significantly reduced HF diet-induced body weight gain, adipose tissue weight, and plasma very low-density lipoprotein cholesterol concentration (P < 0...
October 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29059354/inflammation-and-fibrosis-in-perirenal-adipose-tissue-of-patients-with-aldosterone-producing-adenoma
#12
Chunyan Wu, Huijian Zhang, Jiajun Zhang, Cuihua Xie, Cunxia Fan, Hongbin Zhang, Peng Wu, Qiang Wei, Wanlong Tan, Lingling Xu, Ling Wang, Yaoming Xue, Meiping Guan
The prevalence of primary aldosteronism is much higher than previously thought. Recent studies have shown that primary aldosteronism is related to a higher risk of cardiovascular events. However, the underlying mechanism is not yet clear. Here we investigate the characteristics, including inflammation, fibrosis and adipokine expression, of adipose tissues from different deposits in patients with aldosterone-producing adenoma (APA). Inflammation and fibrosis changes were evaluated in perirenal and subcutaneous adipose tissues obtained from patients with APA (n=16), normotension (NT; n=10) and essential hypertension (EH; n=5) undergoing laparoscopic surgery...
October 19, 2017: Endocrinology
https://www.readbyqxmd.com/read/29030964/transcription-factor-hmg-box-containing-protein-1-hbp1-modulates-mitotic-clonal-expansion-mce-during-adipocyte-differentiation
#13
Chien-Yi Chan, Ping Yu, Feng-Tzu Chang, Zih-Hua Chen, Ming-Fen Lee, Chun-Yin Huang
Transcription factor HMG box-containing protein 1 (HBP1) has been found to be up-regulated in rat adipose tissue and differentiated preadipocyte; however, how HBP1 is involved in adipocyte formation remains unclear. In the present study, we demonstrated that under a standard differentiation protocol HBP1 expression fluctuates with down-regulation in the mitotic clonal expansion (MCE) stage followed by up-regulation in the terminal differentiation stage in both 3T3-L1 and MEF cell models. Also, HBP1 knockdown accelerated cell cycle progression in the MCE stage, but it impaired final adipogenesis...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29027120/elucidating-the-preadipocyte-and-its-role-in-adipocyte-formation-a-comprehensive-review
#14
REVIEW
Christos N Sarantopoulos, Derek A Banyard, Mary E Ziegler, Beatrice Sun, Ashkaun Shaterian, Alan D Widgerow
Adipogenesis is a complex process whereby the multipotent adipose-derived stem cell is converted to a preadipocyte before terminal differentiation into the mature adipocyte. Preadipocytes are present throughout adult life, exhibit adipose fat depot specificity, and differentiate and proliferate from distinct progenitor cells. The mechanisms that promote preadipocyte commitment and maturation involve numerous protein factor regulators, epigenetic factors, and miRNAs. Detailed characterization of this process is currently an area of intense research and understanding the roles of preadipocytes in tissue plasticity may provide insight into novel approaches for tissue engineering, regenerative medicine and treating a host of obesity-related conditions...
October 13, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29021504/ethanol-extracts-of-aster-yomena-kitam-honda-inhibit-adipogenesis-through-the-activation-of-the-ampk-signaling-pathway-in-3t3-l1-preadipocytes
#15
Min Ho Han, Ji-Suk Jeong, Jin-Woo Jeong, Sung Hyun Choi, Sung Ok Kim, Su Hyun Hong, Cheol Park, Byung Woo Kim, Yung Hyun Choi
The leaves of Aster yomena (Kitam.) Honda have long been used as a traditional herb for treating disorders including coughs, asthma, and insect bites. According to recent studies, A. yomena leaf extracts have several pharmacological properties, including anti-inflammatory, antioxidant, and anti-asthmatic activities. However, little information is available regarding their anti-obesity effect. In this study, we investigated the inhibitory effect of the ethanol extracts of A. yomena leaves (EEAY) on adipocyte differentiation and adipogenesis using 3T3-L1 preadipocytes...
October 11, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28984821/mir-425-5p-inhibits-differentiation-and-proliferation-in-porcine-intramuscular-preadipocytes
#16
Fen-Fen Chen, Yan Xiong, Ying Peng, Yun Gao, Jin Qin, Gui-Yan Chu, Wei-Jun Pang, Gong-She Yang
Intramuscular fat (IMF) content affects the tenderness, juiciness, and flavor of pork. An increasing number of studies are focusing on the functions of microRNAs (miRs) during porcine intramuscular preadipocyte development. Previous studies have proved that miR-425-5p was enriched in porcine skeletal muscles and played important roles in multiple physiological processes; however, its functions during intramuscular adipogenesis remain unclear. To explore the role of miR-425-5p in porcine intramuscular adipogenesis, miR-425-5p agomir and inhibitor were used to perform miR-425-5p overexpression and knockdown in intramuscular preadipocytes, respectively...
October 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28965824/theobromine-suppresses-adipogenesis-through-enhancement-of-ccaat-enhancer-binding-protein-%C3%AE-degradation-by-adenosine-receptor-a1
#17
Takakazu Mitani, Shun Watanabe, Yasukiyo Yoshioka, Shigeru Katayama, Soichiro Nakamura, Hitoshi Ashida
Theobromine, a methylxanthine derived from cacao beans, reportedly has various health-promoting properties but molecular mechanism by which effects of theobromine on adipocyte differentiation and adipogenesis remains unclear. In this study, we aimed to clarify the molecular mechanisms of the anti-adipogenic effect of theobromine in vitro and in vivo. ICR mice (4week-old) were administered with theobromine (0.1g/kg) for 7days. Theobromine administration attenuated gains in body and epididymal adipose tissue weights in mice and suppressed expression of adipogenic-associated genes in mouse adipose tissue...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28951635/implication-of-ceramide-kinase-in-adipogenesis
#18
Marta Ordoñez, Natalia Presa, Miguel Trueba, Antonio Gomez-Muñoz
Ceramide kinase (CerK) plays a critical role in the regulation of cell growth and survival and has been implicated in proinflammatory responses. In this work, we demonstrate that CerK regulates adipocyte differentiation, a process associated with obesity, which causes chronic low-grade inflammation. CerK was upregulated during differentiation of 3T3-L1 preadipocytes into mature adipocytes. Noteworthy, knockdown of CerK using specific siRNA to silence the gene encoding this kinase resulted in substantial decrease of lipid droplet formation and potent depletion in the content of triacylglycerols in the adipocytes...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28944626/caveolin-1-secreted-from-adipose-tissues-and-adipocytes-functions-as-an-adipogenesis-enhancer
#19
Chia-Chu Chang, Chen-Yu Chen, Hui-Chin Wen, Chih-Yang Huang, Ming-Shiu Hung, Hsi-Chi Lu, Woan-Ling Chen, Chung-Ho Chang
OBJECTIVE: Caveolin-1 (Cav-1) is expressed abundantly in adipose tissue and involved in many physiological processes. While Cav-1 has been reported to be secreted in pancreatic acinar cells and LNCaP prostate cancer cells, its secretion from adipose tissue awaits investigation. METHODS: Cav-1 secretion from 3T3-L1 adipocytes and fat tissues from normal chow diet- and high-fat diet (HFD)-fed mice was measured. Functions and uptake of secreted Cav-1 proteins were assessed by adding Cav-1 back to preadipocytes and LNCaP cells...
September 25, 2017: Obesity
https://www.readbyqxmd.com/read/28939056/ectopic-overexpression-of-mcpip1-impairs-adipogenesis-by-modulating-micrornas
#20
Magdalena Losko, Agata Lichawska-Cieslar, Maria Kulecka, Agnieszka Paziewska, Izabela Rumienczyk, Michal Mikula, Jolanta Jura
Adipogenesis is a process of preadipocyte differentiation that requires action of numerous factors. Monocyte chemoattractant protein-1-induced protein 1 (MCPIP1) possesses the N-terminus of the PilT protein (PilT N-terminus or PIN domain) that has RNase properties. This protein degrades transcripts coding for inflammation and differentiation - related proteins. Moreover, MCPIP1 is a broad suppressor of the miRNA biogenesis. We previously found that MCPIP1 degrades transcript encoding CCAAT/Enhancer Binding Protein Beta (C/EBPβ) and influences adipogenesis...
September 20, 2017: Biochimica et Biophysica Acta
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