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https://www.readbyqxmd.com/read/28350567/watchful-waiting-versus-surgery-of-mildly-symptomatic-or-asymptomatic-inguinal-hernia-in-men-aged-50-years-and-older-a-randomized-controlled-trial
#1
Barry de Goede, Arthur R Wijsmuller, Gabrielle H van Ramshorst, Bob J van Kempen, Wim C J Hop, Pieter J Klitsie, Marc R Scheltinga, Jeroen de Haan, Walter J B Mastboom, Erwin van der Harst, Maarten P Simons, Gert-Jan Kleinrensink, Johannes Jeekel, Johan F Lange
OBJECTIVE: To compare if watchful waiting is noninferior to elective repair in men aged 50 years and older with mildly symptomatic or asymptomatic inguinal hernia. BACKGROUND: The role of watchful waiting in older male patients with mildly symptomatic or asymptomatic inguinal hernia is still not well-established. METHODS: In this noninferiority trial, we randomly assigned men aged 50 years and older with mildly symptomatic or asymptomatic inguinal hernia to either elective inguinal hernia repair or watchful waiting...
March 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28350504/royal-darwinian-demons-enforced-changes-in-reproductive-efforts-do-not-affect-the-life-expectancy-of-ant-queens
#2
Alexandra Schrempf, Julia Giehr, Ramona Röhrl, Sarah Steigleder, Jürgen Heinze
One of the central tenets of life-history theory is that organisms cannot simultaneously maximize all fitness components. This results in the fundamental trade-off between reproduction and life span known from numerous animals, including humans. Social insects are a well-known exception to this rule: reproductive queens outlive nonreproductive workers. Here, we take a step forward and show that under identical social and environmental conditions the fecundity-longevity trade-off is absent also within the queen caste...
April 2017: American Naturalist
https://www.readbyqxmd.com/read/28350442/engineered-polymer-transferrin-conjugates-as-self-assembling-targeted-drug-delivery-systems
#3
Hiteshri Makwana, Francesca Mastrotto, Johannes Pall Magnusson, Darrell Sleep, Joanna Hay, Karl J Nicholls, Stephanie Allen, Cameron Alexander
Polymer-protein conjugates can be engineered to self-assemble into discrete and well-defined drug delivery systems which combine the advantages of receptor targeting and controlled drug release. We designed specific conjugates of the iron-binding and transport protein, transferrin (Tf), to combine the advantages of this serum-stable protein as a targeting agent for cancer cells with self-assembling polymers to act as carriers of cytotoxic drugs. Tf variants were expressed with cysteine residues at sites spanning different regions of the protein surface and the polymer conjugates grown from these variants were compared with polymer conjugates grown from non-selectively derivatised sites on native Tf...
March 28, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28346259/igg4-related-ophthalmic-disease-presenting-as-choroidal-and-orbital-lesions
#4
William S Gange, Stephen M Holland, Felipe De Alba
PURPOSE: To report a case of IgG4-related ophthalmic disease (IgG4-ROD) which presented as choroidal and orbital lesions. METHODS: Case report. RESULTS: A 64-year-old man presented with left eye photopsias and a history of IgG4-related perirenal fibrosis. Fundoscopic examination showed multiple bilateral yellow choroidal lesions, and optical coherence tomography showed multiple choroidal lesions. Magnetic resonance imaging of the orbits showed an enhancing lesion present circumferential to the optic nerve, but greater medially, abutting the posterior surface of the left globe...
March 24, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28346162/household-chaos-and-sleep-disturbing-behavior-of-family-members-results-of-a-pilot-study-of-african-american-early-adolescents
#5
James C Spilsbury, Sanjay R Patel, Nathan Morris, Aida Ehayaei, Stephen S Intille
BACKGROUND: Although disorganized, chaotic households have been linked to poorer sleep outcomes, how household chaos actually manifests itself in the behaviors of others around the bedtime of a child or adolescent is not well understood. OBJECTIVE: To determine whether household chaos was associated with specific, nightly sleep-disturbing activities of adolescents' family members. DESIGN: Longitudinal study. PARTICIPANTS: Twenty-six African American or multiethnic early adolescent (ages 11-12 years) and parent dyads, recruited from local schools and social-service agencies in greater Cleveland, OH...
April 2017: Sleep Health
https://www.readbyqxmd.com/read/28345071/jolt-accentuation-and-its-value-as-a-sign-in-diagnosis-of-meningitis-in-patients-with-fever-and-headache
#6
Mani Mofidi, Narges Negaresh, Davood Farsi, Mahdi Rezai, Babak Mahshidfar, Saeed Abbasi, Peyman Hafezimoghadam
OBJECTIVES: Meningitis is an important disease among the patients being visited in Emergency Departments (EDs). There are many signs to diagnose it with different sensitivity and specificity reported in previously done studies. Current study tries to evaluate diagnostic accuracy of "Jolt accentuation" in the diagnosis (Dx.) of meningitis in patients with fever and headache. MATERIALS AND METHODS: 48 adult patients, who were referred to two teaching EDs for fever and headache and were diagnosed as suspected meningitis, were included in this prospective observational study...
March 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28343935/blood-derived-products-in-pediatrics-new-laboratory-tools-for-optimizing-potency-assignment-and-reducing-side-effects
#7
REVIEW
Jean Amiral, Jerard Seghatchian
Neonates and children can develop rare bleeding disorders due to congenital/acquired coagulation Factor deficiencies, or allo-immune/autoimmune complications, or can undergo surgeries at high haemorrhagic risk. They then need specialized transfusion of blood components/products, or purified blood extracted products or recombinant proteins. Blood-derived therapies conventionally used for management of affected infants with genetic/acquired deficiencies, bleeding problems (coagulation Factor reduced or missing) or thrombotic disorders (reduced or missing anticoagulant proteins) pose some additional risks...
March 15, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343208/legal-features-of-the-drug-advertising
#8
Vitalii M Pashkov, Andrii A Olefir, Oleksiy Y Bytyak
INTRODUCTION: In the article discribed current trends of advertising in the pharmaceutical market and foreign experience of legal regulation of these relations. As for the advertising of medicines identified it's symptoms, types, basic rules and prohibitions. Modern pharmaceutical companies can not successfully carry out economic activities without advertising. Besides we can mention some fundamental changes in society (information overload, universal access to internet, social media, freedom of movement of goods, labor and finance), also self-medication becomes more popular...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28343173/fast-track-protocols-using-highly-sensitive-troponin-assays-for-ruling-out-and-ruling-in-non-st-elevation-acute-coronary-syndrome
#9
Simona Ferraro, Alberto Dolci, Mauro Panteghini
The introduction of "highly sensitive" cardiac troponin assays (hsTn) has reinforced the evidence that only serial testing incorporated in running algorithms allows a more accurate diagnosis of acute myocardial infarction. In this report, we consider the available evidence supporting the use of fast track protocols for ruling out and ruling in non-ST elevation myocardial infarction (NSTEMI) and compare it with the content of recently released guideline by the European Society of Cardiology, noting some uncomfortable aspects that need urgent clarification and/or revision...
March 27, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28342677/prevalence-of-voice-disorders-in-singers-systematic-review-and-meta-analysis
#10
Pedro Melo Pestana, Susana Vaz-Freitas, Maria Conceição Manso
OBJECTIVE: The study aimed to review the prevalence of self-reported voice disorders in singers. STUDY DESIGN: The study is a systematic review and meta-analysis. METHODS: A systematic review of five major scientific databases was conducted. An extensive search strategy was used considering the rules of each database. Original articles were included only if they had data related to self-perception of dysphonia in the past. Furthermore, heterogeneity and its relative significance were assessed...
March 22, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28342339/a-novel-hybrid-strategy-for-pm2-5-concentration-analysis-and-prediction
#11
Ping Jiang, Qingli Dong, Peizhi Li
The analysis and prediction of air pollutants are of great significance in environmental research today since airborne pollution is a substantial threat, especially in urban agglomerations of China. To develop more effective warning systems and management advice, the authorities and city dwellers need more accurate forecasts of the air pollution. Most previous analysis systems were based on costly observation apparatus at fixed sites, forecasting models were usually built on observations within a certain range, and some observations contained biases...
March 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28341962/tumour-suppressor-ep300-a-modulator-of-paclitaxel-resistance-and-stemness-is-downregulated-in-metaplastic-breast-cancer
#12
Muhammad Asaduzzaman, Stephanie Constantinou, Haoxiang Min, John Gallon, Meng-Lay Lin, Poonam Singh, Selina Raguz, Simak Ali, Sami Shousha, R Charles Coombes, Eric W-F Lam, Yunhui Hu, Ernesto Yagüe
PURPOSE: We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells. Upstream in the pathway, three miRs (miR-106b, miR-93 and miR-25) target EP300, a transcriptional activator of E-cadherin. Upregulation of these miRs leads to the downregulation of EP300 and E-cadherin with initiation of an EMT. However, miRs regulate the expression of many genes, and the contribution to EMT by miR targets other than EP300 cannot be ruled out...
March 24, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28340715/short-wave-infrared-chemical-imaging-as-future-tool-for-analysing-gunshot-residues-patterns-in-targets
#13
F E Ortega-Ojeda, M Torre-Roldán, C García-Ruiz
This work used chemical imaging in the short-wave infrared region for analysing gunshot residues (GSR) patterns in cotton fabric targets shot with conventional and non-toxic ammunition. It presents a non-destructive, non-toxic, highly visual and hiperspectral-based approach. The method was based on classical least squares regression, and was tested with the ammunition propellants and their standard components' spectra. The propellants' spectra were satisfactorily used (R(2) >0.966, and CorrCoef >0.982) for identifying the GSR irrespective of the type of ammunition used for the shooting...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28338472/robust-cardiac-motion-estimation-using-ultrafast-ultrasound-data-a-low-rank-topology-preserving-approach
#14
Angelica I Aviles, Thomas Widlak, Alicia Casals, Maartje Nillesen, Habib Ammari
Cardiac motion estimation is an important diagnostic tool to detect heart diseases and it has been explored with modalities such as MRI and conventional ultrasound (US) sequences. US cardiac motion estimation still presents challenges because of the complex motion patterns and the presence of noise. In this work, we propose a novel approach to estimate the cardiac motion using ultrafast ultrasound data. -- Our solution is based on a variational formulation characterized by the L2-regularized class. The displacement is represented by a lattice of b-splines and we ensure robustness by applying a maximum likelihood type estimator...
March 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28338343/nuggets-of-wisdom-salmonella-enteritidis-outbreaks-and-the-case-for-new-rules-on-uncooked-frozen-processed-chicken
#15
J Leigh Hobbs, Bryna Warshawsky, Anne Maki, Sandra Zittermann, Allana Murphy, Anna Majury, Dean Middleton
In 2014 and 2015, three Canadian Salmonella serotype Enteritidis outbreak investigations implicated uncooked, frozen, processed chicken products produced at the same establishment, namely establishment A. In November 2014, a sustained increase in the number of reported domestically acquired Salmonella Enteritidis cases in Ontario led to the first outbreak investigation, which implicated uncooked, frozen, processed chicken products produced at establishment A. In June 2015, the identification of pulsed-field gel electrophoresis patterns that had not been previously reported in Canada led to a national Salmonella Enteritidis investigation...
March 24, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28337674/painful-hashimoto-s-thyroiditis-myth-or-reality
#16
REVIEW
M Rotondi, V Capelli, P Locantore, A Pontecorvi, L Chiovato
Neck pain is a common complain, being in most cases due to non-thyroidal causes. However, a minority of patients suffer from painful thyroid diseases. Among them, sub-acute thyroiditis (SAT) is the most frequent one. Rare thyroid-related causes of neck pain include hemorrhage within a thyroid nodule as well as Riedel's thyroiditis and suppurative thyroiditis. In the last 30 years, a few cases of a painful variant of Hashimoto's thyroiditis (HT) have been described. Biochemical, ultrasound, and histologic features were clearly suggestive for HT in all of the published cases and definitely ruled out the diagnosis of SAT...
March 24, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28335734/evaluation-of-amstar-to-assess-the-methodological-quality-of-systematic-reviews-in-overviews-of-reviews-of-healthcare-interventions
#17
Michelle Pollock, Ricardo M Fernandes, Lisa Hartling
BACKGROUND: Overviews of reviews (overviews) compile information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making. It is recommended that authors assess and report the methodological quality of SRs in overviews-for example, using A MeaSurement Tool to Assess systematic Reviews (AMSTAR). Currently, there is variation in whether and how overview authors assess and report SR quality, and limited guidance is available. Our objectives were to: examine methodological considerations involved in using AMSTAR to assess the quality of Cochrane and non-Cochrane SRs in overviews of healthcare interventions; identify challenges (and develop potential decision rules) when using AMSTAR in overviews; and examine the potential impact of considering methodological quality when making inclusion decisions in overviews...
March 23, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28335037/lrsam1-mediated-ubiquitylation-is-disrupted-in-axonal-charcot-marie-tooth-disease-2p
#18
Johanna E Hakonen, Vincenzo Sorrentino, Rossella Avagliano Trezza, Marit B de Wissel, Marlene van den Berg, Boris Bleijlevens, Fred van Ruissen, Ben Distel, Frank Baas, Noam Zelcer, Marian A J Weterman
Charcot-Marie-Tooth (CMT) disease type 2 is a genetically heterogeneous group of inherited neuropathies characterized by motor and sensory deficits as a result of peripheral axonal degeneration. We recently reported a frameshift mutation in the RING domain of LRSAM1 (c.2121_2122dup, p.Leu708Argfs) that encodes an E3 ubiquitin ligase, as the cause of axonal type CMT (CMT2P). However, the frequency of LRSAM1 mutations in CMT2 and the functional basis for their association with disease remains unknown. In this study we evaluated LRSAM1 mutations in two large Dutch cohorts...
March 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28333955/producing-or-reproducing-reasoning-socratic-dialog-is-very-effective-but-only-for-a-few
#19
Andrea Paula Goldin, Olivia Pedroncini, Mariano Sigman
Successful communication between a teacher and a student is at the core of pedagogy. A well known example of a pedagogical dialog is 'Meno', a socratic lesson of geometry in which a student learns (or 'discovers') how to double the area of a given square 'in essence, a demonstration of Pythagoras' theorem. In previous studies we found that after engaging in the dialog participants can be divided in two kinds: those who can only apply a rule to solve the problem presented in the dialog and those who can go beyond and generalize that knowledge to solve any square problems...
2017: PloS One
https://www.readbyqxmd.com/read/28333583/an-approximation-of-the-error-backpropagation-algorithm-in-a-predictive-coding-network-with-local-hebbian-synaptic-plasticity
#20
James C R Whittington, Rafal Bogacz
To efficiently learn from feedback, cortical networks need to update synaptic weights on multiple levels of cortical hierarchy. An effective and well-known algorithm for computing such changes in synaptic weights is the error backpropagation algorithm. However, in this algorithm, the change in synaptic weights is a complex function of weights and activities of neurons not directly connected with the synapse being modified, whereas the changes in biological synapses are determined only by the activity of presynaptic and postsynaptic neurons...
March 23, 2017: Neural Computation
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