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https://www.readbyqxmd.com/read/28107093/adult-clonidine-overdose-prolonged-bradycardia-and-central-nervous-system-depression-but-not-severe-toxicity
#1
Geoffrey K Isbister, Simon P Heppell, Colin B Page, Nicole M Ryan
CONTEXT: There are limited reports of adult clonidine overdose. We aimed to describe the clinical effects and treatment of clonidine overdose in adults. METHODS: This was a retrospective review of a prospective cohort of poisoned patients who took clonidine overdoses (>200 μg). Demographic information, clinical effects, treatment, complications (central nervous system and cardiovascular effects) and length of stay (LOS) were extracted from a clinical database or medical records...
January 20, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28100803/a-new-cue-for-torpor-induction-charcoal-ash-and-smoke
#2
Clare Stawski, Julia Nowack, Gerhard Körtner, Fritz Geiser
Recent work has shown that the use of torpor for energy conservation increases after forest fires in heterothermic mammals, probably in response to the reduction of food. However, the specific environmental cues for this increased torpor expression remain unknown. It is possible that smoke and the novel substrate of charcoal and ash act as signals for an impending period of starvation requiring torpor. We therefore tested the hypothesis that the combined cues of smoke, a charcoal/ash substrate and food shortage will enhance torpor expression in a small forest-dwelling marsupial, the yellow-footed antechinus (Antechinus flavipes), because like other animals that live in fire-prone habitats they must effectively respond to fires to ensure survival...
January 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28073319/no-clinically-relevant-effects-in-children-after-accidental-ingestion-of-panaeolina-foenisecii-lawn-mower-s-mushroom
#3
Katharina M Schenk-Jaeger, Katharina E Hofer-Lentner, Bettina Plenert, Dagmar Eckart, Bettina Haberl, Gabriele Schulze, Janine Borchert-Avalone, Uwe Stedtler, Rudolph Pfab
INTRODUCTION: Panaeolina foenisecii is one of the most common and widely distributed lawn mushrooms in Europe and North America, and frequently involved in accidental mushroom ingestion, mainly in children. Nevertheless, there is contradictory information regarding the toxicity profile of P. foenisecii in the literature. Objective of the study was to assess clinical effects with particular attention on psychoactive properties of P. foenisecii in case of accidental oral exposure. METHODS: This observational case series is based on prospectively collected data on mushroom poisoning using a structured data collection form, and it was performed in seven poisons centres in Germany and Switzerland...
January 11, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28060501/discovery-of-multicomponent-heterogeneous-catalysts-via-admixture-screening-pdbite-catalysts-for-aerobic-oxidative-esterification-of-primary-alcohols
#4
David S Mannel, Maaz S Ahmed, Thatcher W Root, Shannon S Stahl
In the present study, we demonstrate the utility of "admixture screening" for the discovery of new multicomponent heterogeneous Pd catalyst compositions that are highly effective for aerobic oxidative methyl esterification of primary alcohols. The identification of possible catalysts for this reaction was initiated by the screening of simple binary and ternary admixtures of Pd/charcoal in combination with one or two metal and/or metalloid components as the catalyst. This approach permitted rapid evaluation of over 400 admixture combinations for the oxidative methyl esterification of 1-octanol at 60 °C in methanol...
January 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28060290/visualization-of-the-charcoal-agar-resazurin-assay-for-semi-quantitative-medium-throughput-enumeration-of-mycobacteria
#5
Ben Gold, Julia Roberts, Yan Ling, Landys Lopez Quezada, Jou Glasheen, Elaine Ballinger, Selin Somersan-Karakaya, Thulasi Warrier, Carl Nathan
There is an urgent need to discover and progress anti-infectives that shorten the duration of tuberculosis (TB) treatment. Mycobacterium tuberculosis, the etiological agent of TB, is refractory to rapid and lasting chemotherapy due to the presence of bacilli exhibiting phenotypic drug resistance. The charcoal agar resazurin assay (CARA) was developed as a tool to characterize active molecules discovered by high-throughput screening campaigns against replicating and non-replicating M. tuberculosis. Inclusion of activated charcoal in bacteriologic agar medium helps mitigate the impact of compound carry-over, and eliminates the requirement to pre-dilute cells prior to spotting on CARA microplates...
December 14, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28057131/-interaction-between-smoking-and-indoor-air-pollution-on-chronic-obstructive-pulmonary-diseases
#6
D X Pan, Y J Qian, C M Wang, Y Guo, Z Bian, K X Xie, L L Chen, Y D Zhang, Q Y Li
Objective: To investigate the prevalence of chronic obstructive pulmonary diseases (COPD) in Tongxiang, Zhejiang province, and analyze the interaction between smoking and indoor air pollution on COPD. Methods: Townships of Chongfu, Zhouquan, Gaoqiao, Shimen, Wuzhen were randomly selected from Tongxiang. All the local people aged 30-79 years were asked to receive questionnaire survey, physical examination and pulmonary function testing. FEV1max/FVC max≤0.7 was the criterion of COPD diagnosis. Logistic regression model was used to analyze the relationship between smoking/indoor air pollution and COPD, multiplied interaction between smoking and indoor air pollution was evaluated, Excel table prepared by Andersson et al...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28043416/antidiarrhoeal-investigation-of-apium-leptophyllum-pers-by-modulation-of-na-k-atpase-nitrous-oxide-and-intestinal-transit-in-rats
#7
Himanshu Bhusan Sahoo, Rakesh Sagar, Anjan Kumar, Amrita Bhaiji, Subrat Kumar Bhattamishra
BACKGROUND: Apium leptophyllum (Pers.) is an annual herb with traditional appreciation for various pharmacological properties; however, the scientific information on this herb is insufficient. The aim of the present investigation was undertaken to evaluate flavonoidal fraction of A. leptophyllum fruit (FFALF) against diarrhoea on albino rats. METHODS: The antidiarrhoeal study was conducted by castor oil induce diarrhoea, prostaglandin E2 (PGE2) induced enteropooling and intestinal transit by charcoal meal test...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28040870/innovative-methods-to-generate-clean-sugar-stream-from-biomass-feedstocks-for-efficient-fermentation
#8
REVIEW
Jung-Eun Lee, Yadhu N Guragain, Krishna P Bastola, Praveen V Vadlani
Sorghum stalks were evaluated to generate clean sugars; enzymatic hydrolysis efficiency of acid pretreated biomass was significantly low (12.3 g sugar/g pretreated biomass) compared to alkali method (49.1 g sugar/g pretreated biomass). Inhibitory compounds derived from acid pretreatment, such as hydroxymethyl furfural (HMF) and furfural, were effectively removed using an appropriate detoxification method using 1% (w/v) activated charcoal. The resin mixture containing cationic exchangers (DOWEX 50WX8) and anionic exchangers (IRA 743) in 7:3 ratio at pH 2...
December 31, 2016: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28011482/galectin-3-is-implicated-in-tumor-progression-and-resistance-to-anti-androgen-drug-through-regulation-of-androgen-receptor-signaling-in-prostate-cancer
#9
Tsogt-Ochir Dondoo, Tomoharu Fukumori, Kei Daizumoto, Tomoya Fukawa, Miho Kohzuki, Minoru Kowada, Yoshito Kusuhara, Hidehisa Mori, Hiroyoshi Nakatsuji, Masayuki Takahashi, Hiro-Omi Kanayama
BACKGROUND: Castration-resistant prostate cancer (CRPC)-related deaths are increasing worldwide. Therefore, clarification of the mechanisms of hormone-related tumor progression and resistance to anti-androgen drugs is useful in order to develop strategies for appropriate treatment of CRPC. Galectin-3 has been shown to be correlated with tumor progression in a variety of cancer types through the regulation of tumor proliferation, angiogenesis, and apoptosis. MATERIALS AND METHODS: We examined tumor cell invasion and migration using the xCELLigence system...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/27997553/solar-aligned-pictographs-at-the-paleoindian-site-of-painel-do-pil%C3%A3-o-along-the-lower-amazon-river-at-monte-alegre-brazil
#10
Christopher Sean Davis
The archaeological sites near Monte Alegre, along Brazil's lower Amazon River, provide new information on the little-known activities and symbolism of South American Paleoindians toward the end of the Ice Age. While paleoindian sites like Monte Verde in Chile, or Guitarrero Cave in Peru, are located near the pacific coast, Monte Alegre lies much further inland, 680 km upriver from the mouth of the Amazon River and the Atlantic Coast. With excavated wood charcoal radiocarbon dated as early as 13,200 calibrated years ago, the hill-as a source of sandstone and quartz lithics-supplied early pioneers with adequate tools needed for colonizing the interior of the continent...
2016: PloS One
https://www.readbyqxmd.com/read/27978459/le-carbone-a-charcoal-supplement-modulates-dss-induced-acute-colitis-in-mice-through-activation-of-ampk%C3%AE-and-downregulation-of-stat3-and-caspase-3-dependent-apoptotic-pathways
#11
Mst Rejina Afrin, Somasundaram Arumugam, Md Azizur Rahman, Vengadeshprabhu Karuppagounder, Remya Sreedhar, Meilei Harima, Hiroshi Suzuki, Takashi Nakamura, Shizuka Miyashita, Kenji Suzuki, Kazuyuki Ueno, Kenichi Watanabe
Le Carbone (LC) is a charcoal supplement, which contains a large amount of dietary fibers. Several studies suggested that charcoal supplement may be beneficial for stomach disorders, diarrhea, gas and indigestion. But no studies address whether LC intake would suppress inflammation, cell proliferation or disease progression in colitis. In the present study, the effect of LC on experimental colitis induced by dextran sulfate sodium (DSS) in mice and its possible mechanism of action were examined. A study was designed for 8days, using C57BL/6 female mice that were administered with 3% DSS in drinking water for 7days followed by another 1day consumption of normal water with or without treatment...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27976016/effect-of-activated-charcoal-on-the-developmental-patterns-polyphenolics-productivity-and-photosynthetic-activity-of-sideritis-scardica-in-vitro
#12
P Koleva, N Petrova, S Krumova, V Velikova, I Aneva, L Evstatieva, E Wolfram, K Danova
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975560/chamomile-flower-myrrh-and-coffee-charcoal-components-of-a-traditional-herbal-medicinal-product-diminish-pro-inflammatory-activation-in-human-macrophages
#13
C Vissiennon, D Hammoud, R Jente, K H Goos, K Nieber, J Arnhold
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975435/synergy-research-investigating-the-combined-action-of-chamomile-myrrh-and-coffee-charcoal-on-chemokine-release-of-activated-human-macrophages
#14
C Vissiennon, D Hammoud, K H Goos, K Nieber, J Arnhold
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27973595/ecologically-different-fungi-affect-arabidopsis-development-contribution-of-soluble-and-volatile-compounds
#15
Salvatore Casarrubia, Sara Sapienza, Héma Fritz, Stefania Daghino, Maaria Rosenkranz, Jörg-Peter Schnitzler, Francis Martin, Silvia Perotto, Elena Martino
Plant growth and development can be influenced by mutualistic and non-mutualistic microorganisms. We investigated the ability of the ericoid endomycorrhizal fungus Oidiodendron maius to influence growth and development of the non-host plant Arabidopsis thaliana. Different experimental setups (non-compartmented and compartmented co-culture plates) were used to investigate the influence of both soluble and volatile fungal molecules on the plant phenotype. O. maius promoted growth of A. thaliana in all experimental setups...
2016: PloS One
https://www.readbyqxmd.com/read/27959299/drug-induced-liver-injury
#16
Leslie A Hamilton, Angela Collins-Yoder, Rachel E Collins
Drug-induced liver injury (DILI) can result from both idiosyncratic and intrinsic mechanisms. This article discusses the clinical impact of DILI from a broad range of medications as well as herbal and dietary supplements. Risk factors for idiosyncratic DILI (IDILI) are the result of multiple host, environmental, and compound factors. Some triggers of IDILI often seen in critical care include antibiotics, antiepileptic medications, statins, novel anticoagulants, proton pump inhibitors, inhaled anesthetics, nonsteroidal anti-inflammatory agents, methotrexate, sulfasalazine, and azathioprine...
October 2016: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/27925506/aliphatic-and-polycyclic-aromatic-hydrocarbons-pahs-in-soils-of-the-northwest-qinling-mountains-patterns-potential-risk-and-an-appraisal-of-the-pah-ratios-to-infer-their-source
#17
Yanhong Liu, Yingqin Wu, Yanqing Xia, Tianzhu Lei, Chuntao Tian, Xiaohuan Hou
Surface soils from the tourist areas of the northwest Qinling Mountains were analyzed to determine the concentrations, probable sources and potential risks of hydrocarbons. Concentrations of aliphatic and aromatic hydrocarbons ranged from 4.18 to 3240 ng g(-1) and 0.0462 to 101 ng g(-1) dry weight, respectively. The extent of soil contamination by hydrocarbons was generally typified by unpolluted to slightly polluted levels. The incremental lifetime cancer risks (ILCRs) for exposure to soil-borne PAHs indicated complete safety for tourists...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27917440/solid-flocculation-and-emulsifying-activities-of-the-lipopolysaccharide-produced-by-trichosporon-mycotoxinivorans-cla2
#18
Vitor S Domingues, Andrea S Monteiro, Gabriella Freitas Ferreira, Vera L Santos
The objective of this study was to evaluate the capability of a lipopolysaccharide, produced by Trichosporon mycotoxinivorans CLA2 using residue of biodiesel processing, to flocculate two different solids in suspension. In addition, the emulsifying activity and the stability of this lipopolysaccharide in response to pH and temperature variations and in the presence of some electrolytes were evaluated. The lipopolysaccharide was used in concentrations ranging from 20 to 80 mgL(-1) to flocculate 100 gL(-1) of kaolin and 50 gL(-1) of charcoal...
December 5, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27910037/effect-of-activated-charcoal-on-rivaroxaban-complex-absorption
#19
Edouard Ollier, Sophie Hodin, Julien Lanoiselée, Jean Escal, Sandrine Accassat, Elodie De Magalhaes, Thierry Basset, Laurent Bertoletti, Patrick Mismetti, Xavier Delavenne
OBJECTIVE: To quantify the impact of activated charcoal (AC) on rivaroxaban exposure in healthy volunteers. METHODS: This was an open-label study with an incomplete cross-over design of single-dose rivaroxaban (40 mg) administered alone or with AC in 12 healthy volunteers. The study comprised three treatment periods in randomised sequence, one with rivaroxaban administered alone and two with AC given at 2, 5 or 8 h post-dose. Rivaroxaban plasma concentration was measured in blood samples drawn at 16 time points...
December 2, 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27909718/enzalutamide-inhibits-proliferation-of-gemcitabine-resistant-bladder-cancer-cells-with-increased-androgen-receptor-expression
#20
Koji Kameyama, Kengo Horie, Kosuke Mizutani, Taku Kato, Yasunori Fujita, Kyojiro Kawakami, Toshio Kojima, Tatsuhiko Miyazaki, Takashi Deguchi, Masafumi Ito
Advanced bladder cancer is treated mainly with gemcitabine and cisplatin, but most patients eventually become resistance. Androgen receptor (AR) signaling has been implicated in bladder cancer as well as other types of cancer including prostate cancer. In this study, we investigated the expression and role of AR in gemcitabine-resistant bladder cancer cells and also the potential of enzalutamide, an AR inhibitor, as a therapeutic for the chemoresistance. First of all, we established gemcitabine-resistant T24 cells (T24GR) from T24 bladder cancer cells and performed gene expression profiling...
January 2017: International Journal of Oncology
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