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Asthma small airway disease

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https://www.readbyqxmd.com/read/28106744/oligonucleotide-therapy-for-obstructive-and-restrictive-respiratory-diseases
#1
REVIEW
Wupeng Liao, Jinrui Dong, Hong Yong Peh, Lay Hong Tan, Kah Suan Lim, Li Li, Wai-Shiu Fred Wong
Inhaled oligonucleotide is an emerging therapeutic modality for various common respiratory diseases, including obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD) and restrictive airway diseases like idiopathic pulmonary fibrosis (IPF). The advantage of direct accessibility for oligonucleotide molecules to the lung target sites, bypassing systemic administration, makes this therapeutic approach promising with minimized potential systemic side effects. Asthma, COPD, and IPF are common chronic respiratory diseases, characterized by persistent airway inflammation and dysregulated tissue repair and remodeling, although each individual disease has its unique etiology...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28102056/asthma-related-outcomes-in-patients-initiating-extrafine-ciclesonide-or-fine-particle-inhaled-corticosteroids
#2
Dirkje S Postma, Richard Dekhuijzen, Thys van der Molen, Richard J Martin, Wim van Aalderen, Nicolas Roche, Theresa W Guilbert, Elliot Israel, Daniela van Eickels, Javaria Mona Khalid, Ron M C Herings, Jetty A Overbeek, Cristiana Miglio, Victoria Thomas, Catherine Hutton, Elizabeth V Hillyer, David B Price
PURPOSE: Extrafine-particle inhaled corticosteroids (ICS) have greater small airway deposition than standard fine-particle ICS. We sought to compare asthma-related outcomes after patients initiated extrafine-particle ciclesonide or fine-particle ICS (fluticasone propionate or non-extrafine beclomethasone). METHODS: This historical, matched cohort study included patients aged 12-60 years prescribed their first ICS as ciclesonide or fine-particle ICS. The 2 cohorts were matched 1:1 for key demographic and clinical characteristics over the baseline year...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28087917/-reasearch-progress-on-the-role-of-neutrophils-in-asthma
#3
Tingting Li, Yuehai Ke, Hongqiang Cheng
Asthma is a phenotypically heterogeneous chronic disease of the airways. Studies have found that neutrophils are crucial to airway inflammation in acute asthma, persistent asthma, particularly in asthma of poor response to glucocorticoid treatment. The role of neutrophils in development of bronchial asthma is complex, as they can release a potent source of cytokines and inflammatory mediators participating in asthma. Differing from eosinophilic inflammatory asthma, neutrophilic inflammatory asthma is not depend on helper T (Th)2 cells, but may be related to Th1 and Th17 cells...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28079597/histologic-findings-of-severe-therapy-resistant-asthma-from-video-assisted-thoracoscopic-surgery-biopsies
#4
Humberto E Trejo Bittar, Daniel Doberer, Mitra Mehrad, Diane C Strollo, Joseph K Leader, Sally Wenzel, Samuel A Yousem
The histologic changes occurring in severe/therapy-resistant asthma (SA) as defined by the European Respiratory Society/American Thoracic Society guidelines, particularly at the level of the distal airways are unknown. This study describes the clinical, radiologic, and histologic characteristics of 29 SA patients who underwent video-assisted thoracoscopic surgery lung biopsy. Pathologic observations were correlated with clinical features, especially the presence of autoimmune disease (AID) (15/29, 51.7%). Ten biopsies (10/29, 34...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28065276/using-imaging-as-a-biomarker-for-asthma
#5
REVIEW
Abhaya Trivedi, Chase Hall, Eric A Hoffman, Jason C Woods, David S Gierada, Mario Castro
There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, including severity of disease and pathology, but also provide unique phenotypes...
January 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28045928/altered-epithelial-gene-expression-in-peripheral-airways-of-severe-asthma
#6
Akul Singhania, Hitasha Rupani, Nivenka Jayasekera, Simon Lumb, Paul Hales, Neil Gozzard, Donna E Davies, Christopher H Woelk, Peter H Howarth
Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, with very few utilizing transcriptomic approaches. The small peripheral airways, which comprise the majority of the airway surface area, remain an unexplored area in severe asthma and were targeted for global epithelial gene expression profiling in this study. Differences between central and peripheral airways were evaluated using transcriptomic analysis (Affymetrix HG U133 plus 2...
2017: PloS One
https://www.readbyqxmd.com/read/27984001/psoriatic-inflammation-enhances-allergic-airway-inflammation-through-il-23-stat3-signaling-in-a-murine-model
#7
Ahmed Nadeem, Naif O Al-Harbi, Mushtaq A Ansari, Mohammed M Al-Harbi, Ahmed M El-Sherbeeny, Khairy M A Zoheir, Sabry M Attia, Mohamed M Hafez, Othman A Al-Shabanah, Sheikh F Ahmad
Psoriasis is an autoimmune inflammatory skin disease characterized by activated IL-23/STAT3/Th17 axis. Recently psoriatic inflammation has been shown to be associated with asthma. However, no study has previously explored how psoriatic inflammation affects airway inflammation. Therefore, this study investigated the effect of imiquimod (IMQ)-induced psoriatic inflammation on cockroach extract (CE)-induced airway inflammation in murine models. Mice were subjected to topical and intranasal administration of IMQ and CE to develop psoriatic and airway inflammation respectively...
January 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27965780/manifesto-on-small-airway-involvement-and-management-in-asthma-and-chronic-obstructive-pulmonary-disease-an-interasma-global-asthma-association-gaa-and-world-allergy-organization-wao-document-endorsed-by-allergic-rhinitis-and-its-impact-on-asthma-aria-and-global
#8
F Braido, N Scichilone, F Lavorini, O S Usmani, L Dubuske, L P Boulet, R Mosges, C Nunes, M Sánchez-Borges, I J Ansotegui, M Ebisawa, F Levi-Schaffer, L J Rosenwasser, J Bousquet, T Zuberbier, G Walter Canonica
Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature review, both organizations developed, discussed, and approved the manifesto, which was subsequently approved and endorsed by the chairs of ARIA and GA(2)LEN. The manifesto describes the evidence gathered to date and defines and proposes issues on small airway involvement and management in asthma and COPD with the aim of challenging assumptions, fostering commitment, and bringing about change...
2016: Asthma research and practice
https://www.readbyqxmd.com/read/27931742/schistosoma-mansoni-antigens-alter-activation-markers-and-cytokine-profile-in-lymphocytes-of-patients-with-asthma
#9
Tarcísio Vila Verde Santana de Almeida, Jamille Souza Fernandes, Diego Mota Lopes, Lorena Santana Andrade, Sérgio Costa Oliveira, Edgar M Carvalho, Maria Ilma Araujo, Álvaro A Cruz, Luciana Santos Cardoso
: Asthma is a chronic disease characterized by airway inflammation, obstruction and hyperresponsiveness. Severe asthma affects a small proportion of subjects but results in most of the morbidity, costs and mortality associated with the disease. Studies have suggested that Schistosoma mansoni infection reduces the severity of asthma and prevent atopy. OBJECTIVE: We evaluated the ability of S. mansoni antigens, Sm29 and Sm29TSP-2 to modulate lymphocyte activation status in response to the allergen of the mite Dermatophagoides pteronyssinus (Der p1) in cell cultures of individuals with asthma...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27905186/severe-asthma-current-management-targeted-therapies-and-future-directions-a-roundtable-report
#10
REVIEW
Vanessa M McDonald, Steven Maltby, Helen K Reddel, Gregory G King, Peter A B Wark, Lorraine Smith, John W Upham, Alan L James, Guy B Marks, Peter G Gibson
Asthma is a chronic respiratory disease characterized by respiratory symptoms, airway inflammation, airway obstruction and airway hyper-responsiveness. Asthma is common and directly affects 10% of Australians, 1-5% of adults in Asia and 300 million people worldwide. It is a heterogeneous disorder with many clinical, molecular, biological and pathophysiological phenotypes. Current management strategies successfully treat the majority of patients with asthma who have access to them. However, there is a subset of an estimated 5-10% of patients with asthma who have severe disease and are disproportionately impacted by symptoms, exacerbations and overall illness burden...
January 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27884601/evaluating-small-airways-disease-in-asthma-the-utility-of-quantitative-computed-tomography-qct
#11
EDITORIAL
Donald P Tashkin, Hyun J Kim, Michelle Zeidler, Eric Kleerup, Jonathan Goldin
No abstract text is available yet for this article.
November 21, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27858495/asthma-associated-with-the-use-of-cocaine-heroin-and-marijuana-a-review-of-the-evidence
#12
Timothy H Self, Samarth Shah, Katherine L March, Christopher W Sands
OBJECTIVE: Review the evidence regarding asthma associated with use of cocaine, heroin, and marijuana. DATA SOURCES: A search of the English literature via PubMed/Medline and EMBASE using the search terms asthma AND cocaine, heroin, and marijuana. When pertinent articles were found, salient references in those articles were assessed. STUDY SELECTION: Due to the relatively small number of studies, we included all studies and cases. RESULTS: For several decades, case reports, retrospective studies, and laboratory investigations have demonstrated that inhalation of cocaine or heroin is associated with increased asthma symptoms and reduced pulmonary function...
November 18, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27800118/manifesto-on-small-airway-involvement-and-management-in-asthma-and-chronic-obstructive-pulmonary-disease-an-interasma-global-asthma-association-gaa-and-world-allergy-organization-wao-document-endorsed-by-allergic-rhinitis-and-its-impact-on-asthma-aria-and-global
#13
F Braido, N Scichilone, F Lavorini, O S Usmani, L Dubuske, L P Boulet, R Mosges, C Nunes, M Sanchez-Borges, I J Ansotegui, M Ebisawa, F Levi-Schaffer, L J Rosenwasser, J Bousquet, T Zuberbier, G Walter Canonica, A Cruz, A Yanez, A Yorgancioglu, D Deleanu, G Rodrigo, J Berstein, K Ohta, P Vichyanond, R Pawankar, S N Gonzalez-Diaz, S Nakajima, T Slavyanskaya, A Fink-Wagner, C Baez Loyola, D Ryan, G Passalacqua, J Celedon, J C Ivancevich, K Dobashi, M Zernotti, M Akdis, S Benjaponpitak, S Bonini, W Burks, L Caraballo, Z Awad El-Sayed, S Fineman, P Greenberger, E Hossny, J A Ortega-Martell, H Saito, M Tang, L Zhang
Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature review, both organizations developed, discussed, and approved the manifesto, which was subsequently approved and endorsed by the chairs of ARIA and GA(2)LEN. The manifesto describes the evidence gathered to date and defines and proposes issues on small airway involvement and management in asthma and COPD with the aim of challenging assumptions, fostering commitment, and bringing about change...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27790779/the-role-of-human-%C3%AE-defensins-in-allergic-diseases
#14
REVIEW
F Niyonsaba, C Kiatsurayanon, H Ogawa
Antimicrobial peptides (AMPs), also referred to as host defence peptides (HDPs), comprise a large family of small molecules broadly distributed throughout the animal and plant kingdom, historically serving as natural antibiotics. In mammals, there are two major families of AMPs/HDPs, the defensins and the cathelicidins. These peptides have evolved to protect against a wide range of infections from bacteria, viruses, fungi and some parasites. However, in addition to their broad-spectrum killing activities, AMPs/HDPs also possess various biological functions...
December 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27759879/the-sparc-protein-an-overview-of-its-role-in-lung-cancer-and-pulmonary-fibrosis-and-its-potential-role-in-chronic-airways-disease
#15
REVIEW
Sharon L I Wong, Maria B Sukkar
The SPARC (secreted protein acidic and rich in cysteine) protein is matricellular molecule regulating interactions between cells and their surrounding extracellular matrix (ECM). This protein thus governs fundamental cellular functions such as cell adhesion, proliferation and differentiation. SPARC also regulates the expression and activity of numerous growth factors and matrix metalloproteinases essential for ECM degradation and turnover. Studies in SPARC-null mice have revealed a critical role for SPARC in tissue development, injury and repair and in the regulation of the immune response...
January 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27753690/bronchiectasis-and-other-chronic-lung-diseases-in-adolescents-living-with-hiv
#16
Engi F Attia, Robert F Miller, Rashida A Ferrand
PURPOSE OF REVIEW: The incidence of pulmonary infections has declined dramatically with improved access to antiretroviral therapy (ART) and cotrimoxazole prophylaxis, but chronic lung disease (CLD) is an increasingly recognized but poorly understood complication in adolescents with perinatally acquired HIV. RECENT FINDINGS: There is a high prevalence of chronic respiratory symptoms, abnormal spirometry and chest radiographic abnormalities among HIV-infected adolescents in sub-Saharan Africa, wherein 90% of the world's HIV-infected children live...
February 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27736259/peripheral-killer-cells-do-not-differentiate-between-asthma-patients-with-or-without-fixed-airway-obstruction
#17
Carolyn Tubby, Ola H Negm, Timothy Harrison, Patrick J Tighe, Ian Todd, Lucy C Fairclough
OBJECTIVE: The three main types of killer cells - CD8(+) T cells, NK cells and NKT cells - have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obstruction (FAO), similar to that seen in COPD, has not been explored. The objective of the present study was to investigate killer cell numbers, phenotype and function in peripheral blood from asthma patients with FAO, asthma patients without FAO, and healthy individuals...
October 13, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27724976/prehospital-treatment-with-continuous-positive-airway-pressure-in-patients-with-acute-respiratory-failure-a-regional-observational-study
#18
Vibe Maria Laden Nielsen, Jacob Madsen, Anette Aasen, Anne Pernille Toft-Petersen, Kenneth Lübcke, Bodil Steen Rasmussen, Erika Frischknecht Christensen
BACKGROUND: Patients with acute respiratory failure are at risk of deterioration during prehospital transport. Ventilatory support with continuous positive airway pressure (CPAP) can be initiated in the prehospital setting. The objective of the study is to evaluate adherence to treatment and effectiveness of CPAP as an addition to standard care. METHODS: In North Denmark Region, patients with acute respiratory failure, whom paramedics assessed as suffering from acute cardiopulmonary oedema, acute exacerbation of chronic obstructive pulmonary disease or asthma were treated with CPAP using 100 % O2 from 1 March 2014 to 3 May 2015...
October 10, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27643599/airway-secretory-micrornaome-changes-during-rhinovirus-infection-in-early-childhood
#19
Maria J Gutierrez, Jose L Gomez, Geovanny F Perez, Krishna Pancham, Stephanie Val, Dinesh K Pillai, Mamta Giri, Sarah Ferrante, Robert Freishtat, Mary C Rose, Diego Preciado, Gustavo Nino
BACKGROUND: Innate immune responses are fine-tuned by small noncoding RNA molecules termed microRNAs (miRs) that modify gene expression in response to the environment. During acute infections, miRs can be secreted in extracellular vesicles (EV) to facilitate cell-to-cell genetic communication. The purpose of this study was to characterize the baseline population of miRs secreted in EVs in the airways of young children (airway secretory microRNAome) and examine the changes during rhinovirus (RV) infection, the most common cause of asthma exacerbations and the most important early risk factor for the development of asthma beyond childhood...
2016: PloS One
https://www.readbyqxmd.com/read/27634639/the-roles-of-mirnas-as-potential-biomarkers-in-lung-diseases
#20
REVIEW
Shamila D Alipoor, Ian M Adcock, Johan Garssen, Esmaeil Mortaz, Mohammad Varahram, Mehdi Mirsaeidi, Aliakbar Velayati
MicroRNAs (miRNAs) are small non-coding RNAs which can act as master regulators of gene expression, modulate almost all biological process and are essential for maintaining cellular homeostasis. Dysregulation of miRNA expression has been associated with aberrant gene expression and may lead to pathological conditions. Evidence suggests that miRNA expression profiles are altered between health and disease and as such may be considered as biomarkers of disease. Evidence is increasing that miRNAs are particularly important in lung homeostasis and development and have been demonstrated to be the involved in many pulmonary diseases such as asthma, COPD, sarcoidosis, lung cancer and other smoking related diseases...
November 15, 2016: European Journal of Pharmacology
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