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Ajay Kirtane

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https://www.readbyqxmd.com/read/28195937/an-updated-protocol-for-evaluating-chest-pain-and-managing-acute-coronary-syndromes
#1
Christopher R Kelly, Ajay J Kirtane, Jennifer Stant, Gregg W Stone, Robert M Minutello, S Chiu Wong, Honeyleen Manuzon, Roxanne Gerow-Smith, Nancy Kelley, LeRoy E Rabbani
Clinical pathways can optimize care both across and within institutions, but regular updates to these pathways based on new clinical trials, professional guidelines, and Food and Drug Administration approvals are essential. Herein we describe the most recent revisions to the New York-Presbyterian Hospital (Columbia University Medical Center and Weill Cornell Medical Center) clinical pathway for acute coronary syndromes and chest pain, which incorporates novel data regarding the timing and administration of P2Y12 inhibition (including the intravenous P2Y12 inhibitor cangrelor) and the appropriateness of prolonged (>1 year) dual antiplatelet therapy for the secondary prevention of ischemic events...
March 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/28193677/sex-differences-in-the-clinical-impact-of-high-platelet-reactivity-after-percutaneous-coronary-intervention-with-drug-eluting-stents-results-from-the-adapt-des-study-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents
#2
Jennifer Yu, Roxana Mehran, Usman Baber, Sze-Yuan Ooi, Bernhard Witzenbichler, Giora Weisz, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Bruce R Brodie, Thomas D Stuckey, Akiko Maehara, Ke Xu, Ori Ben-Yehuda, Ajay J Kirtane, Gregg W Stone
BACKGROUND: Sex differences in the outcomes after percutaneous coronary intervention with drug-eluting stents and in the response to clopidogrel therapy have been reported; however, the differential risk of high platelet reactivity (HPR) on clopidogrel in women versus men is unknown. METHODS AND RESULTS: We compared 8448 patients enrolled in the ADAPT-DES study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) according to sex and the presence/absence of HPR on clopidogrel (defined as P2Y12 reactivity units >208)...
February 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28169091/predictors-of-excess-patient-radiation-exposure-during-chronic-total-occlusion-coronary-intervention-insights-from-a-contemporary-multicentre-registry
#3
Georgios E Christakopoulos, Georgios Christopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Michael R Wyman, William L Lombardi, Muhammad Nauman J Tarar, J Aaron Grantham, David E Kandzari, Nicholas Lembo, Jeffrey W Moses, Ajay J Kirtane, Manish Parikh, Philip Green, Matthew Finn, Santiago Garcia, Anthony H Doing, Raja Hatem, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: High patient radiation dose during chronic total occlusion (CTO) percutaneous coronary intervention (PCI) might lead to procedural failure and radiation skin injury. METHODS: We examined the association between several clinical and angiographic variables on patient air kerma (AK) radiation dose among 748 consecutive CTO PCIs performed at 9 experienced US centres between May 2012 and May 2015. RESULTS: The mean age was 65 ± 10 years, 87% of patients were men, and 35% had previous coronary artery bypass graft surgery (CABG)...
November 11, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28114641/the-importance-of-long-term-follow-up-within-randomized-clinical-trials-of-cardiovascular-devices
#4
Ajay J Kirtane, Robert O Bonow
No abstract text is available yet for this article.
January 18, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28104208/first-in-human-evaluation-of-a-novel%C3%A2-polymer-free-drug-filled-stent-angiographic-ivus-oct-and-clinical-outcomes-from%C3%A2-the%C3%A2-revelution-study
#5
Stephen G Worthley, Alexandre Abizaid, Ajay J Kirtane, Daniel I Simon, Stephan Windecker, Sandeep Brar, Ian T Meredith, Sharad Shetty, Ajay Sinhal, Alexandra Popma Almonacid, Daniel Chamié, Akiko Maehara, Gregg W Stone
OBJECTIVES: This study sought to assess the safety and effectiveness of the drug-filled stent (DFS) (Medtronic, Santa Rosa, California) in the treatment of patients with coronary artery disease. BACKGROUND: Polymer-free drug-eluting stents have the potential to improve clinical outcomes and facilitate shorter durations of dual antiplatelet therapy. The polymer-free DFS is made from a trilayered continuous wire with an outer cobalt chromium layer, a middle tantalum layer, and an inner lumen coated with sirolimus...
January 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28092294/outcomes-of-a-combined-approach-of-percutaneous-coronary-revascularization-and-cardiac-valve-surgery
#6
Orlando Santana, Sandeep Singla, Christos G Mihos, Andrés M Pineda, Gregg W Stone, Paul A Kurlansky, Isaac George, Ajay J Kirtane, Craig R Smith, Nirat Beohar
A subset of patients requiring coronary revascularization and valve surgery may benefit from a combined approach of percutaneous coronary intervention (PCI) and valve surgery, as opposed to the standard median sternotomy approach of combined coronary artery bypass and valve surgery. To evaluate its potential benefits and limitations, a literature search was performed using PubMed, EMBASE, Ovid, and the Cochrane library, through March 2016 to identify all studies involving a combined approach of PCI and valve surgery in patients with coronary artery and valvular disease...
January 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28089997/the-impact-of-age-and-sex-on-in-hospital-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention
#7
Aris Karatasakis, Rahel Iwnetu, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, David E Kandzari, Nicholas J Lembo, Mitul Patel, Ehtisham Mahmud, William L Lombardi, R Michael Wyman, J Aaron Grantham, Anthony H Doing, Catalin Toma, James W Choi, Barry F Uretsky, Jeffrey W Moses, Ajay J Kirtane, Ziad A Ali, Manish Parikh, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the effect of age and sex on procedural outcomes and efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1675 CTO-PCIs performed in 1644 patients between 2012 and 2016 at 15 United States centers. RESULTS: Mean age was 65.3 ± 10 years and 1408 (86%) were men. Overall technical and procedural success rates were 88% and 87%, respectively...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28040289/two-year-outcomes-after-percutaneous-coronary-intervention-of-calcified-lesions-with-drug-eluting-stents
#8
Philippe Généreux, Björn Redfors, Bernhard Witzenbichler, Marie-Pier Arsenault, Giora Weisz, Thomas D Stuckey, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Dominic P Francese, Guillaume Marquis-Gravel, Gary S Mintz, Ajay J Kirtane, Akiko Maehara, Roxana Mehran, Gregg W Stone
BACKGROUND: Percutaneous coronary intervention (PCI) of lesions with coronary arterial calcification (CAC) is common and has been historically associated with an increased risk of adverse events. Whether the association between target lesion calcification (CAC) and outcomes differ across drug-eluting stent generation or between patients with high vs. low residual platelet reactivity (PR) remains unknown. We assessed the association of CAC with adverse ischemic and bleeding events among patients undergoing contemporary PCI with drug-eluting stents (DES)...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28030655/percutaneous-coronary-intervention-with-bioresorbable-scaffolds-in-a-young-child
#9
Tamim M Nazif, Sanjog Kalra, Ziad A Ali, Dimitrios Karmpaliotis, Mariel E Turner, Thomas J Starc, Yang Cao, Charles C Marboe, Michael B Collins, Martin B Leon, Ajay J Kirtane
Importance: Although much less frequent than in adults, coronary artery disease requiring revascularization may develop in children because of homozygous familial hypercholesterolemia or other underlying conditions. Percutaneous coronary intervention (PCI) with a bioresorbable scaffold (BRS) may have advantages over metallic coronary stents in this population. Objective: To present a case of the successful treatment of unstable, multivessel coronary artery disease in a child with PCI with BRS implantation...
December 28, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/28007741/predictors-and-long-term-clinical-impact-of-acute-stent-malapposition-an-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents-adapt-des-intravascular-ultrasound-substudy
#10
Bin Wang, Gary S Mintz, Bernhard Witzenbichler, Cristiano F Souza, D Christopher Metzger, Michael J Rinaldi, Peter L Duffy, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Mitsuaki Matsumura, Myong-Hwa Yamamoto, Rupa Parvataneni, Ajay J Kirtane, Gregg W Stone, Akiko Maehara
BACKGROUND: The impact of acute stent malapposition (ASM) on long-term clinical outcomes in patients undergoing percutaneous coronary intervention is still controversial. We sought to evaluate predictors and long-term clinical outcomes of ASM. METHODS AND RESULTS: ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) was a prospective multicenter study of 8663 patients undergoing percutaneous coronary intervention using drug-eluting stents...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27978944/bleeding-events-before-coronary-angiography-in-patients-with-non-st-segment-elevation-acute%C3%A2-coronary-syndrome
#11
Björn Redfors, Ajay J Kirtane, Stuart J Pocock, Girma Minalu Ayele, Efthymios N Deliargyris, Roxana Mehran, Gregg W Stone, Philippe Généreux
BACKGROUND: Upstream administration of antithrombotic drugs to patients with non-ST-segment elevation acute coronary syndromes before coronary angiography is a common practice despite an incomplete understanding of the risks and benefits. OBJECTIVES: The authors analyzed the incidence of bleeding and ischemic events occurring before angiography and assessed their association with antithrombotic drugs and mortality risk. METHODS: All patients from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial with planned angiography after enrollment were included...
December 20, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27974670/the-syntax-score-does-not-predict-risk-of-adverse-events-in-patients-with-non-st-elevation-acute-coronary-syndrome-who-undergo-coronary-artery-bypass-graft-surgery
#12
Björn Redfors, Chun-Hui He, Tullio Palmerini, Adriano Caixeta, Gennaro Giustino, Girma Minalu Ayele, Ajay J Kirtane, Roxana Mehran, Gregg W Stone, Philippe Généreux
OBJECTIVES: We tested the ability of the SYNTAX score (SS) to predict 1-year adverse outcomes for patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS) who undergo coronary artery bypass graft (CABG) surgery. BACKGROUND: The SS effectively risk stratifies patients who undergo percutaneous coronary intervention, but not patients with stable coronary disease who undergo CABG. METHODS: We calculated the SS for 457 patients with NSTE-ACS in the angiographic substudy of the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) trial who underwent CABG...
February 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27970411/tct-236-effects-of-orbital-versus-rotational-atherectomy-facilitated-pci-on-the-coronary-microcirculation
#13
Keyvan Karimi Galougahi, Navdeep Bhatti, Richard Shlofmitz, Philippe Généreux, Jeffrey Moses, Ajay Kirtane, Gregg Stone, Gary Mintz, Dimitri Karmpaliotis, Akiko Maehara, Martin Leon, Ziad Ali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970410/tct-237-outcomes-after-successful-pci-of-severely-calcified-lesions-using-rotational-atherectomy-cutting-balloon-or-balloon-angioplasty-only-before-second-generation-drug-eluting-stent-implantation
#14
Bjorn Redfors, Philippe Généreux, Akiko Maehara, Ajay Kirtane, Rushad Dordi, Bernhard Witzenbichler, Giora Weisz, Thomas Stuckey, Michael Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy Henry, David Cox, Peter L Duffy, Ernest Mazzaferri, Claire Litherland, Roxana Mehran, Gary Mintz, Gregg Stone
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970352/tct-181-temporal-differences-in-ischemic-and-bleeding-risks-after-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction
#15
Gennaro Giustino, Roxana Mehran, Ajay Kirtane, Bjorn Redfors, Philippe Généreux, George Dangas, Sorin Brener, Jayne Prats, Makis Deliargyris, Gregg Stone
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970339/tct-16-patient-and-procedural-characteristics-and-in-hospital-outcomes-associated-with-the-use-of-retrograde-recanalization-techniques-for-chronic-total-occlusion-pci-a-report-from-the-open-cto-registry
#16
Sanjog Kalra, James Sapontis, Robert Riley, Mohammed Qintar, Philip Jones, Ajay Kirtane, Manish Parikh, Jeffrey Moses, Ziad Ali, William Lombardi, William Nicholson, J Aaron Grantham, Dimitri Karmpaliotis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970337/tct-168-worse-outcomes-in-women-compared-to-men-after-primary-pci-in-stemi-are-not-explained-by-left-ventricular-morphology-and-cardiac-function-a-collaborative-patient-level-pooled-analysis-from-9-randomized-trials
#17
Bjorn Redfors, Ioanna Kosmidou, Rushad Dordi, Ulrich Schaefer, Holger Thiele, Manesh Patel, James Udelson, E Magnus Ohman, Ingo Eitel, Christopher Granger, Akiko Maehara, Ajay Kirtane, Philippe Généreux, Paul Jenkins, Ori Ben-Yehuda, Gregg Stone
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970335/tct-166-correlates-and-prognostic-impact-of-new-onset-heart-failure-after-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-insights-from-the-infuse-ami-trial
#18
Gennaro Giustino, Bjorn Redfors, Sorin Brener, Ajay Kirtane, Philippe Généreux, Akiko Maehara, Thomas Neunteufl, D Christopher Metzger, Roxana Mehran, C Michael Gibson, Gregg Stone
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970332/tct-163-time-to-reperfusion-and-infarct-size-in-patients-with-stemi-undergoing-primary-pci-a-collaborative-patient-level-pooled-analysis-of-10%C3%A2-randomized-trials
#19
Gennaro Giustino, Bjorn Redfors, Ulrich Schaefer, Holger Thiele, Manesh Patel, James Udelson, E Magnus Ohman, Ingo Eitel, Christopher Granger, Akiko Maehara, Ajay Kirtane, Philippe Généreux, Paul Jenkins, Ori Ben-Yehuda, Gregg Stone
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970311/tct-15-use-of-antegrade-dissection-re-entry-in-coronary-chronic-total-occlusion-percutaneous-coronary-intervention-in-a-contemporary-multicenter-registry
#20
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, Anthony Doing, David Kandzari, Nicholas Lembo, Santiago Garcia, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Judit Karacsonyi, Aya Alame, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Pratik Kalsaria, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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