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V A Kudinov, T S Zakharova, T I Torkhovskaya, O M Ipatova, A I Archakov
Literature data on influence of existing and new groups of drug preparations for dyslipidemias correction are systemized, and molecular mechanisms of their effects are reviewed. The results of experimental and clinical investigations aimed at revealing of new pharmacological targets of dyslipidemias correction were analyzed. The approaches for activation of high density lipoproteins functionality are described. The implementation of alternative preparations with new alternative mechanisms of action may be suggested to improve the effectiveness of traditional treatment in the future...
January 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
Cesar Sepúlveda, Iván Palomo, Eduardo Fuentes
Beyond its function in hemostasis, platelets activation has an important role in cardiovascular diseases (CVD) development. There are different clinical conditions that can mediate abnormal platelet activation and favors pathological thrombosis and CVD. These include Hypertension, diabetes and dyslipidemia, all risks factors from CVD development. Different drugs employed in the handled of these conditions have showed decreases platelet activation and related markers. This effect is in part by improved the base condition; however someone of these drugs can modulate platelet targets...
April 2017: Vascular Pharmacology
H R Hady, J Dadan, P Gołaszewski
PURPOSE: Obesity is a widespread health issue caused by chronic impaired balance between energy supply and its expenditure. It leads to gathering of excessive fat tissue and numerous co-morbidities.The aim of this study is to present the influence of laparoscopic adjustable gastric banding (LAGB) on plasma ghrelin, insulin, glucose, triglycerides, total, HDL- and LDL-cholesterol concentration as well as on alanine and aspartate aminotransferase in obese patients and influence on co-morbidities such as type 2 diabetes mellitus, dislipidemy, hypertension and sleep apnea...
June 1, 2012: Advances in Medical Sciences
Lucas Perez de Vasconcellos, Juan Antônio Castro Flores, Mário Luiz Marques Conti, José Carlos Esteves Veiga, Carmen Lúcia Penteado Lancellotti
OBJECTIVE: To describe five cases of giant carotid cavernous aneurysms which evolved with spontaneous thrombosis of internal carotid artery (STICA), with emphasis at epidemiology, clinical presentation, natural history, related factors and neurological outcome. METHOD: There were 711 consecutives patients with 802 aneurysms with and without surgical treatment during a period of 19 years. We selected 35 patients with 40 carotid cavernous aneurysms (5%) of which 20 (50%) were giant aneurysms...
June 2009: Arquivos de Neuro-psiquiatria
Alexandre Azenha Alves de Rezende, Ulrich Graf, Zaira da Rosa Guterres, Warwick Estevam Kerr, Mário Antônio Spanó
Proanthocyanidins (PAs), also known as condensed tannins, are naturally occurring oligomers and polymers of flavan-3-ol monomer units widely found in the leaves, flowers, fruits, seeds, nuts and barks of many plants. Grape seed proanthocyanidins (GSPs) have been used as nutritional supplements, as antioxidants, in preventing atherosclerosis and cardiovascular diseases, and for dislipidemy treatment. The anthracycline antibiotic adriamycin (Doxorubicin, DXR) is a cancer chemotherapeutic agent that interferes with the topoisomerase II enzyme and generates free radicals...
July 2009: Food and Chemical Toxicology
Biscević Azra
Dislipidemie is important risk factor for cardiovascular diseases and food can influence on that on different ways. Aim of this article is to test levels of cholesterol and tryglycerids in participants according to gender, age, level of nourishment and to point on possibilities of prevention and intervention. In analyzed groups, there were 92 adult participants, both genders with no cardiovascular diseases whom were estimated levels of lipid fractions and BMI. Statistical methods in this study were ANOVA and Pearson correlation...
2005: Medicinski Arhiv
Paweł Marek Ginter, Marian Mikołaj Zgoda
Investigation of 3-hydroxy-3-methyl-glutaril-coenzyme A inhibitors (statins) has influenced considerably the process of treatment of dislipidemy; now they belong to the most frequently prescribed hypolipemizing medicines. As it has been proved through randomized clinical examination, it is believed to be related to their complex pharmacological action that statins cause certain clinical effects such as a decrease in the morbidity and mortality rate resulted from vessel diseases referred to artheriosclerotic changes...
2004: Polimery W Medycynie
P T Romagna Cavalheiro, E M da Rosa, A O Vargas Avila
PURPOSE: To evaluate the presence of risk factors (RF) for coronary disease in a group of university students (US). METHODS: We studied 123 US, 88 (71.55%) females, mean age 21 +/- 3.52 years, submitted to questionary, interview, physical examination and serum analises. Eighty six women informed about oral contraceptive use. Serum lipid levels were measured in 66 women and 21 men. Statistical analysis was proceded by analysis descritive. RESULTS: Sedentarism was observed in 51...
December 1995: Arquivos Brasileiros de Cardiologia
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