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https://www.readbyqxmd.com/read/29922222/cognitive-deficits-are-attenuated-in-neuroglobin-overexpressing-mice-exposed-to-a-model-of-obstructive-sleep-apnea
#1
Deepti Nair, Vijay Ramesh, David Gozal
Background: Obstructive sleep apnea (OSA) is a highly prevalent disease manifesting as intermittent hypoxia during sleep (IH) and is increasingly recognized as being independently associated with neurobehavioral deficits. These deficits may be due to increased apoptosis in the hippocampus and cerebral cortex, as well as increased oxidative stress and inflammation. It has been reported that neuroglobin (Ngb) is upregulated in response to hypoxia-ischemia insults and exhibits a protective role in ischemia-reperfusion brain injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29921352/a-pilot-study-exploring-the-effects-of-sleep-deprivation-on-analogue-measures-of-pilot-competencies
#2
Anna Donnla O'Hagan, Johann Issartel, Eoghan McGinley, Giles Warrington
INTRODUCTION: Sleep loss can result in cognitive, motor, and neurobehavioral impairments. In an aviation context, this can cause a serious threat to flight safety. Therefore, the study aimed to investigate the effects of 24-h sleep deprivation on mood, fatigue, and airline pilot competencies. METHODS: Seven subjects attended two 24-h testing periods, one with an 8-h sleep opportunity, and the other with no sleep opportunity (i.e., sleep deprivation). Subjects were required to complete a battery of mood, fatigue, and analogue measures of pilot competency tasks every 8 h (0 h, 8 h, 16 h, 24 h) throughout each testing period...
July 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29920994/sleep-disordered-breathing-brain-volume-and-cognition-in-older-individuals-with-heart-failure
#3
Chooza Moon, Kelsey E Melah, Sterling C Johnson, Lisa C Bratzke
BACKGROUND AND PURPOSE: Sleep-disordered breathing is common in individuals with heart failure and may contribute to changes in the brain and decreased cognition. However, limited research has explored how the apnea-hypopnea index contributes to brain structure and cognition in this population. The aims of this study were to explore how the apnea-hypopnea index is associated with brain volume and cognition in heart failure patients. METHODS: Data of 28 heart failure patients (mean age = 67...
June 19, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29920330/dna-binding-protein-hmgb1-secreted-by-activated-microglia-promotes-the-apoptosis-of-hippocampal-neurons-in-diabetes-complicated-with-osa
#4
Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Feng
Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice (C57 mice) underwent IH or normoxia (control) exposure for 4 weeks...
June 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29915559/obesity-management-what-should-we-do-if-fat-gain-is-necessary-to-maintain-body-homeostasis-in-a-modern-world
#5
Angelo Tremblay
The prevalence of overweight has substantially increased over the last decades despite the intent of health professionals and the general population to prevent this trend. Traditionally, this phenomenon has been attributed to unhealthy dietary macronutrient composition and/or to the decrease in physical activity participation. Beyond the influence of these factors, it is more than likely that other factors have influenced energy balance in a context of modernity. These include inadequate sleep, demanding cognitive effort, chemical pollution, and probably others which also have the potential to promote a positive energy balance but which are also part of the reality of success and productivity in a globalized world...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29915546/effect-of-acute-subacute-and-repeated-exposure-to-high-altitude-5050-m-on-psychomotor-vigilance
#6
Matiram Pun, Sara E Hartmann, Michael Furian, Adrienna M Dyck, Lara Muralt, Mona Lichtblau, Patrick R Bader, Jean M Rawling, Silvia Ulrich, Konrad E Bloch, Marc J Poulin
Aim: High altitude (HA) hypoxia may affect cognitive performance and sleep quality. Further, vigilance is reduced following sleep deprivation. We investigated the effect on vigilance, actigraphic sleep indices, and their relationships with acute mountain sickness (AMS) during very HA exposure, acclimatization, and re-exposure. Methods: A total of 21 healthy altitude-naive individuals (25 ± 4 years; 13 females) completed 2 cycles of altitude exposure separated by 7 days at low altitude (LA, 520 m). Participants slept at 2900 m and spent the day at HA, (5050 m)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29915164/linalool-ameliorates-memory-loss-and-behavioral-impairment-induced-by-rem-sleep-deprivation-through-the-serotonergic-pathway
#7
Bo Kyung Lee, An Na Jung, Yi-Sook Jung
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia , has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations...
June 19, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29913921/applying-dialectical-behavior-therapy-to-chronic-pain-a-case-study
#8
Steven J Linton
Background and aims Chronic pain patients often present with a host of psychological and somatic problems and are unable to work despite receiving traditional pain management. For example, it is common that patients with persistent pain also suffer from a variety of anxiety and depressive symptoms. Indeed, the regulation of emotions may be one important factor that is associated with the development of persistent pain. Dialectical behavior therapy, a form of cognitive-behavioral therapy, focuses on emotion regulation and has successfully addressed other complex problems...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913093/recent-advances-in-the-etiology-and-treatment-of-burning-mouth-syndrome
#9
A Ritchie, J M Kramer
Burning mouth syndrome (BMS) is a debilitating condition that has a striking female predilection. Although the oral mucosa is normal in appearance, patients with BMS experience oral burning that most commonly localizes to the lips and tongue. BMS is a diagnosis of exclusion, and all underlying pathoses associated with allodynia must be ruled out prior to rendering the diagnosis. The etiopathogenesis of BMS remains poorly understood, and thus patient management is challenging. Data indicate that oral and systemic factors both contribute to the development and persistence of the condition...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29912792/neurocognitive-effects-of-agomelatine-treatment-in-schizophrenia-patients-suffering-from-comorbid-depression-results-from-the-agopsych-study
#10
Susanne Englisch, Hanna Sophie Jung, Sarah Eisenacher, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Jascha Thiem, Andreas Meyer-Lindenberg, Mathias Zink
BACKGROUND: Cognitive impairment in schizophrenia is highly disabling and remains one of the major therapeutic challenges. Agomelatine (AGO), an agonist at melatonergic MT1/MT2 receptors and antagonist at 5-HT2C receptors, increases dopamine and norepinephrine in the prefrontal cortex and may therefore have the potential of improving neurocognition in patients with schizophrenia. METHODS: Twenty-seven patients with schizophrenia and comorbid depression were treated with AGO in addition to stable doses of antipsychotic drugs...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29910619/investigation-on-dysfunctional-beliefs-and-attitudes-about-sleep-in-chinese-college-students
#11
Lairun Jin, Jun Zhou, Hui Peng, Shushu Ding, Hui Yuan
Objective: The aims of this study were to evaluate a subset of sleep-related cognitions and to examine whether dysfunctional beliefs and attitudes about sleep were associated with sleep quality in college students. Patients and methods: A total of 1,333 college students were enrolled in this study by randomized cluster sampling. A brief version of Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS-16) was administered to college students at several colleges...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29909398/higher-vitamin-d-intake-could-improve-sleep-and-cognitive-outcomes-in-older-adults-with-heart-failure
#12
Junxin Li
No abstract text is available yet for this article.
June 16, 2018: Evidence-based Nursing
https://www.readbyqxmd.com/read/29908972/bidirectional-relationships-between-sleep-and-amyloid-beta-in-the-hippocampus
#13
Julien Dufort-Gervais, Valérie Mongrain, Jonathan Brouillette
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by progressive hippocampal-dependent explicit memory deficits that begin at the onset of the illness. An early hallmark of AD is the accumulation of amyloid-beta (Aß) proteins in brain structures involved in encoding and consolidation of memory, like the hippocampus and prefrontal cortex. Aß neurotoxicity is known to induce synaptic dysfunctions and neuronal death leading to cognitive decline. Another recurrent event observed in AD is sleep disturbances...
June 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29908300/acute-and-chronic-escitalopram-alter-eeg-gamma-oscillations-differently-relevance-to-therapeutic-effects
#14
Noémi Papp, Szilvia Vas, Emese Bogáthy, Zita Kátai, Diána Kostyalik, György Bagdy
Brain oscillations in the gamma frequency band of the electroencephalogram (EEG) have been implicated in several sensory and cognitive processes, and have also been associated with numerous neuropsychiatric disorders, including depression. The widely prescribed selective serotonin reuptake inhibitors (SSRIs), similarly to other antidepressants, are known to produce markedly different effects on sleep and behavioral measures with acute and chronic administration. Although there are studies examining the acute effect of escitalopram on slower (<30 Hz) oscillations, we hardly could find any data about the effect of the drug on higher-frequency EEG oscillations (>30 Hz) in different sleep-wake stages, particularly comparing the acute and chronic effects of the drug concerning gamma oscillations...
June 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29906629/shorter-sleep-duration-is-associated-with-reduced-cognitive-development-at-two-years-of-age
#15
Lisa Smithson, Tieghan Baird, Sukhpreet K Tamana, Amanda Lau, Jennifer Mariasine, Joyce Chikuma, Diana L Lefebvre, Padmaja Subbarao, Allan B Becker, Stuart E Turvey, Malcolm R Sears, Deryk S Beal, Jacqueline Pei, Piush J Mandhane
BACKGROUND: Both short sleep duration and sleep-disordered breathing (SDB) are associated with poor neurocognitive development. However, the co-contributions of short sleep duration and SDB on neurodevelopment in pre-school children are relatively unknown. METHODS: We assessed both sleep duration and SDB by quarterly questionnaire from three months to two years of age among Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort participants. Group-based modeling determined trajectories of total, daytime, and nighttime sleep duration and SDB...
April 30, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29906207/human-performance-deterioration-due-to-prolonged-wakefulness-can-be-accurately-detected-using-time-varying-spectral-analysis-of-electrodermal-activity
#16
Hugo F Posada-Quintero, Jeffrey B Bolkhovsky, Michael Qin, Ki H Chon
OBJECTIVE: The aim was to determine if indices of the autonomic nervous system (ANS), derived from the electrodermal activity (EDA) and electrocardiogram (ECG), could be used to detect deterioration in human cognitive performance on healthy participants during 24-hour sleep deprivation. BACKGROUND: The ANS is highly sensitive to sleep deprivation. METHODS: Twenty-five participants performed a desktop-computer-based version of the psychomotor vigilance task (PVT) every 2 hours...
June 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29905840/symptom-based-interventions-to-promote-quality-survivorship
#17
Christina Amidei
Survival alone is no longer an adequate outcome for persons with brain tumors; the quality of the survivorship experience should be viewed with equal importance. Symptom management is a significant component of quality survivorship care. Regardless of their histology, brain tumors and therapies used to treat them produce symptoms that affect an individual's ability to function in everyday life. Common symptoms include fatigue, cognitive impairment, distress, and sleep disturbance. Symptom-based interventions for persons with brain tumors focus on prevention, self-management and prescriptive interventions targeted to these problems...
June 13, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29904334/sleep-disorders-associated-with-alzheimer-s-disease-a-perspective
#18
REVIEW
Anna Brzecka, Jerzy Leszek, Ghulam Md Ashraf, Maria Ejma, Marco F Ávila-Rodriguez, Nagendra S Yarla, Vadim V Tarasov, Vladimir N Chubarev, Anna N Samsonova, George E Barreto, Gjumrakch Aliev
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29903598/trial-protocol-cognitive-functional-therapy-compared-with-combined-manual-therapy-and-motor-control-exercise-for-people-with-non-specific-chronic-low-back-pain-protocol-for-a-randomised-controlled-trial
#19
Fabiana Terra Cunha Belache, Cíntia Pereira de Souza, Jessica Fernandez, Julia Castro, Paula Dos Santos Ferreira, Elizana Rodrigues de Sousa Rosa, Nathalia Cristina Gimenez de Araújo, Felipe José Jandre Reis, Renato Santos de Almeida, Leandro Alberto Calazans Nogueira, Luís Cláudio Lemos Correia, Ney Meziat-Filho
INTRODUCTION: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise...
June 11, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29903235/-effects-of-cerium-oxide-nanoparticles-on-cognitive-function-in-48-h-sleep-deprived-male-mice
#20
Dan Zou, Xujun Chu, Wenhao Lu, Jiayi Yan, Mingkang Ye, Shuiyi Hu, Fenju Qin
OBJECTIVE: To study the effects of cerium oxide nanoparticles( CeO_2 NPs)on cognitive function in 48 hours of sleep deprived male mice and explore its mechanism. METHODS: Thirty-six healthy clean ICR male mice( four weeks old) were randomly divided into 6 groups: blank control group, solvent control group, sleep deprivation control group, low, medium and high dose groups of CeO_2 NPs. 1 m L of distilled water were given to mice of blank group, 1 m L of solvent were given to mice of solvent control and sleep deprivation control group, 1 mL of CeO_2 NPs solvent( 4, 8, 16 mg/kg) were administered to mice of low, medium and high dose groups of CeO_2 NPs...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
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