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https://www.readbyqxmd.com/read/29689760/joint-regression-and-classification-via-relational-regularization-for-parkinson-s-disease-diagnosis
#1
Haijun Lei, Zhongwei Huang, Tao Han, Qiuming Luo, Ye Cai, Gang Liu, Baiying Lei
It is known that the symptoms of Parkinson's disease (PD) progress successively, early and accurate diagnosis of the disease is of great importance, which slows the disease deterioration further and alleviates mental and physical suffering. In this paper, we propose a joint regression and classification scheme for PD diagnosis using baseline multi-modal neuroimaging data. Specifically, we devise a new feature selection method via relational learning in a unified multi-task feature selection model. Three kinds of relationships (e...
April 10, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29688285/neural-coding-of-cell-assemblies-via-spike-timing-self-information
#2
Meng Li, Kun Xie, Hui Kuang, Jun Liu, Deheng Wang, Grace E Fox, Zhifeng Shi, Liang Chen, Fang Zhao, Ying Mao, Joe Z Tsien
Cracking brain's neural code is of general interest. In contrast to the traditional view that enormous spike variability in resting states and stimulus-triggered responses reflects noise, here, we examine the "Neural Self-Information Theory" that the interspike-interval (ISI), or the silence-duration between 2 adjoining spikes, carries self-information that is inversely proportional to its variability-probability. Specifically, higher-probability ISIs convey minimal information because they reflect the ground state, whereas lower-probability ISIs carry more information, in the form of "positive" or "negative surprisals," signifying the excitatory or inhibitory shifts from the ground state, respectively...
April 21, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29686598/sleep-related-problems-as-a-nonmotor-symptom-of-dentatorubropallidoluysian-atrophy
#3
Hyeyun Kim, Ji Young Yun, Kyoung-Gyu Choi, Heasoo Koo, Hyun Jeong Han
Dentatorubropallidoluysian atrophy (DRPLA) is a neurodegenerative disease caused by an expansion of a cytosine-adenine-guanine (CAG) repeat encoding a polyglutamine tract in the atrophin-1 protein. Unlike other CAG repeat diseases, sleep related problems have not been reported in patients with DRPLA. There was a 65-year-old man and his family with DRPLA. They suffered from seizure, gait disturbance, and cognitive decline. The patients commonly showed dream enacting sleep disorder, insomnia. The results from overnight polysomnography showed rapid eye movement (REM) without atonia in patients with DRPLA...
April 23, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29684996/low-grade-chronic-inflammation-mediated-by-mast-cells-in-fibromyalgia-role-of-il-37
#4
F Mastrangelo, I Frydas, G Ronconi, S K Kritas, L Tettamanti, Al Caraffa, C D Ovidio, A Younes, C E Gallenga, P Conti
It has been observed that acute stress causes the activation of TH1 cells, while TH2 cells regulate and act on chronic inflammation. Fibromyalgia (FM) is a chronic, idiopathic disorder which affects about twelve million people in the United States. FM is characterized by chronic widespread pain, fatigue, aching, joint stiffness, depression, cognitive dysfunction and non-restorative sleep. The mechanism of induction of muscle pain and inflammation is not yet clear. In FM there is an increase in reactivity of central neurons with increased sensitivity localized mainly in the CNS...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29684473/improved-cognitive-morning-performance-in-healthy-older-adults-following-blue-enriched-light-exposure-on-the-previous-evening
#5
Karine Scheuermaier, Mirjam Münch, Joseph M Ronda, Jeanne F Duffy
OBJECTIVES: Exposure to light can have acute alerting and circadian phase-shifting effects. This study investigated the effects of evening exposure to blue-enriched polychromatic white (BEL) vs. polychromatic white light (WL) on sleep inertia dissipation the following morning in older adults. METHODS: Ten healthy older adults (average age = 63.3 yrs; 6 F) participated in a 13-day study comprising three baseline days, an initial circadian phase assessment, four days with 2-h evening light exposures, a post light exposure circadian phase assessment and three recovery days...
April 20, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29684315/sleep-disorders-in-patients-with-post-traumatic-stress-disorder
#6
REVIEW
Ali A El-Solh, Usman Riaz, Jasmine Roberts
A growing body of evidence supports a bidirectional relationship between post-traumatic stress disorder (PTSD) and sleep disturbances. Fragmented sleep induced by sleep-related breathing disorders, insomnia, and nightmares impacts recovery and treatment outcomes and worsens PTSD symptoms. Despite recent attention, management of these disorders has been unrewarding in the setting of PTSD. This review summarizes the evidence for empirically supported treatments of these sleep ailments as it relates to PTSD including psychotherapeutic and pharmacologic interventions...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29683714/workplace-incivility-and-employee-sleep-the-role-of-rumination-and-recovery-experiences
#7
Caitlin A Demsky, Charlotte Fritz, Leslie B Hammer, Anne E Black
This study examines the role of negative work rumination and recovery experiences in explaining the association between workplace incivility and employee insomnia symptoms. Drawing on the perseverative cognition model of stress and the effort-recovery model, we hypothesize a moderated mediation model in which workplace incivility is associated with insomnia symptoms via negative work rumination. This indirect effect is proposed to be conditional on employees' reported level of recovery experiences (i.e., psychological detachment from work and relaxation during nonwork time)...
April 23, 2018: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/29683228/relationships-between-self-reported-sleep-quality-components-and-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-following-chemotherapy
#8
Ashley M Henneghan, Patricia Carter, Alexa Stuifbergan, Brennan Parmelee, Shelli Kesler
OBJECTIVE: Links have been made between aspects of sleep quality and cognitive function in breast cancer survivors (BCS), but findings are heterogeneous. The objective of this study is to examine relationships between specific sleep quality components (latency, duration, efficiency, daytime sleepiness, sleep disturbance, use of sleep aids) and cognitive impairment (performance and perceived), and determine which sleep quality components are the most significant contributors to cognitive impairments in BCS 6 months to 10 years post chemotherapy...
April 23, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29683125/factors-associated-with-poor-sleep-in-older-women-diagnosed-with-breast-cancer
#9
Janine Overcash, Alai Tan, Keya Patel, Anne M Noonan
OBJECTIVES: To determine the relationship among gait, grip strength, cognition, depression, pain, and fatigue, and to identify which variables are most predictive of poor sleep. SAMPLE & SETTING: 60 women with breast cancer aged 69 years or older who were receiving treatment in the Senior Adult Oncology Program at the James Cancer Hospital at the Ohio State University. METHODS & VARIABLES: The variables were gait and grip strength (functional domains), cognition, depression, pain, and fatigue...
May 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29682871/the-effects-of-anticipating-a-high-stress-task-on-sleep-and-performance-during-simulated-on-call-work
#10
Madeline Sprajcer, Sarah M Jay, Grace E Vincent, Andrew Vakulin, Leon Lack, Sally A Ferguson
On-call work is used to manage around the clock working requirements in a variety of industries. Often, tasks that must be performed while on-call are highly important, difficult and/or stressful by nature and, as such, may impact the level of anxiety that is experienced by on-call workers. Heightened anxiety is associated with poor sleep, which affects next-day cognitive performance. Twenty-four male participants (20-35 years old) spent an adaptation, a control and two counterbalanced on-call nights in a time-isolated sleep laboratory...
April 22, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29680429/repetitive-thought-is-associated-with-both-subjectively-and-objectively-recorded-polysomnographic-indices-of-disrupted-sleep-in-insomnia-disorder
#11
Andrea Galbiati, Enrico Giora, Simone Sarasso, Marco Zucconi, Luigi Ferini-Strambi
BACKGROUND: Repetitive thought is a hallmark of several psychopathological conditions and in particular a perpetuating and maintaining factor in Insomnia Disorder. Accordingly, one of the primary complaints reported by Insomnia patients is the inability to shut-off or control thoughts. Worry and rumination are the two best-known styles of repetitive thought leading to sleep disturbances. The aim of this study was to investigate the relationship of these two cognitive processes on nocturnal sleep indices objectively recorded by polysomnography...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680427/daytime-sleepiness-driving-performance-reaction-time-and-inhibitory-control-during-sleep-restriction-therapy-for-chronic-insomnia-disorder
#12
Hannah Whittall, Meg Pillion, Michael Gradisar
BACKGROUND: Sleep restriction therapy (SRT) is a largely untested single treatment component of cognitive-behaviour therapy for insomnia. To date, the evidence for contraindications for SRT is limited to very few studies. The present study investigated the objective and subjective daytime consequences during the acute phase of SRT for adults diagnosed with Chronic Insomnia Disorder. METHODS: Sixteen adults (age = 36.3 ± 13.4 yrs, 12 females, 4 males) underwent SRT for their insomnia over a two week period based on recommendations by Miller and colleagues (2014) [6]...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29678977/minimizing-icu-neurological-dysfunction-with-dexmedetomidine-induced-sleep-mindds-protocol-for-a-randomised-double-blind-parallel-arm-placebo-controlled-trial
#13
Kenneth T Shelton, Jason Qu, Federico Bilotta, Emery N Brown, Gaston Cudemus, David A D'Alessandro, Hao Deng, Alan DiBiasio, Jacob A Gitlin, Eunice Y Hahm, Lauren E Hobbs, Timothy T Houle, Reine Ibala, Marco Loggia, Kara J Pavone, Shahzad Shaefi, George Tolis, M Brandon Westover, Oluwaseun Akeju
INTRODUCTION: Delirium, which is prevalent in postcardiac surgical patients, is an acute brain dysfunction characterised by disturbances in attention, awareness and cognition not explained by a pre-existing neurocognitive disorder. The pathophysiology of delirium remains poorly understood. However, basic science and clinical studies suggest that sleep disturbance may be a modifiable risk factor for the development of delirium. Dexmedetomidine is a α-2A adrenergic receptor agonist medication that patterns the activity of various arousal nuclei similar to sleep...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677539/fibromyalgia-and-nutrition-therapeutic-possibilities
#14
REVIEW
Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Jan Aaseth
Fibromyalgia (FM) is a complex chronic condition of unknown etiology, characterized by deep and widespread pain, sleep problems, cognitive impairment, fatigue, and other well-known functional symptoms. Recently, it has been proposed that an imbalance of nutritive components, including essential metal ions and vitamins, might play a critical role in the development of FM. Muscle pain has been associated with deficiencies in amino acids, magnesium, selenium, vitamins B and D, as well as with the harmful effects of heavy metals, such as mercury, cadmium, and lead...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677170/development-of-the-who-environmental-noise-guidelines-for-the-european-region-an-introduction
#15
Dorota Jarosińska, Marie-Ève Héroux, Poonum Wilkhu, James Creswick, Jos Verbeek, Jördis Wothge, Elizabet Paunović
Following the Parma Declaration on Environment and Health adopted at the Fifth Ministerial Conference (2010), the Ministers and representatives of Member States in the WHO European Region requested the World Health Organization (WHO) to develop updated guidelines on environmental noise, and called upon all stakeholders to reduce children's exposure to noise, including that from personal electronic devices. The WHO Environmental Noise Guidelines for the European Region will provide evidence-based policy guidance to Member States on protecting human health from noise originating from transportation (road traffic, railway and aircraft), wind turbine noise, and leisure noise in settings where people spend the majority of their time...
April 20, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29676601/poor-cognitive-inhibition-predicts-rumination-about-insomnia-in-a-clinical-sample
#16
Andrea Ballesio, Cristina Ottaviani, Caterina Lombardo
OBJECTIVE/BACKGROUND: According to the Cognitive Model of Insomnia disorder, rumination about lack of sleep and its diurnal consequences plays a crucial role in maintaining insomnia. Consolidated evidence shows that rumination is related to poor executive functions, which are cognitive control processes impacted by insomnia. Despite this evidence, no studies so far investigated the relationship between executive functions and rumination in individuals with insomnia. The aim of this pilot study was to cover this gap by investigating whether poor executive functions are associated with rumination in a sample of individuals with a diagnosis of insomnia disorder...
April 20, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29674967/no-acute-effects-of-cannabidiol-on-the-sleep-wake-cycle-of-healthy-subjects-a-randomized-double-blind-placebo-controlled-crossover-study
#17
Ila M P Linares, Francisco S Guimaraes, Alan Eckeli, Ana C S Crippa, Antonio W Zuardi, Jose D S Souza, Jaime E Hallak, José A S Crippa
Cannabidiol (CBD) is a component of Cannabis sativa that has a broad spectrum of potential therapeutic effects in neuropsychiatric and other disorders. However, few studies have investigated the possible interference of CBD on the sleep-wake cycle. The aim of the present study was to evaluate the effect of a clinically anxiolytic dose of CBD on the sleep-wake cycle of healthy subjects in a crossover, double-blind design. Twenty-seven healthy volunteers that fulfilled the eligibility criteria were selected and allocated to receive either CBD (300 mg) or placebo in the first night in a double-blind randomized design (one volunteer withdrew from the study)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#18
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29673069/short-term-memory-impairment-in-vestibular-patients-can-arise-independently-of-psychiatric-impairment-fatigue-and-sleeplessness
#19
Laura Smith, David Wilkinson, Mayur Bodani, Rowena Bicknell, S S Surenthiran
Vestibular dysfunction is associated with visual short-term memory impairment; however, it remains unclear if this impairment arises as a direct result of the vestibular dysfunction or is a consequence of comorbid changes in mood, affect, fatigue, and/or sleep. To this end, we assessed the concurrence and interdependence of these comorbidities in 101 individuals recruited from a tertiary balance clinic with a neuro-otological diagnosis. Over fifty per cent of the sample showed reduced visuospatial short-term memory, 60% and 37% exceeded cut-off on the Beck Anxiety and Depression Inventories, respectively, 70% exceeded cut-off on the Fatigue Severity Scale, 44% reported daytime sleepiness on the Epworth Sleepiness Scale, and 78% scored above cut-off on the Pittsburgh Sleep Quality Index...
April 19, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29671707/prediction-of-cognitive-performance-and-subjective-sleepiness-using-a-model-of-arousal-dynamics
#20
Svetlana Postnova, Steven W Lockley, Peter A Robinson
A model of arousal dynamics is applied to predict objective performance and subjective sleepiness measures, including lapses and reaction time on a visual Performance Vigilance Test (vPVT), performance on a mathematical addition task (ADD), and the Karolinska Sleepiness Scale (KSS). The arousal dynamics model is comprised of a physiologically based flip-flop switch between the wake- and sleep-active neuronal populations and a dynamic circadian oscillator, thus allowing prediction of sleep propensity. Published group-level experimental constant routine (CR) and forced desynchrony (FD) data are used to calibrate the model to predict performance and sleepiness...
April 2018: Journal of Biological Rhythms
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