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https://www.readbyqxmd.com/read/28222075/a-pilot-study-of-a-cognitive-behavioral-intervention-for-breast-cancer-survivors
#1
Heather Becker, Ashley M Henneghan, Deborah L Volker, Sabrina Q Mikan
PURPOSE/OBJECTIVES: To test combining a group intervention to build self-efficacy for using compensatory strategies and lifestyle adjustments with brain-training practice to improve cognition.
. DESIGN: A quasiexperimental design.
. SETTING: Texas Oncology, a community oncology practice in Austin.
. SAMPLE: 20 women aged 35-65 years, who had finished chemotherapy at least three months before the study, were within five years of completing all treatment, and had self-reported cognitive concerns...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28219749/behavioral-phenotypes-associated-with-mptp-induction-of-partial-lesions-in-common-marmosets-callithrix-jacchus
#2
Kimberley A Phillips, Corinna N Ross, Jennifer Spross, Catherine J Cheng, Alyssa Izquierdo, K C Biju, Cang Chen, Senlin Li, Suzette D Tardif
Parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. Non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and REM sleep disturbances. As the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor PD symptoms and serve as a testing ground for potential therapeutics...
February 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28218661/exploring-the-effect-of-lactium%C3%A2-and-zizyphus-complex-on-sleep-quality-a-double-blind-randomized-placebo-controlled-trial
#3
Andrew Scholey, Sarah Benson, Amy Gibbs, Naomi Perry, Jerome Sarris, Greg Murray
Acute, non-clinical insomnia is not uncommon. Sufferers commonly turn to short-term use of herbal supplements to alleviate the symptoms. This placebo-controlled, double-blind study investigated the efficacy of LZComplex3 (lactium™, Zizyphus, Humulus lupulus, magnesium and vitamin B6), in otherwise healthy adults with mild insomnia. After a 7-day single-blind placebo run-in, eligible volunteers (n = 171) were randomized (1:1) to receive daily treatment for 2 weeks with LZComplex3 or placebo. Results revealed that sleep quality measured by change in Pittsburgh Sleep Quality Index (PSQI) score improved in both the LZComplex3 and placebo groups...
February 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28217811/-quantitative-evaluation-of-inhibitory-effects-of-epileptic-spikes-on-theta-rhythms-in-the-network-of-hippocampal-ca3-and-entorhinal-cortex-in-patients-with-temporal-lobe-epilepsy
#4
Man-Ling Ge, Jun-Dan Guo, Sheng-Hua Chen, Ji-Chang Zhang, Xiao-Xuan Fu, Yu-Min Chen
Epileptic spike is an indicator of hyper-excitability and hyper-synchrony in the neural networks. The inhibitory effects of spikes on theta rhythms (4-8 Hz) might be helpful to understand the mechanism of epileptic damage on the cognitive functions. To quantitatively evaluate the inhibitory effects of spikes on theta rhythms, intracerebral electroencephalogram (EEG) recordings with both sporadic spikes (SSs) and spike-free transient period between adjacent spikes were selected in 4 patients in the status of rapid eyes movement (REM) sleep with temporal lobe epilepsy (TLE) under the pre-surgical monitoring...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28217760/sleep-in-alzheimer-s-disease-beyond-amyloid
#5
Jerrah Holth, Tirth Patel, David M Holtzman
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years before cognitive decline and may be predictive of dementia. A bidirectional relationship between sleep and amyloid β (Aβ) has been well established with disturbed sleep and increased wakefulness leading to increased Aβ production and decreased Aβ clearance; whereas Aβ deposition is associated with increased wakefulness and sleep disturbances. Aβ fluctuates with the sleep wake cycle and is higher during wakefulness and lower during sleep...
January 2017: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/28216256/kleine-levin-syndrome
#6
REVIEW
Olufunke Afolabi-Brown, Thornton B A Mason
Kleine-Levin syndrome (KLS) is a rare disorder characterized by discrete episodes of hypersomnia associated with cognitive and behavioural abnormalities, as well as normal alertness and function between episodes. The prevalence of KLS may be underestimated as it is often misdiagnosed and managed as another sleep disorder, neurological disorder or psychiatric condition. KLS is more typically seen in adolescence than at other ages, and is more common in males than in females. There are currently neither standard biomarkers nor specific imaging study findings, making the diagnosis of KLS a challenge...
December 23, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28215911/conditions-associated-with-rem-sleep-behaviour-disorder-description-of-a-hospital-series
#7
M J Abenza Abildúa, A Miralles Martinez, F J Arpa Gutiérrez, V Lores Gutiérrez, C Algarra Lucas, C Jimeno Montero, B Sánchez García, M Mata Álvarez-Santullano, C Borrue Fernández, G Cordero Martín, G Gutiérrez Cueto, M D Torrecillas Narváez, I Thuissard Vasallo, A Gómez Aceña
INTRODUCTION: REM sleep behaviour disorder (RBD) is characterised by violent behaviours (screaming, kicking, vivid dreams) during REM sleep. It has a prevalence of 1% to 2% of the general population and is especially frequent in men and the population older than 60. In the last decade, RBD has been suggested to be a prodrome of neurodegenerative disease. We analysed associated neurological diseases and responses to drug treatment in 33 patients with RBD treated in the multidisciplinary sleep disorders unit at Hospital Infanta Sofía...
February 16, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28215272/sleep-related-cognitive-processes-arousal-and-emotion-dysregulation-in-insomnia-disorder-the-role-of-insomnia-specific-rumination
#8
Laura Palagini, Umberto Moretto, Liliana Dell'Osso, Colleen Carney
OBJECTIVE: Insomnia-specific rumination has presented in subjects with insomnia. Research has identified hyperarousal as a key factor, with both trait and state components. It has been shown that emotion dysregulation also plays a role in insomnia. Hence, the aim was to investigate how insomnia rumination is associated with both trait- and state-dependent arousal and emotion dysregulation in insomnia. METHODS: Sixty-eight subjects with insomnia disorder (DSM-5) and 36 good sleepers were evaluated using: Insomnia Severity Index (ISI), Daytime Insomnia Symptom Response Scale (DISRS), Arousal Predisposition Scale (APS), Pre-sleep Arousal Scale (PSAS), and Difficulties in Emotion Regulation Scale (DERS)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215271/effect-of-sleep-extension-on-sluggish-cognitive-tempo-symptoms-and%C3%A2-driving-behavior-in-adolescents-with-chronic-short-sleep
#9
Annie A Garner, Ashley Hansen, Catherine Baxley, Stephen P Becker, Craig A Sidol, Dean W Beebe
OBJECTIVE/BACKGROUND: Few adolescents report obtaining adequate amounts of sleep. Correlational studies have linked adolescent short sleep with driving crashes and sluggish cognitive tempo (SCT), a cluster of symptoms that include sluggishness and low persistence that are related to but distinct from inattention and sleepiness. The relationship between SCT and driving is understudied, and no study has experimentally examined the relationship between SCT and sleep. We examined the relationship between SCT and driving problems in a sample of chronically short-sleeping adolescents...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215255/performance-characteristics-of-the-french-version-of-the-severity-hierarchy-score-for-paediatric-sleep-apnoea-screening-in-clinical-settings
#10
Xuân-Lan Nguyên, Pierre Lévy, Nicole Beydon, David Gozal, Bernard Fleury
BACKGROUND: Paediatric obstructive sleep apnoea syndrome (OSAS) is a highly prevalent condition carrying increased risk for impaired cognitive and cardiovascular function. The standard diagnosis consists of full-night polysomnography (PSG), but limited access to PSG leads to substantial under-diagnosis. The use of a validated and simple diagnostic screening tool to predict OSAS could prioritise night sleep recordings in children at risk of OSAS, and help in clinical decision-making. OBJECTIVE: This study aimed to prospectively assess the performance of the French version of the severity hierarchy score (SHS) in paediatric OSAS...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215253/early-features-associated-with-the-neurocognitive-development-at-36-months-of-age-the-aube-study
#11
Sabine Plancoulaine, Camille Stagnara, Sophie Flori, Flora Bat-Pitault, Jian-Sheng Lin, Hugues Patural, Patricia Franco
BACKGROUND: Few studies on the relations between sleep quantity and/or quality and cognition have been conducted among preschoolers from healthy general population. We aimed at identifying, among 36 months old children, early factors associated with intelligence quotient (IQ) estimated through the Weschler Preschool and Primary Scale Intelligence-III test and its indicators: Full-Scale-, Verbal- and Performance-IQs and their subscale scores. METHODS: We included 194 children from the French birth cohort AuBE with both available Weschler Preschool and Primary Scale Intelligence-III scores at three years and sleep data...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215244/driving-home-from-the-night-shift-a-bright-light-intervention-study
#12
Denise M Weisgerber, Maria Nikol, Ralph E Mistlberger
: Sleep deprivation (SD) impairs vigilance and increases the risk of driving accidents during the commute home after night work. Bright light (BL) can enhance alertness and cognitive performance. We examined the effects of BL (5600 lux) versus dim light (DL, 35 lux) at the end of a night awake on driving performance. METHODS: Subjects (N = 19, 22.8 ± 4 ya) completed three conditions, counterbalanced for order at >1 week intervals. The two overnight SD conditions began in the lab at usual bedtime...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215233/task-switching-in-older-adults-with-and-without-insomnia
#13
Kristine A Wilckens, Martica H Hall, Kirk I Erickson, Anne Germain, Vishwajit L Nimgaonkar, Timothy H Monk, Daniel J Buysse
BACKGROUND: Task-switching deficits are common in older adults and in those with insomnia. Such deficits may be driven by difficulties with sleep continuity and dampened homeostatic sleep drive. OBJECTIVE: To identify the aspects of task switching affected by insomnia and its treatment, and to determine whether such effects are associated with sleep continuity and homeostatic sleep drive. METHODS: Polysomnographic sleep and task switching were tested in healthy older adults aged 60-93 years with insomnia (n = 48) and normal sleeping controls (n = 51)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28213988/-contribution-of-mindfulness-meditation-in-cognitive-behavioral-therapy-for-insomnia
#14
H Vanhuffel, M Rey, I Lambert, D Da Fonseca, F Bat-Pitault
INTRODUCTION: Insomnia is considered to be a serious public health issue affecting approximately 10% of adults. Chronic insomnia may increase the risk of health problem, psychological vulnerability and proneness to accidents. Cognitive behavioral therapy for insomnia (CBT-I) is recommended as the first line of treatment. Even though CBT-I is widely considered as an effective therapy, 20 to 30% of patients do not respond to this treatment. Mindfulness therapy, known to reduce rumination and stress, could be an interesting complement to enhance CBT-I...
February 14, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28210999/computational-cognitive-modeling-of-the-temporal-dynamics-of-fatigue-from-sleep-loss
#15
Matthew M Walsh, Glenn Gunzelmann, Hans P A Van Dongen
Computational models have become common tools in psychology. They provide quantitative instantiations of theories that seek to explain the functioning of the human mind. In this paper, we focus on identifying deep theoretical similarities between two very different models. Both models are concerned with how fatigue from sleep loss impacts cognitive processing. The first is based on the diffusion model and posits that fatigue decreases the drift rate of the diffusion process. The second is based on the Adaptive Control of Thought - Rational (ACT-R) cognitive architecture and posits that fatigue decreases the utility of candidate actions leading to microlapses in cognitive processing...
February 16, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28207494/causes-and-consequences-of-fatigue-in-rheumatoid-arthritis
#16
Patricia Katz
PURPOSE OF REVIEW: To review current information on the causes, treatments, and consequences of fatigue in rheumatoid arthritis. RECENT FINDINGS: Disease activity (inflammation, pain, joint symptoms) is associated with greater fatigue. However, disease activity per se accounts for only a small portion of fatigue, and rheumatoid arthritis medications that reduce disease activity have small effects on fatigue. Instead, factors outside the direct effects of rheumatoid arthritis, such as obesity, physical inactivity, sleep disturbance, and depression, explain the majority of variation in fatigue...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28202373/is-fatigue-associated-with-cognitive-dysfunction-in-early-parkinson-s-disease
#17
Benzi M Kluger, Kenn Freddy Pedersen, Ole-Bjorn Tysnes, Solgunn O Ongre, Bjørg Øygarden, Karen Herlofson
INTRODUCTION: Fatigue is a common and disabling symptom which may be seen in early Parkinson's disease (PD). Our understanding of the phenomenology and etiology of fatigue in PD is limited. The objective of this study was to determine whether fatigue was related to cognition in early PD patients. METHODS: The study is part of the Norwegian ParkWest project, a population-based cohort study, comprising 184 de novo, drug-naïve patients with PD. PD was diagnosed according to the Gelb criteria...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28199892/a-prognostic-index-pi-as-a-moderator-of-outcomes-in-the-treatment-of-depression-a-proof-of-concept-combining-multiple-variables-to-inform-risk-stratified-stepped-care-models
#18
Lorenzo Lorenzo-Luaces, Robert J DeRubeis, Annemieke van Straten, Bea Tiemens
BACKGROUND: Prognostic indices (PIs) combining variables to predict future depression risk may help guide the selection of treatments that differ in intensity. We develop a PI and show its promise in guiding treatment decisions between treatment as usual (TAU), treatment starting with a low-intensity treatment (brief therapy (BT)), or treatment starting with a high-intensity treatment intervention (cognitive-behavioral therapy (CBT)). METHODS: We utilized data from depressed patients (N=622) who participated in a randomized comparison of TAU, BT, and CBT in which no statistically significant differences in the primary outcomes emerged between the three treatments...
February 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28193195/assessing-the-burden-of-treatment-emergent-adverse-events-associated-with-atypical-antipsychotic-medications
#19
Pierre-Michel Llorca, Christophe Lançon, Ann Hartry, T Michelle Brown, Dana B DiBenedetti, Siddhesh A Kamat, Clément François
BACKGROUND: Treatment of schizophrenia and major depressive disorder (MDD) with atypical antipsychotics (AAPs) show improved efficacy and reduced side effect burden compared with older antipsychotic medications. However, a risk of treatment-emergent adverse events (TEAEs) remains. TEAEs are hard to quantify and perspectives on the importance of TEAEs differ across patients and between patients and physicians. The current study is a qualitative assessment that investigates TEAEs of AAPs from both patient and physician perspectives to provide better understanding of the occurrence and burden of TEAEs associated with these medications...
February 13, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28190430/delirium-in-critically-ill-patients
#20
A J C Slooter, R R Van De Leur, I J Zaal
Delirium is common in critically ill patients and associated with increased length of stay in the intensive care unit (ICU) and long-term cognitive impairment. The pathophysiology of delirium has been explained by neuroinflammation, an aberrant stress response, neurotransmitter imbalances, and neuronal network alterations. Delirium develops mostly in vulnerable patients (e.g., elderly and cognitively impaired) in the throes of a critical illness. Delirium is by definition due to an underlying condition and can be identified at ICU admission using prediction models...
2017: Handbook of Clinical Neurology
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