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Dementia farmaco

Fiorenzo Mignini, Maurizio Sabbatini, Chiara Pascucci, Fabio Petrelli, Iolanda Grappasonni, Nicola Vanacore
BACKGROUND: In Italy, even though olanzapine has been discouraged for treatment of behaviour disorders in older patients affected by dementia, some physicians chose to prescribe for them. In response to this situation, the Italian Drug Agency (Agenzia Italiana del Farmaco, AIFA) promulgated a cautionary note. MATERIALS AND METHODS: This study examined epidemiological indices for olanzapine prescriptions between 2004 and 2007 in the Marche Region of central Italy and in its provinces, to assess physician compliance with the AIFA note, and to determine whether there were differences in drug prescription between populations of the same territory, or differences based on gender or age group...
2013: Annali Dell'Istituto Superiore di Sanità
Javier Gómez-Pavón, Paloma González García, Inés Francés Román, Maite Vidán Astiz, José Gutiérrez Rodríguez, Gregorio Jiménez Díaz, Nuria Pilar Montero Fernández, Baldomero Alvarez Fernández, José María Jiménez Páez
The elderly are one of the groups at greatest risk for adverse drugs reactions (ADR). The mean prevalence of these reactions in this population is 30%. Dementia is not an independent risk factor of ADR, but is the main condition that increases all risk factors (polypharmacy, comorbidity, inappropriate prescribing, drug-drug interactions, advanced age, and treatment adherence). The present article discusses revised and consensual recommendations for the prevention of ADR in the elderly, as well as recommendations specifically for dementia patients in relation to the management of comorbidity and cognitive, behavioral and psychological symptoms...
March 2010: Revista Española de Geriatría y Gerontología
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