Rodolfo B Serafim, Cibele Cardoso, Camila B Storti, Patrick da Silva, Hongyun Qi, Ramya Parasuram, Geovana Navegante, Jean Pierre S Peron, Wilson A Silva, Enilza M Espreafico, Maria L Paçó-Larson, Brendan D Price, Valeria Valente
HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the association of HJURP with cancer aggressiveness is not well understood. HJURP promotes the loading of the histone H3 variant, CENP-A, at the centromeric chromatin, epigenetically defining the centromeres and supporting proper chromosome segregation. In addition, HJURP is associated with DNA repair but its function in this process is still scarcely explored. Here, we demonstrate that HJURP is recruited to DSBs through a mechanism requiring chromatin PARylation and promotes epigenetic alterations that favor the execution of DNA repair...
January 26, 2024: Oncogene