keyword
https://read.qxmd.com/read/38536568/integration-of-single-cell-and-bulk-rna-seq-data-to-identify-the-cancer-associated-fibroblast-subtypes-and-risk-model-in-glioma
#21
JOURNAL ARTICLE
Xiuwei Yan, Xin Gao, Jiawei Dong, Fang Wang, Xiaoyan Jiang, Xueyan Hu, Jiheng Zhang, Nan Wang, Lei Xu, Zhihui Liu, Shaoshan Hu, Hongtao Zhao
Cancer-associated fibroblasts (CAFs) are an important component of the stroma. Studies showed that CAFs were pivotally in glioma progression which have long been considered a promising therapeutic target. Therefore, the identification of prognostic CAF markers might facilitate the development of novel diagnostic and therapeutic approaches. A total of 1333 glioma samples were obtained from the TCGA and CGGA datasets. The EPIC, MCP-counter, and xCell algorithms were used to evaluate the relative proportion of CAFs in glioma...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536567/mir-374a-b-5p-suppresses-cell-growth-in-papillary-thyroid-carcinoma-through-blocking-exosomal-anxa1-induced-macrophage-m2-polarization
#22
JOURNAL ARTICLE
Sanbao Liu
Papillary thyroid carcinoma (PTC), comprising 85% of all thyroid cancers, is an epithelial malignancy. The potential for malignant transformation in normal cells by thyroid cancer cells via exosomal Annexin A1 (ANXA1) delivery is investigated in this study. Our aim is to determine the impact of PTC cells on macrophage polarization through exosomal ANXA1 secretion and its implications for tumor progression. Exosomes in PTC cells were examined using transmission electron microscopy, exosome labeling, and nanoparticle tracking analysis...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536538/competing-endogenous-rnas-crosstalk-in-hippocampus-a-potential-mechanism-for-neuronal-developing-defects-in-down-syndrome
#23
JOURNAL ARTICLE
Huiru Zhao, Guiyu Lou, Yupu Shao, Tao Wang, Hongdan Wang, Qiannan Guo, Wenke Yang, Hongyan Liu, Shixiu Liao
Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy of all or part of chromosome 21. Competing endogenous RNAs (ceRNAs) play important roles in neuronal development and neurological defects. This study aimed to identify hub genes and synergistic crosstalk among ceRNAs in the DS fetal hippocampus as potential targets for the treatment of DS-related neurodegenerative diseases. We profiled differentially expressed long non-coding RNAs (DElncRNAs), differentially expressed circular RNAs (DEcircRNAs), differentially expressed microRNAs (DEmiRNAs), and differentially expressed messenger RNAs (DEmRNAs) in hippocampal samples from patients with or without DS...
March 27, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38536520/expression-profile-of-circulating-exosomal-micrornas-in-leukoplakia-oral-submucous-fibrosis-and-combined-lesions-of-leukoplakia-and-oral-submucous-fibrosis
#24
JOURNAL ARTICLE
Dinesh Yasothkumar, Pratibha Ramani, Selvaraj Jayaraman, Karthikeyan Ramalingam, W M Tilakaratne
OBJECTIVES: This study aims to elucidate the expression of circulating exosomal miRNAs miRNA 21, miRNA 184, and miRNA 145 in the studied groups, including patients with (i) leukoplakia; (ii) oral submucous fibrosis; (iii) oral submucous fibrosis with leukoplakia; (iv) oral squamous cell carcinoma; and (v) healthy individuals. STUDY DESIGN: An observational study was conducted among 54 patients who reported to the outpatient department of Saveetha Dental College and Hospitals...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536507/oxaloacetate-as-new-inducer-for-osteogenic-differentiation-of-human-adipose-tissue-derived-mesenchymal-stem-cells-in-vitro
#25
JOURNAL ARTICLE
Fatemeh Jamali Shirkoohi, Marzieh Ghollasi, Raheleh Halabian, Elahe Eftekhari, Mohsen Ghiasi
BACKGROUND: Mitochondrial organelles play a crucial role in cellular metabolism so different cell types exhibit diverse metabolic and energy demands. Therefore, alternations in the intracellular distribution, quantity, function, and structure of mitochondria are required for stem cell differentiation. Finding an effective inducer capable of modulating mitochondrial activity is critical for the differentiation of specific stem cells into osteo-like cells for addressing issues related to osteogenic disorders...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536498/effect-of-vitamin-d3-supplementation-on-blood-parameters-and-liver-gene-expression-in-female-rats
#26
JOURNAL ARTICLE
Maria Oczkowicz, Beata Szymczyk, Małgorzata Świątkiewicz, Alicja Wierzbicka, Anna Steg, Tomasz Szmatoła
BACKGROUND: To better understand the molecular mechanism responsible for the therapeutic potential of vitamin D, we conducted an analysis of the liver transcriptomes of adult female rats. METHODS: Adult female rats (n = 18) were divided into three groups, receiving different doses of vitamin D: group I, 0; group II, 1000 U/kg; and group III, 5000 U/kg. Growth, body weight, the weight of main organs, blood haematological and biochemical parameters were evaluated...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536487/peripheral-blood-syndecan-1-levels-after-mechanical-thrombectomy-can-predict-the-clinical-prognosis-of-patients-with-acute-ischemic-stroke
#27
JOURNAL ARTICLE
Bin Xu, Tengkun Yin, Tanggui Sun, Zhongchen Li, Zhiyuan Zhang, Hang Lv, Chonghui Tian, Jiyue Wang, Jiheng Hao, Liyong Zhang
BACKGROUND: Previously, we revealed noticeable dynamic fluctuations in syndecan-1 levels in the peripheral blood of post-stroke patients. We further investigated the clinical prognostic value of syndecan-1 as a biomarker of glycoprotein damage in patients with acute ischaemic stroke (AIS). METHODS: We examined 105 patients with acute large vessel occlusion in the anterior circulation, all of whom underwent mechanical thrombectomy (MT). Peripheral blood syndecan-1 levels were measured 1 day after MT, and patients were categorised into favourable and unfavourable prognostic groups based on the 90-day modified Rankin Scale (mRS) score...
March 27, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38536483/cacna2d1-regulates-the-progression-and-influences-the-microenvironment-of-colon-cancer
#28
JOURNAL ARTICLE
Hiroyuki Inoue, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Yoshiaki Kuriu, Takeshi Kubota, Hitoshi Fujiwara, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
BACKGROUND: Calcium voltage-gated channel auxiliary subunit alpha 2/delta 1 (CACNA2D1), a gene encoding a voltage-gated calcium channel, has been reported as an oncogene in several cancers. However, its role in colon cancer (CC) remains unclear. This study aimed to investigate the function of CACNA2D1 and its effect on the microenvironment in CC. METHODS: Immunohistochemistry (IHC) analysis was performed on samples collected from 200 patients with CC who underwent curative colectomy...
March 27, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38536457/sbys1-and-sbwrky72-regulate-cd-tolerance-and-accumulation-in-sweet-sorghum
#29
JOURNAL ARTICLE
Weitao Jia, Zijing Guo, Sulian Lv, Kangqi Lin, Yinxin Li
SbYS1 and its upstream transcription factor SbWRKY72 were involved in Cd tolerance and accumulation and are valuable for developing sweet sorghum germplasm with high-Cd tolerance or accumulation ability through genetic manipulation. Cadmium (Cd) is highly toxic and can severely affect human health. Sweet sorghum, as an energy crop, shows great potential in extracting cadmium from Cd-contaminated soils. However, its molecular mechanisms of Cd-tolerance and -accumulation remain largely unknown. Here, we isolated a YSL family gene SbYS1 from the sweet sorghum genotype with high Cd accumulation ability and the expression of SbYS1 in roots was induced by cadmium...
March 27, 2024: Planta
https://read.qxmd.com/read/38536434/the-analysis-of-boric-acid-effect-on-epithelial-mesenchymal-transition-of-cd133%C3%A2-%C3%A2-cd117%C3%A2-%C3%A2-lung-cancer-stem-cells
#30
JOURNAL ARTICLE
Tuğba Semerci Sevimli, Murat Sevimli, Aynaz Ghorbani, Varol Şahintürk, Emilia Qomi Ekenel, Tuğba Ertem, Bahar Demir Cevizlidere, Burcugül Altuğ, Özlem Tomsuk, Onur Uysal, Sibel Güneş Bağış, Hüseyin Avci, Fatih Çemrek, Zarifa Ahmadova
Targeting lung cancer stem cells (LC-SCs) for metastasis may be an effective strategy against lung cancer. This study is the first on epithelial-mesenchymal transition (EMT) properties of boric acid (BA) in LC-SCs. LC-SCs were isolated using the magnetic cell sorting (MACS) method. Tumor-sphere formation and flow cytometry confirmed CSC phenotype. The cytotoxic effect of BA was measured by MTT analysis, and the effect of BA on EMT was examined by migration analysis. The expression levels of ZEB1, SNAIL1, ITGA5, CDH1, ITGB1, VIM, COL1A1, and LAMA5 genes were analyzed by RT-qPCR...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38536404/curcumin-mitigates-ochratoxin-a-induced-oxidative-stress-and-alters-gene-expression-in%C3%A2-broiler-chicken-liver-and-kidney
#31
JOURNAL ARTICLE
Benjámin Kövesi, Adanu Paul Worlanyo, Szabina Kulcsár, Zsolt Ancsin, Márta Erdélyi, Erika Zándoki, Miklós Mézes, Krisztián Balogh
The study aimed to evaluate the effect of curcumin (CURC) supplementation on broiler chickens exposed to ochratoxin A (OTA), by examining biochemical parameters and the expression of glutathione redox system genes and their regulation. OTA reduced glutathione content in the liver while increasing glutathione peroxidase activity. CURC showed no significant effects. Kidney parameters remained mostly unaffected. Gene expression analysis revealed OTA-induced upregulation of KEAP1, NRF2, AHR, GPx4 and GSR genes in the liver...
March 26, 2024: Acta Veterinaria Hungarica
https://read.qxmd.com/read/38536233/integrative-methylome-and-transcriptome-analysis-reveals-epigenetic-regulation-of-fusobacterium-nucleatum-in-laryngeal-cancer
#32
JOURNAL ARTICLE
Xiaohui Yuan, Hui-Ching Lau, Huiying Huang, Chi-Yao Hsueh, Hongli Gong, Liang Zhou
The aetiological mechanisms of Fusobacterium nucleatum in laryngeal cancer remain unclear. This study aimed to reveal the epigenetic signature induced by F. nucleatum in laryngeal squamous cell carcinoma (LSCC). Combined analysis of methylome and transcriptome data was performed to address the functional role of F. nucleatum in laryngeal cancer. Twenty-nine differentially expressed methylation-driven genes were identified by mapping the methylation levels of significant differential methylation sites to the expression levels of related genes...
March 2024: Microbial Genomics
https://read.qxmd.com/read/38536214/health-behavior-change-intervention-preferences-expressed-by-american-indian-cancer-survivors-from-a-southwest-tribal-community-semistructured-interview-study
#33
JOURNAL ARTICLE
Jennifer Erdrich, Felina M Cordova-Marks, William O Carson, Jennifer W Bea, William R Montfort, Cynthia A Thomson
BACKGROUND: While many factors, including social determinants of health, affect cancer mortality, one modifiable risk factor that may contribute to cancer disparities is obesity. The prevalence of obesity in the American Indian/Alaska Native population is 48.1% per the Centers for Disease Control and Prevention. The overall cancer mortality for the American Indian/Alaska Native population is 18% higher than the White population as reported by the American Cancer Society. Interventions tailored to American Indian/Alaska Native communities that promote healthy lifestyle behaviors after cancer diagnosis and prior to cancer surgery (prehab) might improve cancer outcomes for this population...
March 27, 2024: JMIR Formative Research
https://read.qxmd.com/read/38536175/physical-activity-and-incident-obesity-across-the-spectrum-of-genetic-risk-for-obesity
#34
JOURNAL ARTICLE
Evan L Brittain, Lide Han, Jeffrey Annis, Hiral Master, Andrew Hughes, Dan M Roden, Paul A Harris, Douglas M Ruderfer
IMPORTANCE: Despite consistent public health recommendations, obesity rates in the US continue to increase. Physical activity recommendations do not account for individual genetic variability, increasing risk of obesity. OBJECTIVE: To use activity, clinical, and genetic data from the All of Us Research Program (AoURP) to explore the association of genetic risk of higher body mass index (BMI) with the level of physical activity needed to reduce incident obesity. DESIGN, SETTING, AND PARTICIPANTS: In this US population-based retrospective cohort study, participants were enrolled in the AoURP between May 1, 2018, and July 1, 2022...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38536089/cloning-and-functional-mechanism-of-the-dwarf-gene-gba-affecting-stem-elongation-and-cellulose-biosynthesis-in-jute-corchorus-olitorius
#35
JOURNAL ARTICLE
Qin Li, Siyuan Chen, Lu Chen, Lingling Zhuang, Huawei Wei, Shaolian Jiang, Chuanyu Wang, Jianmin Qi, Pingping Fang, Jiantang Xu, Aifen Tao, Liwu Zhang
Plant height (PH) is an important factor affecting bast fiber yield in jute. Here, we report the mechanism of dwarfism in the 'Guangbaai' (gba) of jute. The mutant gba had shorter internode length and cell length compared to the standard cultivar 'TaiZi 4' (TZ4). Exogenous GA3 treatment indicated that gba is a GA-insensitive dwarf mutant. Quantitative trait locus (QTL) analysis of three PH-related traits via a high-density genetic linkage map according to re-seq showed that a total of 25 QTLs were identified, including 13 QTLs for PH, with phenotypic variation explained ranging from 2...
March 27, 2024: Plant Journal
https://read.qxmd.com/read/38536023/tim3-and-ctla4-immune-checkpoint-polymorphisms-are-associated-with-acute-myeloid-leukemia-in-saudi-arabia
#36
JOURNAL ARTICLE
Mashael Alqahtani, Ali Aljuaimlani, Jameel Al-Tamimi, Suliman Alomar, Lamjed Mansour
BACKGROUND: Immune checkpoints are receptors on the surface of T cells that function crucially in suppressing the immune response, and they are implicated in autoimmunity and cancer diseases. AIM: The present study aimed to investigate the relationship between functional single nucleotide polymorphisms (SNPs) of two immune checkpoint molecules, CTLA-4 and TIM-3, and acute myeloid leukemia (AML) in a Saudi population. METHODS: Two SNPs in CTLA-4 (rs231775, A > G) and TIM-3 (rs10515746, A > C) were genotyped in 229 subjects, including 98 patients and 131 healthy controls, from the Saudi population using TaqMan assay methods...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38536020/exploration-of-signature-based-on-t-cell-related-genes-in-stomach-adenocarcinoma-by-analysis-of-single-cell-sequencing-data
#37
JOURNAL ARTICLE
Huimei Wang, Nan An, Aiyue Pei, Yongxiao Sun, Shuo Li, Si Chen, Nan Zhang
BACKGROUND: Gastric cancer (GC) is a leading reason for the death of cancer around the world. The immune microenvironment counts a great deal in immunotherapy of advanced tumors, in which T cells exert an indispensable function. METHODS: Single-cell RNA sequencing data were utilized to characterize the expression profile of T cells, followed by T cell-related genes (TCRGs) to construct signature and measure differences in survival time, enrichment pathways, somatic mutation status, immune status, and immunotherapy between groups...
March 25, 2024: Aging
https://read.qxmd.com/read/38536018/identification-and-validation-of-the-biomarkers-related-to-ferroptosis-in-calcium-oxalate-nephrolithiasis
#38
JOURNAL ARTICLE
Chao Hou, Bing Zhong, Shuo Gu, Yunyan Wang, Lu Ji
Ferroptosis is a specific type of programmed cell death characterized by iron-dependent lipid peroxidation. Understanding the involvement of ferroptosis in calcium oxalate (CaOx) stone formation may reveal potential targets for this condition. The publicly available dataset GSE73680 was used to identify 61 differentially expressed ferroptosis-related genes (DEFERGs) between normal kidney tissues and Randall's plaques (RPs) from patients with nephrolithiasis through employing weighted gene co-expression network analysis (WGCNA)...
March 25, 2024: Aging
https://read.qxmd.com/read/38536014/novel-insights-into-the-pathogenesis-of-thyroid-eye-disease-through-ferroptosis-related-gene-signature-and-immune-infiltration-analysis
#39
JOURNAL ARTICLE
Yunyan Ye, Lei Dai, Joseph Mugaanyi, Weina Fu, Feng Hu
Thyroid eye disease (TED) has brought great physical and mental trauma to patients worldwide. Although a few potential signaling pathways have been reported, knowledge of TED remains limited. Our objective is to explore the fundamental mechanism of TED and identify potential therapeutic targets using diverse approaches. To perform a range of bioinformatic analyses, such as identifying differentially expressed genes (DEGs), conducting enrichment analysis, establishing nomograms, analyzing weighted gene correlation network analysis (WGCNA), and studying immune infiltration, the datasets GSE58331, GSE105149, and GSE9340 were integrated...
March 25, 2024: Aging
https://read.qxmd.com/read/38535990/rna-splicing-regulator-eif3d-regulates-the-tumor-microenvironment-through-immunogene-related-alternative-splicing-in-head-and-neck-squamous-cell-carcinoma
#40
JOURNAL ARTICLE
Dandan Lu, Mijti Mihoayi, Yimin Ablikim, Abdeyrim Arikin
Study finds that eukaryotic translation initiation factor 3 subunit D (EIF3D) may play an important role in aberrant alternative splicing (AS) events in tumors. AS possesses a pivotal role in both tumour progression and the constitution of the tumour microenvironment (TME). Regrettably, our current understanding of AS remains circumscribed especially in the context of immunogene-related alternative splicing (IGAS) profiles within Head and Neck Squamous Cell Carcinoma (HNSC). In this study, we comprehensively analyzed the function and mechanism of action of EIF3D by bioinformatics analysis combined with in vitro cellular experiments, and found that high expression of EIF3D in HNSC was associated with poor prognosis of overall survival (OS) and progression-free survival (PFS)...
March 25, 2024: Aging
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