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https://www.readbyqxmd.com/read/28734986/exogenous-hedgehog-antagonist-delays-but-does-not-prevent-fracture-healing-in-young-mice
#1
Xiaochen Liu, Jennifer A McKenzie, Clayton W Maschhoff, Michael J Gardner, Matthew J Silva
Fracture healing recapitulates many aspects of developmental osteogenesis. The hedgehog (Hh) signaling pathway, essential to skeletal development, is upregulated during fracture healing, although its importance is unclear. Our goal was to assess the functional importance of Hh signaling in endochondral fracture healing. We created closed, transverse diaphyseal femur fractures in mice, stabilized with an intramedullary pin, and administered a systemic Hh inhibitor or vehicle. Because Hh pathway activation is mediated by the receptor Smoothened (Smo), we used the Smo antagonist GDC-0449 (GDC, 50mg/kg, twice daily) to target the pathway...
July 19, 2017: Bone
https://www.readbyqxmd.com/read/28715039/erratum-to-computed-tomographic-evaluation-of-femoral-and-tibial-conformation-in-english-staffordshire-bull-terriers-with-and-without-congenital-medial-patellar-luxation
#2
Mark Newman, Katja Voss
OBJECTIVE: To compare hindlimb conformation of English Staffordshire Bull Terriers with and without medial patellar luxation using computed tomography. METHODS: Hindlimb computed tomography (CT) was performed on six English Staffordshire Bull Terriers with grade II or III medial patellar luxation, and six without medial patellar luxation. Inclination angle, femoral condyle trochanteric angle, anteversion angle (AA), distal anteversion angle (DAA), proximal anteversion angle (PAA), femoral varus angle (FVA), tibial valgus angle (TVA), and tibial torsion angle (TTA) were measured...
July 10, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28668738/correlation-of-the-torsion-values-measured-by-rotational-profile-kinematics-and-ct-study-in-cp-patients
#3
Ha Yong Kim, Yong Han Cha, Young Sub Chun, Hyuck Soo Shin
BACKGROUND: The purpose of study was to analyze correlations between bony torsions measured by Staheli's rotation profile, computed tomography (CT) torsional study, and gait analysis in patients with cerebral palsy (CP). MATERIALS & METHOD: The study group comprised of 26 children with CP (spastic diplegia, Gross Motor Function Classification System (GMFCS) 1-2, mean age 12.6 years) with torsional deformities. All subjects were assessed by examining: 1) rotational profile [internal rotation (IR) and external rotation (ER)], 2) CT torsional profile [femoral anteversion (FAV) and tibial torsion (TT)], and 3) gait analysis [mean hip rotation (HR) and mean knee rotation (KR)]...
June 22, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28646823/does-the-surgical-correction-of-tibial-torsion-with-genu-varum-produce-outcomes-similar-to-those-in-varus-correction-alone
#4
Austin T Fragomen, Matthew Meade, Eugene Borst, Joseph Nguyen, S Robert Rozbruch
No abstract text is available yet for this article.
June 24, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28636055/effect-of-headless-compression-screw-on-construct-stability-for-centre-of-rotation-and-angulation-based-levelling-osteotomy-biomechanical-testing-in-flexion-and-torsion
#5
Michelle R Meyer, Mireya A Perez, Mohammad S Hossain, Edward B Silverman, Randall B Fitch, Ryan B Wicker
OBJECTIVE: To compare the biomechanical properties of bone and implant constructs when used for the centre of rotation and angulation (CORA) based levelling osteotomy, with and without implantation of a trans-osteotomy headless compression screw tested under three-point flexural and torsional forces; thereby determining the contribution of a trans-osteotomy headless compression screw with regards to stability of the construct. METHODS: Experimental biomechanical study utilizing 12 pairs of cadaveric canine tibias...
June 21, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28533596/the-ratio-of-medial-and-lateral-hamstring-muscle-thickness-does-not-correlate-with-the-lateral-tibial-rotation-angle-in-the-standing-position-in-healthy-young-adults
#6
Dong-Soo Lee, Sung-Dae Choung, Seung-Won Lee, Hye Rim Suh, Jae-Hoon Shim
[Purpose] To investigate the relationship between the lateral tibial rotation angle during knee joint flexion and the medial and lateral hamstring muscle thickness ratio during knee joint extension while resting, doing nothing, in upright standing position. The lateral tibial torsion is an important factor of orthopedic knee joint diseases as well as other weight bearing joint diseases such as osteoarthritis, meniscus syndrome, anterior cruciate ligament rupture, etc. [Subjects and Methods] Thirty healthy young adults participated in this study...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28474728/pelvic-limb-alignment-measured-by-computed-tomography-in-purebred-english-bulldogs-with-medial-patellar-luxation
#7
Filippo Lusetti, Andrea Bonardi, Chadi Eid, Anna Brandstetter de Belesini, Filippo Maria Martini
OBJECTIVES: The aim of the study was to describe the differences in pelvic limb alignment between healthy purebred English Bulldogs and those with medial patellar luxation through the measurement of femoral and tibial angles on computed tomography images in multiplanar reconstruction modality (MPR-CT). METHODS: Twenty-one purebred English Bulldogs were included and divided into two groups: one including healthy dogs (15 limbs) and the other including those with medial patellar luxation (24 limbs)...
May 10, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28471818/spectrum-of-diagnosis-and-disposition-of-patients-referred-to-a-pediatric-orthopaedic-center-for-a-diagnosis-of-intoeing
#8
Shawne Faulks, Kaitlyn Brown, John G Birch
BACKGROUND: Orthopaedic surgeons frequently evaluate otherwise healthy children for concern of intoed gait. Intoeing in otherwise healthy young children due to metatarsus adductus, internal tibial torsion, and increased femoral anteversion do not typically require orthopaedic treatment. This study reviewed the actual diagnosis, management, and disposition of patients referred to a pediatric orthopaedic specialty hospital for a diagnosis of intoeing; the efficacy of an Advanced Practice Provider (APP) assessment program to screen and triage patients with a primary complaint of intoeing; and parental satisfaction with that program...
May 3, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28470694/a-comparison-of-three-methods-of-measuring-tibial-torsion-in-children-with-myelomeningocele-and-normally-developing-children
#9
Cassie N Borish, Nicole M Mueske, Tishya A L Wren
Abnormal tibial torsion is a common pediatric problem, and there are many existing measurement methods. The purpose of this study was to compare three methods of measuring tibial torsion for its evaluation: computed tomography, physical examination, and motion capture. Twenty healthy children and 20 children with myelomeningocele underwent measures of tibial torsion bilaterally. Measurements were compared using correlation and Bland-Altman plots of the difference between measurements. All three measurements were moderately correlated in controls (r ≥ 0...
May 3, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28467582/minimal-invasive-fixation-of-distal-tibial-fractures-does-not-result-in-rotational-malalignment-a-report-of-24-cases-with-ct-imaging
#10
Mehmet Mesut Sönmez, Deniz Gülabi, Meriç Uğurlar, Metin Uzun, Sezgin Sarban, Ali Şeker
BACKGROUND: Tibial torsion is rotation of the proximal versus the distal articular axis in the transverse plane. This study used computed tomography (CT) to examine rotational malalignment in the crus following use of minimally invasive plate osteosynthesis (MIPO) technique in distal tibial fractures and evaluated effect of rotational difference on clinical outcomes and VAS scores. METHODS: Analysis of 24 patients who were operated on for closed distal tibial fracture with MIPO technique between 2010 and 2012 was conducted...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28331928/computed-tomographic-evaluation-of-femoral-and-tibial-conformation-in-english-staffordshire-bull-terriers-with-and-without-congenital-medial-patellar-luxation
#11
Mark Newman, Katja Voss
OBJECTIVE: To compare hindlimb conformation of English Staffordshire Bull Terriers with and without medial patellar luxation using computed tomography. METHODS: Hindlimb computed tomography (CT) was performed on six English Staffordshire Bull Terriers with grade II or III medial patellar luxation, and six without medial patellar luxation. Inclination angle, femoral condyle trochanteric angle, anteversion angle (AA), distal anteversion angle (DAA), proximal anteversion angle (PAA), femoral varus angle (FVA), tibial valgus angle (TVA), and tibial torsion angle (TTA) were measured...
May 22, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28159052/complex-ankle-arthrodesis-with-step-cut-osteotomy-in-charcot-arthropathy-with-bone-loss
#12
Sean Booth, Moez Ballal, Anand Pillai
We report a case of a complex limb salvage ankle arthrodesis in a patient with Charcot arthropathy. A step-cut osteotomy was performed in order to tackle the issues of anterior tibial bone loss; worsening leg length discrepancy; soft tissue contraction; joint instability and high risk of non-union. The construct formed by the step-cut allowed for the preservation of good bone stock; avoidance of further limb shortening; increased torsional stability and increased surface area for bony union. This resulted in a patient with a stable, plantigrade foot appropriate for footwear...
March 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28154901/femoral-and-tibial-torsion-measurements-in-children-and-adolescents-comparison-of-mri-and-3d-models-based-on-low-dose-biplanar-radiographs
#13
Andrea B Rosskopf, Florian M Buck, Christian W A Pfirrmann, Leonhard E Ramseier
OBJECTIVE: The aim of our study was to evaluate the reliability and interchangeability of femoral (FT) and tibial torsion (TT) measurements in children using magnetic resonance (MR) imaging compared to measurements on 3D models based on biplanar radiographs (BPR). MATERIALS AND METHODS: FT and TT were measured in 60 children (mean age 10.1 years; range 6.2-16.2 years; 28 female) using axial MR images by two readers. MR measurements were compared to measurements based on BPR-3D models by two separate independent readers...
February 3, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28139346/external-torsion-in-a-proximal-tibia-and-internal-torsion-in-a-distal-tibia-occur-independently-in-varus-osteoarthritic-knees-compared-to-healthy-knees
#14
Tomoharu Mochizuki, Osamu Tanifuji, Yoshio Koga, Ryosuke Hata, Takahiro Mori, Katsutoshi Nishino, Takashi Sato, Koichi Kobayashi, Go Omori, Makoto Sakamoto, Yuji Tanabe, Naoto Endo
INTRODUCTION: The relative torsional angle of the distal tibia is dependent on a deformity of the proximal tibia, and it is a commonly used torsional parameter to describe deformities of the tibia; however, this parameter cannot show the location and direction of the torsional deformity in the entire tibia. This study aimed to identify the detailed deformity in the entire tibia via a coordinate system based on the diaphysis of the tibia by comparing varus osteoarthritic knees to healthy knees...
January 27, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28103852/stiffness-of-the-locking-compression-plate-as-an-external-fixator-for-treating-distal-tibial-fractures-a-biomechanics-study
#15
Wei Liu, Lihui Yang, Xiaochuan Kong, Likun An, Gang Hong, Zicheng Guo, Lei Zang
BACKGROUND: Locking compress plate, as external fixator, is an attractive technique for distal tibial fracture treatment. But it still remains unclear whether the external LCP has sufficient stiffness. Thus, the present study aims to make a comprehensive evaluation of the stiffness of external locking compress plate when it is used as an external fixator in distal tibial fractures treatment. METHODS: Composite tibia was used to simulate distal tibia fracture (Orthopedic Trauma Association type 43 A3 fracture)...
January 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28072652/in-vivo-correlation-of-radiographic-scoring-radiographic-union-scale-for-tibia-fractures-and-biomechanical-data-in-a-sheep-osteotomy-model-can-we-define-union-radiographically
#16
Jody Litrenta, Paul Tornetta, William Ricci, Roy W Sanders, Robert V OʼToole, Jason W Nascone, Henry Faber, Darren Wilson
OBJECTIVE: To determine (1) the reliability of the standard and modified Radiographic Union Scale for Tibia fractures (RUST) score in a sheep osteotomy model, and (2) the standard and modified RUST scores that represent biomechanical union. DESIGN: The tibia cortices in a sheep osteotomy model treated by intramedullary nails were radiographically evaluated using standard and modified RUST scores. Scores that correlated with biomechanical union, based on the torsional stiffness of the contralateral tibia, were determined...
March 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28004177/torsional-osteotomies-of-the-tibia-in-patellofemoral-dysbalance
#17
Jörg Dickschas, Aliki Tassika, Christoph Lutter, Jörg Harrer, Wolf Strecker
BACKGROUND AND PURPOSE: Anterior knee pain or patellofemoral instability is common symptom of patellofemoral dysbalance or maltracking. Tibial torsional deformities can be the reason of this pathology. After appropriate diagnostic investigation, the treatment of choice is a torsional osteotomy. This study addresses the diagnostic investigation, treatment, and the outcome of torsional osteotomies of the tibia. Does this treatment result in patellofemoral stability and provide pain relief? METHODS: Forty-nine tibial torsional osteotomies were included...
February 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27957593/-rotation-or-derotation-osteotomy-of-the-tibia
#18
D Kolp, K Ziebarth, T Slongo
OBJECTIVE: Corrections for congenital or posttraumatic malrotation of the lower leg, considering alignment of the contralateral leg, with an osteotomy and fixation using locking compression plates (LCP). INDICATIONS: Posttraumatic deformity due to malunion. Increased tibial torsion in residual clubfoot deformity as long as the foot has been realigned. Idiopathic internal or external rotational deformity if the child is regularly tripping and falling, has psychological problems (other children making fun of the child because of the unusual gait), or is bothered by the deformity (age > 10 years, relative indication)...
December 12, 2016: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/27935008/distal-femoral-lateral-closing-wedge-osteotomy-as-a-component-of-comprehensive-treatment-of-medial-patellar-luxation-and-distal-femoral-varus-in-dogs
#19
Barry E Brower, Michael P Kowaleski, Ann M Peruski, Antonio Pozzi, Jonathan Dyce, Kenneth A Johnson, Randy J Boudrieau
OBJECTIVE: To describe a cohort of dogs with medial patellar luxation managed with a distal femoral lateral closing wedge ostectomy (DFO) as a component of comprehensive treatment, and to report radiographic and long-term clinical outcome of this technique. METHODS: Medical records of dogs that had a lateral closing wedge DFO as part of management of medial patellar luxation at three veterinary teaching hospitals were reviewed. Surgical reports as well as the preoperative, postoperative, and follow-up radiographs were reviewed...
January 16, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27919511/metaphyseal-locking-plate-as-an-external-fixator-for-open-tibial-fracture-clinical-outcomes-and-biomechanical-assessment
#20
Ching-Hou Ma, Chin-Hsien Wu, Jiun-Ru Jiang, Yuan-Kun Tu, Ting-Sheng Lin
OBJECTIVE: This study aimed to evaluate the outcome of using a metaphyseal locking plate as a definitive external fixator for treating open tibial fractures based on biomechanical experiments and analysis of clinical results. METHODS: A metaphyseal locking plate was used as an external fixator in 54 open tibial fractures in 52 patients. The mean follow-up was 38 months (range, 20-52 months). Moreover, static axial compression and torsional tests were performed to evaluate the strength of the fixation techniques...
February 2017: Injury
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