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https://www.readbyqxmd.com/read/29329906/development-of-a-quick-bioassay-for-the-evaluation-of-transmission-properties-of-acquired-prion-diseases
#1
Yoshiko Munesue, Taishi Shimazaki, Zechen Qi, Norikazu Isoda, Hirofumi Sawa, Keisuke Aoshima, Takashi Kimura, Shirou Mohri, Tetsuyuki Kitamoto, Atsushi Kobayashi
Evaluation of transmission properties is important for the differential diagnosis of a subgroup of acquired Creutzfeldt-Jakob disease (CJD) with methionine homozygosity at polymorphic codon 129 of the PRNP gene, an intermediate type abnormal prion protein (PrP), and kuru plaques, denoted as acquired CJD-MMiK. The present study aimed to develop a quick evaluation system of the transmission properties of acquired CJD-MMiK. In the PrP-humanized mice intraperitoneally inoculated with brain homogenates from an acquired CJD-MMiK patient, accumulation of abnormal PrP was observed in follicular dendritic cells of the spleen at 75 days post-inoculation...
January 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29313299/websites-on-bladder-cancer-an-appropriate-source-of-patient-information
#2
Johannes Salem, Pia Paffenholz, Christian Bolenz, Melanie von Brandenstein, Angelika Cebulla, Axel Haferkamp, Timur Kuru, Cheryl T Lee, David Pfister, Igor Tsaur, Hendrik Borgmann, Axel Heidenreich
A growing number of patients search for health information online. An early investigation of websites about bladder cancer (BCa) revealed mostly incomplete and particularly inaccurate information. We analyzed the quality, readability, and popularity of the most frequented websites on BCa. An Internet search on www.google.com was performed for the term "bladder cancer." After selecting the most frequented websites for patient information, HONcode quality certification, Alexa popularity rank, and readability scores (according to US grade levels) were investigated...
January 8, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29311645/author-correction-fluorescent-d-amino-acids-reveal-bi-cellular-cell-wall-modifications-important-for-bdellovibrio-bacteriovorus-predation
#3
Erkin Kuru, Carey Lambert, Jonathan Rittichier, Rob Till, Adrien Ducret, Adeline Derouaux, Joe Gray, Jacob Biboy, Waldemar Vollmer, Michael VanNieuwenhze, Yves V Brun, R Elizabeth Sockett
In the original version of this Article, a grant number and acknowledgement were omitted. The Acknowledgements section should have stated that one of the 3D SIM microscopes used for this research was supported by Medical Research Council UK grant (MR/K015753/1) to S. Foster, University of Sheffield, UK, and that the authors thank C. Walther and S. Foster for the access and their kind help with this. This has now been corrected in all versions of the Article.
January 8, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29301968/engineering-posttranslational-proofreading-to-discriminate-nonstandard-amino-acids
#4
Aditya M Kunjapur, Devon A Stork, Erkin Kuru, Oscar Vargas-Rodriguez, Matthieu Landon, Dieter Söll, George M Church
Incorporation of nonstandard amino acids (nsAAs) leads to chemical diversification of proteins, which is an important tool for the investigation and engineering of biological processes. However, the aminoacyl-tRNA synthetases crucial for this process are polyspecific in regard to nsAAs and standard amino acids. Here, we develop a quality control system called "posttranslational proofreading" to more accurately and rapidly evaluate nsAA incorporation. We achieve this proofreading by hijacking a natural pathway of protein degradation known as the N-end rule, which regulates the lifespan of a protein based on its amino-terminal residue...
January 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29245740/description-of-i-almafuerte-i-a-new-genus-of-ground-spiders-from-south-america-araneae-gnaphosidae
#5
Cristian J Grismado, Nicolás López Carrión
A new genus of gnaphosid spiders, Almafuerte, gen. nov., is described for seven species from Southern South America. The new genus is diagnosed by a conspicuous retrolateral tegular projection on the male palp, and by having three teeth on the cheliceral retromargin. It comprises six species from Argentina, A. peripampasica sp. nov. (type species), from Central Argentina, also present in Uruguay, A. kuru sp. nov., from Santiago del Estero, A. vigorosa sp. nov., from Corrientes, A. goloboffi sp. nov., from Salta and Jujuy, A...
October 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29241441/antibody-separation-using-lectin-modified-poly-hema-edma-hydrogel-membranes
#6
Esra Feyzioğlu Demir, Cansu Ilke Kuru, Murat Uygun, Deniz Aktaş Uygun, Sinan Akgöl
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the as-synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10...
December 15, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29232946/huntingtin-polyglutamine-dependent-protein-aggregation-in-reconstituted-cells
#7
Kodai Machida, Kuru Kanzawa, Tomoaki Shigeta, Yuki Yamamoto, Kanta Tsumoto, Hiroaki Imataka
One of the aims of synthetic biology is bottom-up construction of reconstituted human cells for medical uses. To that end, we generated giant unilamella vesicles (GUVs) that contained a HeLa cell extract, which comprises a cell-free protein synthesis (CFPS) system. Then we expressed Huntingtin protein fragments that contained polyglutamine (polyQ) sequences (Htt-polyQ), a hallmark of Huntington's disease. That system produced polyQ-dependent protein aggregates, as previously demonstrated in living cells. We next simplified the system by generating GUVs that contained purified human factors, which reconstituted a CFPS system...
December 12, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29198926/does-the-application-of-ankaferd-blood-stopper-rectally-have-positive-effects-on-the-healing-of-colorectal-anastomosis-and-prevention-of-anastomotic-leakage-an-experimental-study
#8
Serdar Kuru, Kemal Kismet, Yusuf Murat Bag, Aziz Mutlu Barlas, Mehmet Senes, Murat Durak, Nihat Yumusak, Mustafa Kemal Urhan, Turgut Cavusoglu, Recep Pekcici
The purpose of this experimental study was to evaluate the potential effects on the healing of colorectal anastomoses of the rectal administration of Ankaferd Blood Stopper (ABS). Thirty Wistar-Albino male rats were randomly separated into 3 groups. In the sham group, only laparotomy and colonic mobilization was performed. In the other 2 groups, colon transection and anastomosis were carried out. Saline (2 mL, 0.9% NaCl) was given rectally via a feeding tube for 10 days after the surgical procedure in the sham and control groups...
November 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29169405/atypical-creutzfeldt-jakob-disease-with-prp-amyloid-plaques-in-white-matter-molecular-characterization-and-transmission-to-bank-voles-show-the-m1-strain-signature
#9
Marcello Rossi, Daniela Saverioni, Michele Di Bari, Simone Baiardi, Afina Willemina Lemstra, Laura Pirisinu, Sabina Capellari, Annemieke Rozemuller, Romolo Nonno, Piero Parchi
Amyloid plaques formed by abnormal prion protein (PrPSc) aggregates occur with low frequency in Creutzfeldt-Jakob disease, but represent a pathological hallmark of three relatively rare disease histotypes, namely variant CJD, sporadic CJDMV2K (methionine/valine at PRNP codon 129, PrPSc type 2 and kuru-type amyloid plaques) and iatrogenic CJDMMiK (MM at codon 129, PrPSc of intermediate type and kuru plaques). According to recent studies, however, PrP-amyloid plaques involving the subcortical and deep nuclei white matter may also rarely occur in CJDMM1 (MM at codon 129 and PrPSc type 1), the most common CJD histotype...
November 23, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29160366/erdosteine-ameliorates-the-harmful-effects-of-ischemia-reperfusion-injury-on-the-liver-of-rats
#10
Aziz Mutlu Barlas, Kemal Kismet, Serap Erel, Serdar Kuru, Turgut Cavusoglu, Mehmet Senes, Zeynep Adiyaman, Pinar Celepli, Sema Hucumenoglu, Recep Pekcici
PURPOSE: To investigate the potential protective effects of erdosteine against the harmful effects of ischemia-reperfusion injury on the liver in an experimental rat model. METHODS: Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. No other manipulation or treatment was performed. In the other groups, ischemia was achieved by clamping the hepatic pedicle for 60 min. After that, 90 min reperfusion was provided. In the control group, no treatment was given...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29114425/relationships-between-initial-probing-depth-and-changes-in-the-clinical-parameters-following-non-surgical-periodontal-treatment-in-chronic-periodontitis
#11
Suleyman Emre Meseli, Bahar Kuru, Leyla Kuru
Purpose: The aim of this study was to evaluate the relationship between initial probing depth (IPD) and changes in clinical parameters following non-surgical periodontal treatment (NPT) in chronic periodontitis patients. Subjects and Methods: A total of 1672 periodontal pockets having 3mm≤IPD≤9mm of depth in 15 chronic periodontitis patients were included. NPT consisting of oral hygiene instructions, scaling and root planing was applied in two sessions. Probing depth (PD), clinical attachment level, gingival recessions (GR) were measured before and eight weeks after treatment...
2017: Journal of Istanbul University Faculty of Dentistry
https://www.readbyqxmd.com/read/29107031/prospective-multicenter-phase-ii-study-on-focal-therapy-hemiablation-of-the-prostate-with-high-intensity-focused-ultrasound-hifu
#12
Roman Ganzer, Boris Hadaschik, Sascha Pahernik, Daniel Koch, Daniel Baumunk, Timur Kuru, Axel Heidenreich, Jens-Uwe Stolzenburg, Martin Schostak, Andreas Blana
PURPOSE: To evaluate Focal therapy (FT) by means of high-intensity focussed ultrasound (HIFU) hemiablation in a prospective trial. MATERIALS AND METHODS: Prospective multicentre single arm study in patients with unilateral low/intermediate risk PC, treated from April 2013 through March 2016 in Germany (AUO study protocol AP 68/11). Unilateral PC was assessed by transrectal ultrasound (TRUS)-guided biopsy and multiparametric magnetic resonance imaging (mpMRI). Hemiablation was performed with the Ablatherm or Focal One device...
October 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29105545/electron-microscopic-and-confocal-laser-microscopy-analysis-of-amyloid-plaques-in-chronic-wasting-disease-transmitted-to-transgenic-mice
#13
Beata Sikorska, Agata Gajos, Andrzej Bogucki, Emil Zielonka Christina Sigurdson, Pawel P Liberski
We report here on the ultrastructure of amyloid plaques in chronic wasting disease (CWD) transmitted to Tg20 transgenic mice overexpressing prion protein (PrP(c)). We identified three main types of amyloid deposits in mCWD: large amyloid deposits, unicentric plaques similar to kuru plaques in human prion diseases and multicentric plaques reminiscent of plaques typical of GSS. The most unique type of plaques were large subpial amyloid deposits. They were composed of large areas of amyloid fibrils but did not form "star-like" appearances of unicentric plaques...
November 6, 2017: Prion
https://www.readbyqxmd.com/read/29055817/retroperitoneal-nodal-metastasis-in-primary-adult-type-granulosa-cell-tumor-of-the-ovary-can-routine-lymphadenectomy-be-omitted
#14
Oguzhan Kuru, Gokhan Boyraz, Hasan Uckan, Anıl Erturk, Murat Gultekin, Nejat Ozgul, Coskun Salman, Kunter Yuce
OBJECTIVE: To investigate the incidence of retroperitoneal lymph node metastasis among patients with primary adult type granulosa cell tumor (AGCT) of the ovary. STUDY DESIGN: Between January 1982 and February 2017, patients with a pathological diagnosis of AGCT were identified. Clinical and pathological data were obtained from database records. RESULTS: A total of 151 patients with primary AGCT were identified with a mean age of 47.8 years (range, 17-91 years)...
December 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29026882/efficient-measurement-and-factorization-of-high-order-drug-interactions-in-mycobacterium-tuberculosis
#15
Murat Cokol, Nurdan Kuru, Ece Bicak, Jonah Larkins-Ford, Bree B Aldridge
Combinations of three or more drugs are used to treat many diseases, including tuberculosis. Thus, it is important to understand how synergistic or antagonistic drug interactions affect the efficacy of combination therapies. However, our understanding of high-order drug interactions is limited because of the lack of both efficient measurement methods and theoretical framework for analysis and interpretation. We developed an efficient experimental sampling and scoring method [diagonal measurement of n-way drug interactions (DiaMOND)] to measure drug interactions for combinations of any number of drugs...
October 2017: Science Advances
https://www.readbyqxmd.com/read/28989665/full-color-palette-of-fluorescent-d-amino-acids-for-in-situ-labeling-of-bacterial-cell-walls
#16
Yen-Pang Hsu, Jonathan Rittichier, Erkin Kuru, Jacob Yablonowski, Erick Pasciak, Srinivas Tekkam, Edward Hall, Brennan Murphy, Timothy K Lee, Ethan C Garner, Kerwyn Casey Huang, Yves V Brun, Michael S VanNieuwenhze
Fluorescent d-amino acids (FDAAs) enable efficient in situ labeling of peptidoglycan in diverse bacterial species. Conducted by enzymes involved in peptidoglycan biosynthesis, FDAA labeling allows specific probing of cell wall formation/remodeling activity, bacterial growth and cell morphology. Their broad application and high biocompatibility have made FDAAs an important and effective tool for studies of peptidoglycan synthesis and dynamics, which, in turn, has created a demand for the development of new FDAA probes...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28987186/prion-diseases
#17
James W Ironside, Diane L Ritchie, Mark W Head
The human prion diseases comprise Creutzfeldt-Jakob disease, variably protease-sensitive prionopathy, Gerstmann-Sträussler-Scheinker disease, fatal familial insomnia, and kuru. Each is a uniformly fatal rare neurodegenerative disease in which conformational changes in the prion protein are thought to be the central pathophysiologic event. The majority of cases of human prion diseases occur worldwide in the form of sporadic Creutzfeldt-Jakob disease and a minority of around 10-15% are associated with mutations of the prion protein gene, termed PRNP, in the forms of genetic Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28974693/fluorescent-d-amino-acids-reveal-bi-cellular-cell-wall-modifications-important-for-bdellovibrio-bacteriovorus-predation
#18
Erkin Kuru, Carey Lambert, Jonathan Rittichier, Rob Till, Adrien Ducret, Adeline Derouaux, Joe Gray, Jacob Biboy, Waldemar Vollmer, Michael VanNieuwenhze, Yves V Brun, R Elizabeth Sockett
Modification of essential bacterial peptidoglycan (PG)-containing cell walls can lead to antibiotic resistance; for example, β-lactam resistance by L,D-transpeptidase activities. Predatory Bdellovibrio bacteriovorus are naturally antibacterial and combat infections by traversing, modifying and finally destroying walls of Gram-negative prey bacteria, modifying their own PG as they grow inside prey. Historically, these multi-enzymatic processes on two similar PG walls have proved challenging to elucidate. Here, with a PG-labelling approach utilizing timed pulses of multiple fluorescent D-amino acids, we illuminate dynamic changes that predator and prey walls go through during the different phases of bacteria:bacteria invasion...
October 3, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28971033/acute-hypophysitis-secondary-to-nivolumab-immunotherapy-in-a-patient-with-metastatic-melanoma
#19
Sugabramya Kuru, Nazia Khan, Hamid Shaaban
The treatment for melanoma is challenging because of its nature of being refractory particularly in metastatic stages. Treatment options include surgical resection of the lesion, radiation therapy, chemotherapy, and immunotherapy. Immunotherapy such as anti-cytotoxic T-lymphocyte antigen-4 and anti-programmed cell death protein 1 (PD-1) are increasingly being used in the treatment of metastatic malignant melanoma. Nivolumab is a PD-1 inhibitor used for the treatment of malignant melanoma. In our case, an 83-year-old patient presented with enlarged inguinal lymphadenopathy 2 years after curative surgical resection of her toes secondary to melanoma...
July 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28968232/the-effect-of-kinesio%C3%A2-taping-on-pain-functionality-mobility-and-endurance-in-the-treatment-of-chronic-low-back-pain-a-randomized-controlled-study
#20
Fahri Köroğlu, Tuğba Kuru Çolak, M Gülden Polat
BACKGROUND: Low back pain is one of the most important causes of morbidity. OBJECTIVE: This study was designed to evaluate the effect of Kinesio® taping on pain, functionality, mobility and endurance in chronic low back pain treatment. METHODS: Patients with chronic low back pain were randomly divided into three groups. Therapeutic ultrasound, hot packs, and transcutaneous electrical nerve stimulation were applied to each group for ten sessions during two weeks, and therapeutic exercises were applied in the clinic under physiotherapist supervision starting from the sixth session...
September 22, 2017: Journal of Back and Musculoskeletal Rehabilitation
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