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https://www.readbyqxmd.com/read/28515997/primary-myxoid-melanoma-with-dermoscopic-findings
#1
Tugba K Uzuncakmak, Ilkin Zindanci, Ebru I Zemheri, Ayse S Karadag, Burce C Kuru, Necmettin Akdeniz
Myxoid melanoma is a rare variant of melanoma, which is characterized by atypical spindle cells and dense mucin deposition in dermis. This tumor is usually seen in elderly people with a similar progress in other variants of melanoma. A 28-year-old male presented to our outpatient clinic with a 6-month history of a slowly growing asymptomatic pink lesion on his arm. Dermoscopic examination revealed pink-white cristalline structures and blue-grayish ovoid globules. The lesion was totally excised with initial diagnosis of basosquamous carcinoma, amelanotic melanoma and basal cell carcinoma...
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28437890/does-propolis-have-any-effect-on-non-alcoholic-fatty-liver-disease
#2
Kemal Kismet, Cigdem Ozcan, Serdar Kuru, Omur Gencay Celemli, Pinar Celepli, Mehmet Senes, Tuncay Guclu, Kadriye Sorkun, Sema Hucumenoglu, Tanju Besler
The aim of this study was to evaluate the therapeutic effect of propolis on non-alcoholic fatty liver disease (NAFLD) in rats. The rats were randomly divided into 3 groups of 10 as the NAFLD, NAFLD+100 and NAFLD+200 groups. The rats were fed with a fatty diet (25g/kg/day) to provoke NAFLD. Then after the formation of fatty liver, a standard diet (SD) (25g/kg/day) was given to the NAFLD group and the other two groups were fed with SD and 100mg/kg (NAFLD+100 Group) or 200mg/kg propolis (NAFLD+200 Group) for two weeks...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28421536/lysosomal-quality-control-in-prion-diseases
#3
REVIEW
Priyanka Majumder, Oishee Chakrabarti
Prion diseases are transmissible, familial or sporadic. The prion protein (PrP), a normal cell surface glycoprotein, is ubiquitously expressed throughout the body. While loss of function of PrP does not elicit apparent phenotypes, generation of misfolded forms of the protein or its aberrant metabolic isoforms has been implicated in a number of neurodegenerative disorders such as scrapie, kuru, Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Sträussler-Scheinker and bovine spongiform encephalopathy...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28406122/effects-of-810-nanometer-diode-laser-as-an-adjunct-to-mechanical-periodontal-treatment-on-clinical-periodontal-parameters-and-gingival-crevicular-fluid-volume-of-residual-periodontal-pockets
#4
S E Meseli, B Kuru, L Kuru
BACKGROUND: Aim of this randomized controlled parallel-designed study was to evaluate the effects of diode laser as an adjunct to mechanical periodontal treatment on clinical parameters and gingival crevicular fluid (GCF) volume of the residual pockets diagnosed following initial periodontal treatment in chronic periodontitis (CP) patients. MATERIALS AND METHODS: A total of 84 residual pockets on single-rooted teeth in 11 CP patients were included and randomly assigned into three groups...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28383902/prediction-of-antibiotic-interactions-using-descriptors-derived-from-molecular-structure
#5
Daniel J Mason, Ian Stott, Stephanie Ashenden, Zohar B Weinstein, Idil Karakoc, Selin Meral, Nurdan Kuru, Andreas Bender, Murat Cokol
Combination antibiotic therapies are clinically important in the fight against bacterial infections. However, the search space of drug combinations is large, making the identification of effective combinations a challenging task. Here, we present a computational framework that uses substructure profiles derived from the molecular structures of drugs and predicts antibiotic interactions. Using a previously published data set of 153 drug pairs, we showed that substructure profiles are useful in predicting synergy...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28374836/a-semi-synchronous-label-propagation-algorithm-with-constraints-for-community-detection-in-complex-networks
#6
Jia Hou Chin, Kuru Ratnavelu
Community structure is an important feature of a complex network, where detection of the community structure can shed some light on the properties of such a complex network. Amongst the proposed community detection methods, the label propagation algorithm (LPA) emerges as an effective detection method due to its time efficiency. Despite this advantage in computational time, the performance of LPA is affected by randomness in the algorithm. A modified LPA, called CLPA-GNR, was proposed recently and it succeeded in handling the randomness issues in the LPA...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331769/the-main-topics-at-the-oncoplastic-breast-surgery-course-and-expert-panel
#7
Mustafa Emiroğlu, Bekir Kuru, Mehmet Ali Gülçelik, M Kemal Atahan, Atakan Y Sezer, Cem Karaali, Bahadır Güllüoğlu
The Oncoplastic and Reconstructive Breast Surgery course was held in Izmir by the Izmir Breast Diseases Federation in collaboration with the Breast Diseases Federation of Turkey. The techniques of oncoplasty, the application details and experience in this subject were shared. In this text, the main topics and outcomes are briefly summarised. These evaluations can be considered highly valuable on both local and regional scales.
January 2017: Journal of Breast Health (2013)
https://www.readbyqxmd.com/read/28330337/cogenerating-synthetic-parts-toward-a-self-replicating-system
#8
Jun Li, Wilhelm Haas, Kirsten Jackson, Erkin Kuru, Michael C Jewett, Z Hugh Fan, Steven Gygi, George M Church
To build replicating systems with new functions, the engineering of existing biological machineries requires a sensible strategy. Protein synthesis Using Recombinant Elements (PURE) system consists of the desired components for transcription, translation, aminoacylation and energy regeneration. PURE might be the basis for a radically alterable, lifelike system after optimization. Here, we regenerated 54 E. coli ribosomal (r-) proteins individually from DNA templates in the PURE system. We show that using stable isotope labeling with amino acids, mass spectrometry based quantitative proteomics could detect 26 of the 33 50S and 20 of the 21 30S subunit r-proteins when coexpressed in batch format PURE system...
March 29, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28280581/cultural-factors-that-affected-the-spatial-and-temporal-epidemiology-of-kuru
#9
J T Whitfield, W H Pako, J Collinge, M P Alpers
Kuru is a prion disease which became epidemic among the Fore and surrounding linguistic groups in Papua New Guinea, peaking in the late 1950s. It was transmitted during the transumption (endocannibalism) of dead family members at mortuary feasts. In this study, we aimed to explain the historical spread and the changing epidemiological patterns of kuru by analysing factors that affected its transmission. We also examined what cultural group principally determined a family's behaviour during mortuary rituals...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28209898/treadmilling-by-ftsz-filaments-drives-peptidoglycan-synthesis-and-bacterial-cell-division
#10
Alexandre W Bisson-Filho, Yen-Pang Hsu, Georgia R Squyres, Erkin Kuru, Fabai Wu, Calum Jukes, Yingjie Sun, Cees Dekker, Seamus Holden, Michael S VanNieuwenhze, Yves V Brun, Ethan C Garner
The mechanism by which bacteria divide is not well understood. Cell division is mediated by filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to the division site. To understand how these components coordinate to divide cells, we visualized their movements relative to the dynamics of cell wall synthesis during cytokinesis. We found that the division septum was built at discrete sites that moved around the division plane. FtsAZ filaments treadmilled circumferentially around the division ring and drove the motions of the peptidoglycan-synthesizing enzymes...
February 17, 2017: Science
https://www.readbyqxmd.com/read/28193766/molecular-mechanisms-of-chronic-wasting-disease-prion-propagation
#11
Julie A Moreno, Glenn C Telling
Prion disease epidemics, which have been unpredictable recurrences, are of significant concern for animal and human health. Examples include kuru, once the leading cause of death among the Fore people in Papua New Guinea and caused by mortuary feasting; bovine spongiform encephalopathy (BSE) and its subsequent transmission to humans in the form of variant Creutzfeldt-Jakob disease (vCJD), and repeated examples of large-scale prion disease epidemics in animals caused by contaminated vaccines. The etiology of chronic wasting disease (CWD), a relatively new and burgeoning prion epidemic in deer, elk, and moose (members of the cervid family), is more enigmatic...
February 13, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28110369/neuroradiology-of-human-prion-diseases-diagnosis-and-differential-diagnosis
#12
REVIEW
Simona Gaudino, Emma Gangemi, Raffaella Colantonio, Annibale Botto, Emanuela Ruberto, Rosalinda Calandrelli, Matia Martucci, Maria Gabriella Vita, Carlo Masullo, Alfonso Cerase, Cesare Colosimo
Human transmissible spongiform encephalopathies (TSEs), or prion diseases, are invariably fatal conditions associated with a range of clinical presentations. TSEs are classified as sporadic [e.g. sporadic Creutzfeldt-Jakob disease (sCJD), which is the most frequent form], genetic (e.g. Gerstmann-Straussler-Scheinker disease, fatal familial insomnia, and inherited CJD), and acquired or infectious (e.g. Kuru, iatrogenic CJD, and variant CJD). In the past, brain imaging played a supporting role in the diagnosis of TSEs, whereas nowadays magnetic resonance imaging (MRI) plays such a prominent role that MRI findings have been included in the diagnostic criteria for sCJD...
May 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28088271/adamts-3-13-16-and-19-levels-in-patients-with-habitual-abortion
#13
Meryem Kuru Pekcan, Esma Sarıkaya, Aytekin Tokmak, Murat Alışık, Afra Alkan, Gülnur Özakşit, Özcan Erel
A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function. The aim of this study was to investigate serum ADAMTS-3, -13, -16, and -19 levels in women with habitual abortions compared with those in healthy controls. A total of 86 women were enrolled in this prospective case-control study. ADAMTS-3, -13, -16, and -19 values were recorded and analyzed in association with demographic and clinical parameters...
January 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28078435/the-effects-of-therapeutic-exercises-on-pain-muscle-strength-functional-capacity-balance-and-hemodynamic-parameters-in-knee-osteoarthritis-patients-a-randomized-controlled-study-of-supervised-versus-home-exercises
#14
Tuğba Kuru Çolak, Bahar Kavlak, Onur Aydoğdu, Emir Şahin, Gönül Acar, İlkşan Demirbüken, Zübeyir Sarı, İlker Çolak, Güven Bulut, M Gülden Polat
The aim of the study was to compare the effects of low-intensity exercise programs for lower extremities, either supervised or at home, on pain, muscle strength, balance and the hemodynamic parameters of knee osteoarthritis (OA) patients. This randomized study included 78 patients with knee OA in 2 groups of supervised and home-based exercise program. Exercises were applied to the first group in the clinic as a group exercise program and were demonstrated to the second group to be performed at home. Before and after the 6-week exercise program, assessment was made of pain, quadriceps and hamstring muscle strengths, 6-min walk test (6MWT), and non-invasive hemodynamic parameters...
March 2017: Rheumatology International
https://www.readbyqxmd.com/read/28049644/functional-prions-in-the-brain
#15
REVIEW
Joseph B Rayman, Eric R Kandel
Prions are proteins that can adopt self-perpetuating conformations and are traditionally regarded as etiological agents of infectious neurodegenerative diseases in humans, such as Creutzfeldt-Jakob disease, kuru, and transmissible encephalopathies. More recently, a growing consensus has emerged that prion-like, self-templating mechanisms also underlie a variety of neurodegenerative disorders, including amyotrophic lateral sclerosis, Alzheimer's disease, and Huntington's disease. Perhaps most surprising, not all prion-like aggregates are associated with pathological changes...
January 3, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28042411/clomiphene-citrate-treatment-cycle-outcomes-of-polycystic-ovary-syndrome-patients-based-on-basal-high-sensitive-c-reactive-protein-levels-a-cross-sectional-study
#16
Serkan Kahyaoglu, Omer Hamid Yumuşak, Sebnem Ozyer, Meryem Kuru Pekcan, Merve Erel, Mahmut Nedim Cicek, Salim Erkaya, Yasemin Tasci
BACKGROUND: Polycystic ovary syndrome (PCOS) is highly associated with an ovulatory infertility, features of the metabolic syndrome, including obesity, insulin resistance and dyslipidemia. Serum concentrations of high sensitive C-reactive protein (hs-CRP) were significantly higher in obese than in non-obese PCOS patients at baseline, suggesting a relationship between elevated hs-CRP levels and obesity. The aim of this study was to evaluate whether cycle day 3 hs-CRP levels before clomiphene citrate (CC) treatment would predict cycle outcomes in women with PCOS...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28039730/erratum-factors-predicting-non-sentinel-lymph-node-metastasis-in-t1-2-invasive-breast-cancer-with-1-2-axillary-sentinel-lymph-node-metastases-presentation-of-ondokuz-mayis-scoring-system
#17
Bekir Kuru, Yurdanur Sullu, Savas Yuruker, Ilkay Koray Bayrak, Necati Ozen
In this article published in Volume 21, issue 5, the Results section of the Pubmed abstract appeared as: "There were 68 (33%) and 108 (52%) patients with a the score of ? 4 (predicted probability of ?10%) with a false negative rate (FNR% of 4.4%, and ?5 (predicted probability of ?15%) with a FNR of 7.4%, respectively. The area under the curve (AUC) value for the Ondokuz Mayis scoring system was 0.88 (95% CI 0.83-0.93%)." The correct Results section of the abstract is: "There were 68 (33%) and 108 (52%) patients with a the score of ≤4 (predicted probability of ≤10%) with a false negative rate (FNR) of 4...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28035911/low-back-pain-during-pregnancy-and-kinesio-tape-application
#18
Aycan Çakmak Reyhan, Elif Elçin Dereli, Tuğba Kuru Çolak
BACKGROUND AND OBJECTIVE: Low back pain is a common problem during pregnancy. Although the pain usually occurs in the third trimester, it might be seen in the first trimester, too. There are various types of applications for the treatment of low back pain during pregnancy. However, there is a lack of evidence for the effectiveness of each method. If there is not an obvious deficit, bed rest, exercise, conventional physiotherapy, using protective principles for the lumbar area are recommended, since the main and the only complaint is low back pain...
2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28030514/the-effect-of-vitamin-d-supplementation-on-pain-quality-of-life-and-nerve-conduction-studies-in-women-with-chronic-widespread-pain
#19
Gulseren Akyuz, Canan Sanal-Toprak, Ilker Yagci, Esra Giray, Pinar Kuru-Bektasoglu
The aim of this study was to investigate the effects of vitamin D supplementation on pain, quality of life, and nerve conduction studies (NCSs) in women with chronic widespread pain (CWP) diagnosed with Vitamin D insufficiency. Thirty-three female participants with CWP and vitamin D insufficiency were included in this open-label trial. They were evaluated by routine NCSs in upper and lower limbs, pain scales, and the Nottingham Health Profile before and 8 weeks after starting vitamin D supplementation therapy...
December 27, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28028952/mastalgia-due-to-degenerative-changes-of-the-spine
#20
Okay Pirti, Aziz M Barlas, Serdar Kuru, Selim Temel, Mustafa K Urhan, Kemal Kismet, Adnan Hasanoglu, Osman Guler
BACKGROUND: Mastalgia is a common and enigmatic condition; the cause and optimal treatment are still inadequately defined. Cervical radiculopathy, which is the result of cervical nerve root pathology often caused by spaceoccupying lesions such as cervical disc herniation, spondylosis, or osteophytosis, is frequently encountered in physical therapy. OBJECTIVES: The aim of the study was to evaluate the incidence of vertebral pathologies in patients with non-cyclic mastalgia and the efficacy of conservative treatment of these pathologies on relieving breast pain...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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