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https://www.readbyqxmd.com/read/28929834/the-association-between-serological-markers-of-celiac-disease-and-idiopathic-recurrent-pregnancy-loss
#1
Esma Sarikaya, Aytekin Tokmak, Rifat Taner Aksoy, Meryem Kuru Pekcan, Murat Alisik, Afra Alkan
INTRODUCTION: Antiphospholipid syndrome, uterine anomalies, and chromosomal aberrations are identifiable causes of recurrent pregnancy loss (RPL). Herein, our aim is to investigate the relationship between celiac disease (CD) specific antitransglutaminase antibodies (ATA) and unexplained RPL. MATERIALS AND METHODS: This was a cross sectional case-control study conducted on 86 women (45 RPL and 41 controls) in a tertiary level maternity hospital. Elisa kit was used to determine ATA IgA and IgG levels...
September 20, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28914592/effect-of-topically-applied-hyaluronic-acid-on-pain-and-palatal-epithelial-wound-healing-an-examiner-blind-randomized-controlled-clinical-trial
#2
Selin Yıldırım, Hafize Öztürk Özener, Başak Doğan, Bahar Kuru
BACKGROUND: This study aimed to evaluate the effects of two different concentrations of topical hyaluronic-acid on post-operative patient discomfort and wound healing of palatal donor sites following free gingival graft (FGG) surgery. METHODS: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-blind, randomized-controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% hyaluronic-acid gels were used in the test-1 and -2 groups, respectively...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28905103/influence-of-the-mif-polymorphism-173g%C3%A2-%C3%A2-c-on-turkish-postmenopausal-women-with-osteoporosis
#3
A Z Ozsoy, N Karakus, S Tural, S Yigit, N Kara, G Alayli, M K Tumer, O Kuru
BACKGROUND: MIF, a proinflammatory cytokine, contributes to the pathogenesis of acute, chronic, and autoimmune inflammatory disorders and balances the suppressive effect of glucocorticoids on the immune system. There is an interaction between bone metabolism and the immune system via the production of cytokines. We aimed to analyze the relationship between the MIF gene -173G > C promoter polymorphism and osteoporosis. METHODS: In this case-control study performed in a university hospital, 286 samples (136 women with osteoporosis and 150 healthy age-matched controls) participated...
September 13, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28866783/what-is-the-impact-of-stromal-microinvasion-on-oncologic-outcomes-in-borderline-ovarian-tumors-a-multicenter-case-control-study
#4
Gokhan Boyraz, Mehmet Coskun Salman, Murat Gultekin, Nazlı Topfedaisi Ozkan, Hasan H Uckan, Kemal Gungorduk, Varol Gulseren, Hulya Ayik, Tayfun Toptas, Oguzhan Kuru, Hamdullah Sozen, Anıl Erturk, Nejat Ozgul, Mehmet Mutlu Meydanlı, Muzaffer Sanci, Taner Turan, Tayfun Gungor, Tayup Simsek, Samet Topuz, Kunter Yuce
PURPOSE: To investigate clinicopathological characteristics and oncological outcome of women with microinvasive BOTs. METHODS: A retrospective multicenter case-control study was conducted on 902 patients with BOT, who underwent surgery from January 2002 to December 2015 at six participating gynecologic oncology centers from Turkey. Among 902 patients, 69 had microinvasive BOT. For every patient with microinvasive BOT, two controls were randomly selected from another database based on decade of age and stage of disease at diagnosis...
September 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28862488/some-lectin-binding-properties-of-the-tongue-of-the-mole-rat-nannospalax-xanthodon
#5
N Kuru, K Cinar, E Demirbag, R Ilgun
We investigated carbohydrate residues on the epithelial surface, in the epithelial cells and in gland cells of the tongue of the mole rat using histochemical methods. We used horseradish peroxidase-conjugated lectins from Helix pomatia (HPA), Arachishypogaea (PNA), Ulexeuropaeus (UEA I), Canavaliaensiformis (Con A). The most intense reactivity was observed in the keratin layer with HPA, UEA I and Con A, and in the epithelial cells with UEA I and Con A. In the glands, we found strong reactivity in serous cells with HPA and Con A, and in mucous cells with HPA and UEA I...
September 1, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28856386/-focal-therapy-of-prostate-cancer
#6
R Ganzer, T Franiel, J Köllermann, T Kuru, D Baumunk, A Blana, B Hadaschik, J von Hardenberg, T Henkel, K-U Köhrmann, U-B Liehr, S Machtens, A Roosen, G Salomon, H-P Schlemmer, L Sentker, J Wendler, U Witzsch, M Schostak
The target of focal therapy (FT) in prostate cancer (PC) is partial treatment of the prostate aiming at preserving surrounding anatomical structures. The intention is to minimize typical side effects of radical treatment options combined with local tumor control. Numerous established and new technologies are used. Results of published studies showed a good safety profile, few side effects and good preservation of functional results. Oncologic long-term data are lacking so far. Photodynamic therapy (PDT) is the only technology that has been studied in a published prospective randomized trial...
August 30, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28851967/generation-of-a-new-infectious-recombinant-prion-a-model-to-understand-gerstmann-str%C3%A3-ussler-scheinker-syndrome
#7
Saioa R Elezgarai, Natalia Fernández-Borges, Hasier Eraña, Alejandro M Sevillano, Jorge M Charco, Chafik Harrathi, Paula Saá, David Gil, Qingzhong Kong, Jesús R Requena, Olivier Andréoletti, Joaquín Castilla
Human transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome (GSS), and fatal familial insomnia. GSS is a genetically determined TSE caused by a range of mutations within the prion protein (PrP) gene. Several animal models, based on the expression of PrPs carrying mutations analogous to human heritable prion diseases, support that mutations might predispose PrP to spontaneously misfold...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838658/prion-protein-and-genetic-susceptibility-to-diseases-caused-by-its-misfolding
#8
George A Carlson
Early genetic studies on scrapie, an infectious neurodegenerative disease of sheep that was adapted to mice, provided evidence in support of the hypothesis that the agent was a slow virus with a nucleic acid genome independent of the host. Particularly compelling support for an independent genome came from the existence of strains of scrapie agent, some of which were true breeding, while others appeared to mutate under selective pressure. Kuru, a neurodegenerative disease in the remote highlands of Papua New Guinea, had pathological changes similar to those in scrapie and also proved to be transmissible...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28753102/the-influence-of-a-bifidobacterium-animalis-probiotic-on-gingival-health-a-randomized-controlled-clinical-trial
#9
Bahar Eren Kuru, Isabelle Laleman, Tuğçe Yalnızoğlu, Leyla Kuru, Wim Teughels
BACKGROUND: There is a growing interest for probiotics in periodontal therapy, however, until to date, most research is focused on lactobacilli probiotics. The aim of this study was to evaluate the effect of the 4-week usage of a Bifidobacterium animalis subsp. lactis DN-173010 supplemented yoghurt versus a placebo yoghurt, followed by a 5-day non-brushing period. METHODS: Individuals were included in this single-blind, randomized controlled study if probing depth was (PD) ≤ 3 mm and attachment loss ≤ 2 mm...
July 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28729125/comparative-effects-of-vitamin-d-and-methylprednisolone-against-ischemia-reperfusion-injury-of-rabbit-spinal-cords
#10
Bora Gürer, Abdullah Karakoç, Pınar Kuru Bektaşoğlu, Hayri Kertmen, Mehmet Ali Kanat, Ata Türker Arıkök, Berrin İmge Ergüder, Mustafa Fevzi Sargon, Özden Çağlar Öztürk, Erhan Çelikoğlu
INTRODUCTION: Recent studies have demonstrated the neuroprotective and immunomodulatory effects of 1,25-dihydroxyvitamin D3 (calcitriol), but no previous study has examined these effects on spinal cord ischemia/reperfusion (I/R) injury. Therefore, the present study aimed to evaluate whether calcitriol protects the spinal cord from I/R injury. METHODS: Rabbits were randomized into four groups of eight animals: group 1 (laparotomy control), group 2 (ischemia control), group 3 (30mg/kg intraperitoneal methylprednisolone at surgery), and group 4 (0...
July 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28702280/dissecting-limiting-factors-of-the-protein-synthesis-using-recombinant-elements-pure-system
#11
Jun Li, Chi Zhang, Poyi Huang, Erkin Kuru, Eliot T C Forster-Benson, Taibo Li, George M Church
Reconstituted cell-free protein synthesis systems such as the Protein synthesis Using Recombinant Elements (PURE) system give high-throughput and controlled access to in vitro protein synthesis. Here we show that compared with the commercial S30 crude extract based RTS 100 E. coli HY system, the PURE system has less mRNA degradation and produces up to ∼6-fold full-length proteins. However the majority of polypeptides PURE produces are partially translated or inactive since the signal from firefly luciferase (Fluc) translated in PURE is only ∼2/3(rd) of that measured using the RTS 100 E...
2017: Translation
https://www.readbyqxmd.com/read/28633132/radon-emanation-from-fresh-altered-and-disturbed-granitic-rock-characterized-by-14-c-pmma-impregnation-and-autoradiography
#12
Karl-Heinz Hellmuth, Marja Siitari-Kauppi, Hannu Arvela, Antero Lindberg, Lionel Fonteneau, Paul Sardini
Radon emanation from intact samples of fresh ("BG"), altered ("Fract") and disturbed ("EDZ") Finnish granitic rock from Kuru (Finland) and its dependence on humidity and rock structural factors was studied. The pore network of the rock was characterized by microscopy and impregnation with (14)C-PMMA (polymethylmethacrylate) resin and autoradiography. The radon emanation factor was increasing linearly with the relative humidity. (14)C-PMMA autoradiography of the altered zones and the EDZ indicated significant, mineral-specific increase of porosity and porosity gradients towards the fracture surfaces (Fract) and microcracks within the EDZ...
June 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28618768/psychosocial-functioning-in-pediatric-patients-with-pectus-excavatum-and-pectus-carinatum
#13
Aliye Tuğba Bahadir, Pınar Kuru Bektaşoğlu, Aylin Çakiroğlu Eser, Ceyda Afacan, Mustafa Yüksel
BACKGROUND/AIM: Pectus excavatum and pectus carinatum are the most commonly seen anterior chest wall deformities. Recent studies reveal that minimal invasive repair of pectus deformities improves the quality of life. Our aim is to assess the psychosocial functioning and sociodemographic characteristics of pediatric patients with pectus deformities and evaluate the differences between patients operated on with minimal invasive repair techniques and nonoperated patients. MATERIALS AND METHODS:  Thirty-two patients with pectus deformities who were operated on 6 months or more before and 31 nonoperated patients participated in the study...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28568896/an-autopsied-case-of-mv2k%C3%A2-%C3%A2-c-type-sporadic-creutzfeldt-jakob-disease-presenting-with-widespread-cerebral-cortical-involvement-and-kuru-plaques
#14
Yasushi Iwasaki, Yufuko Saito, Ikuko Aiba, Atsushi Kobayashi, Maya Mimuro, Tetsuyuki Kitamoto, Mari Yoshida
MV2-type sporadic Creutzfeldt-Jakob disease (sCJD), which was previously called "Kuru-plaque variant", was gradually revealed to have a wide spectrum and has been classified into three pathological subtypes: MV2K, MV2C and MV2K + C. We herein describe the detailed clinical findings and neuropathologic observations from an autopsied MV2K + C-type Japanese sCJD case with widespread cerebral cortical pathology and Kuru plaques. In the early stages of the disease, the patient exhibited gait disturbance with ataxia and dysarthria as well as gradual appearance of cognitive dysfunction...
June 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28515997/primary-myxoid-melanoma-with-dermoscopic-findings
#15
Tugba K Uzuncakmak, Ilkin Zindanci, Ebru I Zemheri, Ayse S Karadag, Burce C Kuru, Necmettin Akdeniz
Myxoid melanoma is a rare variant of melanoma, which is characterized by atypical spindle cells and dense mucin deposition in dermis. This tumor is usually seen in elderly people with a similar progress in other variants of melanoma. A 28-year-old male presented to our outpatient clinic with a 6-month history of a slowly growing asymptomatic pink lesion on his arm. Dermoscopic examination revealed pink-white cristalline structures and blue-grayish ovoid globules. The lesion was totally excised with initial diagnosis of basosquamous carcinoma, amelanotic melanoma and basal cell carcinoma...
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28437890/does-propolis-have-any-effect-on-non-alcoholic-fatty-liver-disease
#16
Kemal Kismet, Cigdem Ozcan, Serdar Kuru, Omur Gencay Celemli, Pinar Celepli, Mehmet Senes, Tuncay Guclu, Kadriye Sorkun, Sema Hucumenoglu, Tanju Besler
The aim of this study was to evaluate the therapeutic effect of propolis on non-alcoholic fatty liver disease (NAFLD) in rats. The rats were randomly divided into 3 groups of 10 as the NAFLD, NAFLD+100 and NAFLD+200 groups. The rats were fed with a fatty diet (25g/kg/day) to provoke NAFLD. Then after the formation of fatty liver, a standard diet (SD) (25g/kg/day) was given to the NAFLD group and the other two groups were fed with SD and 100mg/kg (NAFLD+100 Group) or 200mg/kg propolis (NAFLD+200 Group) for two weeks...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28421536/lysosomal-quality-control-in-prion-diseases
#17
REVIEW
Priyanka Majumder, Oishee Chakrabarti
Prion diseases are transmissible, familial or sporadic. The prion protein (PrP), a normal cell surface glycoprotein, is ubiquitously expressed throughout the body. While loss of function of PrP does not elicit apparent phenotypes, generation of misfolded forms of the protein or its aberrant metabolic isoforms has been implicated in a number of neurodegenerative disorders such as scrapie, kuru, Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Sträussler-Scheinker and bovine spongiform encephalopathy...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28406122/effects-of-810-nanometer-diode-laser-as-an-adjunct-to-mechanical-periodontal-treatment-on-clinical-periodontal-parameters-and-gingival-crevicular-fluid-volume-of-residual-periodontal-pockets
#18
S E Meseli, B Kuru, L Kuru
BACKGROUND: Aim of this randomized controlled parallel-designed study was to evaluate the effects of diode laser as an adjunct to mechanical periodontal treatment on clinical parameters and gingival crevicular fluid (GCF) volume of the residual pockets diagnosed following initial periodontal treatment in chronic periodontitis (CP) patients. MATERIALS AND METHODS: A total of 84 residual pockets on single-rooted teeth in 11 CP patients were included and randomly assigned into three groups...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28383902/prediction-of-antibiotic-interactions-using-descriptors-derived-from-molecular-structure
#19
Daniel J Mason, Ian Stott, Stephanie Ashenden, Zohar B Weinstein, Idil Karakoc, Selin Meral, Nurdan Kuru, Andreas Bender, Murat Cokol
Combination antibiotic therapies are clinically important in the fight against bacterial infections. However, the search space of drug combinations is large, making the identification of effective combinations a challenging task. Here, we present a computational framework that uses substructure profiles derived from the molecular structures of drugs and predicts antibiotic interactions. Using a previously published data set of 153 drug pairs, we showed that substructure profiles are useful in predicting synergy...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28374836/a-semi-synchronous-label-propagation-algorithm-with-constraints-for-community-detection-in-complex-networks
#20
Jia Hou Chin, Kuru Ratnavelu
Community structure is an important feature of a complex network, where detection of the community structure can shed some light on the properties of such a complex network. Amongst the proposed community detection methods, the label propagation algorithm (LPA) emerges as an effective detection method due to its time efficiency. Despite this advantage in computational time, the performance of LPA is affected by randomness in the algorithm. A modified LPA, called CLPA-GNR, was proposed recently and it succeeded in handling the randomness issues in the LPA...
April 4, 2017: Scientific Reports
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