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https://www.readbyqxmd.com/read/27908842/role-of-versican-and-adamts-1-in-polycystic-ovary-syndrome
#1
Sibel Özler, Efser Öztaş, Aytekin Tokmak, Merve Ergin, Meryem Pekcan Kuru, Başak Güler Gümüş, Halil İbrahim Yakut, Nafiye Yılmaz
OBJECTIVE: Background: ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex, under the effect of luteinizing hormone surge in the periovulatory period. Altered levels of it may have a role in the disease pathogenesis. OBJECTIVE: We aimed to detect serum versican and a disintegrin and metalloproteinase with thrombospondin motif- 1 (ADAMTS-1) levels in polycystic ovary syndrome (PCOS) patients, and compare the results with the healthy controls...
December 2, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27858697/health-related-quality-of-life-and-perception-of-deformity-in-patients-with-adolescent-idiopathic-scoliosis
#2
Tuğba Kuru Çolak, Turgut Akgül, İlker Çolak, Elif Elçin Dereli, Mehmet Chodza, Fatih Dikici
BACKGROUND: Quality of life and cosmethic appearance have gained importance as outcomes in AIS treatment. Improving aesthetic appearance and quality of life are defined as the primary aims of scoliosis treatment by health professionals. Studies that assess and compare the different treatment results in the field of quality of life and cosmethics are some what limited. OBJECTIVE: A cross-sectional study was designed to compare quality of life and deformity perception in patients with adolescent idiopathic scoliosis (AIS) received conservative (exercise or exercise + brace) or surgical treatment...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27824042/the-role-of-salvage-extended-lymph-node-dissection-in-patients-with-rising-psa-and-pet-ct-scan-detected-nodal-recurrence-of-prostate-cancer
#3
D Porres, D Pfister, A Thissen, T H Kuru, V Zugor, R Buettner, R Knuechel, F A Verburg, A Heidenreich
BACKGROUND: Non-prostatic bed recurrence of prostate cancer (PCa) is usually treated with androgen deprivation therapy (ADT). We analyzed the impact of salvage extended lymph node dissection (sLND) on cancer control in patients with rising PSA and lymph node (LN) metastases. METHODS: Between 2009 and 2016 we performed sLND in 87 patients with biochemical recurrence (BCR) and positive LNs on (18)FEC and (68)Ga-PSMA positron emission tomography/X-ray computer tomography (PET/CT) after primary treatment (PT) of PCa...
November 8, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27809706/oxidative-stress-and-mitochondrial-dysfunction-linked-neurodegenerative-disorders
#4
Md Torequl Islam
Reactive species play an important role in physiological functions. Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins, and genetic materials such as DNA and RNA. Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, leading to oxidation of mitochondrial proteins, lipids, and DNA...
November 3, 2016: Neurological Research
https://www.readbyqxmd.com/read/27749817/the-mechanism-of-force-transmission-at-bacterial-focal-adhesion-complexes
#5
Laura M Faure, Jean-Bernard Fiche, Leon Espinosa, Adrien Ducret, Vivek Anantharaman, Jennifer Luciano, Sébastien Lhospice, Salim T Islam, Julie Tréguier, Mélanie Sotes, Erkin Kuru, Michael S Van Nieuwenhze, Yves V Brun, Olivier Théodoly, Aravind L, Marcelo Nollmann, Tâm Mignot
Various rod-shaped bacteria mysteriously glide on surfaces in the absence of appendages such as flagella or pili. In the deltaproteobacterium Myxococcus xanthus, a putative gliding motility machinery (Agl-Glt) localizes to so-called Focal Adhesion sites (FA) that form stationary contact points with the underlying surface. We discovered that the Agl-Glt machinery contains an inner-membrane motor complex that moves intracellularly along a right-handed helical path, and when it becomes stationary at FA sites, it powers a left-handed rotation of the cell around its long axis...
October 5, 2016: Nature
https://www.readbyqxmd.com/read/27721641/comparative-study-of-gabapentin-and-isoflavone-in-menopausal-vasomotor-symptoms
#6
Savita Rani Singhal, Wansalan Kuru Shullai
OBJECTIVE: This study was planned to compare the effects of gabapentin and isoflavones in menopausal vasomotor symptoms. MATERIALS AND METHODS: This prospective comparative study was conducted on 100 patients with complaints of hot flashes, divided into two groups of 50 each. Group I received 900 mg of gabapentin and Group II received 60 mg of isoflavones daily for 3 months. The patients were interviewed to calculate hot flash, global and depression scores and were rescored after 2, 4, 8, and 12 weeks...
July 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27688417/the-influence-of-different-nonsteroidal-anti-inflammatory-drugs-on-alveolar-bone-in-rats-an-experimental-study
#7
Mujgan Gungor Hatipoglu, Sermet Inal, Sahin Kabay, Muhammet Kasim Cayci, Ayşenur Deger, Halil Isa Kuru, Sayit Altikat, Gizem Akkas
THE AIM: The aim of this study was to investigate the effect of dexketoprofen trometamol, meloxicam, diclofenac sodium on any untreated alveolar bone when they are used as drugs for another indication. MATERIALS AND METHODS: Twenty eight male Spraque-Dawley rats were randomized into four groups as dexketoprofen trometamol (Group I), meloxicam (Group II), diclofenac sodium (Group III) and control group. Nonsteroidal anti-inflammatory drugs (NSAID) were administered after a fibula fracture for 10 days...
December 2015: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/27686502/does-intrauterine-insemination-timing-matter-for-achieving-pregnancy-during-ovulation-induction-using-gonadotropins-a-retrospective-cohort-study
#8
Omer Hamid Yumusak, Serkan Kahyaoglu, Meryem Kuru Pekcan, Esra Isci, Mehmet Cinar, Yasemin Tasci
BACKGROUND: Intrauterine insemination (IUI) is a commonly used procedure to increase the infertile couples' chance of pregnancy. Single or double insemination and different timing choices are modifications of this intervention. The aim of this study was to elucidate the effect of the IUI procedure on clinical pregnancy rates when performed at 24 hours or 36 hours after ovulation triggered by human chorionic gonadotropin (hCG) following ovulation induction with gonadotropins. METHODS: One hundred and thirteen women diagnosed with polycystic ovarian syndrome (PCOS) (as per Rotterdam's criteria) or unexplained infertility, who were treated using gonadotropins for ovulation induction and IUI for increasing fertilization potential, were recruited from the medical records of the infertility clinic...
September 26, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27665028/muscle-development-in-healthy-children-evaluated-by-bioelectrical-impedance-analysis
#9
Tomoka Uchiyama, Takahiro Nakayama, Satoshi Kuru
OBJECTIVES: This study aimed to use bioelectrical impedance analysis (BIA) to generate a new muscle density index (MDI), the MDI_BIA, to evaluate muscle development, and to demonstrate the changes that occur in the BIA-based muscle cross-sectional area index (MCAI_BIA) that accompany growth. We also sought to determine the traceability of chronological changes in the MDI_BIA and MCAI_BIA. METHODS: Healthy children (n=112) aged 8.68±3.16years (0.33-14.00years) underwent bioelectrical impedance (BI) measurements of their upper arms, thighs, and lower legs...
September 21, 2016: Brain & Development
https://www.readbyqxmd.com/read/27648389/isolated-giant-molluscum-contagiosum-mimicking-epidermoid-cyst
#10
Tugba K Uzuncakmak, Burce C Kuru, Ebru I Zemheri, Ilkin Zindanci, Zafer Turkoglu, Mukaddes Kavala
Molluscum contagiosum is a benign cutaneous viral infection which is caused by double- stranded DNA poxvirus. It affects mainly children and young adults and usually presents with single or multiple umblicated papules or nodules on face, arms, legs and anogenital regions. It may present in atypical size and clinical appearance in patients with altered or impaired immunity and rarely in immuncompetent patients. Herein we present an immuncompetent young adult patient with isolated giant molluscum contagiosum, which was mimicking epidermoid cyst clinically...
July 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27640332/a-historical-perspective-simian-aids-an-accidental-windfall
#11
Murray Gardner
BACKGROUND: For the past 30 years, Simian AIDS has provided an indispensible animal model for the human disease. This historical perspective highlights the circumstances leading to the creation of this experimental model. METHODS: Historical information and stored non-human primate (NHP) specimens, including isolates of Simian immunodeficiency virus (SIV), were analyzed by molecular epidemiologic methods to trace the lineage and transmission of SIV among NHPs at US primate centers...
October 2016: Journal of Medical Primatology
https://www.readbyqxmd.com/read/27600487/pedobarographic-and-radiological-analysis-after-treating-a-talus-neck-fracture
#12
Tuğba Kuru Çolak, İlker Çolak, Eren Timurtaş, Güven Bulut, M Gülden Polat
Misalignment of the talar neck after surgical repair can redistribute the load among the posterior, middle, and anterior facets of the subtalar joints, which can change the joint biomechanics, cause arthritis, and impair function. However, we found no studies analyzing the plantar pressures after treatment of talus neck fracture. We determined the dynamic plantar pedobarographic and radiographic characteristics and ankle range of motion, function, and pain among patients after surgical repair of talar neck fractures...
September 2, 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27585242/nuchal-cord-is-it-really-the-silent-risk-of-pregnancy
#13
Hatice Akkaya, Barış Büke, Meryem Kuru Pekcan, Kıvanç Şahin, Gülsüm Uysal, Gülin Feykan Yeğin, Ayşe Filiz Avşar, Fulya Çağlı
OBJECTIVE: To evaluate the relationship between entanglement of umbilical cord around the fetal neck and adverse perinatal outcomes. METHODS: In this prospective cohort study, perinatal outcomes of 218 pregnancies complicated with nuchal cord (NC) (study group) were compared with 190 uncomplicated pregnancies (control group). Main outcome measures were umbilical cord pH values, APGAR scores and cesarean section (C/S) rates. Fetal distress was stated as an abnormal heart rate pattern on electronic fetal heart monitorization...
September 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27547681/which-is-the-best-intrauterine-insemination-timing-choice-following-exogenous-hcg-administration-during-ovulation-induction-by-using-clomiphene-citrate-treatment-a-retrospective-study
#14
Omer Hamid Yumusak, Serkan Kahyaoglu, Meryem Kuru Pekcan, Esra Isci, Şebnem Ozyer, Mahmut Nedim Cicek, Yasemin Tasci, Salim Erkaya
OBJECTIVE: To evaluate the impact of intrauterine insemination timing performed 24 or 36 h later following ovulation trigger on clinical pregnancy rate during ovulation induction with clomiphene citrate among infertile women was the objective of this study. METHODS: The medical records of 280 infertile patients who have underwent ovulation induction by using clomiphene citrate have been evaluated and cycle outcomes of the patients have been investigated specifically based on the timing of intrauterine insemination during the treatment cycle...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27537696/an-enduring-shell-artefact-tradition-from-timor-leste-oliva-bead-production-from-the-pleistocene-to-late-holocene-at-jerimalai-lene-hara-and-matja-kuru-1-and-2
#15
Michelle C Langley, Sue O'Connor
In this paper, we describe 485 Oliva spp. shell beads recovered from four archaeological cave sites Jerimalai, Lene Hara, Matja Kuru 1, and Matja Kuru 2, located in Timor-Leste, Island Southeast Asia. While Pleistocene-aged examples of modified marine shells used for personal ornamentation are common in African and Eurasian assemblages, they are exceedingly rare in Southeast Asia, leading some researchers to suggest that these Modern Human societies were less complex than those found further west. In Timor-Leste, the lowest Oliva bead to be recovered was directly dated to ca...
2016: PloS One
https://www.readbyqxmd.com/read/27529062/prion-diseases-immunotargets-and-therapy
#16
REVIEW
Jennifer T Burchell, Peter K Panegyres
Transmissible spongiform encephathalopathies or prion diseases are a group of neurological disorders characterized by neuronal loss, spongiform degeneration, and activation of astrocytes or microglia. These diseases affect humans and animals with an extremely high prevalence in some species such as deer and elk in North America. Although rare in humans, they result in a devastatingly swift neurological progression with dementia and ataxia. Patients usually die within a year of diagnosis. Prion diseases are familial, sporadic, iatrogenic, or transmissible...
2016: ImmunoTargets and Therapy
https://www.readbyqxmd.com/read/27524671/influence-of-patient-training-on-persistence-compliance-and-tolerability-of-different-dosing-frequency-regimens-of-bisphosphonate-therapy-an-observational-study-in-turkish-patients-with-postmenopausal-osteoporosis
#17
Ülkü Akarırmak, Hikmet Koçyiğit, Nurten Eskiyurt, Sina Esmaeilzadeh, Ömer Kuru, Ebru Yılmaz Yalçinkaya, Özlen Peker, Ayşe Aydemir Ekim, Neşe Özgirgin, Mustafa Çalış, Aylin Rezvani, Alev Çevikol, Sibel Eyigör, Ömer Faruk Şendur, Jale İrdesel
OBJECTIVE: In our study, we aimed to evaluate the influence of training on compliance and persistence with bisphosphonate treatment given on a weekly vs. monthly basis in postmenopausal osteoporosis patients. METHODS: A total of 979 patients with postmenopausal osteoporosis (mean age: 63.2 ± 7.2 years) were included in this national, multicenter, prospective non-interventional observational cohort registry study. Patients were randomized into training (n = 492, 50...
August 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27517514/sorption-and-diffusion-of-selenium-oxyanions-in-granitic-rock
#18
Jussi Ikonen, Mikko Voutilainen, Mervi Söderlund, Lalli Jokelainen, Marja Siitari-Kauppi, Andrew Martin
The processes controlling diffusion and sorption of radionuclides have been studied extensively in the laboratory, whereas, only a few in-situ experiments have been carried out in order to study in-situ diffusion over the long-term (several years). This is largely due to the fact that in-situ experiments are typically time consuming and cost intensive, and it is commonly accepted that laboratory scale tests are well-established approaches to characterizing the properties of geological media. In order to assess the relevance of laboratory experiments, the Swiss National Cooperative for Disposal of Radioactive Waste (Nagra) have been conducting extensive experiments in the Underground Rock Laboratory (URL) at the Grimsel Test Site (GTS) in order to study radionuclide transport and retention in-situ...
September 2016: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/27454770/evaluation-of-an-automated-analysis-tool-for-prostate-cancer-prediction-using-multiparametric-magnetic-resonance-imaging
#19
Matthias C Roethke, Timur H Kuru, Maya B Mueller-Wolf, Erik Agterhuis, Christopher Edler, Markus Hohenfellner, Heinz-Peter Schlemmer, Boris A Hadaschik
OBJECTIVE: To evaluate the diagnostic performance of an automated analysis tool for the assessment of prostate cancer based on multiparametric magnetic resonance imaging (mpMRI) of the prostate. METHODS: A fully automated analysis tool was used for a retrospective analysis of mpMRI sets (T2-weighted, T1-weighted dynamic contrast-enhanced, and diffusion-weighted sequences). The software provided a malignancy prediction value for each image pixel, defined as Malignancy Attention Index (MAI) that can be depicted as a colour map overlay on the original images...
2016: PloS One
https://www.readbyqxmd.com/read/27398585/enhanced-power-conversion-efficiency-of-graphene-silicon-heterojunction-solar-cells-through-nio-induced-doping
#20
Cihan Kuru, Serdar Yavuz, Alireza Kargar, Duyoung Choi, Chulmin Choi, Cyrus Rustomji, Sungho Jin, Prabhakar R Bandaru
We report a doping strategy, where nickel oxide (NiO) nanoparticle film coating is employed for graphene/Si heterojunction solar cells to improve the power conversion efficiency (PCE). NiO doping has been shown to improve the short circuit current (J(SC)) by 12%, open circuit voltage (V(OC)) by 25% and fill factor (FF) by 145% of the cells, in turn increasing the PCE from 1.37% to 4.91%. Furthermore, NiO doped graphene/Si solar cells don't show any significant performance degradation over 10 days revealing that NiO doping can be a promising approach for practical applications of graphene in solar cells...
January 2016: Journal of Nanoscience and Nanotechnology
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