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https://www.readbyqxmd.com/read/28331769/the-main-topics-at-the-oncoplastic-breast-surgery-course-and-expert-panel
#1
Mustafa Emiroğlu, Bekir Kuru, Mehmet Ali Gülçelik, M Kemal Atahan, Atakan Y Sezer, Cem Karaali, Bahadır Güllüoğlu
The Oncoplastic and Reconstructive Breast Surgery course was held in Izmir by the Izmir Breast Diseases Federation in collaboration with the Breast Diseases Federation of Turkey. The techniques of oncoplasty, the application details and experience in this subject were shared. In this text, the main topics and outcomes are briefly summarised. These evaluations can be considered highly valuable on both local and regional scales.
January 2017: J Breast Health (2013)
https://www.readbyqxmd.com/read/28330337/co-generating-synthetic-parts-toward-a-self-replicating-system
#2
Jun Li, Wilhelm Haas, Kirsten Jackson, Erkin Kuru, Michael C Jewett, Z Hugh Fan, Steven P Gygi, George M Church
To build replicating systems with new functions, the engineering of existing biological machineries requires a sensible strategy. Protein synthesis Using Recombinant Elements (PURE) system consists of the desired components for transcription, translation, aminoacylation and energy regeneration. PURE, might be the basis for a radically alterable, lifelike system after optimization. Here, we regenerated 54 E. coli ribosomal (r-) proteins individually from DNA templates in the PURE system. We show that using stable isotope labeling with amino acids, mass spectrometry based quantitative proteomics could detect 26 of the 33 50S and 20 of the 21 30S subunit r-proteins when co-expressed in batch format PURE system...
March 23, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28280581/cultural-factors-that-affected-the-spatial-and-temporal-epidemiology-of-kuru
#3
J T Whitfield, W H Pako, J Collinge, M P Alpers
Kuru is a prion disease which became epidemic among the Fore and surrounding linguistic groups in Papua New Guinea, peaking in the late 1950s. It was transmitted during the transumption (endocannibalism) of dead family members at mortuary feasts. In this study, we aimed to explain the historical spread and the changing epidemiological patterns of kuru by analysing factors that affected its transmission. We also examined what cultural group principally determined a family's behaviour during mortuary rituals...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28209898/treadmilling-by-ftsz-filaments-drives-peptidoglycan-synthesis-and-bacterial-cell-division
#4
Alexandre W Bisson-Filho, Yen-Pang Hsu, Georgia R Squyres, Erkin Kuru, Fabai Wu, Calum Jukes, Yingjie Sun, Cees Dekker, Seamus Holden, Michael S VanNieuwenhze, Yves V Brun, Ethan C Garner
The mechanism by which bacteria divide is not well understood. Cell division is mediated by filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to the division site. To understand how these components coordinate to divide cells, we visualized their movements relative to the dynamics of cell wall synthesis during cytokinesis. We found that the division septum was built at discrete sites that moved around the division plane. FtsAZ filaments treadmilled circumferentially around the division ring and drove the motions of the peptidoglycan-synthesizing enzymes...
February 17, 2017: Science
https://www.readbyqxmd.com/read/28193766/molecular-mechanisms-of-chronic-wasting-disease-prion-propagation
#5
Julie A Moreno, Glenn C Telling
Prion disease epidemics, which have been unpredictable recurrences, are of significant concern for animal and human health. Examples include kuru, once the leading cause of death among the Fore people in Papua New Guinea and caused by mortuary feasting; bovine spongiform encephalopathy (BSE) and its subsequent transmission to humans in the form of variant Creutzfeldt-Jakob disease (vCJD), and repeated examples of large-scale prion disease epidemics in animals caused by contaminated vaccines. The etiology of chronic wasting disease (CWD), a relatively new and burgeoning prion epidemic in deer, elk, and moose (members of the cervid family), is more enigmatic...
February 13, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28110369/neuroradiology-of-human-prion-diseases-diagnosis-and-differential-diagnosis
#6
REVIEW
Simona Gaudino, Emma Gangemi, Raffaella Colantonio, Annibale Botto, Emanuela Ruberto, Rosalinda Calandrelli, Matia Martucci, Maria Gabriella Vita, Carlo Masullo, Alfonso Cerase, Cesare Colosimo
Human transmissible spongiform encephalopathies (TSEs), or prion diseases, are invariably fatal conditions associated with a range of clinical presentations. TSEs are classified as sporadic [e.g. sporadic Creutzfeldt-Jakob disease (sCJD), which is the most frequent form], genetic (e.g. Gerstmann-Straussler-Scheinker disease, fatal familial insomnia, and inherited CJD), and acquired or infectious (e.g. Kuru, iatrogenic CJD, and variant CJD). In the past, brain imaging played a supporting role in the diagnosis of TSEs, whereas nowadays magnetic resonance imaging (MRI) plays such a prominent role that MRI findings have been included in the diagnostic criteria for sCJD...
January 21, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28088271/adamts-3-13-16-and-19-levels-in-patients-with-habitual-abortion
#7
Meryem Kuru Pekcan, Esma Sarıkaya, Aytekin Tokmak, Murat Alışık, Afra Alkan, Gülnur Özakşit, Özcan Erel
A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function. The aim of this study was to investigate serum ADAMTS-3, -13, -16, and -19 levels in women with habitual abortions compared with those in healthy controls. A total of 86 women were enrolled in this prospective case-control study. ADAMTS-3, -13, -16, and -19 values were recorded and analyzed in association with demographic and clinical parameters...
January 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28078435/the-effects-of-therapeutic-exercises-on-pain-muscle-strength-functional-capacity-balance-and-hemodynamic-parameters-in-knee-osteoarthritis-patients-a-randomized-controlled-study-of-supervised-versus-home-exercises
#8
Tuğba Kuru Çolak, Bahar Kavlak, Onur Aydoğdu, Emir Şahin, Gönül Acar, İlkşan Demirbüken, Zübeyir Sarı, İlker Çolak, Güven Bulut, M Gülden Polat
The aim of the study was to compare the effects of low-intensity exercise programs for lower extremities, either supervised or at home, on pain, muscle strength, balance and the hemodynamic parameters of knee osteoarthritis (OA) patients. This randomized study included 78 patients with knee OA in 2 groups of supervised and home-based exercise program. Exercises were applied to the first group in the clinic as a group exercise program and were demonstrated to the second group to be performed at home. Before and after the 6-week exercise program, assessment was made of pain, quadriceps and hamstring muscle strengths, 6-min walk test (6MWT), and non-invasive hemodynamic parameters...
March 2017: Rheumatology International
https://www.readbyqxmd.com/read/28049644/functional-prions-in-the-brain
#9
REVIEW
Joseph B Rayman, Eric R Kandel
Prions are proteins that can adopt self-perpetuating conformations and are traditionally regarded as etiological agents of infectious neurodegenerative diseases in humans, such as Creutzfeldt-Jakob disease, kuru, and transmissible encephalopathies. More recently, a growing consensus has emerged that prion-like, self-templating mechanisms also underlie a variety of neurodegenerative disorders, including amyotrophic lateral sclerosis, Alzheimer's disease, and Huntington's disease. Perhaps most surprising, not all prion-like aggregates are associated with pathological changes...
January 3, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28042411/clomiphene-citrate-treatment-cycle-outcomes-of-polycystic-ovary-syndrome-patients-based-on-basal-high-sensitive-c-reactive-protein-levels-a-cross-sectional-study
#10
Serkan Kahyaoglu, Omer Hamid Yumuşak, Sebnem Ozyer, Meryem Kuru Pekcan, Merve Erel, Mahmut Nedim Cicek, Salim Erkaya, Yasemin Tasci
BACKGROUND: Polycystic ovary syndrome (PCOS) is highly associated with an ovulatory infertility, features of the metabolic syndrome, including obesity, insulin resistance and dyslipidemia. Serum concentrations of high sensitive C-reactive protein (hs-CRP) were significantly higher in obese than in non-obese PCOS patients at baseline, suggesting a relationship between elevated hs-CRP levels and obesity. The aim of this study was to evaluate whether cycle day 3 hs-CRP levels before clomiphene citrate (CC) treatment would predict cycle outcomes in women with PCOS...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28039730/erratum-factors-predicting-non-sentinel-lymph-node-metastasis-in-t1-2-invasive-breast-cancer-with-1-2-axillary-sentinel-lymph-node-metastases-presentation-of-ondokuz-mayis-scoring-system
#11
Bekir Kuru, Yurdanur Sullu, Savas Yuruker, Ilkay Koray Bayrak, Necati Ozen
In this article published in Volume 21, issue 5, the Results section of the Pubmed abstract appeared as: "There were 68 (33%) and 108 (52%) patients with a the score of ? 4 (predicted probability of ?10%) with a false negative rate (FNR% of 4.4%, and ?5 (predicted probability of ?15%) with a FNR of 7.4%, respectively. The area under the curve (AUC) value for the Ondokuz Mayis scoring system was 0.88 (95% CI 0.83-0.93%)." The correct Results section of the abstract is: "There were 68 (33%) and 108 (52%) patients with a the score of ≤4 (predicted probability of ≤10%) with a false negative rate (FNR) of 4...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28035911/low-back-pain-during-pregnancy-and-kinesio-tape-application
#12
Aycan Çakmak Reyhan, Elif Elçin Dereli, Tuğba Kuru Çolak
BACKGROUND AND OBJECTIVE: Low back pain is a common problem during pregnancy. Although the pain usually occurs in the third trimester, it might be seen in the first trimester, too. There are various types of applications for the treatment of low back pain during pregnancy. However, there is a lack of evidence for the effectiveness of each method. If there is not an obvious deficit, bed rest, exercise, conventional physiotherapy, using protective principles for the lumbar area are recommended, since the main and the only complaint is low back pain...
December 23, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28030514/the-effect-of-vitamin-d-supplementation-on-pain-quality-of-life-and-nerve-conduction-studies-in-women-with-chronic-widespread-pain
#13
Gulseren Akyuz, Canan Sanal-Toprak, Ilker Yagci, Esra Giray, Pinar Kuru-Bektasoglu
The aim of this study was to investigate the effects of vitamin D supplementation on pain, quality of life, and nerve conduction studies (NCSs) in women with chronic widespread pain (CWP) diagnosed with Vitamin D insufficiency. Thirty-three female participants with CWP and vitamin D insufficiency were included in this open-label trial. They were evaluated by routine NCSs in upper and lower limbs, pain scales, and the Nottingham Health Profile before and 8 weeks after starting vitamin D supplementation therapy...
December 27, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28028952/mastalgia-due-to-degenerative-changes-of-the-spine
#14
Okay Pirti, Aziz M Barlas, Serdar Kuru, Selim Temel, Mustafa K Urhan, Kemal Kismet, Adnan Hasanoglu, Osman Guler
BACKGROUND: Mastalgia is a common and enigmatic condition; the cause and optimal treatment are still inadequately defined. Cervical radiculopathy, which is the result of cervical nerve root pathology often caused by spaceoccupying lesions such as cervical disc herniation, spondylosis, or osteophytosis, is frequently encountered in physical therapy. OBJECTIVES: The aim of the study was to evaluate the incidence of vertebral pathologies in patients with non-cyclic mastalgia and the efficacy of conservative treatment of these pathologies on relieving breast pain...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28017374/biallelic-mutations-in-mypn-encoding-myopalladin-are-associated-with-childhood-onset-slowly-progressive-nemaline-myopathy
#15
Satoko Miyatake, Satomi Mitsuhashi, Yukiko K Hayashi, Enkhsaikhan Purevjav, Atsuko Nishikawa, Eriko Koshimizu, Mikiya Suzuki, Kana Yatabe, Yuzo Tanaka, Katsuhisa Ogata, Satoshi Kuru, Masaaki Shiina, Yoshinori Tsurusaki, Mitsuko Nakashima, Takeshi Mizuguchi, Noriko Miyake, Hirotomo Saitsu, Kazuhiro Ogata, Mitsuru Kawai, Jeffrey Towbin, Ikuya Nonaka, Ichizo Nishino, Naomichi Matsumoto
Nemaline myopathy (NM) is a common form of congenital nondystrophic skeletal muscle disease characterized by muscular weakness of proximal dominance, hypotonia, and respiratory insufficiency but typically not cardiac dysfunction. Wide variation in severity has been reported. Intranuclear rod myopathy is a subtype of NM in which rod-like bodies are seen in the nucleus, and it often manifests as a severe phenotype. Although ten mutant genes are currently known to be associated with NM, only ACTA1 is associated with intranuclear rod myopathy...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28003112/study-of-duchenne-muscular-dystrophy-long-term-survivors-aged-40-years-and-older-living-in-specialized-institutions-in-japan
#16
Toshio Saito, Mitsuru Kawai, En Kimura, Katsuhisa Ogata, Toshiaki Takahashi, Michio Kobayashi, Hiroto Takada, Satoshi Kuru, Takashi Mikata, Tsuyoshi Matsumura, Naohiro Yonemoto, Harutoshi Fujimura, Saburo Sakoda
The national muscular dystrophy wards database of Japan lists 118 long-term Duchenne muscular dystrophy (DMD) patients who were at least 40 years old as of October 1, 2013. To elucidate the clinical features of DMD patients aged 40 years and older, we obtained gene analysis and muscle biopsy findings, as well as medical condition information. Ninety-four of the registered patients consented to participate, of whom 55 meeting genetic or biochemical criteria confirming DMD were analyzed. The mean age at the time of the study was 43...
November 25, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27982486/the-effect-of-laughter-therapy-on-the-quality-of-life-of-nursing-home-residents
#17
Nilgun Kuru, Gulumser Kublay
AIMS AND OBJECTIVES: To evaluate the effect of Laughter therapy on the quality of life of nursing home residents. BACKGROUND: By improving the quality of life of residents living in nursing homes and allowing them to have a healthier existence, their lives can be extended. Therefore, interventions impacting the quality of life of older adults are of critical importance. DESIGN: Quasi-experimental design. METHOD: The study was conducted between 2 March - 25 May 2015...
December 16, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27956775/relationship-between-hepcidin-and-oxidant-antioxidant-status-in-calves-with-suspected-neonatal-septicemia
#18
E E Erkilic, H M Erdogan, M Ogun, A H Kirmizigul, E Gokce, M Kuru, A Kukurt
AIM: This study has been conducted for the purpose of determining serum hepcidin, total antioxidant status (TAS), total oxidant status (TOS), and Fe levels in calves with suspected neonatal septicemia before and after treatment and the clinical significance of hepcidin in calves with suspected neonatal septicemia. MATERIALS AND METHODS: The study material consisted of 15 calves of different ages and sexes brought to the Training, Research and Application Center at the Kafkas University Faculty of Veterinary Medicine with suspected neonatal septicemia...
November 2016: Veterinary World
https://www.readbyqxmd.com/read/27956511/experimental-and-numerical-study-of-drill-bit-drop-tests-on-kuru-granite
#19
Marion Fourmeau, Alexandre Kane, Mikko Hokka
This paper presents an experimental and numerical study of Kuru grey granite impacted with a seven-buttons drill bit mounted on an instrumented drop test machine. The force versus displacement curves during the impact, so-called bit-rock interaction (BRI) curves, were obtained using strain gauge measurements for two levels of impact energy. Moreover, the volume of removed rock after each drop test was evaluated by stereo-lithography (three-dimensional surface reconstruction). A modified version of the Holmquist-Johnson-Cook (MHJC) material model was calibrated using Kuru granite test results available from the literature...
January 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27908842/role-of-versican-and-adamts-1-in-polycystic-ovary-syndrome
#20
Sibel Özler, Efser Öztaş, Aytekin Tokmak, Merve Ergin, Meryem Kuru Pekcan, Başak Gümüş Güler, Halil İbrahim Yakut, Nafiye Yılmaz
OBJECTIVE: ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex under the effect of luteinizing hormone surge in the periovulatory period. Altered levels may have a role in the pathogenesis of polycystic ovary syndrome (PCOS). We aimed to determine the serum versican and ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) levels in PCOS patients and compare the results with healthy controls. METHODS: Thirty-eight patients with PCOS and forty healthy controls aged between 15 and 22 years were included in the study...
March 1, 2017: Journal of Clinical Research in Pediatric Endocrinology
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