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https://www.readbyqxmd.com/read/29779118/change-in-kidney-function-after-unilateral-adrenalectomy-in-patients-with-primary-aldosteronism-identification-of-risk-factors-for-decreased-kidney-function
#1
Il Young Kim, In Seong Park, Min Jeong Kim, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Sang Heon Song, Hyun Chul Chung
PURPOSE: Glomerular filtration rate (GFR) has been reported to decrease after unilateral adrenalectomy in patients with primary aldosteronism (PA). The aim of this study was to identify clinical predictors for decreased GFR after adrenalectomy in patients with PA. METHODS: The records of 187 patients (98 patients with PA and 89 with non-PA adrenal disease) who were followed up for at least 6 months after unilateral adrenalectomy were retrospectively analyzed. Estimated GFR (eGFR) was investigated at 1, 3, and 6 months postoperatively...
May 19, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29778957/how-can-we-value-an-environmental-asset-that-very-few-have-visited-or-heard-of-lessons-learned-from-applying-contingent-and-inferred-valuation-in-an-australian-wetlands-case-study
#2
Daniel Gregg, Sarah Ann Wheeler
To date, the majority of environmental assets studied in the economic valuation literature clearly have high amenity and recreational use values. However there are many cases where small, but nevertheless unique and important, ecosystems survive as islands amongst large areas of modified, productive, or urban, landscapes. Development encroaches on the landscape and as urban landscapes become more concentrated these types of conservation islands will become increasingly more important. Previous experience with economic valuation suggests that lower total values for smaller contributions to conservation are more liable to be swamped by survey and hypothetical bias measures...
May 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29777497/assessing-the-external-benefits-of-contaminated-soil-remediation-in-korea-a-choice-experiment-study
#3
Seul-Ye Lim, Hyo-Jin Kim, Seung-Hoon Yoo
Korean government has made and will continue to make a considerable investment in contaminated soil remediation to rectify the problems that arise from soil pollution. Quantitative information on the benefits of contaminated soil remediation is widely demanded by the public as well as the government. This article aims to assess the external benefits of contaminated soil remediation. A survey of 1000 randomly selected households was undertaken in Korea. The results show that the marginal willingness to pay values for a 1% decrease in human health hazard, a 1% improvement in biodiversity restoration, and 1000 new job creation by contaminated soil remediation are estimated to be KRW 204 (USD 0...
May 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29771566/the-evil-of-banality-when-choosing-between-the-mundane-feels-like-choosing-between-the-worst
#4
Amitai Shenhav, Carolyn K Dean Wolf, Uma R Karmarkar
Our most important decisions often provoke the greatest anxiety, whether we seek the better of two prizes or the lesser of two evils. Yet many of our choices are more mundane, such as selecting from a slate of mediocre but acceptable restaurants. Previous research suggests that choices of decreasing value should provoke decreasing anxiety. Here we show that this is not the case. Across three behavioral studies and one fMRI study, we find that anxiety and its neural correlates demonstrate a U-shaped function of choice set value, greatest when choosing between both the highest value and lowest value sets...
May 17, 2018: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/29770662/-construction-and-expression-of-multi-gene-recombinant-plasmid-peg-fp-n1-hbsag-rop2
#5
Ma Rong, Xiao Ting, Li Jin, Sun Hui, Xu Chao, Huang Bing-Cheng, Yin Kun, Zhao Gui-Hua, Cui Yong, Zhu Song, Liu Gong-Zhen, Yan Ge, Wei Qing-Kuan
OBJECTIVE: To construct pEGFP-N1-HBsAg-ROP2 recombinant expression plasmid and transfect HEK293T cells for expression, and pay a way for Toxoplasma gondii nucleic acid vaccine development. METHODS: According to the HBsAg gene sequence and pcDNA3-p30-ROP2 recombinant plasmid restriction sites, the HBsAg gene was amplified by PCR. The HBsAg gene was cloned into the pcDNA3-p30-ROP2 and instead of p30 gene. The HBsAg-ROP2 fragment was amplified by PCR and digested with Hind Ⅲ and Kpn Ⅰ to clone into the pEGFP-N1 eukaryotic expression vector and construct the recombinant pEGFP-N1-HBsAg-ROP2...
March 14, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29765775/potential-impact-of-introducing-the-pneumococcal-conjugate-vaccine-into-national-immunisation-programmes-an-economic-epidemiological-analysis-using-data-from-india
#6
Itamar Megiddo, Eili Klein, Ramanan Laxminarayan
Pneumococcal pneumonia causes an estimated 105 000 child deaths in India annually. The planned introduction of the serotype-based pneumococcal conjugate vaccine (PCV) is expected to avert child deaths, but the high cost of PCV relative to current vaccines provided under the Universal Immunization Programme has been a concern. Cost-effectiveness studies from high-income countries are not readily comparable because of differences in the distribution of prevalent serotypes, population and health systems. We extended IndiaSim, our agent-based simulation model representative of the Indian population and health system, to model the dynamics of Streptococcus pneumoniae ...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29764166/chimeric-antigen-receptor-t-cells-a-savior-with-a-high-price
#7
Gilberto de Lima Lopes, George R Nahas
Chimeric antigen receptor (CAR) T cells represent a medical and scientific breakthrough that may represent a paradigm for the future of personalized medicine in the age of cancer immunotherapy. As with many new cancer agents, such novel and incredible results come with a high price. At the time of the writing of this article, there are two CAR T cells available, Kymriah, produced by Novrtis with a price tag of US$475,000 and Yescarta produced by Gilead Pharmaceuticals with a price tag of US$373,000, neither price including the required hospital admission in order to administer the agent in addition to potential treatment of side effects...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29761255/considering-axiological-integrity-a-methodological-analysis-of-qualitative-evidence-syntheses-and-its-implications-for-health-professions-education
#8
REVIEW
Martina Kelly, Rachel H Ellaway, Helen Reid, Heather Ganshorn, Sarah Yardley, Deirdre Bennett, Tim Dornan
Qualitative evidence synthesis (QES) is a suite of methodologies that combine qualitative techniques with the synthesis of qualitative knowledge. They are particularly suited to medical education as these approaches pool findings from original qualitative studies, whilst paying attention to context and theoretical development. Although increasingly sophisticated use is being made of qualitative primary research methodologies in health professions education (HPE) the use of secondary qualitative reviews in HPE remains underdeveloped...
May 14, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29758417/exploring-the-value-of-overseas-biodiversity-to-chinese-netizens-based-on-willingness-to-pay-for-the-african-elephants-protection
#9
Zhengzao Wang, Yazhen Gong, Xianqiang Mao
For a long time, Chinese people have been considered to be concerned only with commercial interests but not ecological systems and biodiversity conservation, even though their trade and investment footprints are globalizing rapidly. This study intended to reveal the non-market valuation on the non-use value of African elephant to Chinese people. Taking the ban of ivory trade as the background, in this study, Chinese netizens' willingness to pay for African elephant conservation was investigated using the contingent valuation method...
May 10, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29754389/cost-effectiveness-of-forced-air-warming-during-sedation-in-the-cardiac-catheterisation-laboratory
#10
Aaron Conway, Jed Duff, Joanna Sutherland
AIM: To determine the cost-effectiveness of forced air warming during sedation in a cardiac catheterisation laboratory. BACKGROUND: Forced air warming improves thermal comfort in comparison with standard care. It is not known whether the extra costs required for forced air warming are good value. DESIGN: Cost-effectiveness analysis alongside a randomised controlled trial conducted in 2016-2017. METHODS: A cost-effectiveness analysis was undertaken using Monte Carlo simulations from input distributions to estimate costs and effects associated with using forced air warming to reduce risk of thermal discomfort for patients receiving sedation in a cardiac catheterisation laboratory...
May 13, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29754114/the-value-of-continuing-professional-development-a-realistic-evaluation-of-a-multi-disciplinary-workshop-for-health-visitors-dealing-with-children-with-complex-needs
#11
Alison Steven, Valerie Larkin, Jane Stewart, Belinda Bateman
BACKGROUND: Continuing Professional Development is important for maintaining and developing knowledge and skills. Evidence regarding direct impact on practice is limited. Existing literature often lacks sufficient detail regarding the initiative or its evaluation, making transferability problematic. OBJECTIVE: To explore the impact and perceived value of multi-disciplinary Continuing Professional Development workshops for Health Visitors who support families with children with complex health needs...
April 21, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29753361/mothers-preferences-and-willingness-to-pay-for-human-papillomavirus-vaccination-for-their-daughters-a-discrete-choice-experiment-in-hong-kong
#12
Carlos K H Wong, Kenneth K C Man, Patrick Ip, Mike Kwan, Sarah M McGhee
OBJECTIVES: To determine the preference of mothers in Hong Kong and their willingness to pay (WTP) for human papillomavirus (HPV) vaccination for their daughters. METHOD: A discrete choice experiment survey with a two-alternative study design was developed. Data were collected from pediatric specialist outpatient clinics from 482 mothers with daughters aged between 8 and 17 years. Preferences of the four attributes of HPV vaccines (protection against cervical cancer, protection duration, side effects, and out-of-pocket costs) were evaluated...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29753352/patient-access-to-medicines-for-rare-diseases-in-european-countries
#13
Andreja Detiček, Igor Locatelli, Mitja Kos
BACKGROUND: The number of authorized orphan and non-orphan medicines for rare diseases has increased in Europe. Patient access to these medicines is affected by high costs, weak efficacy/safety evidence, and societal value. European health care systems must determine whether paying for expensive treatments for only a few patients is sustainable. OBJECTIVES: This study aimed to evaluate patient access to orphan and non-orphan medicines for rare diseases in 22 European countries during 2005 to 2014...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29753295/major-depressive-disorder-in-epilepsy-clinics-a-meta-analysis
#14
REVIEW
Minjung Kim, Young-Soo Kim, Do-Hyung Kim, Tae-Won Yang, Oh-Young Kwon
BACKGROUND AND PURPOSE: Although depression is a frequent psychiatric comorbidity in people with epilepsy (PWE), its prevalence has been underestimated. Comorbid depression has negative impacts on treatment outcomes and quality of life (QOL). It also causes various problems in PWE, such as fatigue, irritability, and suicidality. This meta-analysis was performed to estimate the frequency of major depression disorder (MDD) in clinics managing PWE. METHODS: We searched MEDLINE, EMBASE, Cochrane Library, Web of Science, and SCOPUS to identify studies...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29742475/valuing-the-visual-impact-of-wind-farms-a-calculus-method-for-synthesizing-choice-experiments-studies
#15
REVIEW
Cheng Wen, Martin Dallimer, Steve Carver, Guy Ziv
Despite the great potential of mitigating carbon emission, development of wind farms is often opposed by local communities due to the visual impact on landscape. A growing number of studies have applied nonmarket valuation methods like Choice Experiments (CE) to value the visual impact by eliciting respondents' willingness to pay (WTP) or willingness to accept (WTA) for hypothetical wind farms through survey questions. Several meta-analyses have been found in the literature to synthesize results from different valuation studies, but they have various limitations related to the use of the prevailing multivariate meta-regression analysis...
May 6, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29740804/colorectal-cancer-screening-preferences-past-behavior-and-future-intentions
#16
Carol Mansfield, Donatus U Ekwueme, Florence K L Tangka, Derek S Brown, Judith Lee Smith, Gery P Guy, Chunyu Li, Brett Hauber
BACKGROUND: Screening rates for colorectal cancer are below the Healthy People 2020 goal. There are several colorectal cancer screening tests that differ in terms of accuracy, recommended frequency, and administration. In this article, we compare how a set of personal characteristics correlates with preferences for colorectal cancer screening test attributes, past colorectal cancer screening behavior, and future colorectal cancer screening intentions. METHODS: We conducted a discrete-choice experiment survey to assess relative preferences for attributes of colorectal cancer screening tests among adults aged 50-75 years in USA...
May 9, 2018: Patient
https://www.readbyqxmd.com/read/29734609/promoting-biodiversity-values-of-small-forest-patches-in-agricultural-landscapes-ecological-drivers-and-social-demand
#17
Elsa Varela, Kris Verheyen, Alicia Valdés, Mario Soliño, Jette B Jacobsen, Pallieter De Smedt, Steffen Ehrmann, Stefanie Gärtner, Elena Górriz, Guillaume Decocq
Small forest patches embedded in agricultural (and peri-urban) landscapes in Western Europe play a key role for biodiversity conservation with a recognized capacity of delivering a wide suite of ecosystem services. Measures aimed to preserve these patches should be both socially desirable and ecologically effective. This study presents a joint ecologic and economic assessment conducted on small forest patches in Flanders (Belgium) and Picardie (N France). In each study region, two contrasted types of agricultural landscapes were selected...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29727313/nivolumab-in-the-treatment-of-metastatic-renal-cell-carcinoma-a-cost-utility-analysis
#18
Jacques Raphael, Zhuolu Sun, Georg A Bjarnason, Joelle Helou, Beate Sander, David M Naimark
INTRODUCTION: Nivolumab improves overall survival and health-related quality of life compared with everolimus in metastatic renal cell carcinoma (mRCC). This study assesses the cost-utility of nivolumab from the Canadian health care payer perspective. MATERIALS AND METHODS: To evaluate the cost-utility of nivolumab, a Markov cohort model that incorporated data from the phase 3 CheckMate-025 trial and other sources was developed. The incremental cost per quality-adjusted life month (QALM) gained for nivolumab was calculated...
May 4, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29722245/-a-diachronic-study-on-resettlers-perceptions-toward-ecological-relocation-in-world-heritage-site-a-case-study-of-wulingyuan-scenic-area-china
#19
Kai Wang, Qin Chang Chen, Zhi Miao Li
Perceptions of residents in ecological resettlement area are important for evaluating the implementation effect of ecological relocation and sustainable development of world heritage site. With the residents from three different resettlement communities in Wulingyuan Scenic Area as the research object, we carried out a diachronic study on changes of the resettlers' perceptions of ecological relocation at different times and the main driving factors based on systematic survey data in 2010 and 2016. The results showed that in the year 2010 and 2016, resettlers reacted negatively to the indicators such as "enhancement of employment opportunity", "improvement of education and training opportunity", "enhanced environment in scenic area", "recognizing the identity change 'from rural to non-rural' after relocation"...
March 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29714597/youth-experience-with-community-pharmacy-services-and-their-perceptions-toward-implementation-of-medication-therapy-management-services-by-community-pharmacists-in-the-western-region-of-saudi-arabia
#20
Mahmoud S Alhaddad
BACKGROUND: Pharmacists are the part of the health care team who can counsel patients on the most appropriate use of medications. This study aims to measure patients' experience with services provided by community pharmacists and their perceptions toward providing medication therapy management (MTM) services by community pharmacists in the Western Region of Saudi Arabia. In addition, this study aims to measure patients' willingness to pay (WTP) for participating in the MTM program led by community pharmacists...
January 1, 2018: Therapeutic Innovation & Regulatory Science
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